Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging (Unbekannt)
- Neue Suche nach: Dempsey, Graham T.
- Neue Suche nach: Chaudhary, Khuram W.
- Neue Suche nach: Atwater, Nicholas
- Neue Suche nach: Nguyen, Cuong
- Neue Suche nach: Brown, Barry S.
- Neue Suche nach: McNeish, John D.
- Neue Suche nach: Cohen, Adam E.
- Neue Suche nach: Kralj, Joel M.
- Neue Suche nach: Dempsey, Graham T.
- Neue Suche nach: Chaudhary, Khuram W.
- Neue Suche nach: Atwater, Nicholas
- Neue Suche nach: Nguyen, Cuong
- Neue Suche nach: Brown, Barry S.
- Neue Suche nach: McNeish, John D.
- Neue Suche nach: Cohen, Adam E.
- Neue Suche nach: Kralj, Joel M.
In:
Journal of pharmacological and toxicological methods
;
81
;
240-250
;
2016
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ISSN:
- Aufsatz (Zeitschrift) / Print
-
Titel:Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging
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Beteiligte:Dempsey, Graham T. ( Autor:in ) / Chaudhary, Khuram W. ( Autor:in ) / Atwater, Nicholas ( Autor:in ) / Nguyen, Cuong ( Autor:in ) / Brown, Barry S. ( Autor:in ) / McNeish, John D. ( Autor:in ) / Cohen, Adam E. ( Autor:in ) / Kralj, Joel M. ( Autor:in )
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Erschienen in:Journal of pharmacological and toxicological methods ; 81 ; 240-250
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Verlag:
- Neue Suche nach: Elsevier Science B.V., Amsterdam.
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Erscheinungsdatum:01.01.2016
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Format / Umfang:11 pages
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ISSN:
-
Medientyp:Aufsatz (Zeitschrift)
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Format:Print
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Sprache:Unbekannt
- Neue Suche nach: 615.9
- Weitere Informationen zu Dewey Decimal Classification
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Klassifikation:
DDC: 615.9 -
Datenquelle:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Inhaltsverzeichnis – Band 81
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Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.
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- 15
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The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progressColatsky, Thomas / Fermini, Bernard / Gintant, Gary / Pierson, Jennifer B. / Sager, Philip / Sekino, Yuko / Strauss, David G. / Stockbridge, Norman et al. | 2016
- 21
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Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementationCavero, Icilio / Guillon, Jean-Michel / Ballet, Veronique / Clements, Mike / Gerbeau, Jean-Frédéric / Holzgrefe, Henry et al. | 2016
- 37
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The emerging role of in vitro electrophysiological methods in CNS safety pharmacologyAccardi, Michael V. / Pugsley, Michael K. / Forster, Roy / Troncy, Eric / Huang, Hai / Authier, Simon et al. | 2016
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Human ex-vivo action potential model for pro-arrhythmia risk assessmentPage, Guy / Ratchada, Phachareeya / Miron, Yannick / Steiner, Guido / Ghetti, Andre / Miller, Paul E. / Reynolds, Jack A. / Wang, Ken / Greiter-Wilke, Andrea / Polonchuk, Liudmila et al. | 2016
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Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessmentZhang, X. / Guo, L. / Zeng, H. / White, S. L. / Furniss, M. / Balasubramanian, B. / Lis, E. / Lagrutta, A. / Sannajust, F. / Zhao, L. L. et al. | 2016
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- 223
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- 233
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- 240
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Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imagingDempsey, Graham T. / Chaudhary, Khuram W. / Atwater, Nicholas / Nguyen, Cuong / Brown, Barry S. / McNeish, John D. / Cohen, Adam E. / Kralj, Joel M. et al. | 2016
- 251
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- 335
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- 335
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- 341
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Inducible CaV1.2 cell line optimized for automated patch clamp assaysDanker, Timm / Frey, Manfred / Guenther, Elke et al. | 2016
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Cardiac safety assessment of drugs using three-dimensional heart simulatorOkada, J. i. / Yoshinaga, T. / Kurokawa, J. / Washio, T. / Furukawa, T. / Sawada, K. / Sugiura, S. / Hisada, T. et al. | 2016
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Towards unravelling the mechanism of cardiotoxicity of citalopram: Utilisation of mechanistic cardiac electrophysiology modelling with the Simcyp cardiac safety simulator (CSS) to explore various hypothesesPatel, N. / Jamei, M. / Polak, S. et al. | 2016
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Zero-magnesium model of seizure like events and anticonvulsant potential of SK-channel agonists in vitroRaza, Muhammad Liaquat / Heinemann, Uwe et al. | 2016
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Can late sodium current inhibition attenuate QT prolonging effects caused by hERG blockers in in silico modelsRohrbacher, Jutta / Damiano, Bruce P. / Teisman, Ard / Gallacher, David J. et al. | 2016
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A holistic approach to the safety assessment of exploratory drug targetsVenhorst, Jennifer / Rankouhi, Tanja Rouhani / Verschuren, Lars / van Someren, Eugene P. / Kuper, Frieke C. / Wolterbeek, Andre P.M. / van de Brug, Fred J. / Folkertsma, Simon / Krul, Cyrille A.M. et al. | 2016
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A heart compartmental model for the prediction of cardiac amitriptyline concentrationTylutki, Zofia / Jornil, Jakob / Polak, Sebastian et al. | 2016
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Prediction of clinical risks by analysis of preclinical and clinical adverse eventsClark, M. et al. | 2016
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Identifying site-specific molecular signatures for sub-acute drug induced kidney injurySnelling, Sara / Dremier, Sarah / De Ron, Pierrette / Glineur, Stephanie / Da Costa, André et al. | 2016
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Systems Pharmacology based approach utilized for prediction of the cardiac consequences of drug–drug interactionsWiśniowska, Barbara / Badyra, Bogna / Lisowski, Bartosz / Polak, Sebastian et al. | 2016
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Recent cardiac ion channel data helped to better understand the QT prolongation/Torsades de Pointes risk of hydroxyzine (Atarax®), a first generation antihistamineDelaunois, A. / Colomar, A. / Peters, C. / Schlit, A. F. / Valentin, J. P. et al. | 2016
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Myocardial electrotonic coupling modulates repolarization heterogeneities in vivo: Implications for the assessment of pro-arrhythmic liabilities in vitro and in silicodel Rio, Carlos / Hamlin, Robert / Billman, George et al. | 2016
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Off-target cardiac Na-channel inhibition in preclinical and clinical development—A case studyDeurinck, M. / Pruimboom, I. / Ju, H. / Dumotier, B. / Traebert, M. et al. | 2016
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Inter-study variability and translational value of preclinical exposure-QTc predictions—A pharmacokinetic/pharmacodynamic (PK/PD) meta-analysisGotta, Verena / Cools, Frank / van Ammel, Karel / Gallacher, David J. / Visser, Sandra A.G. / Sannajust, Frederic / Morissette, Pierre / Danhof, Meindert / van der Graaf, Piet H. et al. | 2016
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Bayesian-hierarchical pharmacokinetic/pharmacodynamic (PK/PD) model to characterize the exposure-QT effect relationship for decision making in early drug developmentDubois, Vincent F.S. / Boulton, Muriel / Bursi, Roberta et al. | 2016
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Translational prediction of sensitivity to hERG-mediated QTc-prolongation using a systems pharmacology modelGotta, V. / Cools, F. / van Ammel, K. / Gallacher, D. J. / Visser, S. A. / Sannajust, F. / Morissette, P. / Danhof, M. / van der Graaf, P. H. et al. | 2016
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Proactively developing assay schemes based on an understanding of the goal of testing and the nature of the safety endpointLeishman, Derek et al. | 2016
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Comparison of binding and functional data on a set of safety-related GPCRsJolas, T. / Migeon, J. / Fouchaq, B. et al. | 2016
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Mechanistic investigation into a delayed onset QTc prolongationGray, K. / Pointon, A. / Rose, A. / Philp, K. / Moors, J. / Skinner, M. / Bridgland-Taylor, M. / Harmer, A. et al. | 2016
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The non-invasive translational biomarker — Index of cardiac electrophysiological balance (iCEB) predicts potential risk of cardiac arrhythmias in preclinical models and in patients: Superior to current biomarkers such as QT?Lu, Hua Rong / Robyns, Tomas / Nuyens, Dieter / Janssens, Stefan / Yan, Gan-Xin / Teisman, Ard / Gallacher, David J. et al. | 2016
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Translation to human: Not just a simple correlation exercise between preclinical and clinical data: A qualitative/semi-quantitative analysisLoenders, Brigitte / Van Ammel, Karel / Gallacher, David J. et al. | 2016
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Applying probabilistic 'weight-of-evidence' assessments to diverse safety endpointsLeishman, Derek et al. | 2016
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Dual inhibition of VEGF and DLL4 ameliorates anti-DLL4 cardiac endothelial hypertrophy in cynomolgus monkeysMeisner, Rene / Argast, Gretchen / Liu, Yu-Wang / Wallace, Breanna / Wang, Min / Kapoun, Ann / Hoey, Tim et al. | 2016
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Patient-specific QT risk assessment: Case study of an oncology agent and an anti-emeticPollard, C. / Philp, K. / Easter, A. / Moors, J. / Prior, H. et al. | 2016
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Biomarkers of hypercoagulability in a rat sepsis-induced model of non-overt disseminated intravascular coagulation (DIC)Brooks, M.B. / Turk, J.R. / Fishman, C.E. / Besteman, E.G. / Wilson, D.W. / Schultze, A.E. / Pierson, J.B. / Parish, S. / Pugsley, M.K. et al. | 2016
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An in silico PBPK-PD coupled approach to assess zolpidem effect on pre-clinically and clinically measured cardiac repolarisation parameters in the absence and presence of a circadian model of plasma ion concentrationSmall, B. G. / Jamei, M. / Rostami-Hodjegan, A. / Polak, S. et al. | 2016
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Incorporation of safety pharmacology endpoints in toxicology studies in monkeysQu, L. / Wu, R. / McPherson, S. / Jin, Y. et al. | 2016
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Assessment of cardiac biomarkers in patients undergoing coronary artery bypass grafting (CABG) surgerySabah, E. / Kamal, A. / Al-Saffar, A. et al. | 2016
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Left ventricular pressure may improve predictivity of preclinical cardiovascular assays to clinical outcomesRoche, B. / Brandon Borders, R. / Appleby, C. / Kieper, J. / Landis, K. / Kearney, K. / Adkins, J. / Vidmar, T. / Atterson, P. et al. | 2016
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Translation: Lessons learned of a quantitative analysis with 5 clinically tested compounds. Just a walk in the park… or a shot in the dark?Van Ammel, Karel / Loenders, Brigitte / Gallacher, David et al. | 2016
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In vitro to clinical translation to improve proarrhythmic risk assessmentStrauss, D. / Vicente, J. / Mason, J. / Crumb, W. / Hosseini, M. / Stockbridge, N. / Johannesen, L. et al. | 2016
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Pharmacovigilance study of iron chelators in thalassemic patientsUsta, C. k. / Kurtoğlu, E. / Bedel, A. / Kurtoğlu, A. e. et al. | 2016
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Importance of parameter control in cardiac models for robust pro-arrhythmic risk predictionWang, K. / Davies, M. / Caruso, A. / Mirams, G. / Noble, D. / Walz, A. C. / Lavé, T. / Schuler, F. / Singer, T. / Polonchuk, L. et al. | 2016
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Considerations for in vitro systems to reflect in vivo toxicities to facilitate drug developmentZabka, T. / Kim, A. / Uppal, H. / Kauss, A. / Dhawan, P. / Liederer, B. / Lin, T. / McCray, B. / Nguyen, T. / Chou, C. et al. | 2016
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Tiron offers protection from doxorubicin induced myocardial injuryChiuzbaian, O. / Gharanei, M. / Mee, C. / Maddock, H. / Hatch, E. et al. | 2016
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Ex vivo model to investigate anticancer drug-induced chronic cardiotoxicityDucroq, J. / Didier, H. l. / Salvetat, C. l. / Le Grand, M. et al. | 2016
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Work-loop assay to predict inotropic drug effects of checkpoint kinase inhibitorsGharanei, M. / Wallis, R. / Babba, M. / Varcianna, A. / Maddock, H. et al. | 2016
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An in vitro assay for assessing cardiac contractility effects of test compounds using the rat myocardial work loop assayGharanei, M. / Wallis, R. / Babba, M. / Maddock, H. et al. | 2016
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PK and cardiac assessment in rats administered doxorubicinHenderson, Kim / Ross, John / Borders, Brandon / Gibbs, Seth / Hong, Peter / Wood, Brandon / Vinci, Tom / Roche, Brian / Smith, Jeremy et al. | 2016
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Use of the human trabeculae muscle work loop assay to predict adverse drug effects on heart contractilityGharanei, Mayel / Wallis, Rob / Babba, Maryam / Maddock, Helen et al. | 2016
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Development of an in vitro rat phrenic nerve–diaphragm muscle preparationRoof, S. / del Rio, C. / Patil, P. / Strauch, S. / Hamlin, R. et al. | 2016
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Preclinical assessment of neuronal network activity and compound-dependent seizure liability using an MEA based in vitro platformCato, Matthew / Shen, Frank / Smith, Randall / Bradley, Jenifer / Murphy, Dennis / Chaudhary, Khuram et al. | 2016
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Comparative analysis of data sciences international PhysioTel™ D70 and PhysioTel™ digital telemetry platformsKearney, Kenneth / Appleby, Cory / Kieper, Jason / Atterson, Philip et al. | 2016
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Kinetic image cytometry and high content analysis assay of neurotoxicityMcDonough, P. / Basa, R. / Cai, B. / Batchelder, E. / Feng, S. / Price, J. et al. | 2016
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Addition of left ventricular pressure measurement to a cardio-respiratory model, using telemetry and plethysmography in the conscious ratBeaudoin, S. / Williams, C. / Melliti, K. / Meecham, K. / Milner, V. et al. | 2016
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Comparison of left ventricular contractility to RR interval relationship in freely-moving rats, dogs and monkeysAuthier, Simon / Abtout, Samir / Ascah, Alexis / Pouliot, Mylene / Bujold, Kim / Troncy, Eric / Forster, Roy / Pugsley, Michael K. et al. | 2016
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Left ventricular pressure (LVP) and contractility in freely-moving rats: The application of marginal distribution analysisAuthier, S. / Abtout, S. / Bujold, K. / Ascah, A. / Pouliot, M. / Troncy, E. / Forster, R. / Pugsley, M. K. et al. | 2016
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The tilt test in non-human primate (NHP) using manual restraint: An improved method to investigate orthostatic hypotensionBetat, Anne-Marie / Delpy, Eric / Bureau, Marie / Veillard, Jérémie / La Rochelle, Christophe Drieu et al. | 2016
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Comparison of dog and guinea pig cardiovascular telemetryCseko, Csongor / Komlódi, Zsolt / Makó, Éva / Balázs, Ottilia et al. | 2016
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Evaluation of apnea in the dog: A guidance on preclinical evaluations and correlation to clinical sleep apnea scoringRenninger, J. / DiPasquale, J. / Murphy, D. et al. | 2016
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Alterations of the PR interval in chronically instrumented dogs and monkeysDalton, J. / Abernathy, M. / O'Donohue, K. / Gesaman, J. / Harter, M. / May, J. / Baird, T. et al. | 2016
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How preclinical neurobehavioural data can predict drug related effects on cardiovascular parametersGarbati, N. / Fasdelli, N. / Pilla, M. / Maraschiello, C. et al. | 2016
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Investigation of hemodynamic changes induced by CompoundX in Wistar Han ratsTang, Hai-Ming / Flaherty, Meghan / Aibo, Daher Ibrahim / Walker, Dana / Shenoy, Neeta / Vostiar, Igor / Stiehl, Daniel / Ju, Haisong / Friedrichs, Gregory et al. | 2016
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QT interval correction for drug-induced changes in body temperature in dogsEl Amrani, Abdel-Ilah / El Amrani, Francine / Loriot, Stephane / Singh, Pramila / Forster, Roy et al. | 2016
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Why may the ECG vary so much when a “Modified Lead II” is taken by telemetry?Hamlin, R. et al. | 2016
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Assessment of electrocardiography (ECG) parameter variability when building ECG template librariesRoss, R. / Kremer, J. / Aschcroft-Hawley, K. / Michael Foley, C. / Osinski, M. / Carneal-Frazer, N. et al. | 2016
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Incorporation of safety pharmacology endpoints in the toxicological assessment of a potential diagnostic positron emission tomography (PET) imaging agentHirani, E. / Daalsgard, G. / Hoppmann, S. / Evans, P. et al. | 2016
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A comparison of baseline heart rates, left ventricular and systolic pressure in group housed versus single housed beagle dogs and the effects of housing on sensitivity to detect changes in contractility following Pimobendan administrationSadekova, Nataliya / Boudreau, Ghislaine / Norton, Kevin et al. | 2016
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Microsampling—A Refinement to the Home Cage Rat Telemetry ModelPhilp, K. / Moors, J. / Skinner, M. / MacDonald, R. / Ngeny, M. / Redfern, W. et al. | 2016
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Evaluation of minimally invasive blood pressure telemetry devices in conscious Beagle dogsSkinner, M. / Milne, A. / Grant, C. / Meyer, O. / Stanton, A. / Sutherland, J. / Moors, J. / Bradley, A. et al. | 2016
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Evaluation of Digital Implantable Telemetry in Multiple Social Housing Paradigms for Cynomolgus MonkeyTichenor, Stephen / Regalia, Douglas / Holzgrefe, Henry / Lilly, Brittany / Wilcox, Angela / Kaiser, Robert et al. | 2016
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The electromechanical window (EMw): A heart-rate independent biomarker for delayed repolarization of the heartWaiz, David / Roberts, Sonia / Jenni, Roland / Greiter-Wilke, Andrea et al. | 2016
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Evaluation of conscious free moving dual pressure telemetered guinea pigs as a model for safety pharmacology studyUeyama, Y. / Mittelstadt, S. / del Rio, C. / Roof, S. / Youngblood, B. / Wallery, J. / Hamlin, R. et al. | 2016
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Comparison of alternative in vivo ECG endpoints for arrhythmia predictionWu, X. / Payseur, J. / Murphy, D. / Rossman, E. et al. | 2016
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Physiological differences between brachycephalic and non-brachycephalic dogs after 6min walking test at high altitudeArango, S. / Durán, A. / Florez, S. n. / Vargas-Pinto, P. et al. | 2016
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Assessing cardiotoxicity in the zebrafish embryoAlzualde, A. / Holgado, O. / Bertran, E. / Geiter-Wilke, A. / Muriana, A. / Roberts, S. et al. | 2016
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Echocardiography in a toxicology settingEngwall, M. / Vargas, H. et al. | 2016
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A model of acute congestion with progressive induction of pulmonary edema in sheep with chronic ischemic left-ventricular dysfunction: Preliminary resultsGeist, Gail E. / del Rio, Carlos / Youngblood, Bradley / Render, Kevin / Ueyama, Yukie / Hamlin, Robert et al. | 2016
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Promising approach for the preclinical assessment of cardiac risks using left ventricular pressure–volume loop analyses in anesthetized monkeysIshizaka, T. / Yoshimatsu, Y. / Maeda, Y. / Takasaki, W. / Chiba, K. / Mori, K. et al. | 2016
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Plasma miR-208: A robust early biomarker of cardiac drug induced injury in ratsGlineur, Stephanie / de Ron, Pierrette / Hanon, Etienne / Valentin, Jean-Pierre / Dremier, Sarah / da Costa, Andre Nogueira et al. | 2016
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Dronedarone prevents atrial fibrillation in dog model of sustained atrial fibrillationSaengklub, Nakkawee / Limprasutr, Vudhiporn / del Rio, Carlos / Hamlin, Robert L. / Kijtawornrat, Anusak et al. | 2016
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Selective actions of lead acetate, aluminum and cadmium sulfate in the corpus cavernosum and their effects on erectile function in ratsSaad, Evan / Senbel, Amira / Taha, Safaa / Fouad, Hosny et al. | 2016
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Inotropy and chronotropy screens in engineered human myocardiumMeyer, Tim / Tiburcy, Malte / Zimmermann, Wolfram-Hubertus et al. | 2016
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Effects of body weight on electrophysiology, hemodynamics and plasma exposure in anesthetized guinea-pigs: An impact on preclinical safety margin analysisUrmaliya, Vijay / Lauryssen, Laura / Daems, Hanne / Verrelst, Jan / Teisman, Ard / Gallacher, David J. et al. | 2016
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6min walking test in healthy dogs and in dogs with pulmonary hypertension (before and after sildenafil) at high altitudeVargas-Pinto, Pedro / Tapasco, Lina / Betancourt, Estefanía / Carrero, Maria / Bechara, Estefanía / Pedraza-Toscano, Adriana / Vargas-Pinto, Piero et al. | 2016
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Effects on iCEB and EMw after levcromakalim infusions in normal and reduced coronary flow anesthetized dog modelsvan der Linde, Henk / Van Deuren, Bruno / Somers, Yves / Teisman, Ard / Gallacher, David et al. | 2016
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CNS safety of spadinChamperoux, Pascal / Maleysson, Vincent / Bracq, Emmanuel / Maurin, Anne / Mazella, Jean / Heurteaux, Catherine / Borsotto, Marc / Richard, Serge et al. | 2016
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Characterization of canine models of heart failure with reduced and preserved ejection fractionYoungblood, Brad / del Rio, Carlos / Render, Kevin / Geist, Beth / Ueyama, Yukie / Wallery, Jeff / Hamlin, Robert et al. | 2016
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The predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trialsMead, A. / Amouzadeh, H. / Chapman, K. / Ewart, L. / Giarola, A. / Jackson, S. / Jarvis, P. / Jordaan, P. / Redfern, W. / Traebert, M. et al. | 2016
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NeuroSafe: A human integrated in vitro Neurotoxicity Safety PlatformRedaelli, L. / Maresca, G. / Tremolada, S. / Kuhn, C. / Brioschi, M. / Hess, D. / Guenther, E. / Scarabottolo, L. et al. | 2016
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Utility of an in vitro platform to assess neuronal toxicity using human iPSC-derived neuronsMisner, Dinah / Snyder, Chelsea / Ngo, Tin / Yu, Lanlan / Stagg, Nicola / Staflin, Karin et al. | 2016
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Enhance in pentylenetetrazole or maximal electro shock induced seizures in experimental models of ulcerative colitis: An interplay of altered cytokines level, adhesion molecules, blood brain barrier disruptionMedhi, B. / Sewal, R. K. / Modi, M. / Saikia, U. N. / Chakrabarti, A. et al. | 2016
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Use of stem cell derived peripheral neurons as a model of chemotherapeutic induced peripheral neuropathyDelaney, S. / Wing, C. / Favre, N. / Luerman, G. / Dolan, E. et al. | 2016
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How to improve the respiratory safety evaluation: Impact of animal welfare?Dudzicki, A. / Lemos-de-Andrade, E. / Momtaz, A. / Baudet, H. M. / Guillon, J. M. / Boixel, C. et al. | 2016
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Respiratory measurements in rats as indicator of adverse respiratory reactions to inhaled drugsLarsson, M.H. / Gustavsson, M. / Kärrman-Mårdh, C. / Kirk, S. / Öhlin, S. / Österlund, A. / Åberg, P. / Edmunds, N. / Conlon, K. et al. | 2016
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Treatment for established hypoxia-semaxanib induced pulmonary arterial hypertension in rats: Riociguat and sildenafil improve pulmonary hemodynamics and right ventricular hypertrophy using a disease intervention strategyHock, F. / Huang, J. / Janssen, D. / Zammit, M. / Neves, L. / Senese, P. / Gralinski, M. et al. | 2016
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Global Cross-company Data-sharing on the Housing of Non-rodents During the Recording of Cardiovascular Telemetry Data on Safety Pharmacology and Toxicology StudiesBottomley, A. / Prior, H. / Cordes, J. et al. | 2016
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Effect of a HIF-prolyl hydroxylase inhibitor on aortic pressure, heart rate and peak right ventricular pressure in rats exposed to acute hypoxiaKohrs, L. / Renninger, J. / Murphy, D. et al. | 2016
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Simultaneous evaluation of cardiovascular and respiratory functions in the conscious dogRompion, S. / Guillaume, P. / Goineau, S. / Froget, G. et al. | 2016
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Safety assessment of a formulation for 68Ga-DOTATOC (68Ga-edotreotide or 68Ga-DOTA0-Tyr3-octreotide) preparation: Case studies in rats and rabbitsChicco, D. / Orlandi, F. / Venturella, S. / Di Manno, P. / Manno, R. A. et al. | 2016
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Drugs withdrawn from the market over the last 50years: Contribution of adverse effects within the sphere of influence of safety pharmacologyRedfern, W. et al. | 2016
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Assessment of HER-2/neu gene amplification and expression as a biomarker for radiotherapy and hormonal treated breast cancer patients in Upper EgyptEsmat, M. / AbdelWanis, M. / Mosad, E. / EL-maghraby, T. / Othman, A. et al. | 2016
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Comprehensive assessment of multiple induced pluripotent stem cell-derived cardiomyocyte cell lines with microelectrode arrays and voltage sensitive dyesBlinova, Ksenia / Stohlman, Jayna / Vicente, Jose / Chan, Dulciana / Hortigon, Maria / Rodriguez, Victor Zamora / Smith, Godfrey / Ross, James / Brock, Mathew / Chvatal, Stacie et al. | 2016
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Simulated micro-electrode array recordings from stem cell-derived cardiomyocytesBowler, Louise / Harris, Kate / Gavaghan, David / Mirams, Gary et al. | 2016
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How much of a cardiomyocyte can we get from stem cells? Setting up metrics for cardiac cell modelsChabria, M. / Hoflack, J. C. / Badi, L. / Flint, N. / Burcin, M. / Graf, M. / Singer, T. / Alvarez-Sanchez, R. / Schuler, F. / Polonchuk, L. et al. | 2016
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Impedance based Assay on iPS cardiomyocytes: An efficient way of discriminating between cardioactive and non cardioactive drugsColomar, Aurore / Haen, Lucille / Toussaint, Gaëlle / Loïodice, Simon / Kopp, Benjamin / Atienzar, Franck / Valentin, Jean-Pierre et al. | 2016
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Cardiotoxicity testing in human iPSC-derived cardiomyocytes for the CiPA pilot study using all-optical electrophysiologyDempsey, Graham / Atwater, Nicholas / Nguyen, Cuong et al. | 2016
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A highly scalable embryonic stem cell platform for in vitro genetics of drug responseBergseid, Jacqueline / Joshi-Barr, Shivanjali / Page, Lesley / Carlo, Amy / Brown, Stephanie / Choi, Ted et al. | 2016
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Assessing the predictivity of a human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) multielectrode array (MEA) assay for preclinical cardiac electrophysiology safety screeningHarris, K. / Graham, S. / Sridhar, A. / Louttit, J. et al. | 2016
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Human iPS-derived cardiac myocyte-fibroblast 3D co-cultures: A predictive in vitro model to assess drug-induced contractile and metabolic liabilitiesGoßmann, Matthias / Palm, Thomas / Kettenhofen, Ralf / Bohlen, Heribert / Lu, Hua Rong / Gallacher, David J. / Artmann, Gerhard / Epple, Matthias / Artmann, Aysegül Temiz et al. | 2016
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Early screening for cardiac arrhythmic liabilities: Comparison of a new assay measuring Ca2+ transients in human stem cell-derived cardiomyocytes to the more traditional assays (isolated guinea-pig right atrium model and HERG assay)Hermans, An N. / Geyskens, Danny / Rohrbacher, Jutta / Lu, Hua Rong / Lammens, Lieve / Gallacher, David J. et al. | 2016
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Characterization of the physiology and cardiotoxicity of cardiac 3D microtissues of hiPSC-derived cardiomyocytes (hiPSC-CMs)Hortigon-Vinagre, M. P. / Zamora, V. / Alageswaran, V. / Craig, D. / Fluri, D. / Bruton, F. L. / Agarkova, I. / Kelm, J. M. / Craig, M. A. / Smith, G. L. et al. | 2016
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Usefulness of motion vector prediction system for evaluating drug-induced functional changes of human induced pluripotent stem cell-derived cardiomyocytesHonda, Masaki / Ishitomi, Akihiro / Okai, Yoshiko / Kitamura, Tetsuo / Isobe, Takehito / Matsune, Keiko / Araki, Sei-ichi et al. | 2016
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Image-based evaluation of contractile characteristics of hiPS-CMs: A tool for pre-clinical cardiovascular drug discoveryHuang, Minxue / Shi, Hong / Zhu, Jialong / Levesque, Paul et al. | 2016
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CSAHi study: Evaluation of MED64 multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmiaKitaguchi, T. / Moriyama, Y. / Miyamoto, N. / Taniguchi, T. / Ojima, A. / Ando, H. / Uda, T. / Otabe, K. / Oguchi, M. / Shimizu, S. et al. | 2016
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Assessment of drug-induced QT prolongation using human iPS cell-derived mature cardiomyocytesKanda, Yasunari / Li, Min / Ashihara, Takashi / Sekino, Yuko / Furukawa, Tetsushi / Kurokawa, Junko et al. | 2016
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Human iPSC-derived Cor.4U cardiomyocytes as a predictive tool for different comprehensive in vitro proarrhythmia assay endpointsKettenhofen, Ralf / Duenbostell, Anika / Luerman, Greg / Li, Ping / Yue, Yimei / Bronson, Jared / Horai, Hirofumi / D'Angelo, Jean Marc / Niedereichholz, Thomas / Gibson, John Ken et al. | 2016
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CSAHi study: Usability assessment of multi-electrode array in combination with human iPS cell-derived cardiomyocytes for prediction of drug-induced QT prolongation and arrhythmia — Multi Channel Systems (MEA60 and MEA2100)Kunimatsu, T. / Nozaki, Y. / Honda, Y. / Watanabe, H. / Yamanishi, A. / Nogawa, H. / Endo, H. / Saiki, S. / Nagasawa, C. / Nakamori, C. et al. | 2016
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Could in vitro animal assays be replaced by human stem cell-based assays for drug-induced cardiac risks: Beyond QT-prolongation/CIPA?Lu, H. R. / Hermans, A. / Kopljar, I. / Rohrbacher, J. / Teisman, A. / Gallacher, D. J. et al. | 2016
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An in vitro assessment of delayed HDAC inhibitor-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytesKopljar, I. / Vlaminckx, E. / Lu, H. R. / Gallacher, D. et al. | 2016
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Action potential duration and proarrhythmia assay by kinetic image cytometry in hiPS-cardiomyocytes for the FDA/HESI CiPA initiativePfeiffer, Emily / Whittaker, Ross / Hilton, Jeffrey / Ingermanson, Randy / Price, Jeffrey et al. | 2016
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Humoral factor from rodent astrocytes promoted the synaptic transmission and augmented synchronized population bursts in human induced pluripotent stem cell-derived neuronsMiyamoto, Norimasa / Sawada, Kohei et al. | 2016
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Assessment of reverse use-dependent blocking actions of dofetilide in stimulated human induced pluripotent stem cell derived (hiPSC) cardiomyocytesShi, H. / Huang, M. / Levesque, P. et al. | 2016
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iNCENS (iPSC non-clinical experiments for nervous system): A project to establish the CNS safety pharmacological evaluation to predict risks of cognitive impairment and epilepsy by in vitro use of human induced pluripotent stem cell-derived neuronsSato, K. / Takahashi, K. / Shigemoto-Mogami, Y. / Shimizu, H. / Ikegaya, Y. / Koyama, R. / Hiragi, T. / Miyamoto, N. / Shirao, T. / Sekino, Y. et al. | 2016
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Differential effects of astemizole on the neurite growth and synaptogenesis of neuronsShirao, T. / Ishizauka, Y. / Hanamura, K. / Koganezawa, N. / Ootsu, M. / Yamazaki, H. et al. | 2016
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Single site CiPA cardiomyocyte pilot study results on two MEA platforms with two hiPSC sourcesShi, H. / Huang, M. / Lewen, G. / Levesque, P. et al. | 2016
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Comprehensive in vitro cardiac safety assessment using human stem cell technology—Overview of CSAHi HEART initiativeTakasuna, Kiyoshi / Asakura, Keiichi / Araki, Seiichi / Ando, Hiroyuki / Kazusa, Katsuyuki / Kitaguchi, Takashi / Kunimatsu, Takeshi / Suzuki, Shinobu / Miyamoto, Norimasa et al. | 2016
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Organ-on-Chip: A synthetic mimic for human myocardiumvan Meer, Berend / Ribeiro, Marcelo / Tertoolen, Leon / Birket, Matthew / Passier, Robert / Mummery, Christine et al. | 2016
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The unbound concentration of multimodal drugs in the assay medium used in the multi-electrode array system for cardiac risk assessment with iPS cell-derived cardiomyocytesYoshinaga, Takashi / Shinkyo, Raku / Kikuchi, Kiyomi / Taniguchi, Tomohiko / Sekino, Yuko / Sawada, Kohei et al. | 2016
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Electrophysiological characterization of iCell2 hiPSC derived cardiomyocytes: The new generation of CDI hiPSC-CMsTaylor, A. E. / Zamora, V. / Hortigon-Vinagre, M. P. / Allan, A. / Burton, F. L. / Anson, B. D. / Craig, M. A. / Smith, G. L. et al. | 2016
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Gastroinstestinal motility: Motility and motor migrating complex (MMC) evaluations in rats, dogs and non-human primatesAuthier, S. / Tang, H. M. / Abtout, S. / Ascah, A. / Pouliot, M. / Bujold, K. / Troncy, E. / Pugsley, M. K. / Forster, R. et al. | 2016
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Use of inulin and PAH for renal drug safety evaluations in conscious dogsAbernathy, M. / Dalton, J. / Harter, M. / Gauvin, D. / Baird, T. et al. | 2016
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A comparison of drug-induced changes in electrical excitability using optogenetic sensors and conventional field stimulation in hiPS-derived cardiomyocytes (hiPSC-CMs)Zamora, Victor / Hortigon-Vinagre, Maria / Allan, Andrew / Lu, Hua Rong / Burton, Francis / Gallacher, David / Smith, Godfrey et al. | 2016
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Citrulline — A Potential Translational Safety Biomarker for the Small IntestinePipp, Frederic / Hellmann, Jürgen / Poetzsch, Sven / Hewitt, Philip / Schmitt, Michael et al. | 2016
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A HESI consortium update on cardiac contractility endpointsPugsley, Michael K. / Guth, Brian / Chiang, Alan / Doyle, Jennifer / Engwall, Mike / Guillon, Jean-Michel / Hoffmann, Peter / Koerner, John / Mittelstadt, Scott / Ottinger, Sean et al. | 2016
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Cloud analysis of rat cardiac contractility: Determining changes in left ventricular dP/dt without correcting for heart rateBrandon Borders, R. / Pittman, Rhea / Roche, Brian et al. | 2016
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Editorial Board| 2016