Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels (Englisch)

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, Göttingen; 2018
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Imaging synaptic activity in the form of calcium transients occurring in dendritic spines is advancing our understanding of nerve cell function beyond what can be achieved using electrophysiological methods alone. I have developed an analytical approach (which I name Activity-based Automatic Region of interest Generation (AARG) analysis) that facilitates the analysis of synaptic events simultaneously imaged across many dendritic spines. The approach automatically assigns regions of interest (ROIs) based on patterns of compartmentalized calcium transients in spines and generally emphasizes a...

Dokumentinformationen

  • Titel:
    Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels
  • Autor / Urheber:
  • Sonstige Beteiligte:
    Dean, Camin (AkademischeR BetreuerIn) / Schild, Detlev (GutachterIn) / Schlüter, Oliver (GutachterIn) / Rhee, Jeong (GutachterIn) / Dresbach, Thomas (GutachterIn) / Hörner, Michael (GutachterIn)
  • Hochschulschrift:
    Dissertation, Georg-August-Universität Göttingen; 2018
  • Erscheinungsort:
    Göttingen
  • Erscheinungsjahr:
    2018
  • Format / Umfang:
    1 Online-Ressource
  • Anmerkungen:
    Illustrationen, Diagramme
  • Medientyp:
    Hochschulschrift
  • Format:
    Elektronische Ressource
  • Sprache:
    Englisch
  • Klassifikation:
    DDC:    570

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