Cross-Dehydrogenative Coupling Reactions for the Functionalization of α-Amino Acid Derivatives and Peptides (Englisch)

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The functionalization of typically unreactive C(sp3)–H bondsholds great promise for reducing the reliance on existing functionalgroups while improving atom-economy and energy efficiency. As a re-sult, this topic is a matter of genuine concern for scientists in order toachieve greener chemical processes. The site-specific modification of α-amino acid and peptides based upon C(sp3)–H functionalization stillrepresents a great challenge of utmost synthetic importance. This shortreview summarizes the most recent advances in ‘Cross-Dehydrogenative Couplings’ of α-amino carbonyl compounds and peptide derivativeswith a variety of nucleophilic coupling partners. ; We are grateful to MINECO (CTQ2016-78395-P) and Gobierno Vasco (IT_1033-16) for financial support. A. C. thanks MINECO for a Ramón y Cajal research contract (RYC-2012-09873). Cost-CHAOS action (CA15106) is also acknowledged.