Synthesis and in vitro cytocompatibility of segmented poly (esther-urethane)s and poly (ester-urea-urethane)s for bone tissue engineering (Englisch)

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Two series of segmented polyurethanes were obtained and their mechanical properties, 12 biodegradability and cytotoxicity were evaluated. The chemical nature of the polyurethanes was 13 varied by using either 1,4 butanodiol (Poly-ester-urethanes, PEUs) or L-lysine ester dihydrocloryde 14 (poly-ester-urea-uretanes PEUUs) as chain extender. Results show that varying the hard segment 15 influence the thermal and mechanical properties of the obtained polymers. PEUs show strain values 16 about 10- 20 MPa and hardness about 10-65 MPa, those values are greater than the obtained values 17 for PEUUs due to the phase segregation and mayor crystallinity observed for polyester-urethanes 18 (PEUs), the phase segregation is also observed and analyzed by XRD and DSC. Moreover both series 19 of polymers probed their hydrolytic degradation submerged in PBS until 90 days, losing about 20% 20 of weight. In vitro tests using Human Osteoblastic cell line (Hob), show an average of 80% of cell 21 viability and good adhesion for both series of polymers. ; CONACYT for the fellowship and fund DPI 2017-90147-R 386 from MINECO-AEI. Spain ; Peer reviewed