Food entrains clock genes but not metabolic genes in the liver of suprachiasmatic nucleus lesioned rats (Englisch)

In: FEBS Letters   ;  588 ,  17  ;  3104-3110  ;  2014
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Highlights Physiological feeding cycles entrain the liver clock of SCNx rats, and persist under fasting. Similar as the liver clock, Rev-erbα and PPARα can be entrained by feeding cycles. Transcription of Nampt in the liver of SCNx rats does not reflect the rhythm of the clock genes. Hepatic expression of Nampt and Sirt1 requires the SCN to reflect the metabolic status. The SCN is essential for the robust time-dependent differential expression of Id2 in liver.

Abstract Hepatic circadian transcription, considered to be driven by the liver clock, is largely influenced by food even uncoupling it from the suprachiasmatic nucleus (SCN). In SCN lesioned rats (SCNx) we determined the influence of a physiological feeding schedule on the entrainment of clock and clock-controlled (CCG) genes in the liver. We show that clock genes and the CCG Rev-erbα and peroxisome proliferator-activated receptor alpha (PPARα) in food-scheduled intact and SCNx have a robust diurnal differential expression persisting after a 24h fast. However, hepatic nicotinamide phosphoribosyl transferase (Nampt) shows time dependent changes that are lost in intact animals under fasting; moreover, it is unresponsive to the nutrient status in SCNx, indicating a poor reliance on liver clock genes and highlighting the relevance of SCN-derived signals for its metabolic status-related expression.

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