Oral Silica Nanoparticles Lack of Neurotoxic Effects in a Parkinson’s Disease Model: A Possible Nanocarrier? (Englisch)

In: IEEE Transactions on NanoBioscience   ;  18 ,  4  ;  535-541  ;  2019

Wie erhalte ich diesen Titel?

Download
Kommerziell Vergütung an den Verlag: 27,65 € Grundgebühr: 4,00 € Gesamtpreis: 31,65 €
Akademisch Vergütung an den Verlag: 27,65 € Grundgebühr: 2,00 € Gesamtpreis: 29,65 €

Silica nanoparticles (SiO2-NP) are an option as drug carriers due to their biodegradability, biocompatibility, and capacity to bind themselves to other compounds. However, until now, the effect of these particles on the brain when neurodegeneration occurs is unknown. Hence, this work focused on the in vivo evaluation of the neurotoxic effects of SiO2-NP when oxidative and inflammation are present during the development of Parkinson’s disease. To determine whether SiO2-NP may act as a non-neurotoxic carrier we evaluated if the intragastric administration (ig) of SiO2-NP of 150 nm (25, 50 and 100 mg/kg administered for five consecutive days) increased neuronal damage induced with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. SiO2-NP administration did not further decrease cell viability assessed by MTT reduction, nor increased lipid peroxidation measured by TBARS or TNF $\alpha $ levels in the striatum and the substantia nigra in the MPTP model. Furthermore, we observed no additional reduction in striatal dopamine levels. The present results suggest that SiO2-NP of 150 nm are suitable nanocarrier for Parkinson’s disease drugs without generating any additional damage.

Inhaltsverzeichnis – Band 18, Ausgabe 4

Zeige alle Jahrgänge und Ausgaben

Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.

517
Table of contents
| 2019
519
Guest Editorial Special Section on Advances in NanoBioEngineering ICNBE 2018
Morones-Ramirez, Jose Ruben | 2019
522
Electrospun Membranes Based on Schizophyllan-PVOH and Hamamelis Virginiana Extract: Antimicrobial Activity Against Microorganisms of Medical Importance
Solis-Arevalo, Karla Katiushka / Garza-Gonzalez, Maria Teresa / Lopez-Calderon, Hector Daniel / Solis-Rojas, Carlos / Arevalo-Nino, Katiushka | 2019
528
Bactericidal In-Vitro Effect of Zinc Ferrite Nanoparticles and the Orange Wax Extracts on Three Phytopathogen Microorganisms
Garcia-Cruz, Ariel / Rincon-Enriquez, Gabriel / Ilyina, Anna / Guizar-Gonzalez, Cecilia / Mtz-Enriquez, Arturo I. / Diaz-Jimenez, Lourdes / Quinones-Aguilar, Evangelina E. / Enriquez-Vara, Jhony / Ramos-Gonzalez, Rodolfo / Aguilar-Gonzalez, Cristobal N. | 2019
535
Oral Silica Nanoparticles Lack of Neurotoxic Effects in a Parkinson’s Disease Model: A Possible Nanocarrier?
Guzman-Ruiz, Mara A. / de La Mora, Maria Beatriz / Torres, Ximena / Meza, Claudia / Garcia, Esperanza / Chavarria, Anahi | 2019
542
Interaction Between Cobalt Ferrite Nanoparticles and $Aspergillus~niger$ Spores
Garcia Torres, Sandy Gabriela / Ilyina, Anna / Ramos-Gonzalez, Rodolfo / Hernandez, Salvador Carlos / Diaz-Jimenez, Lourdes | 2019
549
Application of a Multisystem Coating Based on Polymeric Nanocapsules Containing Essential Oil of Thymus Vulgaris L. to Increase the Shelf Life of Table Grapes (Vitis Vinifera L.)
Pina-Barrera, Andres M. / Alvarez-Roman, Rocio / Baez-Gonzalez, Juan G. / Amaya-Guerra, Carlos A. / Rivas-Morales, Catalina / Gallardo-Rivera, Claudia T. / Galindo-Rodriguez, Sergio A. | 2019
558
Microfluidics and Surface-Enhanced Raman Spectroscopy: A Perfect Match for New Analytical Tools
Ochoa-Vazquez, Gustavo / Kharisov, Boris / Arizmendi-Morquecho, Ana / Cario, Anais / Aymonier, Cyril / Marre, Samuel / Lopez, Israel | 2019
567
Loop Enhanced Conformational Resampling Method for Protein Structure Prediction
Li, Zhang-Wei / Sun, Ke / Hao, Xiao-Hu / Hu, Jun / Ma, Lai-Fa / Zhou, Xiao-Gen / Zhang, Gui-Jun | 2019
578
Integrating Bipartite Network Projection and KATZ Measure to Identify Novel CircRNA-Disease Associations
Zhao, Qi / Yang, Yingjuan / Ren, Guofei / Ge, Erxia / Fan, Chunlong | 2019
585
The Clock-Free Asynchronous Receiver Design for Molecular Timing Channels in Diffusion-Based Molecular Communications
Li, Qingchao | 2019
597
Tunable Hybrid Biopolymeric Hydrogel Scaffolds Based on Atomic Force Microscopy Characterizations for Tissue Engineering
Li, Mi / Xi, Ning / Wang, Yuechao / Liu, Lianqing | 2019
611
Oscillatory Dynamics of p53 Genetic Network Induced by Feedback Loops and Time Delays
Wang, Conghua / Liu, Haihong / Zhou, Jin | 2019
622
Polarization-Independent Perfect Optical Metamaterial Absorber as a Glucose Sensor in Food Industry Applications
Vafapour, Zohreh | 2019
628
Quality and Capacity Analysis of Molecular Communications in Bacterial Synthetic Logic Circuits
Martins, Daniel P. / Barros, Michael Taynnan / Balasubramaniam, Sasitharan | 2019
640
Albumin Coating Prevents Cardiac Effect of the Magnetic Nanoparticles
Nunes, Allancer D. C. / Gomes-Silva, Lorrany A. / Zufelato, Nicholas / Prospero, Andre G. / Quini, Caio C. / Matos, Ronaldo V. R. / Miranda, Jose R. A. / Bakuzis, Andris F. / Castro, Carlos H. | 2019
651
Optimal Transmitted Molecules and Decision Threshold for Drift-Induced Diffusive Molecular Channel With Mobile Nanomachines
Chouhan, Lokendra / Sharma, Prabhat Kumar / Varshney, Neeraj | 2019
661
Enhancing Thermal Effect of Focused Ultrasound Therapy Using Gold Nanoparticles
Sadeghi-Goughari, Moslem / Jeon, Soo / Kwon, Hyock-Ju | 2019
669
Latticed Channel Model of Touchable Communication Over Capillary Microcirculation Network
Zhou, Yu / Chen, Yifan | 2019
679
Development of Multi-Dimensional Cell Co-Culture via a Novel Microfluidic Chip Fabricated by DMD-Based Optical Projection Lithography
Ge, Zhixing / Yu, Haibo / Yang, Wenguang / Yang, Jia / Liu, Bin / Wang, Xiaoduo / Liu, Zhu / Liu, Lianqing | 2019
687
2019 Index IEEE Transactions on NanoBioscience Vol. 18
| 2019
C1
Front cover
| 2019
C2
IEEE Transactions on NanoBioscience publication information
| 2019
C3
IEEE Transactions on NanoBioscience information for authors
| 2019