Estradiol Upregulates Kisspeptin Expression in the Preoptic Area of both the Male and Female Rhesus Monkey (Macaca mulatta): Implications for the Hypothalamic Control of Ovulation in Highly Evolved Primates (Englisch)

In: Neuroendocrinology   ;  105 ,  1  ;  77-89  ;  2017

Wie erhalte ich diesen Titel?

Kommerziell Vergütung an den Verlag: 24,00 € Grundgebühr: 4,00 € Gesamtpreis: 28,00 €
Akademisch Vergütung an den Verlag: 10,00 € Grundgebühr: 2,00 € Gesamtpreis: 12,00 €

The aim of this immunohistochemical study was to evaluate the distribution of kisspeptin neurons in the preoptic area (POA) of gonadally intact adult male and female rhesus monkeys, and to determine whether imposition of an estradiol (E2)-positive feedback signal in the castrate male increased kisspeptin in the POA. Additionally, kisspeptin in the POA of the intact female was examined during an LH surge induced prematurely by E2 administered in the early follicular phase. The number of kisspeptin neurons in the POA of males and females was similar. Immunoactive kisspeptin perikarya were not observed in the POA of castrate adult males, but such neurons in these animals were present within 12 h of imposing an increment in circulating E2 concentrations that in a screening study conducted 4-6 weeks earlier had elicited an LH surge. As expected, premature induction of an LH surge by E2 early in the follicular phase was associated with upregulation of kisspeptin in the POA. These results represent the first description of immunoreactive kisspeptin cell bodies in the POA of the macaque brain and provide further support for the view that (1) kisspeptin neurons in the POA of the female monkey are a target for the positive feedback action of E2 and (2) the hypothalamic mechanism which mediates this action of E2 in primates is not subjected to perinatal programming by testicular testosterone. Moreover, our findings indicate that maintenance of the kisspeptin content in the POA of intact male monkeys requires the action of E2, presumably generated by aromatization of testicular testosterone at the hypothalamic level.

Inhaltsverzeichnis – Band 105, Ausgabe 1

Zeige alle Jahrgänge und Ausgaben

Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.

Effect of Gonadal Hormones on Neurotransmitters Implicated in the Pathophysiology of Obsessive-Compulsive Disorder: A Critical Review
Karpinski, Marta / Mattina, Gabriella Francesca / Steiner, Meir | 2017
Abstracts of the 14th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease. March 8-10, 2017, Barcelona, Spain: Abstracts
| 2017
High Frequency of MKRN3 Mutations in Male Central Precocious Puberty Previously Classified as Idiopathic
Bessa, Danielle S. / Macedo, Delanie B. / Brito, Vinicius N. / França, Monica M. / Montenegro, Luciana R. / Cunha-Silva, Marina / Silveira, Leticia G. / Hummel, Tiago / Bergadá, Ignacio / Braslavsky, Debora et al. | 2017
Not All Patients with a Pancreatic Neuroendocrine Tumour Will Benefit from All Approved or Recommended Therapeutic Options: A Real-Life Retrospective Study
Berdelou, Amandine / Boige, Valérie / Arfi-Rouche, Julia / Malka, David / Ederhy, Stéphane / Izzedine, Hassan / Leboulleux, Sophie / Chougnet, Cécile N. / Burtin, Pascal / De Baere, Thierry et al. | 2017
Melatonin Receptor 1 Deficiency Affects Feeding Dynamics and Pro-OpiomelanocortinExpression in the Arcuate Nucleus and Pituitary of Mice
Fischer, Claudia / Mueller, Tanja / Pfeffer, Martina / Wicht, Helmut / von Gall, Charlotte / Korf, Horst-Werner | 2017
Somatostatin Receptor Expression in GH-Secreting Pituitary Adenomas Treated with Long-Acting Somatostatin Analogues in Combination with Pegvisomant
Franck, Sanne E. / Gatto, Federico / van der Lely, Aart Jan / Janssen, Joseph A.M.J.L. / Dallenga, Alof H.G. / Nagtegaal, A. Paul / Hofland, Leo J. / Neggers, Sebastian J.C.M.M. | 2017
Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer
Yu, Di / Leja-Jarblad, Justyna / Loskog, Angelica / Hellman, Per / Giandomenico, Valeria / Oberg, Kjell / Essand, Magnus | 2017
Professional Practices and Diagnostic Issues in Neuroendocrine Tumour Pathology: Results of a Prospective One-Year Survey among French Pathologists (the PRONET Study)
Scoazec, Jean-Yves / Couvelard, Anne / Monges, Geneviève / Guyétant, Serge / Bisot-Locard, Segolène / Parot, Xavier / Lepage, Côme | 2017
Estradiol Upregulates Kisspeptin Expression in the Preoptic Area of both the Male and Female Rhesus Monkey (Macaca mulatta): Implications for the Hypothalamic Control of Ovulation in Highly Evolved Primates
Vargas Trujillo, Marcela / Kalil, Bruna / Ramaswamy, Suresh / Plant, Tony M. | 2017
Inhibition of mTOR's Catalytic Site by PKI-587 Is a Promising Therapeutic Option for Gastroenteropancreatic Neuroendocrine Tumor Disease
Freitag, Helma / Christen, Friederike / Lewens, Florentine / Grass, Irina / Briest, Franziska / Iwaszkiewicz, Sara / Siegmund, Britta / Grabowski, Patricia | 2017
Title Page / Table of Contents
| 2017
Front & Back Matter
| 2017