The Effect of the Benzodiazepine Adumbran on the Resting and Sleep EEG and on the Visual Evoked Potential in Adult Man (Englisch)

The administration of 20 to 40 mg of Adumbran gave rise to no significant clinical changes in vigilance in the waking state and no appreciable change in the EEG pattern, particularly as regards frequency. In tests to determine psychic disturbances after eliminating or shortening paradoxical sleep, the effect of Adumbran on the sleep EEG was recorded polygraphically. The overall duration of sleep lengthened under medication, with a simultaneous intensification of slow sleep. The visual evoked potential suffered only a slight reduction in amplitude, while there was no appreciable increase in latency.

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