Enhancing the depth of tissue microscope imaging using two-photon excitation of the second singlet state of fluorescent agents (Englisch)

In: Proc. SPIE   ;  8940 ;  2014

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Increasing the depth to image inside tissue is critical in biomedicine. Two-photon (2P) excitation of the second singlet (S2) state of a group of fluorescent agents with near infrared emission, Chlorophyll a (Chl a) and Indocyanine green (ICG), is used to extend the optical imaging regime of 2PM into “tissue optical window” for deep tissue penetration. The fast nonradiative from S2 to S1 yields both emission and absorption wavelengths in the therapeutic window. The salient feature is to place both the 2P excitation and emission wavelengths of the imaging agents falling into the “tissue optical window”. As a first step to achieve deeper optical imaging, Chl a and ICG are investigated and demonstrated as imaging agents for 2P S2 excitation microscope image.

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Cundiff, S.T. / SPIE (Society) | 2014
Cross-phase modulation in optical Kerr media: review of discovery experiments (Invited Paper) [8940-38]
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Zhou, Y. / Liu, C. / Li, J. / Li, Z. / Zhou, L. / Chen, K. / Pu, Y. / He, Y. / Zhu, K. / Li, Q. et al. | 2014
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Rubina, S. / Sathe, P. / Dora, T.K. / Chopra, S. / Maheshwari, A. / Krishna, C.M. / SPIE (Society) | 2014
Measurement of fluorescent probes concentration ratio in the cerebrospinal fluid for early detection of Alzheimer's disease [8940-29]
Harbater, O. / Gannot, I. / SPIE (Society) | 2014
Enhancing the depth of tissue microscope imaging using two-photon excitation of the second singlet state of fluorescent agents [8940-39]
Pu, Y. / Shi, L. / Pratavieira, S. / Alfano, R.R. / SPIE (Society) | 2014
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Ting, M. / Krueger, J. / Gareau, D. / SPIE (Society) | 2014
Brain metastasis detection by resonant Raman optical biopsy method [8940-11]
Zhou, Y. / Liu, C. / Cheng, G. / Zhou, L. / Zhang, C. / Pu, Y. / Li, Z. / Liu, Y. / Li, Q. / Wang, W. et al. | 2014
Noninvasive diagnosis of oral cancer by Stokes shift spectroscopy [8940-20]
Ebenezar, J. / Ganesan, S. / Aruna, P. / Muralinaidu, R. / SPIE (Society) | 2014
Parametric study of different contributors to tumor thermal profile [8940-24]
Tepper, M. / Gannot, I. / SPIE (Society) | 2014
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Doronin, A. / Milione, G. / Meglinski, I. / Alfano, R.R. / SPIE (Society) | 2014
Diffusing-wave polarimetry for tissue diagnostics [8940-6]
Macdonald, C. / Doronin, A. / Pena, A.F. / Eccles, M. / Meglinski, I. / SPIE (Society) | 2014
Optical characterization of ex-vivo axillary lymph nodes of breast-cancer patients using a custom-built spectrophotometer [8940-25]
Sampathkumar, A. / Lizzi, F.L. / Saegusa-Beecroft, E. / Mamou, J. / Chitnis, P.V. / Machi, J. / Feleppa, E.J. / SPIE (Society) | 2014
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Demos, S.G. / Urayama, S. / SPIE (Society) | 2014
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Sordillo, L.A. / Pratavieira, S. / Pu, Y. / Salas-Ramirez, K. / Shi, L. / Zhang, L. / Budansky, Y. / Alfano, R.R. / SPIE (Society) | 2014