Tumor margin detection using optical biopsy techniques (Englisch)

In: Proc. SPIE   ;  8940 ;  2014

Wie erhalte ich diesen Titel?

Download
Kommerziell Vergütung an den Verlag: 15,55 € Grundgebühr: 4,00 € Gesamtpreis: 19,55 €
Akademisch Vergütung an den Verlag: 15,55 € Grundgebühr: 2,00 € Gesamtpreis: 17,55 €

The aim of this study is to use the Resonance Raman (RR) and fluorescence spectroscopic technique for tumor margin detection with high accuracy based on native molecular fingerprints of breast and gastrointestinal (GI) tissues. This tumor margins detection method utilizes advantages of RR spectroscopic technique in situ and in real-time to diagnose tumor changes providing powerful tools for clinical guiding intraoperative margin assessments and postoperative treatments. The tumor margin detection procedures by RR spectroscopy were taken by scanning lesion from center or around tumor region in ex-vivo to find the changes in cancerous tissues with the rim of normal tissues using the native molecular fingerprints. The specimens used to analyze tumor margins include breast and GI carcinoma and normal tissues. The sharp margin of the tumor was found by the changes of RR spectral peaks within 2 mm distance. The result was verified using fluorescence spectra with 300 nm, 320 nm and 340 nm excitation, in a typical specimen of gastric cancerous tissue within a positive margin in comparison with normal gastric tissues. This study demonstrates the potential of RR and fluorescence spectroscopy as new approaches with labeling free to determine the intraoperative margin assessment.

Inhaltsverzeichnis Konferenzband

Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.

89400A
Automated cellular pathology in noninvasive confocal microscopy
Ting, Monica / Krueger, James / Gareau, Daniel | 2014
89400C
Brain metastasis detection by resonant Raman optical biopsy method
Zhou, Yan / Liu, Cheng-hui / Cheng, Gangge / Zhou, Lixin / Zhang, Chunyuan / Pu, Yang / Li, Zhongwu / Liu, Yulong / Li, Qingbo / Wang, Wei et al. | 2014
89400D
Raman microspectroscopic study of oral buccal mucosa
Behl, Isha / Mamgain, Hitesh / Deshmukh, Atul / Kukreja, Lekha / Hole, Arti R. / Krishna, C. Murali | 2014
89400E
In vivoRaman spectroscopy of cervix cancers
Rubina, S. / Sathe, Priyanka / Dora, Tapas Kumar / Chopra, Supriya / Maheshwari, Amita / Krishna, C. Murali | 2014
89400H
Autofluorescence lifetime metrology for label-free detection of cartilage matrix degradation
Nickdel, Mohammad B. / Lagarto, João L. / Kelly, Douglas J. / Manning, Hugh B. / Yamamoto, Kazuhiro / Talbot, Clifford B. / Dunsby, Christopher / French, Paul / Itoh, Yoshifumi | 2014
89400L
Noninvasive diagnosis of oral cancer by Stokes shift spectroscopy
Ebenezar, Jeyasingh / Ganesan, Singaravelu / Aruna, Prakasrao / Muralinaidu, Radhakrishnan | 2014
89400O
Wavelength-dependent measurement of contrast in NIR and extended NIR spectral range (650-1600 nm) in phantoms
Salo, Daniel / Kim, David M. / Berezin, Mikhail Y. | 2014
89400P
Parametric study of different contributors to tumor thermal profile
Tepper, Michal / Gannot, Israel | 2014
89400Q
Optical characterization ofex-vivoaxillary lymph nodes of breast-cancer patients using a custom-built spectrophotometer
Sampathkumar, Ashwin / Saegusa-Beecroft, Emi / Mamou, Jonathan / Chitnis, Parag V. / Machi, Junji / Feleppa, Ernest J. | 2014
89400R
Enhanced visualization of the bile duct via parallel white light and indocyanine green fluorescence laparoscopic imaging
Demos, Stavros G. / Urayama, Shiro | 2014
89400U
Measurement of fluorescent probes concentration ratio in the cerebrospinal fluid for early detection of Alzheimer's disease
Harbater, Osnat / Gannot, Israel | 2014
89400V
Third therapeutic spectral window for deep tissue imaging
Sordillo, Laura A. / Pratavieira, Sebastião / Pu, Yang / Salas-Ramirez, Kaliris / Shi, Lingyan / Zhang, Lin / Budansky, Yury / Alfano, R. R. | 2014
89400X
Ultimate ultrafast white light's first observations: early discovery circa 1970
Alfano, Robert R. | 2014
89400Y
Evolution of the supercontinuum source
Taylor, James Roy | 2014
89400Z
Supercontinuum generation in optical fibers and its biomedical applications
Agrawal, Govind P. | 2014
894001
Front Matter: Volume 8940
| 2014
894006
Propagation and scattering of vector light beam in turbid scattering medium
Doronin, Alexander / Milione, Giovanni / Meglinski, Igor / Alfano, Robert R. | 2014
894007
Diffusing-wave polarimetry for tissue diagnostics
Macdonald, Callum / Doronin, Alexander / Peña, Adrian F. / Eccles, Michael / Meglinski, Igor | 2014
894010
White light for the fast lane: supercontinuum generation in all-normal dispersion fibers for ultrafast photonics
Heidt, Alexander M. | 2014
894011
Supercontinuum generation in microstructure fiber at the advent of femtosecond combs
Cundiff, Steven T. | 2014
894012
Collapsing light really shines
Gaeta, Alexander L. | 2014
894013
Cross-phase modulation in optical Kerr media: review of discovery experiments
Baldeck, Patrice L. | 2014
894014
Tumor margin detection using optical biopsy techniques
Zhou, Yan / Liu, Cheng-hui / Li, Jiyou / Li, Zhongwu / Zhou, Lixin / Chen, Ke / Pu, Yang / He, Yong / Zhu, Ke / Li, Qingbo et al. | 2014
894015
Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy
Zhang, Lin / Pu, Yang / Xue, Jianpeng / Pratavieira, Sebastião / Xu, Baogang / Achilefu, Samuel / Alfano, R. R. | 2014
894016
Grading of cervical intraepithelial neoplasia using spatial frequency for optical histology
Pu, Yang / Jagtap, Jaidip / Pradhan, Asima / Alfano, Robert R. | 2014
894017
Enhancing the depth of tissue microscope imaging using two-photon excitation of the second singlet state of fluorescent agents
Pu, Yang / Shi, Lingyan / Pratavieira, Sebastião / Alfano, R. R. | 2014
894018
Diffuse optical methods for assessing breast cancer chemotherapy
Tromberg, Bruce J. | 2014
In vivo Raman spectroscopy of cervix cancers [8940-13]
Rubina, S. / Sathe, P. / Dora, T.K. / Chopra, S. / Maheshwari, A. / Krishna, C.M. / SPIE (Society) | 2014
Measurement of fluorescent probes concentration ratio in the cerebrospinal fluid for early detection of Alzheimer's disease [8940-29]
Harbater, O. / Gannot, I. / SPIE (Society) | 2014
Enhancing the depth of tissue microscope imaging using two-photon excitation of the second singlet state of fluorescent agents [8940-39]
Pu, Y. / Shi, L. / Pratavieira, S. / Alfano, R.R. / SPIE (Society) | 2014
Automated cellular pathology in noninvasive confocal microscopy [8940-9]
Ting, M. / Krueger, J. / Gareau, D. / SPIE (Society) | 2014
Autofluorescence lifetime metrology for label-free detection of cartilage matrix degradation [8940-16]
Nickdel, M.B. / Lagarto, J.L. / Kelly, D.J. / Manning, H.B. / Yamamoto, K. / Talbot, C.B. / Dunsby, C. / French, P. / Itoh, Y. / SPIE (Society) | 2014
Enhanced visualization of the bile duct via parallel white light and indocyanine green fluorescence laparoscopic imaging [8940-26]
Demos, S.G. / Urayama, S. / SPIE (Society) | 2014
Grading of cervical intraepithelial neoplasia using spatial frequency for optical histology [8940-40]
Pu, Y. / Jagtap, J. / Pradhan, A. / Alfano, R.R. / SPIE (Society) | 2014
Brain metastasis detection by resonant Raman optical biopsy method [8940-11]
Zhou, Y. / Liu, C. / Cheng, G. / Zhou, L. / Zhang, C. / Pu, Y. / Li, Z. / Liu, Y. / Li, Q. / Wang, W. et al. | 2014
Noninvasive diagnosis of oral cancer by Stokes shift spectroscopy [8940-20]
Ebenezar, J. / Ganesan, S. / Aruna, P. / Muralinaidu, R. / SPIE (Society) | 2014
Parametric study of different contributors to tumor thermal profile [8940-24]
Tepper, M. / Gannot, I. / SPIE (Society) | 2014
Propagation and scattering of vector light beam in turbid scattering medium [8940-5]
Doronin, A. / Milione, G. / Meglinski, I. / Alfano, R.R. / SPIE (Society) | 2014
Diffusing-wave polarimetry for tissue diagnostics [8940-6]
Macdonald, C. / Doronin, A. / Pena, A.F. / Eccles, M. / Meglinski, I. / SPIE (Society) | 2014
Optical characterization of ex-vivo axillary lymph nodes of breast-cancer patients using a custom-built spectrophotometer [8940-25]
Sampathkumar, A. / Lizzi, F.L. / Saegusa-Beecroft, E. / Mamou, J. / Chitnis, P.V. / Machi, J. / Feleppa, E.J. / SPIE (Society) | 2014
Diffuse optical methods for assessing breast cancer chemotherapy [8940-57]
Tromberg, B.J. / SPIE (Society) | 2014
Third therapeutic spectral window for deep tissue imaging [8940-30]
Sordillo, L.A. / Pratavieira, S. / Pu, Y. / Salas-Ramirez, K. / Shi, L. / Zhang, L. / Budansky, Y. / Alfano, R.R. / SPIE (Society) | 2014
Wavelength-dependent measurement of contrast in NIR and extended NIR spectral range (650-1600 nm) in phantoms [8940-23]
Salo, D. / Kim, D.M. / Berezin, M.Y. / SPIE (Society) | 2014
Supercontinuum generation in microstructure fiber at the advent of femtosecond combs (Invited Paper) [8940-36]
Cundiff, S.T. / SPIE (Society) | 2014
Cross-phase modulation in optical Kerr media: review of discovery experiments (Invited Paper) [8940-38]
Baldeck, P.L. / SPIE (Society) | 2014
Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy [8940-41]
Zhang, L. / Pu, Y. / Xue, J. / Pratavieira, S. / Xu, B. / Achilefu, S. / Alfano, R.R. / SPIE (Society) | 2014
Raman microspectroscopic study of oral buccal mucosa [8940-12]
Behl, I. / Mamgain, H. / Deshmukh, A. / Kukreja, L. / Hole, A.R. / Krishna, C.M. / SPIE (Society) | 2014
Tumor margin detection using optical biopsy techniques [8940-42]
Zhou, Y. / Liu, C. / Li, J. / Li, Z. / Zhou, L. / Chen, K. / Pu, Y. / He, Y. / Zhu, K. / Li, Q. et al. | 2014