Diffuse reflectance spectroscopy from 400-1600 nm to evaluate tumor resection margins during head and neck surgery (Conference Presentation) (Englisch)

In: Proc. SPIE   ;  10039 ;  2017

Wie erhalte ich diesen Titel?

Kommerziell Vergütung an den Verlag: 15,17 € Grundgebühr: 4,00 € Gesamtpreis: 19,17 €
Akademisch Vergütung an den Verlag: 15,17 € Grundgebühr: 2,00 € Gesamtpreis: 17,17 €

This ex vivo study evaluates the feasibility of diffuse reflectance spectroscopy (DRS) for discriminating tumor from healthy oral tissue, with the aim to develop a technique that can be used to determine a complete excision of tumor through intraoperative margin assessment. DRS spectra were acquired on fresh surgical specimens from patients with an oral squamous cell carcinoma. The spectra represent a measure of diffuse light reflectance (wavelength range of 400-1600 nm), detected after illuminating tissue with a source fiber at 1.0 and 2.0 mm distances from a detection fiber. Spectra were obtained from 23 locations of tumor tissue and 16 locations of healthy muscle tissue. Biopsies were taken from all measured locations to facilitate an optimal correlation between spectra and pathological information. The area under the spectrum was used as a parameter to classify spectra of tumor and healthy tissue. Next, a receiver operating characteristics (ROC) analysis was performed to provide the area under the receiver operating curve (AUROC) as a measure for discriminative power. The area under the spectrum between 650 and 750 nm was used in the ROC analysis and provided AUROC values of 0.99 and 0.97, for distances of 1 mm and 2 mm between source and detector fiber, respectively. DRS can discriminate tumor from healthy oral tissue in an ex vivo setting. More specimens are needed to further evaluate this technique with component analyses and classification methods, prior to in vivo patient measurements.

Inhaltsverzeichnis Konferenzband

Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Einzelnachweisen der enthaltenen Beiträge. Die Anzeige der Inhaltsverzeichnisse kann daher unvollständig oder lückenhaft sein.

3-D rendition (Conference Presentation)
Izdebski, Krzysztof / Blanco, Matthew / Sova, Jaroslaw / Di Lorenzo, Enrico | 2017
Analysis of laryngeal amyloidosis using high speed digital phonoscopy and acoustics (Conference Presentation)
Blanco, Matthew / Cruz, Raul M. / Izdebski, Krzysztof / Yan, Yuling | 2017
Diffuse reflectance spectroscopy from 400-1600 nm to evaluate tumor resection margins during head and neck surgery (Conference Presentation)
Brouwer de Koning, Susan G. / Baltussen, E.J.M. / Karakullukcu, M. Baris / Smit, L. / van Veen, R. L. P. / Hendriks, Benno H. W. / Sterenborg, H.J.C.M. / Ruers, Theo J. M. | 2017
Autofluorescence lifetime imaging during transoral robotic surgery: a clinical validation study of tumor detection (Conference Presentation)
Lagarto, João L. / Phipps, Jennifer E. / Unger, Jakob / Faller, Leta M. / Gorpas, Dimitris / Ma, Dinglong M. / Bec, Julien / Moore, Michael G. / Bewley, Arnaud F. / Yankelevich, Diego R. et al. | 2017
Medical imaging feasibility in body fluids using Markov chains
Kavehrad, M. / Armstrong, A. D. | 2017
Wide-field OCT imaging of oral lesions in vivo: quantification and classification (Conference Presentation)
Raizada, Rashika / Lee, Anthony M. D. / Liu, Kelly Y. / MacAulay, Calum E. / Ng, Samson / Poh, Catherine F. / Lane, Pierre M. | 2017
Longitudinal monitoring of head and neck lymphatics in response to cancer treatment
Rasmussen, John C. / Tan, I-Chih / Naqvi, Syed / Aldrich, Melissa B. / Maus, Erik A. / Blanco, Angel I. / Karni, Ron J. / Sevick-Muraca, Eva M. | 2017
The mechanism of tissue welding using a green laser: revisited
Richter, C.-P. / Bellam, R. / Hezarkhani, E. / Fiebig, T. | 2017
Transplantation of rib cartilage reshaped with 1.56 μm laser radiation in rabbits
Sobol, E. / Baum, O. / Alexandrovskaya, Yu. / Shekhter, A. / Selezneva, L. / Svistuskin, V. | 2017
Front Matter: Volume 10039
| 2017
Extratympanic imaging of middle and inner ear structures of mouse and rat using optical coherence tomography
Oh, Se-Joon / Lee, Il-Woo / Wang, Soo-Geun / Kong, Soo-Keun / Kim, Hong-Ki / Goh, Eui-Kyung | 2017
The morphological changes of optically cleared cochlea using optical coherence tomography (Conference Presentation)
Lee, Jaeyul / Song, Jaewon / Jeon, Mansik / Kim, Jeehyun | 2017
Multimodal optical imager for inner ear hearing loss diagnosis (Conference Presentation)
Park, Jesung / Maguluri, Gopi N. / Zhao, Youbo / Iftimia, Nicusor V. | 2017
Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging
Balakrishnan, Santosh / Bu, Ruofei / Price, Hillel / Zdanski, Carlton / Oldenburg, Amy L. | 2017
Thermographic imaging of facial and ventilatory activity during vocalization, speech and expiration (Conference Presentation)
Izdebski, Krzysztof / Jarosz, Paweł / Usydus, Ireneusz | 2017
High speed digital phonoscopy of selected extreme vocalization (Conference Presentation)
Izdebski, Krzysztof / Blanco, Matthew / Di Lorenzo, Enrico / Yan, Yuling | 2017