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Selective Detection and Quantification of Modified DNA with Solid- State Nanopores (Englisch)

In: Nano Letters   ;  14 ,  10  ;  5488-5492  ;  2014
  • ISSN:
    1530-6984
  • Aufsatz (Zeitschrift)  /  Print

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We demonstrate a solid-state nanopore assay for the unambiguous discrimination and quantification of modified DNA. Individual streptavidin proteins are employed as high-affinity tags for DNA containing a single biotin moiety. We establish that the rate of translocation events corresponds directly to relative concentration of protein-DNA complexes and use the selectivity of our approach to quantify modified oligonucleotides from among a background of unmodified DNA in solution.

Inhaltsverzeichnis – Band 14, Ausgabe 10

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