The Omics Revolution Continues: The Maturation of High-Throughput Biological Data Sources (Englisch)

In: Yearbook of Medical Informatics   ;  27 ,  01  ;  211-222  ;  2018

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Objective: The aim is to provide a comprehensive review of state-of-the art omics approaches, including proteomics, metabolomics, cell-free DNA, and patient cohort matching algorithms in precision oncology.

Methods: In the past several years, the cancer informatics revolution has been the beneficiary of a data explosion. Different complementary omics technologies have begun coming into their own to provide a more nuanced view of the patient-tumor interaction beyond that of DNA alterations. A combined approach is beneficial to the patient as nearly all new cancer therapeutics are designed with an omics biomarker in mind. Proteomics and metabolomics provide us with a means of assaying in real-time the response of the tumor to treatment. Circulating cell-free DNA may allow us to better understand tumor heterogeneity and interactions with the host genome.

Results: Integration of increasingly available omics data increases our ability to segment patients into smaller and smaller cohorts, thereby prompting a shift in our thinking about how to use these omics data. With large repositories of patient omics-outcomes data being generated, patient cohort matching algorithms have become a dominant player.

Conclusions: The continued promise of precision oncology is to select patients who are most likely to benefit from treatment and to avoid toxicity for those who will not. The increased public availability of omics and outcomes data in patients, along with improved computational methods and resources, are making precision oncology a reality.

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Cover IMIA Yearbook of Medical Informatics 2018
| 2018
001
Taking up the Gavel
Lehmann, Christoph U. | 2018
003
In Memoriam: Diarmuid Ua Conaill
Kulikowski, Casimir A. / Haux, Reinhold / Lorenzi, Nancy M. / Rienhoff, Otto | 2018
005
A 21st Century Embarrassment of Riches: The Balance Between Health Data Access, Usage, and Sharing
Holmes, John H. / Soualmia, Lina F. / Séroussi, Brigitte | 2018
007
Visions for IAHSI, the International Academy of Health Sciences Informatics
Haux, Reinhold | 2018
010
Through Patients' Eyes: Regulation, Technology, Privacy, and the Future
Petersen, Carolyn | 2018
016
Advances in Sharing Multi-sourced Health Data on Decision Support Science 2016-2017
Shankar, Prabhu / Anderson, Nick | 2018
025
The Safe and Effective Use of Shared Data Underpinned by Stakeholder Engagement and Evaluation Practice
Georgiou, Andrew / Magrabi, Farah / Hyppönen, Hannele / Wong, Zoie Shui-Yee / Nykänen, Pirkko / Scott, Philip J. / Ammenwerth, Elske / Rigby, Michael | 2018
029
Balancing Between Privacy and Patient Needs for Health Information in the Age of Participatory Health and Social Media: A Scoping Review
Househ, Mowafa / Grainger, Rebecca / Petersen, Carolyn / Bamidis, Panagiotis / Merolli, Mark | 2018
037
Ethics Certification of Health Information Professionals
Kluge, Eike-Henner / Lacroix, Paulette / Ruotsalainen, Pekka | 2018
041
The Privacy and Security Implications of Open Data in Healthcare
Kobayashi, Shinji / Kane, Thomas B. / Paton, Chris | 2018
048
Balancing Health Information Exchange and Privacy Governance from a Patient-Centred Connected Health and Telehealth Perspective
Kuziemsky, Craig E. / Gogia, Shashi B. / Househ, Mowafa / Petersen, Carolyn / Basu, Arindam | 2018
055
Between Access and Privacy: Challenges in Sharing Health Data
Malin, Bradley / Goodman, Kenneth | 2018
059
Best Paper Selection
| 2018
060
Access and Disclosure of Personal Health Information: A Challenging Privacy Landscape in 2016-2018
Kloss, Linda L. / Brodnik, Melanie S. / Rinehart-Thompson, Laurie A. | 2018
067
Findings from 2017 on Health Information Management
Bloomrosen, Meryl / Berner, Eta S. | 2018
074
Expanding Human Computer Interaction Methods to Understand User Needs in the Design Process of Personal Health Systems
Siek, Katie A. | 2018
079
Findings from the 2018 Yearbook Section on Human Factors and Organizational Issues
Pelayo, Sylvia / Kaipio, Johanna | 2018
083
Recent Advancement of Clinical Information Systems: Opportunities and Challenges
Islam, Md. Mohaimenul / Poly, Tahmina Nasrin / Li, Yu-Chuan Jack | 2018
091
On the Way to Close the Loop in Information Logistics: Data from the Patient — Value for the Patient
Hackl, Werner O / Hoerbst, Alexander | 2018
098
Deep Learning on 1-D Biosignals: a Taxonomy-based Survey
Ganapathy, Nagarajan / Swaminathan, Ramakrishnan / Deserno, Thomas M. | 2018
110
Sensor, Signal, and Imaging Informatics in 2017
Hsu, William / Deserno, Thomas M / Kahn, Charles E. | 2018
114
Behavioral Economics Interventions in Clinical Decision Support Systems
Cho, Insook / Bates, David W. | 2018
122
Contributions from the 2017 Literature on Clinical Decision Support
Koutkias, V. / Bouaud, J. | 2018
129
Recent Developments in Clinical Terminologies — SNOMED CT, LOINC, and RxNorm
Bodenreider, Oliver / Cornet, Ronald / Vreeman, Daniel J. | 2018
140
As Ontologies Reach Maturity, Artificial Intelligence Starts Being Fully Efficient: Findings from the Section on Knowledge Representation and Management for the Yearbook 2018
Dhombres, Ferdinand / Charlet, Jean | 2018
146
Consumer Health Informatics Adoption among Underserved Populations: Thinking beyond the Digital Divide
Huh, Jina / Koola, Jejo / Contreras, Alejandro / Castillo, Alanah KP. / Ruiz, Melissa / Tedone, Keely G. / Yakuta, Melissa / Schiaffino, Melody K. | 2018
156
Benefit-risk of Patients' Online Access to their Medical Records: Consensus Exercise of an International Expert Group
Liyanage, Harshana / Liaw, Siaw-Teng / Konstantara, Emmanouela / Mold, Freda / Schreiber, Richard / Kuziemsky, Craig / Terry, Amanda L. / de Lusignan, Simon | 2018
163
Findings from 2017 on Consumer Health Informatics and Education: Health Data Access and Sharing
Staccini, Pascal / Lau, Annie Y. S. | 2018
170
Between Scylla and Charybdis: Charting the Wicked Problem of Reusing Health Data for Clinical Research Informatics
Lea, Nathan C. / Nicholls, Jacqueline / Fitzpatrick, Natalie K. | 2018
177
Clinical Research Informatics: Contributions from 2017
Daniel, Christel / Kalra, Dipak | 2018
184
Advancing the State of the Art in Clinical Natural Language Processing through Shared Tasks
Filannino, Michele / Uzuner, Özlem | 2018
193
Expanding the Diversity of Texts and Applications: Findings from the Section on Clinical Natural Language Processing of the International Medical Informatics Association Yearbook
Névéol, Aurélie / Zweigenbaum, Pierre | 2018
199
Public and Population Health Informatics: The Bridging of Big Data to Benefit Communities
Gamache, Roland / Kharrazi, Hadi / Weiner, Jonathan P. | 2018
207
Artificial Intelligence in Public Health and Epidemiology
Thiébaut, Rodolphe / Thiessard, Frantz | 2018
211
The Omics Revolution Continues: The Maturation of High-Throughput Biological Data Sources
Mathé, Ewy / Hays, John L. / Stover, Daniel G. / Chen, James L. | 2018
223
Cancer Informatics in 2017: A New Beginning and a Bright Future
Warner, Jeremy L. / Patt, Debra A. | 2018
227
Terminology Services: Standard Terminologies to Control Health Vocabulary
González Bernaldo de Quirós, Fernán / Otero, Carlos / Luna, Daniel | 2018
234
The Datafication of Everything — Even Toilets
Lun, Kwok-Chan | 2018
237
Five Years of Clinical Informatics Board Certification for Physicians in the United States of America
Lehmann, Christoph U. / Gundlapalli, Adi V. / Williamson, Jeffrey J. / Fridsma, Douglas B. / Hersh, William R. / Krousel-Wood, Marie / Ondrula, Christopher J. / Munger, Benson | 2018
243
History of Romanian Medical Informatics: Learning from the Past to Reshape the Future
Mihalas, George I. / Stoicu-Tivadar, Lacramioara | 2018
252
Welcome to IMIA!
| 2018
255
Honorary Fellows
| 2018
256
IMIA Member Societies and Corresponding Members
| 2018
257
Institutional Members
| 2018
259
Addresses of IMIA Member Societies
| 2018
275
APAMI
Cho, Kyung-Hee | 2018
281
Helina
Kouematchoua Tchuitcheu, Ghislain B. | 2018
283
IMIA LAC
Espinosa, Amado | 2018
286
Middle East and North African Health Informatics Association (MENAHIA): Building Sustainable Collaboration
Al-Shorbaji, Najeeb / Househ, Mowafa / Taweel, Adel / Alanizi, Abdullah / Mohammed, Bennani Othmani / Abaza, Haitham / Bawadi, Hala / Rasuly, Hamayon / Alyafei, Khalid / Fernandez-Luque, Luis et al. | 2018
292
North American Medical Informatics (NAMI)
Kushniruk, Andre / Greenwood, Karen / Casselman, Mark | 2018
296
EFMI
Lovis, Christian / Mihalas, George / Mantas, John / Peek, Niels / Balicer, Ran / Masic, Izet M. / Stoicu-Tivadar, Lacramioara / Moen, Anne | 2018
302
Implementation of a National Framework to Promote Health Data Sharing
Knaup, Petra / Deserno, Thomas M. / Prokosch, Hans-Ulrich / Sax, Ulrich | 2018
305
Contributors to the 2018 IMIA Yearbook of Medical Informatics
| 2018
306
Reviewers for the 2018 IMIA Yearbook of Medical Informatics
| 2018
307
IMIA Yearbook Special Topics
| 2018
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Contents IMIA Yearbook of Medical Informatics 2018
| 2018