Relevance of anaesthesia for dofetilide‐induced torsades de pointes in α1‐adrenoceptor‐stimulated rabbits (Englisch)

in British Journal of Pharmacology ; 153 , 1 ; 75-89
British Journal of Pharmacology

No information is available concerning the effects of anaesthetics in the most frequently used in vivo pro‐arrhythmia model. Accordingly, in this study we examined the effect of pentobarbital, propofol or α‐chloralose anaesthesia on the pro‐arrhythmic activity of the class III anti‐arrhythmic dofetilide in α1‐adrenoceptor‐stimulated rabbits.

Rabbits anaesthetized intravenously with pentobarbital, propofol or α‐chloralose were infused simultaneously with the α1‐adrenoceptor agonist phenylephrine (15 μg kg−1 min−1, i.v.) and dofetilide (0.04 mg kg−1 min−1, i.v.). The electrocardiographic QT interval, the T peakT end interval and certain QT variability parameters were measured. The heart rate variability and the baroreflex sensitivity were utilized to assess the vagal nerve activity. The spectral power of the systolic arterial pressure was calculated in the frequency range 0.15–0.5 Hz to assess the sympathetic activity.

Pentobarbital considerably reduced, whereas propofol did not significantly affect the incidence of dofetilide‐induced torsades de pointes (TdP) as compared with the results with α‐chloralose (40% (P=0.011) and 70% (P=0.211) vs 100%, respectively). In additional experiments, neither doubling of the rate of the dofetilide infusion nor tripling of the rate of phenylephrine infusion elevated the incidence of TdP to the level seen with α‐chloralose. None of the repolarization‐related parameters predicted TdP. The indices of the parasympathetic and sympathetic activity were significantly depressed in the α‐chloralose and propofol anaesthesia groups.

In rabbits, anaesthetics may affect drug‐induced TdP genesis differently, which must be considered when results of different studies are compared.

British Journal of Pharmacology (2008) 153, 75–89; doi:10.1038/sj.bjp.0707536; published online 29 October 2007

Wie erhalte ich diesen Titel?
Download
Kommerziell Vergütung an den Verlag: 44,19 € Grundgebühr: 4,00 € Gesamtpreis: 48,19 €
Akademisch Vergütung an den Verlag: 44,19 € Grundgebühr: 2,00 € Gesamtpreis: 46,19 €

Dokumentinformationen


Inhaltsverzeichnis – Band 153, Ausgabe 1

Zeige alle Jahrgänge und Ausgaben

Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Nachweisen der enthaltenen Aufsätze. Die Anzeige der Jahrgänge kann aufgrund fehlender Aufsatznachweise unvollständig oder lückenhaft sein, obwohl die Zeitschrift komplett in der TIB verfügbar ist.

1
Reperfusion and calculated RISKs: pharmacological postconditioning of human myocardium
Baxter, G F / Burley, D S | 2008
4
Evidence against C‐type natriuretic peptide as an arterial ‘EDHF’
Garland, C J / Dora, K A | 2008
6
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors
Negre‐Salvayre, A / Coatrieux, C / Ingueneau, C / Salvayre, R | 2008
21
Inflammatory response and cardioprotection during open‐heart surgery: the importance of anaesthetics
Suleiman, M‐S / Zacharowski, K / Angelini, G D | 2008
34
[Pt(O,O′‐acac)(γ‐acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF‐7 breast cancer cells via the mitochondrial apoptotic pathway
Muscella, A / Calabriso, N / Fanizzi, F P / De Pascali, S A / Urso, L / Ciccarese, A / Migoni, D / Marsigliante, S | 2008
50
Erythropoietin protects the human myocardium against hypoxia/reoxygenation injury via phosphatidylinositol‐3 kinase and ERK1/2 activation
Mudalagiri, N R / Mocanu, M M / Di Salvo, C / Kolvekar, S / Hayward, M / Yap, J / Keogh, B / Yellon, D M | 2008
57
C‐type natriuretic peptide and endothelium‐dependent hyperpolarization in the guinea‐pig carotid artery
Leuranguer, V / Vanhoutte, P M / Verbeuren, T / Félétou, M | 2008
66
Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression
Zhong, J‐C / Yu, X‐Y / Lin, Q‐X / Li, X‐H / Huang, X‐Z / Xiao, D‐Z / Lin, S‐G | 2008
75
Relevance of anaesthesia for dofetilide‐induced torsades de pointes in α1‐adrenoceptor‐stimulated rabbits
Vincze, D / Farkas, A S / Rudas, L / Makra, P / Csík, N / Leprán, I / Forster, T / Csanády, M / Papp, J G / Varró, A et al. | 2008
90
Effects of angiotensin II blockade on inflammation‐induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers
Hanafy, S / Dagenais, N J / Dryden, W F / Jamali, F | 2008
100
The hydrogen sulphide‐releasing derivative of diclofenac protects against ischaemia–reperfusion injury in the isolated rabbit heart
Rossoni, G / Sparatore, A / Tazzari, V / Manfredi, B / Soldato, P Del / Berti, F | 2008
110
Electromechanical characterization of cinnamophilin, a natural thromboxane A2 receptor antagonist with anti‐arrhythmic activity, in guinea‐pig heart
Chang, G‐J / Su, M‐J / Wu, T‐S / Chen, W‐P / Kuo, C‐M | 2008
124
The use of the Chandler loop to examine the interaction potential of NXY‐059 on the thrombolytic properties of rtPA on human thrombi in vitro
Mutch, N J / Moore, N R / Mattsson, C / Jonasson, H / Green, A R / Booth, N A | 2008
132
Effects of chronic in vivo administration of nitroglycerine on ACh‐induced endothelium‐dependent relaxation in rabbit cerebral arteries
Watanabe, Y / Kusama, N / Itoh, T | 2008
140
Analysis of sphingosine 1‐phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools
Salomone, S / Potts, E M / Tyndall, S / Ip, P C / Chun, J / Brinkmann, V / Waeber, C | 2008
148
Platelet‐dependent accumulation of leukocytes in sinusoids mediates hepatocellular damage in bile duct ligation‐induced cholestasis
Laschke, M W / Dold, S / Menger, M D / Jeppsson, B / Thorlacius, H | 2008
157
AS601245, a c‐Jun NH2‐terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils
Carboni, S / Boschert, U / Gaillard, P / Gotteland, J‐P / Gillon, J‐Y / Vitte, P‐A | 2008
164
Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic‐pharmacodynamic modelling approach
Lehr, T / Staab, A / Tillmann, C / Nielsen, E Ø / Trommeshauser, D / Schaefer, H G / Kloft, C | 2008

Ähnliche Titel