LOW CORONARY DRIVING PRESSURE IS ASSOCIATED WITH SUBENDOCARDIAL REMODELLING AND LEFT VENTRICULAR DYSFUNCTION IN AORTOCAVAL FISTULA (Englisch)

Clinical and Experimental Pharmacology and Physiology

The role of haemodynamic changes in left ventricular remodelling has been poorly investigated, especially in the context of volume overload cardiac hypertrophy. Low diastolic blood pressure and high left ventricular filling pressure are expected to affect coronary driving pressure negatively and thereby put in jeopardy subendocardial perfusion in particular. The consequences to global left ventricular remodelling remain undetermined. The aim of the present study was to investigate the role of coronary driving pressure in the development of subendocardial remodelling and the conceivable effects on cardiac function, using a rat model of aortocaval fistula.

Wistar rats, weighing 330–350 g, were submitted to aortocaval fistula (ACF group) or sham (control group) operations. Two haemodynamic measurements were determined following surgery, the initial measurement at week 1 and the final measurement at week 8. Cytokine expression, myeloperoxidase (MPO) activity, metalloproteinase expression and activity and fibrosis were assessed in two distinct left ventricular myocardial layers: the subendocardium (SE) and the non‐subendocardium (non‐SE).

The ACF group showed lower initial and final coronary driving pressure and lower final +dP/dt and –dP/dt compared with the control group. Multivariate analyses disclosed initial coronary driving pressure as the only haemodynamic parameter independently associated with SE fibrosis (R2 = 0.76; P <� 0.0001) and with +dP/dt (R2 = 0.55; P = 0.0004) and –dP/dt (R2 = 0.91; P <� 0.0001). Matrix metalloproteinase (MMP)‐2 expression and activity predominated in the SE of ACF animals, particularly in those with low coronary driving pressure. Increased levels of interleukin (IL)‐6 and IL‐1β also predominated in the SE of the ACF group. Otherwise, MPO activity and levels of tumour necrosis factor‐α and IL‐10 were similar in both groups. Final coronary driving pressure correlated with both the expression and activity of MMP‐2.

Low coronary driving pressure early in the course of ACF determines SE damage and, by this mechanism, interferes negatively in left ventricular function.

Wie erhalte ich diesen Titel?
Download
Kommerziell Vergütung an den Verlag: 38,00 € Grundgebühr: 4,00 € Gesamtpreis: 42,00 €
Akademisch Vergütung an den Verlag: 38,00 € Grundgebühr: 2,00 € Gesamtpreis: 40,00 €

Dokumentinformationen


Inhaltsverzeichnis – Band 34, Ausgabe 11

Zeige alle Jahrgänge und Ausgaben

Die Inhaltsverzeichnisse werden automatisch erzeugt und basieren auf den im Index des TIB-Portals verfügbaren Nachweisen der enthaltenen Aufsätze. Die Anzeige der Jahrgänge kann aufgrund fehlender Aufsatznachweise unvollständig oder lückenhaft sein, obwohl die Zeitschrift komplett in der TIB verfügbar ist.

1091
AGE‐RELATED CHANGES IN THE STRUCTURE AND FUNCTION OF SKELETAL MUSCLES
Faulkner, John A / Larkin, Lisa M / Claflin, Dennis R / Brooks, Susan V | 2007
1097
MODULATION OF SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION (STAT) FACTOR PATHWAYS DURING FOCAL CEREBRAL ISCHAEMIA: A GENE EXPRESSION ARRAY STUDY IN RAT HIPPOCAMPUS AFTER MIDDLE CEREBRAL ARTERY OCCLUSION
Sun, Sheng‐Li / Li, Tie‐Jun / Yang, Peng‐Yuan / Qiu, Yan / Rui, Yao‐Cheng | 2007
1102
PROTEASOME INHIBITOR LACTACYSTIN ABLATES LIVER INJURY INDUCED BY INTESTINAL ISCHAEMIA–REPERFUSION
Yao, Ji‐Hong / Li, Ying‐Hua / Wang, Zhen‐Zhen / Zhang, Xue‐Song / Wang, Yu‐Zhu / Yuan, Jin‐Chan / Zhou, Qin / Liu, Ke‐Xin / Tian, Xiao‐Feng | 2007
1109
EFFECTS OF RESVERATROL ON NUMBER AND ACTIVITY OF ENDOTHELIAL PROGENITOR CELLS FROM HUMAN PERIPHERAL BLOOD
Wang, Xiao‐Bin / Huang, Jun / Zou, Jian‐Gang / Su, En‐Ben / Shan, Qi‐Jun / Yang, Zhi‐Jian / Cao, Ke‐Jiang | 2007
1116
FLAVONE INHIBITS VASCULAR CONTRACTION BY DECREASING PHOSPHORYLATION OF THE MYOSIN PHOSPHATASE TARGET SUBUNIT
Jeon, Su Bun / Kim, Gutae / Kim, Jee In / Seok, Young Mi / Kim, Sang‐Hyun / Suk, Kyoungho / Shin, Heung‐Mook / Lee, Young‐Ho / Kim, In Kyeom | 2007
1121
SPINAL a-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTORS MAY MEDIATE THE ANALGESIC EFFECTS OF EMULSIFIED HALOGENATED ANAESTHETICS
Hang, L. H. / Shao, D. H. / Yang, Y. H. / Dai, T. J. / Zeng, Y. M. | 2007
1121
SPINAL α‐AMINO‐3‐HYDROXY‐5‐METHYL‐4‐ISOXAZOLEPROPIONIC ACID RECEPTORS MAY MEDIATE THE ANALGESIC EFFECTS OF EMULSIFIED HALOGENATED ANAESTHETICS
Hang, Li‐Hua / Shao, Dong‐Hua / Yang, Ying‐Hong / Dai, Ti‐Jun / Zeng, Yin‐Ming | 2007
1126
S100B LEVELS IN THE CEREBROSPINAL FLUID OF RATS ARE SEX AND ANAESTHETIC DEPENDENT
Vicente, Évelin / Tramontina, Francine / Leite, Marina C / Nardin, Patricia / Silva, Mariane / Karkow, Ana R / Adolf, Rafael / Lucion, Aldo B / Netto, Carlos A / Gottfried, Carmem et al. | 2007
1131
STRONTIUM FRUCTOSE 1,6‐DIPHOSPHATE RESCUES ADENINE‐INDUCED MALE HYPOGONADISM AND UPREGULATES THE TESTICULAR ENDOTHELIN‐1 SYSTEM
Feng, Yu / Zhang, Qi / Dai, De‐Zai / Ying, Han‐Jie / Dai, Yin | 2007
1138
EXPRESSION OF CYP3A ISOFORMS AND P‐GLYCOPROTEIN IN HUMAN STOMACH, JEJUNUM AND ILEUM
Canaparo, Roberto / Finnström, Niklas / Serpe, Loredana / Nordmark, Anna / Muntoni, Elisabetta / Eandi, Mario / Rane, Anders / Zara, Gian Paolo | 2007
1145
DESENSITIZATION OF GUINEA‐PIG TAENIA CAECI SMOOTH MUSCLE INDUCED BY A LOW CONCENTRATION OF CARBACHOL
Hishinuma, Shigeru / Sato, Ryo / Saito, Masaki | 2007
1151
EFFECTS OF AGAR AND PECTIN ON GASTRIC EMPTYING AND POST‐PRANDIAL GLYCAEMIC PROFILES IN HEALTHY HUMAN VOLUNTEERS
Sanaka, Masaki / Yamamoto, Takatsugu / Anjiki, Hajime / Nagasawa, Kunitaka / Kuyama, Yasushi | 2007
1156
ACTIVATION OF PERIPHERAL CHEMORECEPTORS CAUSES POSITIVE INOTROPIC EFFECTS IN A WORKING HEART–BRAINSTEM PREPARATION OF THE RAT
Braga, Valdir A / Zoccal, Daniel B / Soriano, Renato N / Antunes, Vagner R / Paton, Julian F / Machado, Benedito H / Nalivaiko, Eugene | 2007
1160
RESTORATION OF ANTIBIOTIC SUSCEPTIBILITY IN METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS BY TARGETING MECR1 WITH A PHOSPHOROTHIOATE DEOXYRIBOZYME
Hou, Zheng / Meng, Jing‐Ru / Niu, Chao / Wang, Hai‐Fang / Liu, Jie / Hu, Ben‐Quan / Jia, Min / Luo, Xiao‐Xing | 2007
1165
LOW CORONARY DRIVING PRESSURE IS ASSOCIATED WITH SUBENDOCARDIAL REMODELLING AND LEFT VENTRICULAR DYSFUNCTION IN AORTOCAVAL FISTULA
Guido, Maria C / De Carvalho Frimm, Clovis / Koike, Márcia K / Cordeiro, Fernanda F / Moretti, Ana IS / Godoy, Luiz C | 2007
1173
NITRIC OXIDE MODULATES AIR EMBOLISM‐INDUCED LUNG INJURY IN RATS WITH NORMOTENSION AND HYPERTENSION
Liu, Yen Chin / Kao, Shang Jyh / Chuang, I Chun / Chen, Hsing I | 2007
1181
NOVEL EVIDENCE SUGGESTING AN ANTI‐OXIDANT PROPERTY FOR ERYTHROPOIETIN ON VANCOMYCIN‐INDUCED NEPHROTOXICITY IN A RAT MODEL
Cetin, Hasan / Olgar, şeref / Oktem, Faruk / Ciris, Metin / Uz, Efkan / Aslan, Çaǧatay / Ozguner, Fehmi | 2007
1186
ACTIONS OF THE ENDOCANNABINOID TRANSPORT INHIBITOR AM404 IN NEUROPATHIC AND INFLAMMATORY PAIN MODELS
Mitchell, Vanessa A / Greenwood, Ruth / Jayamanne, Angelo / Vaughan, Christopher W | 2007
1191
ANGIOTENSIN II RECEPTORS SUBTYPES MEDIATE DIVERSE GENE EXPRESSION PROFILE IN ADULT HYPERTROPHIC CARDIOMYOCYTES
Zhou, Juan / Xu, Xin / Liu, Jin‐Jun / Lin, Yuan‐Xi / Gao, Guang‐Dao | 2007
1199
DIABETES‐INDUCED CHANGES IN 5‐HYDROXYTRYPTAMINE MODULATION OF VAGALLY INDUCED BRADYCARDIA IN RAT HEART
García, Mónica / Morán, Asunción / Martín, M Luisa / Ortizde Urbina, A Vega / San Román, Luis | 2007
1207
GENOTYPE AND ALLELE FREQUENCIES OF N‐ACETYLTRANSFERASE 2 AND GLUTATHIONE S‐TRANSFERASE IN THE IRANIAN POPULATION
Torkaman‐Boutorabi, Anahita / Hoormand, Mahmood / Naghdi, Naser / Bakhshayesh, Masoomeh / Milanian, Iraj | 2007
1212
EARLY RENAL DENERVATION PREVENTS DEVELOPMENT OF HYPERTENSION IN GROWTH‐RESTRICTED OFFSPRING
Ojeda, Norma B / Johnson, W Russell / Dwyer, Terry M / Alexander, Barbara T | 2007
1217
AMELIORATION OF l‐THYROXINE‐INDUCED HYPERTHYROIDISM BY COUMARIN (1,2‐BENZOPYRONE) IN FEMALE RATS
Panda, Sunanda / Kar, Anand | 2007

Ähnliche Titel