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International journal of drug regulatory affairs : IJDRA
Free accessGWLB - Gottfried Wilhelm Leibniz Bibliothek | 1.2013 - -
Antibody-Drug Conjugates: The New Frontier of Chemotherapy
Free accessDOAJ | 2020|In recent years, antibody-drug conjugates (ADCs) have become promising antitumor agents to be used as one of the tools in personalized ...Keywords: Antibody-Drug Conjugate, drug targeting -
Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)
Free accessDOAJ | 2021|drug resistance, different response to the drug, the possibility of using reliable methods to assess the control of seizures and side effects ...Keywords: drug-resistant epilepsy -
Editorial of Special Issue “Regulatory Roles of Inflammasomes in Human Diseases”
Free accessDOAJ | 2021|step) and triggering (activation step). The key feature of the triggering step is the activation of inflammasomes that are intracellular ... -
Current Perspective Regarding the Immunopathogenesis of Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS/DRESS)
Free accessDOAJ | 2021|Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe type of adverse drug ...Keywords: drug-induced hypersensitivity syndrome, drug reaction with eosinophilia and systemic symptoms -
The Role of Regulatory T Cells in Cancer Treatment Resistance
Free accessDOAJ | 2023|patients. One of the main causes is regulatory T lymphocytes (Tregs), which suppress excessive inflammatory responses via the secretion of ...Keywords: regulatory T cell -
mRNA: Vaccine or Gene Therapy? The Safety Regulatory Issues
Free accessDOAJ | 2023|at the time they were marketed. The regulatory agencies therefore adapted them as a matter of urgency. Now that the pandemic emergency has ...Keywords: drug regulation -
Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer
Free accessDOAJ | 2016|advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in ...Keywords: drug resistance -
Pharmacological Enhancement of Regeneration-Dependent Regulatory T Cell Recruitment in Zebrafish
Free accessDOAJ | 2019|in mammals are due to impaired recruitment and/or function of homologous mammalian regulatory T cell (Treg) populations. Here, we explore the ...Keywords: regulatory t cell -
Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression
Free accessDOAJ | 2017|The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological ... -
Drug Approval Process – In United States of America, European Union and India: A Review
Bentham Science Publishers | 2014|The regulatory process, by which a person or an organization or a sponsor or an innovator gets authorization to launch a drug in the market ...Keywords: United States of America, International Conference on Harmonization (ICH), regulatory process., Clinical Trials & Regulatory Affairs -
Roles of Regulatory T Cell-Derived Extracellular Vesicles in Human Diseases
Free accessDOAJ | 2022|Regulatory T (Treg) cells play crucial roles in maintaining immune self-tolerance and immune homeostasis, and closely associated with many ...Keywords: regulatory T cells -
Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening
Free accessDOAJ | 2020|reactions, autoimmune diseases, and cancer. Macrophages are a prime target for drug discovery due to their major regulatory role in health and ...Keywords: drug discovery -
RUCAM in Drug and Herb Induced Liver Injury: The Update
Free accessDOAJ | 2015|RUCAM (Roussel Uclaf Causality Assessment Method) or its previous synonym CIOMS (Council for International Organizations of Medical ...Keywords: drug induced liver injury, drug hepatotoxicity -
Scientific and Regulatory Perspectives in Herbal and Dietary Supplement Associated Hepatotoxicity in the United States
Free accessDOAJ | 2016|regulated by the Food and Drug Administration (FDA) as a special category of foods. Under this designation, regulatory scientists do not routinely ...Keywords: US Food and Drug Administration, drug induced liver injury -
Actin-Myosin Interaction: Structure, Function and Drug Discovery
Free accessDOAJ | 2018|sites for essential (ELC) and regulatory light chains (RLC). High-resolution crystal structures of isolated actin and myosin, along with cryo ...Keywords: drug discovery -
Integrated Computational Approaches and Tools for Allosteric Drug Discovery
Free accessDOAJ | 2020|drug discovery due to the benefits and versatility of allosteric modulators in providing desirable selectivity against protein targets while ...Keywords: drug resistance -
Integrative Analysis of Regulatory Module Reveals Associations of Microgravity with Dysfunctions of Multi-body Systems and Tumorigenesis
Free accessDOAJ | 2020|Previous studies have demonstrated that microgravity could lead to health risks. The investigation of the molecular mechanisms from the ...Keywords: drug, regulatory network -
Systems Approach to Pathogenic Mechanism of Type 2 Diabetes and Drug Discovery Design Based on Deep Learning and Drug Design Specifications
Free accessDOAJ | 2020|drug targets and a systematic drug discovery strategy to design a potential multiple-molecule targeting drug for type 2 diabetes (T2D ...Keywords: drug design specification, multiple-molecule targeting drug
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