Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure-Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides (English)
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In:
JOURNAL OF MEDICINAL CHEMISTRY
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41
, 6
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787-797
;
1998
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ISSN:
- Article (Journal) / Print
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Title:Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure-Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamides
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Contributors:Smith, P. W. ( author ) / Sollis, S. L. ( author ) / Howes, P. D. ( author ) / Cherry, P. C. ( author ) / Starkey, I. D. ( author ) / Cobley, K. N. ( author ) / Weston, H. ( author ) / Scicinski, J. ( author ) / Merritt, A. ( author ) / Whittington, A. ( author )
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Published in:JOURNAL OF MEDICINAL CHEMISTRY ; 41, 6 ; 787-797
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Publisher:
- New search for: ACS AMERICAN CHEMICAL SOCIETY
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Publication date:1998-01-01
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Size:11 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
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Classification:
DDC: 615 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 41, Issue 6
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 775
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Acetamidine Lysine Derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide Dihydrochloride: A Highly Selective Inhibitor of Human Inducible Nitric Oxide SynthaseHallinan, E. Ann / Tsymbalov, Sofya / Finnegan, Patricia M. / Moore, William M. / Jerome, Gina M. / Currie, Mark G. / Pitzele, Barnett S. et al. | 1998
- 778
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High-Affinity Aptamers Selectively Inhibit Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)Bridonneau, Philippe / Chang, Ying-Fon / O'Connell, Dan / Gill, Stanley C. / Snyder, David W. / Johnson, Lea / Goodson,, Theodore / Herron, David K. / Parma, David H. et al. | 1998
- 787
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Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4H-pyran-6-carboxamidesSmith, Paul W. / Sollis, Steven L. / Howes, Peter D. / Cherry, Peter C. / Starkey, Ian D. / Cobley, Kevin N. / Weston, Helen / Scicinski, Jan / Merritt, Andrew / Whittington, Andrew et al. | 1998
- 798
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Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 2. Crystallographic and Molecular Modeling Study of Complexes of 4-Amino-4H-pyran-6-carboxamides and Sialidase from Influenza Virus Types A and BTaylor, Neil R. / Cleasby, Anne / Singh, Onkar / Skarzynski, Tadeusz / Wonacott, Alan J. / Smith, Paul W. / Sollis, Steven L. / Howes, Peter D. / Cherry, Peter C. / Bethell, Richard et al. | 1998
- 808
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(E)-3-(2-(N-Phenylcarbamoyl)vinyl)pyrrole-2-carboxylic Acid Derivatives. A Novel Class of Glycine Site AntagonistsBalsamini, Cesarino / Bedini, Annalida / Diamantini, Giuseppe / Spadoni, Gilberto / Tontini, Andrea / Tarzia, Giorgio / Di Fabio, Romano / Feriani, Aldo / Reggiani, Angelo / Tedesco, Giovanna et al. | 1998
- 821
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1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of AsthmaChristensen, Siegfried B. / Guider, Aimee / Forster, Cornelia J. / Gleason, John G. / Bender, Paul E. / Karpinski, Joseph M. / DeWolf,, Walter E. / Barnette, Mary S. / Underwood, David C. / Griswold, Don E. et al. | 1998
- 836
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Comparative Binding Energy Analysis of HIV-1 Protease Inhibitors: Incorporation of Solvent Effects and Validation as a Powerful Tool in Receptor-Based Drug DesignPérez, Carlos / Pastor, Manuel / Ortiz, Angel R. / Gago, Federico et al. | 1998
- 853
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Molecular Properties and Pharmacokinetic Behavior of Cetirizine, a Zwitterionic H1-Receptor AntagonistPagliara, Alessandra / Testa, Bernard / Carrupt, Pierre-Alain / Jolliet, Pascale / Morin, Christophe / Morin, Didier / Urien, Saïk / Tillement, Jean-Paul / Rihoux, Jean-Pierre et al. | 1998
- 864
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(−)-3β-Substituted Ecgonine Methyl Esters as Inhibitors for Cocaine Binding and Dopamine UptakeLieske, Spencer F. / Yang, Biao / Eldefrawi, Mohyee E. / MacKerell,, Alexander D. / Wright, Jeremy et al. | 1998
- 864
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(-)-3b-Substituted Ecgonine Methyl Esters as Inhibitors for Cocaine Binding and Dopamine UptakeLieske, Spencer F. et al. | 1998
- 877
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Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazineMallams, Alan K. / Rossman, Randall R. / Doll, Ronald J. / Girijavallabhan, Viyyoor M. / Ganguly, Ashit K. / Petrin, Joanne / Wang, Lynn / Patton, Robert / Bishop, W. Robert / Carr, Donna M. et al. | 1998
- 894
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Ethnobotanical-Directed Discovery of the Antihyperglycemic Properties of Cryptolepine: Its Isolation from Cryptolepis sanguinolenta, Synthesis, and in Vitro and in Vivo Activities †Bierer, Donald E. / Fort, Diana M. / Mendez, Christopher D. / Luo, Jian / Imbach, Patricia A. / Dubenko, Larisa G. / Jolad, Shivanand D. / Gerber, R. Eric / Litvak, Joane / Lu, Qing et al. | 1998
- 902
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Novel 17-Azolyl Steroids, Potent Inhibitors of Human Cytochrome 17α-Hydroxylase-C17,20-lyase (P45017 α): Potential Agents for the Treatment of Prostate CancerNjar, Vincent C. O. / Kato, Katsuya / Nnane, Ivo P. / Grigoryev, Dmitry N. / Long, Brian J. / Brodie, Angela M. H. et al. | 1998
- 902
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Novel 17-Azolyl Steroids, Potent Inhibitors of Human Cytochrome 17a-Hydroxylase-C17,20-lyase (P45017a): Potential Agents for the Treatment of Prostate CancerNjar, Vincent C.O. et al. | 1998
- 913
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2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine Analogues of Trimethoprim as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate ReductaseRosowsky, Andre / Papoulis, Andrew T. / Queener, Sherry F. et al. | 1998
- 919
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A Backbone-Cyclic, Receptor 5-Selective Somatostatin Analogue: Synthesis, Bioactivity, and Nuclear Magnetic Resonance Conformational Analysis †Gilon, Chaim / Huenges, Martin / Mathä, Barbara / Gellerman, Gary / Hornik, Vered / Afargan, Michel / Amitay, Oved / Ziv, Ofer / Feller, Etty / Gamliel, Asher et al. | 1998
- 930
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Excitatory Amino Acid Receptor Ligands: Resolution, Absolute Stereochemistry, and Enantiopharmacology of 2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic AcidJohansen, Tommy N. / Ebert, Bjarke / Bräuner-Osborne, Hans / Didriksen, Michael / Christensen, Inge T. / Søby, Karina K. / Madsen, Ulf / Krogsgaard-Larsen, Povl / Brehm, Lotte et al. | 1998
- 940
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Orally Active Antimalarial 3-Substituted Trioxanes: New Synthetic Methodology and Biological EvaluationPosner, Gary H. / Cumming, Jared N. / Woo, Soon-Hyung / Ploypradith, Poonsakdi / Xie, Suji / Shapiro, Theresa A. et al. | 1998
- 952
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Design, Synthesis, Derivatization, and Structure−Activity Relationships of Simplified, Tricyclic, 1,2,4-Trioxane Alcohol Analogues of the Antimalarial ArtemisininCumming, Jared N. / Wang, Dasong / Park, Sheldon B. / Shapiro, Theresa A. / Posner, Gary H. et al. | 1998
- 965
-
Intensely Potent Doxorubicin Analogues: Structure−Activity RelationshipFarquhar, David / Cherif, Abdallah / Bakina, Elena / Nelson, J. Arly et al. | 1998
- 973
-
Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol AbsorptionRosenblum, Stuart B. / Huynh, Tram / Afonso, Adriano / Davis, Harry R. / Yumibe, Nathan / Clader, John W. / Burnett, Duane A. et al. | 1998
- 981
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Design, Synthesis, and Evaluation of the Multidrug Resistance-Reversing Activity of d-Glucose Mimetics of HapalosinDinh, Tam Q. / Smith, Charles D. / Du, Xiaohui / Armstrong, Robert W. et al. | 1998
- 988
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Molecular Features Associated with Polyamine Modulation of NMDA ReceptorsLewin, Anita H. / Sun, Guobin / Fudala, Louise / Navarro, Hernan / Zhou, Li-Ming / Popik, Piotr / Faynsteyn, Alexander / Skolnick, Phil et al. | 1998
- 996
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Novel Biologically Active Nonpeptidic Inhibitors of MyristoylCoA:Protein N-MyristoyltransferaseDevadas, Balekudru / Freeman, Sandra K. / McWherter, Charles A. / Kishore, Nandini S. / Lodge, Jennifer K. / Jackson-Machelski, Emily / Gordon, Jeffrey I. / Sikorski, James A. et al. | 1998
- 1001
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Synthesis and Pharmacological Evaluation of Ring-Methylated Derivatives of 3,4-(Methylenedioxy)amphetamine (MDA)Parker, Matthew A. / Marona-Lewicka, Danuta / Kurrasch, Deborah / Shulgin, Alexander T. / Nichols, David E. et al. | 1998
- 1006
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Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N‘-(3-substituted phenyl)-N‘-methylguanidines As N-Methyl-d-aspartate Receptor Ion-Channel BlockersHu, Lain-Yen / Guo, Junqing / Magar, Sharad S. / Fischer, James B. / Burke-Howie, Kathleen J. / Durant, Graham J. et al. | 1998