Design and identification of selective HER-2 sheddase inhibitors via P1prime manipulation and unconventional P2prime perturbations to induce a molecular metamorphosis (English)
- New search for: Yao, W.
- New search for: Zhuo, J.
- New search for: Burns, D. M.
- New search for: Li, Y. L.
- New search for: Qian, D. Q.
- New search for: Zhang, C.
- New search for: He, C.
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- New search for: Shi, E.
- New search for: Li, Y.
- New search for: Yao, W.
- New search for: Zhuo, J.
- New search for: Burns, D. M.
- New search for: Li, Y. L.
- New search for: Qian, D. Q.
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In:
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
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18
, 1
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159-163
;
2008
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ISSN:
- Article (Journal) / Print
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Title:Design and identification of selective HER-2 sheddase inhibitors via P1prime manipulation and unconventional P2prime perturbations to induce a molecular metamorphosis
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Contributors:Yao, W. ( author ) / Zhuo, J. ( author ) / Burns, D. M. ( author ) / Li, Y. L. ( author ) / Qian, D. Q. ( author ) / Zhang, C. ( author ) / He, C. ( author ) / Xu, M. ( author ) / Shi, E. ( author ) / Li, Y. ( author )
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Published in:BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS ; 18, 1 ; 159-163
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2008-01-01
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Size:5 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 572.5
- Further information on Dewey Decimal Classification
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Classification:
DDC: 572.5 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 18, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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Graphical contents list| 2007
- 23
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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifsYoung, Robert J. / Borthwick, Alan D. / Brown, David / Burns-Kurtis, Cynthia L. / Campbell, Matthew / Chan, Chuen / Charbaut, Marie / Chung, Chun-wa / Convery, Máire A. / Kelly, Henry A. et al. | 2007
- 28
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Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifsYoung, Robert J. / Borthwick, Alan D. / Brown, David / Burns-Kurtis, Cynthia L. / Campbell, Matthew / Chan, Chuen / Charbaut, Marie / Convery, Máire A. / Diallo, Hawa / Hortense, Eric et al. | 2007
- 34
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Amino acid derivatives as histone deacetylase inhibitorsHubbs, Jed L. / Zhou, Hua / Kral, Astrid M. / Fleming, Judith C. / Dahlberg, William K. / Hughes, Bethany L. / Middleton, Richard E. / Szewczak, Alexander A. / Secrist, J. Paul / Miller, Thomas A. et al. | 2007
- 39
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Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitorsLy, Kiev S. / Letavic, Michael A. / Keith, John M. / Miller, Jennifer M. / Stocking, Emily M. / Barbier, Ann J. / Bonaventure, Pascal / Lord, Brian / Jiang, Xiaohui / Boggs, Jamin D. et al. | 2007
- 44
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Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfonesBandarage, Upul K. / Wang, Tiansheng / Come, Jon H. / Perola, Emanuele / Wei, Yunyi / Rao, B. Govinda et al. | 2007
- 49
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Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activityZhao, Zhijian / Robinson, Ronald G. / Barnett, Stanley F. / Defeo-Jones, Deborah / Jones, Raymond E. / Hartman, George D. / Huber, Hans E. / Duggan, Mark E. / Lindsley, Craig W. et al. | 2007
- 54
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Carboxylic acid based quinolines as liver X receptor modulators that have LXRb receptor binding selectivityHu, B. / Quinet, E. / Unwalla, R. / Collini, M. / Jetter, J. / Dooley, R. / Andraka, D. / Nogle, L. / Savio, D. / Halpern, A. et al. | 2008
- 54
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Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivityHu, Baihua / Quinet, Elaine / Unwalla, Rayomand / Collini, Mike / Jetter, James / Dooley, Rebecca / Andraka, Diane / Nogle, Lisa / Savio, Dawn / Halpern, Anita et al. | 2007
- 60
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Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phaseWisén, Susanne / Androsavich, John / Evans, Christopher G. / Chang, Lyra / Gestwicki, Jason E. et al. | 2007
- 66
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Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolinesDouty, Brent / Wayland, Brian / Ala, Paul J. / Bower, Michael J. / Pruitt, James / Bostrom, Lori / Wei, Min / Klabe, Ronald / Gonneville, Lucie / Wynn, Richard et al. | 2007
- 72
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New ultra-short acting hypnotic: Synthesis, biological evaluation, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124)El-Subbagh, Hussein I. / El-Kashef, Hassan A. / Kadi, Adnan A. / Abdel-Aziz, Alaa A.-M. / Hassan, Ghada S. / Tettey, Justice / Lehmann, Jochen et al. | 2007
- 78
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Delayed fibril formation of amylin(20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesisBrouwer, Arwin J. / Elgersma, Ronald C. / Jagodzinska, Monika / Rijkers, Dirk T.S. / Liskamp, Rob M.J. et al. | 2007
- 85
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1-Toluene-sulfonyl-3-[(3′-hydroxy-5′-substituted)-γ-butyrolactone]-indoles: Synthesis, COX-2 inhibition and anti-cancer activitiesSingh, Palwinder / Mittal, Anu / Bhardwaj, Atul / Kaur, Satwinderjeet / Kumar, Subodh et al. | 2007
- 85
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1-Toluene-sulfonyl-3-[(3prime-hydroxy-5prime-substituted)-g-butyrolactone]-indoles: Synthesis, COX-2 inhibition and anti-cancer activitiesSingh, P. / Mittal, A. / Bhardwaj, A. / Kaur, S. / Kumar, S. et al. | 2008
- 90
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The discovery of GSK221149A: A potent and selective oxytocin antagonistLiddle, John / Allen, Michael J. / Borthwick, Alan D. / Brooks, David P. / Davies, David E. / Edwards, Richard M. / Exall, Anne M. / Hamlett, Chris / Irving, Wendy R. / Mason, Andrew M. et al. | 2007
- 95
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Determination of absolute stereochemistry, total synthesis, and evaluation of peptides from the myxomycete Physarum melleumHanazawa, Shuwa / Arai, Midori A. / Li, Xiaofan / Ishibashi, Masami et al. | 2007
- 99
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Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthineHuang, Sheng-Tung / Liao, Jian-Sheng / Fang, Hsu-Wei / Lin, Chun-Mao et al. | 2007
- 104
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Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivativesOh, Ki-Bong / Lee, Ji Hye / Chung, Soon-Chun / Shin, Jongheon / Shin, Hee Jae / Kim, Hye-Kyeong / Lee, Hyi-Seung et al. | 2007
- 109
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Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complexChen, Xiaoqiang / Wang, Jingyun / Sun, Shiguo / Fan, Jiangli / Wu, Song / Liu, Jianfeng / Ma, Saijian / Zhang, Lizhu / Peng, Xiaojun et al. | 2007
- 114
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The expedient synthesis of 1,5-benzothiazepines as a family of cytotoxic drugsArya, Kapil / Dandia, Anshu et al. | 2007
- 120
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(2S,2′R)-Analogue of LG190178 is a major active isomerHakamata, Wataru / Sato, Yukiko / Okuda, Haruhiro / Honzawa, Shinobu / Saito, Nozomi / Kishimoto, Seishi / Yamashita, Atsushi / Sugiura, Takayuki / Kittaka, Atsushi / Kurihara, Masaaki et al. | 2007
- 120
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(2S,2primeR)-Analogue of LG190178 is a major active isomerHakamata, W. / Sato, Y. / Okuda, H. / Honzawa, S. / Saito, N. / Kishimoto, S. / Yamashita, A. / Sugiura, T. / Kittaka, A. / Kurihara, M. et al. | 2008
- 124
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Diastereoselective synthesis of (R)-(alkyl)-β-d-galactopyranoside by using β-galactosidase (Aspergillus oryzae) in low-water mediaMajumder, Abir B. / Singh, Bhupender / Gupta, Munishwar N. et al. | 2007
- 124
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Diastereoselective synthesis of (R)-(alkyl)-b-d-galactopyranoside by using b-galactosidase (Aspergillus oryzae) in low-water mediaMajumder, A. B. / Singh, B. / Gupta, M. N. et al. | 2008
- 129
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Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptorChen, Chen / Jiang, Wanlong / Tran, Joe A. / Tucci, Fabio C. / Fleck, Beth A. / Markison, Stacy / Wen, Jenny / Madan, Ajay / Hoare, Sam R. / Foster, Alan C. et al. | 2007
- 137
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Sulfonate chalcone as new class voltage-dependent K+ channel blockerYarishkin, Oleg V. / Ryu, Hyung Won / Park, Jae-Yong / Yang, Min Suk / Hong, Seong-Geun / Park, Ki Hun et al. | 2007
- 141
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2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agentsEmami, Saeed / Foroumadi, Alireza / Falahati, Mehraban / Lotfali, Ensieh / Rajabalian, Saeed / Ebrahimi, Soltan-Ahmed / Farahyar, Shirin / Shafiee, Abbas et al. | 2007
- 147
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Development of CXCR3 antagonists. Part 3: Tropenyl and homotropenyl-piperidine urea derivativesWatson, Robert J. / Allen, Daniel R. / Birch, Helen L. / Chapman, Gayle A. / Galvin, Frances C. / Jopling, Louise A. / Knight, Roland L. / Meier, Dorica / Oliver, Kathryn / Meissner, Johannes W.G. et al. | 2007
- 152
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Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studiesGüzel, Özlen / Temperini, Claudia / Innocenti, Alessio / Scozzafava, Andrea / Salman, Aydın / Supuran, Claudiu T. et al. | 2007
- 159
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Design and identification of selective HER-2 sheddase inhibitors via P1prime manipulation and unconventional P2prime perturbations to induce a molecular metamorphosisYao, W. / Zhuo, J. / Burns, D. M. / Li, Y. L. / Qian, D. Q. / Zhang, C. / He, C. / Xu, M. / Shi, E. / Li, Y. et al. | 2008
- 159
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Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosisYao, Wenqing / Zhuo, Jincong / Burns, David M. / Li, Yun-Long / Qian, Ding-Quan / Zhang, Colin / He, Chunhong / Xu, Meizhong / Shi, Eric / Li, Yanlong et al. | 2007
- 164
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Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3Moulin, Aline / Demange, Luc / Ryan, Joanne / M’Kadmi, Céline / Galleyrand, Jean-Claude / Martinez, Jean / Fehrentz, Jean-Alain et al. | 2007
- 169
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Discovery of new small molecules that influence neuroblast cell migration from the subventricular zoneRolland, Amandine / Boquet, Isabelle / Norreel, Jean-Chrétien / Moret, Vincent / Laras, Younes / Kraus, Jean-Louis et al. | 2007
- 175
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Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretaseBergstrom, Carl P. / Sloan, Charles P. / Wang, Henry H. / Parker, Michael F. / Smith, David W. / Zheng, Ming / Hansel, Steven B. / Polson, Craig T. / Barber, Lauren E. / Bursuker, Isia et al. | 2007
- 175
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Nitrogen-appended N-alkylsulfonamides as inhibitors of g-secretaseBergstrom, C. P. / Sloan, C. P. / Wang, H. H. / Parker, M. F. / Smith, D. W. / Zheng, M. / Hansel, S. B. / Polson, C. T. / Barber, L. E. / Bursuker, I. et al. | 2008
- 179
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Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38a MAP kinase inhibitors with excellent in vivo antiinflammatory propertiesMader, M. / de Dios, A. / Shih, C. / Bonjouklian, R. / Li, T. / White, W. / de Uralde, B. L. / Sanchez-Martinez, C. / del Prado, M. / Jaramillo, C. et al. | 2008
- 179
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Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory propertiesMader, Mary / de Dios, Alfonso / Shih, Chuan / Bonjouklian, Rosanne / Li, Tiechao / White, Wesley / de Uralde, Beatriz López / Sánchez-Martinez, Concepción / del Prado, Miriam / Jaramillo, Carlos et al. | 2007
- 184
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Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivativesRebollo, Oscar / del Olmo, Esther / Ruiz, Grace / López-Pérez, José L. / Giménez, Alberto / San Feliciano, Arturo et al. | 2007
- 188
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7-Azaindole derivatives as potential partial nicotinic agonistsStoit, Axel R. / den Hartog, Arnold P. / Mons, Harry / van Schaik, Sjoerd / Barkhuijsen, Nynke / Stroomer, Cees / Coolen, Hein K.A.C. / Reinders, Jan Hendrik / Adolfs, Tiny J.P. / van der Neut, Martina et al. | 2007
- 194
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Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seedsKwon, Hyun Sook / Kim, Min-Jung / Jeong, Hyung Jae / Yang, Min Suk / Park, Ki Hun / Jeong, Tae-Sook / Lee, Woo Song et al. | 2007
- 199
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Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cellsKim, So-Yeon / Park, Kyoung-Wuk / Kim, Jae-Yong / Jeong, Il-Yun / Byun, Myung-Woo / Park, Jung-Eun / Yee, Sung-Tae / Kim, Kee-Hong / Rhim, Johng S. / Yamada, Koji et al. | 2007
- 205
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Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitorsNam, Dong Hyuk / Lee, Kwang Seob / Kim, Sang Hoon / Kim, Sung Min / Jung, Seo Yun / Chung, Sung Hyun / Kim, Hyoung Ja / Kim, Nam Doo / Jin, Changbae / Lee, Yong Sup et al. | 2007
- 210
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Identification and synthesis of a unique thiocarbazate cathepsin L inhibitorMyers, Michael C. / Shah, Parag P. / Diamond, Scott L. / Huryn, Donna M. / Smith, Amos B. III et al. | 2007
- 215
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Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active g-secretase inhibitorsMcBriar, M. D. / Clader, J. W. / Chu, I. / Del Vecchio, R. A. / Favreau, L. / Greenlee, W. J. / Hyde, L. A. / Nomeir, A. A. / Parker, E. M. / Pissarnitski, D. A. et al. | 2008
- 215
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Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitorsMcBriar, Mark D. / Clader, John W. / Chu, Inhou / Del Vecchio, Robert A. / Favreau, Leonard / Greenlee, William J. / Hyde, Lynn A. / Nomeir, Amin A. / Parker, Eric M. / Pissarnitski, Dmitri A. et al. | 2007
- 220
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5′-Fluoro-5′-deoxyaristeromycinLi, Weikuan / Yin, Xueqiang / Schneller, Stewart W. et al. | 2007
- 220
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5prime-Fluoro-5prime-deoxyaristeromycinLi, W. / Yin, X. / Schneller, S. W. et al. | 2008
- 223
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Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonistsWeyler, Stefanie / Baqi, Younis / Hillmann, Petra / Kaulich, Marko / Hunder, Andrea M. / Müller, Ingrid A. / Müller, Christa E. et al. | 2007
- 228
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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonistsBiju, Purakkattle / Taveras, Arthur / Yu, Younong / Zheng, Junying / Chao, Jianhua / Rindgen, Diane / Jakway, James / Hipkin, R. William / Fossetta, James / Fan, Xuedong et al. | 2007
- 232
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Sterol C24-methyltransferase: Mechanistic studies of the C-methylation reaction with 24-fluorocycloartenolWang, Junqing / Liu, Jialin / Song, Zhihong / Nes, W. David et al. | 2007
- 236
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Development of dimeric modulators for anti-apoptotic Bcl-2 proteinsWang, Liangyou / Kong, Fansen / Kokoski, Candis L. / Andrews, David W. / Xing, Chengguo et al. | 2007
- 241
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Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitorsDuan, James J.-W. / Chen, Lihua / Lu, Zhonghui / Xue, Chu-Biao / Liu, Rui-Qin / Covington, Maryanne B. / Qian, Mingxin / Wasserman, Zelda R. / Vaddi, Krishna / Christ, David D. et al. | 2007
- 241
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Discovery of b-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitorsDuan, J. J. / Chen, L. / Lu, Z. / Xue, C. B. / Liu, R. Q. / Covington, M. B. / Qian, M. / Wasserman, Z. R. / Vaddi, K. / Christ, D. D. et al. | 2008
- 247
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Azaterphenyl diamidines as antileishmanial agentsHu, Laixing / Arafa, Reem K. / Ismail, Mohamed A. / Wenzler, Tanja / Brun, Reto / Munde, Manoj / Wilson, W. David / Nzimiro, Sandra / Samyesudhas, Serene / Werbovetz, Karl A. et al. | 2007
- 252
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Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilidesAli, Abdelselam / Altamore, Timothy M. / Bliese, Marianne / Fisara, Petr / Liepa, Andris J. / Meyer, Adam G. / Nguyen, Oahn / Sargent, Roger M. / Sawutz, David G. / Winkler, David A. et al. | 2007
- 256
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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidationPeters, Jens-Uwe / Lübbers, Thomas / Alanine, Alexander / Kolczewski, Sabine / Blasco, Francesca / Steward, Lucinda et al. | 2007
- 262
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Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetrationPeters, Jens-Uwe / Lübbers, Thomas / Alanine, Alexander / Kolczewski, Sabine / Blasco, Francesca / Steward, Lucinda et al. | 2007
- 267
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Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17Pinto-Bazurco Mendieta, Mariano A.E. / Negri, Matthias / Jagusch, Carsten / Hille, Ulrike E. / Müller-Vieira, Ursula / Schmidt, Dirk / Hansen, Klaus / Hartmann, Rolf W. et al. | 2007
- 274
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Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2prime-deoxycytidinesSumino, M. / Ohkubo, A. / Taguchi, H. / Seio, K. / Sekine, M. et al. | 2008
- 274
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Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2′-deoxycytidinesSumino, Masanori / Ohkubo, Akihiro / Taguchi, Haruhiko / Seio, Kohji / Sekine, Mitsuo et al. | 2007
- 278
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Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalystKhabazzadeh, Hojatollah / Saidi, Kazem / Sheibani, Hassan et al. | 2007
- 281
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Phosphoramidate derivatives of hydroxysteroids as inhibitors of prostate-specific membrane antigenWu, Lisa Y. / Do, Jacinda C. / Kazak, Marat / Page, Helen / Toriyabe, Yoko / Anderson, Marc O. / Berkman, Clifford E. et al. | 2007
- 285
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Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screeningUsui, Taikou / Ban, Hyun Seung / Kawada, Junpei / Hirokawa, Takatsugu / Nakamura, Hiroyuki et al. | 2007
- 289
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Thiophene containing triarylmethanes as antitubercular agentsParai, Maloy Kumar / Panda, Gautam / Chaturvedi, Vinita / Manju, Y.K. / Sinha, Sudhir et al. | 2007
- 293
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Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizersYao, Jianzhong / Zhang, Wannian / Sheng, Chunquan / Miao, Zhenyuan / Yang, Feng / Yu, Jianxin / Zhang, Ling / Song, Yunlong / Zhou, Ting / Zhou, Youjun et al. | 2007
- 298
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Synthesis, characterization and DNA-binding properties of four Zn(II) complexes with bis(pyrrol-2-yl-methyleneamine) ligandsWang, Yuan / Yang, Zheng-Yin / Chen, Zhong-Ning et al. | 2007
- 304
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Substituted 2-oxo-azepane derivatives are potent, orally active g-secretase inhibitorsKitas, E. A. / Galley, G. / Jakob-Roetne, R. / Flohr, A. / Wostl, W. / Mauser, H. / Alker, A. M. / Czech, C. / Ozmen, L. / David-Pierson, P. et al. | 2008
- 304
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Substituted 2-oxo-azepane derivatives are potent, orally active γ-secretase inhibitorsKitas, Eric A. / Galley, Guido / Jakob-Roetne, Roland / Flohr, Alexander / Wostl, Wolfgang / Mauser, Harald / Alker, André M. / Czech, Christian / Ozmen, Laurence / David-Pierson, Pascale et al. | 2007
- 309
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4-Aminopyridine derivatives with anticholinesterase and antiamnesic activityScipione, Luigi / De Vita, Daniela / Musella, Alessandra / Flammini, Lisa / Bertoni, Simona / Barocelli, Elisabetta et al. | 2007
- 313
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pH sensing in living cells using fluorescent microspheresBradley, Mark / Alexander, Lois / Duncan, Karen / Chennaoui, Mourad / Jones, Anita C. / Sánchez-Martín, Rosario M. et al. | 2007
- 318
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Biphenyl amide p38 kinase inhibitors 1: Discovery and binding modeAngell, Richard M. / Bamborough, Paul / Cleasby, Anne / Cockerill, Stuart G. / Jones, Katherine L. / Mooney, Christopher J. / Somers, Donald O. / Walker, Ann L. et al. | 2007
- 324
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Biphenyl amide p38 kinase inhibitors 2: Optimisation and SARAngell, Richard M. / Angell, Tony D. / Bamborough, Paul / Brown, David / Brown, Murray / Buckton, Jacky B. / Cockerill, Stuart G. / Edwards, Chris D. / Jones, Katherine L. / Longstaff, Tim et al. | 2007
- 329
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Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFκB activity within two separate high-throughput screens of NFκB activationXie, Yuli / Deng, ShiXian / Thomas, Craig J. / Liu, Yidong / Zhang, Ya-Qin / Rinderspacher, Alison / Huang, Wenwei / Gong, Gangli / Wyler, Michael / Cayanis, Efithia et al. | 2007
- 329
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Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkB activity within two separate high-throughput screens of NFkB activationXie, Y. / Deng, S. / Thomas, C. J. / Liu, Y. / Zhang, Y. Q. / Rinderspacher, A. / Huang, W. / Gong, G. / Wyler, M. / Cayanis, E. et al. | 2008
- 336
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Discovery of a series of aminopiperidines as novel iNOS inhibitorsBourdonnec, Bertrand Le / Leister, Lara K. / Ajello, Christopher A. / Cassel, Joel A. / Seida, Pamela R. / O’Hare, Heather / Gu, Minghua / Chu, Guo-Hua / Tuthill, Paul A. / DeHaven, Robert N. et al. | 2007
- 344
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Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharidesLiu, Ligong / Bytheway, Ian / Karoli, Tomislav / Fairweather, Jon K. / Cochran, Siska / Li, Caiping / Ferro, Vito et al. | 2007
- 350
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Uncovering false positives on a virtual screening search for cruzain inhibitorsMalvezzi, Alberto / de Rezende, Leandro / Izidoro, Mario Augusto / Cezari, Maria Helena Sedenho / Juliano, Luiz / Amaral, Antonia T.-do et al. | 2007
- 355
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In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical seriesNersesian, Diana L. / Black, Lawrence A. / Miller, Thomas R. / Vortherms, Timothy A. / Esbenshade, Timothy A. / Hancock, Arthur A. / Cowart, Marlon D. et al. | 2007
- 360
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Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agentsGirard, Denis / Weagle, Glenn / Gupta, Atul / Bérubé, Gervais / Chapados, Camille et al. | 2007
- 366
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Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitorsNguyen, Jeffrey-Tri / Zhang, Meihui / Kumada, Henri-Obadja / Itami, Ayako / Nishiyama, Keiji / Kimura, Tooru / Cheng, Maosheng / Hayashi, Yoshio / Kiso, Yoshiaki et al. | 2007
- 371
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Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure–activity relationshipsHosono, Tetsuji / Yokomizo, Kazumi / Hamasaki, Akiyuki / Okamoto, Yoshinari / Okawara, Tadashi / Otsuka, Masami / Mukai, Ryozaburo / Suzuki, Keitarou et al. | 2007
- 375
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Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as g-secretase inhibitorsSparey, T. / Clarke, E. / Hannam, J. / Harrison, T. / Madin, A. / Shearman, M. / Sohal, B. et al. | 2008
- 375
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Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as γ-secretase inhibitorsSparey, Tim / Clarke, Earl / Hannam, Joanne / Harrison, Timothy / Madin, Andrew / Shearman, Mark / Sohal, Bindi et al. | 2007
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Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase AChenna, Bala Chandra / Shinkre, Bidhan A. / King, Jason R. / Lucius, Aaron L. / Narayana, Sthanam V.L. / Velu, Sadanandan E. et al. | 2007
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Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitorsDai, Yujia / Hartandi, Kresna / Soni, Niru B. / Pease, Lori J. / Reuter, David R. / Olson, Amanda M. / Osterling, Donald J. / Doktor, Stella Z. / Albert, Daniel H. / Bouska, Jennifer J. et al. | 2007
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Design, synthesis, and studies of small molecule STAT3 inhibitorsBhasin, Deepak / Cisek, Katryna / Pandharkar, Trupti / Regan, Nicholas / Li, Chenglong / Pandit, Bulbul / Lin, Jiayuh / Li, Pui-Kai et al. | 2007
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Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolinesVerhaeghe, Pierre / Azas, Nadine / Gasquet, Monique / Hutter, Sébastien / Ducros, Christophe / Laget, Michèle / Rault, Sylvain / Rathelot, Pascal / Vanelle, Patrice et al. | 2007
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Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABAC receptorsHinton, Tina / Chebib, Mary / Johnston, Graham A.R. et al. | 2007
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Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)Zhang, Yue-Mei / Fan, Xiaodong / Yang, Shyh-Ming / Scannevin, Robert H. / Burke, Sharon L. / Rhodes, Kenneth J. / Jackson, Paul F. et al. | 2007
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1-Hydroxy-2-pyridinone-based MMP inhibitors: Synthesis and biological evaluation for the treatment of ischemic strokeZhang, Yue-Mei / Fan, Xiaodong / Chakaravarty, Devraj / Xiang, Bangping / Scannevin, Robert H. / Huang, Zhihong / Ma, Jianya / Burke, Sharon L. / Karnachi, Prabha / Rhodes, Kenneth J. et al. | 2007
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Potent pyrrolidine- and piperidine-based BACE-1 inhibitorsIserloh, U. / Wu, Y. / Cumming, J.N. / Pan, J. / Wang, L.Y. / Stamford, A.W. / Kennedy, M.E. / Kuvelkar, R. / Chen, X. / Parker, E.M. et al. | 2007
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Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitorIserloh, U. / Pan, J. / Stamford, A.W. / Kennedy, M.E. / Zhang, Q. / Zhang, L. / Parker, E.M. / McHugh, N.A. / Favreau, L. / Strickland, C. et al. | 2007
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Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compoundsPiazzi, Lorna / Cavalli, Andrea / Colizzi, Francesco / Belluti, Federica / Bartolini, Manuela / Mancini, Francesca / Recanatini, Maurizio / Andrisano, Vincenza / Rampa, Angela et al. | 2007
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Substrate specificity and screening of the integral membrane protease PlaAgarkov, Anton / Chauhan, Sadhana / Lory, Pedro J. / Gilbertson, Scott R. / Motin, Vladimir L. et al. | 2007
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Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferationThimmegowda, N.R. / Nanjunda Swamy, S. / Ananda Kumar, C.S. / Sunil Kumar, Y.C. / Chandrappa, S. / Yip, George W. / Rangappa, K.S. et al. | 2007
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Eco-friendly and efficient one-pot synthesis of alkyl- or aryl-14H-dibenzo[a,j]xanthenes in waterDabiri, Minoo / Baghbanzadeh, Mostafa / Nikcheh, Maryam Shakouri / Arzroomchilar, Elham et al. | 2007
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Instructions to contributors| 2007
- IFC
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Editorial board| 2007