N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor (English)
- New search for: Bautista-Aguilera, O.M.
- New search for: Samadi, A.
- New search for: Chioua, M.
- New search for: Nikolic, K.
- New search for: Filipic, S.
- New search for: Agbaba, D.
- New search for: Soriano, E.
- New search for: de Andres, L.
- New search for: Rodriguez-Franco, M.I.
- New search for: Alcaro, S.
- New search for: Bautista-Aguilera, O.M.
- New search for: Samadi, A.
- New search for: Chioua, M.
- New search for: Nikolic, K.
- New search for: Filipic, S.
- New search for: Agbaba, D.
- New search for: Soriano, E.
- New search for: de Andres, L.
- New search for: Rodriguez-Franco, M.I.
- New search for: Alcaro, S.
In:
JOURNAL OF MEDICINAL CHEMISTRY
;
57
, 24
;
10455-10463
;
2014
-
ISSN:
- Article (Journal) / Print
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Title:N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor
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Contributors:Bautista-Aguilera, O.M. ( author ) / Samadi, A. ( author ) / Chioua, M. ( author ) / Nikolic, K. ( author ) / Filipic, S. ( author ) / Agbaba, D. ( author ) / Soriano, E. ( author ) / de Andres, L. ( author ) / Rodriguez-Franco, M.I. ( author ) / Alcaro, S. ( author )
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Published in:JOURNAL OF MEDICINAL CHEMISTRY ; 57, 24 ; 10455-10463
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Publisher:
- New search for: ACS AMERICAN CHEMICAL SOCIETY
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Publication date:2014-01-01
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Size:9 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 615
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615 -
Source:
© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 57, Issue 24
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 10205
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Targeting Matrix Metalloproteinases: Exploring the Dynamics of the S1′ Pocket in the Design of Selective, Small Molecule InhibitorsFabre, Benjamin / Ramos, Ana / de Pascual-Teresa, Beatriz et al. | 2014
- 10220
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Oligonucleotide Analogues as Modulators of the Expression and Function of Noncoding RNAs (ncRNAs): Emerging Therapeutics ApplicationsAvitabile, Concetta / Cimmino, Amelia / Romanelli, Alessandra et al. | 2014
- 10241
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DNA Repair and Redox Activities and Inhibitors of Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor 1 (APE1/Ref-1): A Comparative Analysis and Their Scope and Limitations toward Anticancer Drug DevelopmentKaur, Gagandeep / Cholia, Ravi P. / Mantha, Anil K. / Kumar, Raj et al. | 2014
- 10257
-
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved PharmaceuticalsVitaku, Edon / Smith, David T. / Njardarson, Jon T. et al. | 2014
- 10275
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Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung InfectionBoukerb, Amine M. / Rousset, Audric / Galanos, Nicolas / Méar, Jean-Baptiste / Thépaut, Marion / Grandjean, Teddy / Gillon, Emilie / Cecioni, Samy / Abderrahmen, Claire / Faure, Karine et al. | 2014
- 10290
-
Synthesis and Structure–Activity Relationship Studies of Small Molecule Disruptors of EWS-FLI1 Interactions in Ewing’s SarcomaTosso, Perrer N. / Kong, Yali / Scher, Lauren / Cummins, Ryan / Schneider, Jeffrey / Rahim, Said / Holman, K. Travis / Toretsky, Jeffrey / Wang, Kan / Üren, Aykut et al. | 2014
- 10304
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Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic AgentShao, Yong-xian / Huang, Manna / Cui, Wenjun / Feng, Ling-Jun / Wu, Yinuo / Cai, Yinghong / Li, Zhe / Zhu, Xinhai / Liu, Peiqing / Wan, Yiqian et al. | 2014
- 10314
-
Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex ActivityMatharu, Daljit S. / Flaherty, Daniel P. / Simpson, Denise S. / Schroeder, Chad E. / Chung, Donghoon / Yan, Dan / Noah, James W. / Jonsson, Colleen B. / White, E. Lucile / Aubé, Jeffrey et al. | 2014
- 10329
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Synthesis, Antitumor Activity, and Mechanism of Action of Benzo[b]chromeno[6,5‑g][1,8]naphthyridin-7-one Analogs of AcronycineTian, Wen / Yougnia, Rodrigue / Depauw, Sabine / Lansiaux, Amélie / David-Cordonnier, Marie-Hélène / Pfeiffer, Bruno / Kraus-Berthier, Laurence / Léonce, Stéphane / Pierré, Alain / Dufat, Hanh et al. | 2014
- 10343
-
G-Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGRS) Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage PhenotypeHogenauer, K. / Arista, L. / Schmiedeberg, N. / Werner, G. / Jaksche, H. / Bouhelal, R. / Nguyen, D.G. / Bhat, B.G. / Raad, L. / Rauld, C. et al. | 2014
- 10343
-
G‑Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage PhenotypeHögenauer, Klemens / Arista, Luca / Schmiedeberg, Niko / Werner, Gudrun / Jaksche, Herbert / Bouhelal, Rochdi / Nguyen, Deborah G. / Bhat, B. Ganesh / Raad, Layla / Rauld, Celine et al. | 2014
- 10355
-
Novel Insights into Structure and Function of Factor XIIIa-Inhibitor TrideginBöhm, Miriam / Bäuml, Charlotte A. / Hardes, Kornelia / Steinmetzer, Torsten / Roeser, Dirk / Schaub, Yvonne / Than, Manuel E. / Biswas, Arijit / Imhof, Diana et al. | 2014
- 10366
-
Electrophilic Warhead-Based Design of Compounds Preventing NLRP3 Inflammasome-Dependent PyroptosisCocco, Mattia / Garella, Davide / Di Stilo, Antonella / Borretto, Emily / Stevanato, Livio / Giorgis, Marta / Marini, Elisabetta / Fantozzi, Roberto / Miglio, Gianluca / Bertinaria, Massimo et al. | 2014
- 10383
-
Synthesis and Biological Evaluation of Pentacyclic Strychnos Alkaloids as Selective Modulators of the ABCC10 (MRP7) Efflux PumpTeijaro, Christiana N. / Munagala, Surendrachary / Zhao, Senzhi / Sirasani, Gopal / Kokkonda, Praveen / Malofeeva, Ekaterina V. / Hopper-Borge, Elizabeth / Andrade, Rodrigo B. et al. | 2014
- 10391
-
Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with TubulinVilanova, Concepción / Díaz-Oltra, Santiago / Murga, Juan / Falomir, Eva / Carda, Miguel / Redondo-Horcajo, Mariano / Díaz, J. Fernando / Barasoain, Isabel / Marco, J. Alberto et al. | 2014
- 10404
-
Synthesis and Biological Evaluation of Novel Sigma‑1 Receptor Antagonists Based on Pyrimidine Scaffold As Agents for Treating Neuropathic PainLan, Yu / Chen, Yin / Cao, Xudong / Zhang, Juecheng / Wang, Jie / Xu, Xiangqing / Qiu, Yinli / Zhang, Tan / Liu, Xin / Liu, Bi-Feng et al. | 2014
- 10424
-
Optimization of Sphingosine-1-phosphate‑1 Receptor Agonists: Effects of Acidic, Basic, and Zwitterionic Chemotypes on Pharmacokinetic and Pharmacodynamic ProfilesSkidmore, John / Heer, Jag / Johnson, Christopher N. / Norton, David / Redshaw, Sally / Sweeting, Jennifer / Hurst, David / Cridland, Andrew / Vesey, David / Wall, Ian et al. | 2014
- 10443
-
Discovery of 2‑(Cyclohexylmethylamino)pyrimidines as a New Class of Reversible Valosine Containing Protein InhibitorsCervi, Giovanni / Magnaghi, Paola / Asa, Daniela / Avanzi, Nilla / Badari, Alessandra / Borghi, Daniela / Caruso, Michele / Cirla, Alessandra / Cozzi, Liviana / Felder, Eduard et al. | 2014
- 10455
-
N‑Methyl‑N‑((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)‑1H‑indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual InhibitorBautista-Aguilera, Oscar M. / Samadi, Abdelouahid / Chioua, Mourad / Nikolic, Katarina / Filipic, Slavica / Agbaba, Danica / Soriano, Elena / de Andrés, Lucía / Rodríguez-Franco, María Isabel / Alcaro, Stefano et al. | 2014
- 10464
-
Synthesis and κ‑Opioid Receptor Activity of Furan-Substituted Salvinorin A AnaloguesRiley, Andrew P. / Groer, Chad E. / Young, David / Ewald, Amy W. / Kivell, Bronwyn M. / Prisinzano, Thomas E. et al. | 2014
- 10464
-
Synthesis and k-Opioid Receptor Activity of Furan-Substituted Salvinorin A AnaloguesRiley, A.P. / Groer, C.E. / Young, D. / Ewald, A.W. / Kivell, B.M. / Prisinzano, T.E. et al. | 2014
- 10476
-
Identification of Potent and Selective Hydantoin Inhibitors of Aggrecanase‑1 and Aggrecanase‑2 That Are Efficacious in Both Chemical and Surgical Models of OsteoarthritisDurham, Timothy B. / Klimkowski, Valentine J. / Rito, Christopher J. / Marimuthu, Jothirajah / Toth, James L. / Liu, Chin / Durbin, Jim D. / Stout, Stephanie L. / Adams, Lisa / Swearingen, Craig et al. | 2014
- 10486
-
Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindolesAguilar, Angelo / Sun, Wei / Liu, Liu / Lu, Jianfeng / McEachern, Donna / Bernard, Denzil / Deschamps, Jeffrey R. / Wang, Shaomeng et al. | 2014
- 10499
-
Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 InteractionRew, Yosup / Sun, Daqing / Yan, Xuelei / Beck, Hilary P. / Canon, Jude / Chen, Ada / Duquette, Jason / Eksterowicz, John / Fox, Brian M. / Fu, Jiasheng et al. | 2014
- 10512
-
Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of DiabetesGriffith, David A. / Kung, Daniel W. / Esler, William P. / Amor, Paul A. / Bagley, Scott W. / Beysen, Carine / Carvajal-Gonzalez, Santos / Doran, Shawn D. / Limberakis, Chris / Mathiowetz, Alan M. et al. | 2014
- 10527
-
Discovery of Cytotoxic Dolastatin 10 Analogues with N‑Terminal ModificationsMaderna, Andreas / Doroski, Matthew / Subramanyam, Chakrapani / Porte, Alexander / Leverett, Carolyn A. / Vetelino, Beth C. / Chen, Zecheng / Risley, Hud / Parris, Kevin / Pandit, Jayvardhan et al. | 2014
- 10544
-
Synthesis, in Vitro Evaluation and Cocrystal Structure of 4‑Oxo-[1]benzopyrano[4,3‑c]pyrazole Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase (CpIMPDH) InhibitorsSun, Zhuming / Khan, Jihan / Makowska-Grzyska, Magdalena / Zhang, Minjia / Cho, Joon Hyung / Suebsuwong, Chalada / Vo, Pascal / Gollapalli, Deviprasad R. / Kim, Youngchang / Joachimiak, Andrzej et al. | 2014
- 10551
-
Internalization and Stability of a Thymidylate Synthase Peptide Inhibitor in Ovarian Cancer CellsCannazza, Giuseppe / Cazzato, Addolorata Stefania / Marraccini, Chiara / Pavesi, Giorgia / Pirondi, Silvia / Guerrini, Remo / Pelà, Michela / Frassineti, Chiara / Ferrari, Stefania / Marverti, Gaetano et al. | 2014
- 10557
-
Synthesis of Gallinamide A Analogues as Potent Falcipain Inhibitors and AntimalarialsConroy, Trent / Guo, Jin T. / Elias, Nabiha / Cergol, Katie M. / Gut, Jiri / Legac, Jennifer / Khatoon, Lubna / Liu, Yang / McGowan, Sheena / Rosenthal, Philip J. et al. | 2014
- 10564
-
Correction to Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine PhosphataseBaguley, Tyler D. / Xu, Hai-Chao / Chatterjee, Manavi / Nairn, Angus C. / Lombroso, Paul J. / Ellman, Jonathan A. et al. | 2014