Physiological differences between brachycephalic and non-brachycephalic dogs after 6min walking test at high altitude (Unknown)
- New search for: Arango, Susana
- New search for: Durán, Amelia
- New search for: Florez, Sebastián
- New search for: Vargas-Pinto, Pedro
- New search for: Arango, Susana
- New search for: Durán, Amelia
- New search for: Florez, Sebastián
- New search for: Vargas-Pinto, Pedro
In:
Journal of pharmacological and toxicological methods
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81
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371
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2016
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ISSN:
- Article (Journal) / Print
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Title:Physiological differences between brachycephalic and non-brachycephalic dogs after 6min walking test at high altitude
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Contributors:Arango, Susana ( author ) / Durán, Amelia ( author ) / Florez, Sebastián ( author ) / Vargas-Pinto, Pedro ( author )
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Published in:
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Publisher:
- New search for: Elsevier Science B.V., Amsterdam.
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Publication date:2016-01-01
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Size:371 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:Unknown
- New search for: 615.9
- Further information on Dewey Decimal Classification
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Classification:
DDC: 615.9 -
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© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 81
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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Recalibration of nonclinical safety pharmacology assessment to anticipate evolving regulatory expectationsPugsley, Michael K. / Authier, Simon / Hayes, Eric S. / Hamlin, Robert L. / Accardi, Michael V. / Curtis, Michael J. et al. | 2016
- 9
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Pharmacotherapy of inborn errors of metabolism illustrating challenges in orphan diseasesDas, A. M. et al. | 2016
- 15
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The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progressColatsky, T. / Fermini, B. / Gintant, G. / Pierson, J. B. / Sager, P. / Sekino, Y. / Strauss, D. G. / Stockbridge, N. et al. | 2016
- 21
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Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementationCavero, I. / Guillon, J. M. / Ballet, V. / Clements, M. / Gerbeau, J. F. / Holzgrefe, H. et al. | 2016
- 37
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Safety pharmacology investigations on the nervous system: An industry surveyAuthier, Simon / Arezzo, Joseph / Delatte, Marcus S. / Kallman, Mary-Jeanne / Markgraf, Carrie / Paquette, Dominique / Pugsley, Michael K. / Ratcliffe, Sian / Redfern, William S. / Stevens, Joanne et al. | 2016
- 47
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The emerging role of in vitro electrophysiological methods in CNS safety pharmacologyAccardi, M. V. / Pugsley, M. K. / Forster, R. / Troncy, E. / Huang, H. / Authier, S. et al. | 2016
- 60
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The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogsSadekova, N. / Boudreau, G. / Jalbert, B. / Norton, K. et al. | 2016
- 75
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Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studiesPrior, Helen / Bottomley, Anna / Champéroux, Pascal / Cordes, Jason / Delpy, Eric / Dybdal, Noel / Edmunds, Nick / Engwall, Mike / Foley, Mike / Hoffmann, Michael et al. | 2016
- 88
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ECG telemetry in conscious guinea pigsRuppert, S. / Vormberge, T. / Igl, B. W. / Hoffmann, M. et al. | 2016
- 99
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Unlock the information in your data: Software to find, classify, and report on data patterns and arrhythmiasMehendale, A. C. / Doyle, J. M. / Kolin, C. M. / Kroehle, J. P. et al. | 2016
- 107
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Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogsRegan, Christopher P. / Stump, Gary L. / Detwiler, Theodore J. / Chen, Li / Regan, Hillary K. / Gilberto, David B. / DeGeorge, Joseph J. / Sannajust, Frederick J. et al. | 2016
- 115
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Evaluation of a method utilizing PhysioFlow®, a novel signal morphology-based form of impedance cardiography, to measure cardiac output in the conscious beaglePayseur, Jason D. / Rigney, John J. / Turner, Sandra L. / Wu, XueJun / Murphy, Dennis J. / Rossman, Eric I. et al. | 2016
- 120
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Rat cardiovascular telemetry: Marginal distribution applied to positive control drugsAccardi, M.V. / Troncy, E. / Abtout, S. / Ascah, A. / Maghezzi, S. / Authier, S. et al. | 2016
- 128
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Statistical power analysis of cardiovascular safety pharmacology studies in conscious ratsBhatt, Siddhartha / Li, Dingzhou / Flynn, Declan / Wisialowski, Todd / Hemkens, Michelle / Steidl-Nichols, Jill et al. | 2016
- 136
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QT interval correction for drug-induced changes in body temperature during integrated cardiovascular safety assessment in regulatory toxicology studies in dogs: A case studyEl Amrani, A. I. / El Amrani-Callens, F. / Loriot, S. p. / Singh, P. / Forster, R. et al. | 2016
- 144
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Cardiovascular safety assessments in the cynomolgus monkey: Unmasking potential background arrhythmias in general toxicity studiesGreiter-Wilke, A. / Baird, T. / O'Donohue, K. / Koerner, A. et al. | 2016
- 151
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Assessment of drug-induced proarrhythmia: The importance of study design in the rabbit left ventricular wedge modelLu, Hua Rong / Gallacher, David J. / Yan, Gan-Xin et al. | 2016
- 161
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How to determine cardiac ion channels targeted by drugs using the isolated rabbit ventricular wedge modelLiu, Guizhi / Liu, Tong / Cohen, Daniel / Liu, Tengxian / Yan, Gan-Xin et al. | 2016
- 171
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Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug developmentMorissette, P. / Regan, C. / Fitzgerald, K. / Gerenser, P. / Travis, J. / Wang, S. / Fanelli, P. / Sannajust, F. et al. | 2016
- 183
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Human ex-vivo action potential model for pro-arrhythmia risk assessmentPage, G. / Ratchada, P. / Miron, Y. / Steiner, G. / Ghetti, A. / Miller, P. E. / Reynolds, J. A. / Wang, K. / Greiter-Wilke, A. / Polonchuk, L. et al. | 2016
- 196
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Points to consider for a validation study of iPS cell-derived cardiomyocytes using a multi-electrode array systemKanda, Y. / Yamazaki, D. / Kurokawa, J. / Inutsuka, T. / Sekino, Y. et al. | 2016
- 201
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Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessmentZhang, Xiaoyu / Guo, Liang / Zeng, Haoyu / White, Stephen L. / Furniss, Michael / Balasubramanian, Bharathi / Lis, Edward / Lagrutta, Armando / Sannajust, Frederick / Zhao, Li Leyna et al. | 2016
- 217
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Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytesZeng, Haoyu / Roman, Maria I. / Lis, Edward / Lagrutta, Armando / Sannajust, Frederick et al. | 2016
- 223
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Safety pharmacology studies using EFP and impedanceObergrussberger, A. / Juhasz, K. / Thomas, U. / Stölzle-Feix, S. / Becker, N. / Dörr, L. / Beckler, M. / Bot, C. / George, M. / Fertig, N. et al. | 2016
- 233
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A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channelLi, Zhihua / Dutta, Sara / Sheng, Jiansong / Tran, Phu N. / Wu, Wendy / Colatsky, Thomas et al. | 2016
- 240
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Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imagingDempsey, G. T. / Chaudhary, K. W. / Atwater, N. / Nguyen, C. / Brown, B. S. / McNeish, J. D. / Cohen, A. E. / Kralj, J. M. et al. | 2016
- 251
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An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panelCrumb, William J. / Vicente, Jose / Johannesen, Lars / Strauss, David G. et al. | 2016
- 263
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Specific prediction of clinical QT prolongation by kinetic image cytometry in human stem cell derived cardiomyocytesPfeiffer, E. R. / Vega, R. / McDonough, P. M. / Price, J. H. / Whittaker, R. et al. | 2016
- 274
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EEG in non-clinical drug safety assessments: Current and emerging considerationsAuthier, Simon / Delatte, Marcus S. / Kallman, Mary-Jeanne / Stevens, Joanne / Markgraf, Carrie et al. | 2016
- 286
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CNS safety pharmacology: A focus on cognitive functionsHernier, Anne Marie / Froger-Colléaux, Christelle / Castagné, Vincent et al. | 2016
- 295
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Drug discrimination: A versatile tool for characterization of CNS safety pharmacology and potential for drug abuseSwedberg, M. D. et al. | 2016
- 306
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Functional neurotoxicity evaluation of noribogaine using video-EEG in cynomolgus monkeysAuthier, Simon / Accardi, Michael V. / Paquette, Dominique / Pouliot, Mylène / Arezzo, Joseph / Stubbs, R. John / Gerson, Ronald J. / Friedhoff, Lawrence T. / Weis, Holger et al. | 2016
- 313
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The “induced hyperactivity” test for the de-risking of potential off-target activity of antihypertensive drugsHimmel, H. M. / Hoffmann, M. et al. | 2016
- 323
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Frequency, types, severity, preventability and costs of Adverse Drug Reactions at a tertiary care hospitalGeer, M.I. / Koul, P.A. / Tanki, S.A. / Shah, M.Y. et al. | 2016
- 335
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Evaluation and comparison of drug discrimination assessments with cocaine, amphetamine, desipramine, and morphine of male and female ratsToot, J. / Bennett, M. / Hackman, M. / Coffee, M. / Fennell, B. / Loris, S. / Neely, A. / Atterson, P. et al. | 2016
- 335
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Auditory brainstem response evaluations in cynomolgus macaques: Considerations for anesthesia and waveform data collection and analysisAbernathy, Matthew / Yoder, Joshua / Brian, Wilson / Richardson, Jared / Tapp, Rachel / McComb, Margaret / Gauvin, David / Baird, Theodore et al. | 2016
- 335
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Bioanalytical analysis of plasma cocaine exposure in a preliminary self-administration study utilizing different concentrations of cyclodextrinToot, Jonathan / Donegan, Mike / Orens, Paula / Gibbs, Amber / Neely, Aaron / Bennett, Matt / Boggs, Jason / Atterson, Philip et al. | 2016
- 335
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Abstracts from the SPS Meeting Presentations, September 2015| 2016
- 336
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Evaluation of gross behavioral and physiological status following administration of a psychostimulant and sedative using a functional observational battery assessment adapted for trained cynomolgus monkeysGayheart-Walsten, P. / Baublits, J. / Love, S. / Botchway, A. et al. | 2016
- 336
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The assessment of single-housed vs. pair-housed rats on the Irwin testCoffee, Matthew / Shaffer, Jennifer / Adkins, James / Atterson, Philip et al. | 2016
- 336
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Neurobehavioral endpoints in non-human primates integrated in toxicology studiesBlanchard, R. H. / Ponchet-Lac, A. / Lebatard, M. / Boixel, C. / Mazelin-Winum, L. / Magnon, M. / Perrin, C. / Truphémus, P. / Mathieu-Kia, A. M. / Caron, A. et al. | 2016
- 337
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Challenges in detection of premonitory electroencephalographic (EEG) changes of drug-induced seizure using a non-human primate EEG telemetry modelShiotani, M. / Nagano, N. / Ishikawa, A. / Sakai, K. / Yoshinaga, T. / Kato, H. / Teramoto, T. / Furuya, Y. / Sawada, K. et al. | 2016
- 337
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Developing a heat map for CNS profiling based on the Irwin testde Ron, P. / Martin, F. / da Costa, A. N. / Valentin, J. P. et al. | 2016
- 337
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Effects of different vehicles used in preclinical studies on the neurobehavioral profile and general activity of Sprague Dawley ratsde Ron, P. / Berwaer, M. / Briône, W. / Delaunois, A. / Valentin, J. P. / da Costa, A. N. et al. | 2016
- 338
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Development and evaluation of a Middle Ear PinPort™ for use in otic histology studiesTapp, Rachel / McComb, Margaret / Cole, Phaedra / Sweet, Jenifer / Gesamen, Janelle / Tawoda, Lindsay / May, Jonelle / Gauvin, David / Baird, Theodore et al. | 2016
- 338
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Critical role for drug discrimination studies in the assessment of abuse liability of novel compoundsSwedberg, Michael et al. | 2016
- 338
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Rodent Big Brother: A home cage automated behavioural monitoring system for safety pharmacology and toxicology studiesTse, K. / Rimmer, V. / Grant, C. / Simpson, D. / Klein, S. / Armstrong, J. D. / Lukins, T. / Chartsias, A. / O'Callaghan, E. / Sillito, R. et al. | 2016
- 338
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Irwin/FOB tests for CNS safety assessment: What are we doing?Heers, Cara / van Amsterdam, Christoph / Habermann, Christopher / Schauerte, Heike / van der Linde, Henk / Himmel, Herbert / Traebert, Martin / Dinklo, Theo et al. | 2016
- 339
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Simulating the effect of anti-diabetic drugs on ATP-sensitive potassium (KATP) channels inhibition in a human cardiac cell model (ORd)Abbasi, Mitra / Polak, Sebastian et al. | 2016
- 339
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Exploring temperature-dependence of hERG channel kinetics using sine wave voltage protocolsBeattie, Kylie / Melgari, Dario / Hancox, Jules / Mirams, Gary et al. | 2016
- 339
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Is manual patch clamp still the gold standard assay for ion channels?Ballini, Elisa / Carignani, Corrado / Bettini, Ezio / Pilla, Maria et al. | 2016
- 340
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LPS-induced cytokine storm produces QTc prolongation which can be prevented by an anti-inflammatory eutectic blendBouchard, A. / Sordillo, P. / Helson, L. / Shopp, G. / Baillargeon, S. / Shaw, W. / Salvail, D. et al. | 2016
- 340
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Bridging functional and structural cardiotoxicity assays using human stem cell-derived cardiomyocytes for a more comprehensive risk assessmentClements, M. / Millar, V. et al. | 2016
- 340
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Optimization of optical imaging of cardiac tissue slices as a tool in safety pharmacologyBollensdorff, Christian / Wang, Ken / Mu-u-min, Razik / Sathappan, Abbirami / Terrar, Derek / Yacoub, Magdi et al. | 2016
- 341
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Inducible CaV1.2 cell line optimized for automated patch clamp assaysDanker, Timm / Frey, Manfred / Guenther, Elke et al. | 2016
- 341
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Variability in cardiac ion channel assays: A major challenge for CiPA paradigm implementationDelaunois, Annie / Colomar, Aurore / Valentin, Jean-Pierre et al. | 2016
- 341
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Mitogen activated kinase kinase 7 is involved in Sunitinib induced myocardial injuryCooper, S. / Maddock, H. / Hussain, A. / Sandhu, H. et al. | 2016
- 341
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Use of high throughput electric field stimulation (EFS) coupled with intracellular Ca2+ kinetics measurements on iPSC-derived cardiomyocytesKato, Natsumi / Yamamoto, Satoshi / Ito, Taira / Matsubara, Masanori / Du, Shouming / Kataoka, Takuji / Iwase, Fumio / Kettenhofen, Ralf / von Haniel, Felix / d'Angelo, Jean Marc et al. | 2016
- 342
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Electrophysiologic actions of diverse CIPA compounds on Cor.4U cardiomyocytesGibson, John / Yue, Yimei / Li, Ping / Luermann, Gregory et al. | 2016
- 342
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Complementary automated patch clamp, extracellular field potential and impedance recordings of iPSCs: Safety screening tool box for the futureDragicevic, E. / Becker, N. / Stölzle-Feix, S. / Thomas, U. / Juhasz, K. / Doerr, L. / Rapedius, M. / Nicolini, A. / Millard, D. / Beckler, M. et al. | 2016
- 342
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An integrative biophysical model linking changes in protein function to emergent cellular phenotypes in left ventricular myocytesFernandez-Chas, Margarita / Niederer, Steven A. et al. | 2016
- 343
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Cell-specific mathematical models of cardiac electrophysiologyJohnstone, R. / Bardenet, R. m. / de Boer, T. / Gavaghan, D. / Davies, M. / Polonchuk, L. / Mirams, G. et al. | 2016
- 343
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Analysis of field potential from hiPS-derived cardiomyocytes with pharmacological tools: Quantitative correlations with preclinical and clinical endpointsMomtaz, Abdelhaq / Rousseau, Emilie / Carriot, Thierry / Chantoiseau, Céline / Hoët, Delphine / Guillon, Jean-Michel et al. | 2016
- 343
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Comparison of ion-channel data between physiological and room temperature for predicting drug-induced proarrhythmiaKatayama, Y. / Izumi, T. / Tomizawa, S. / Yamaguchi, M. / Kanno, A. et al. | 2016
- 344
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Developing a package of in vitro human cardiac ion channel assays to predict clinical arrhythmia riskKirby, R. / Tang, R. / Webdale, L. / Ridley, J. / Rogers, M. et al. | 2016
- 344
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The late sodium current participates in repolarization of hiPSC-derived cardiac myocytesPourier, M. / Gibson, J. / Luerman, G. / Fedida, D. et al. | 2016
- 344
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Identification of CV liabilities in the xCELLigence system using human iPS-derived cardiomyocytesKazusa, Katsuyuki / Watanabe, Yudai / Nagata, Keisuke / Sato, Yumiko / Fujimori, Chikara / Shirakawa, Takafumi / Okada, Akinobu et al. | 2016
- 344
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Updating probabilistic assessment of proarrhythmia liability with in silico action potential modelingLeishman, D. et al. | 2016
- 345
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CiPA validation of moxifloxacin as a positive control to assess cardiac riskObejero-Paz, C. / Bruening-Wright, A. / Kramer, J. / Brown, A. et al. | 2016
- 345
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Vanoxerine: A case study supporting quantitative profiling for assessing cardiac riskObejero-Paz, C. / Bruening-Wright, A. / Kramer, J. / Tatalovic, M. / Dittrich, H. / Brown, A. et al. | 2016
- 345
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In silico prediction of drug effects on human ventricular electrophysiology using the Virtual Assay software and comparison to in vitro dataPassini, Elisa / Britton, Oliver / Lu, Hua Rong / Gallacher, David J. / Rohrbacher, Jutta / An, Hermans / Bueno-Orovio, Alfonso / Rodriguez, Blanca et al. | 2016
- 346
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Novel assessment of cardiomyocyte functions with hybrid MEA-impedance technology on CardioExcyte96Polonchuk, L. / Thomas, U. / Davies, M. / Sanchez, R. A. / Schuler, F. / Singer, T. / Stoelzle_Feix, S. et al. | 2016
- 346
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Comprehensive in vitro proarrythmic evaluation of cardiomyocytes using a multi-electrode arrayRenganathan, M. / Benjamin, C. / Wei, H. et al. | 2016
- 346
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Detection of hERG-trafficking in vitro: A comparison of functional and protein expression methodsQu, Y. / Crumb, W. / Vargas, H. et al. | 2016
- 347
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Improved functional maturation of human induced pluripotent stem cell (hiPSC) derived ventricular cardiomyocytes in vitro: Multi-electrode array (MEA) based electrophysiological characterizationVlaming, M. / Stevenhagen, F. / de Korte, T. / Langenberg, K. / Dunska, M. / Tertoolen, L. / Mummery, C. / Grandela, C. / Braam, S. et al. | 2016
- 347
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Comparison of HERG ion channel effects in HEK cells and action potential duration in human iPSC cardiomyocytesSaxena, Priyanka / Hortigon-Vinagre, Maria P. / Costa, Ana / Timin, Eugen / Beyl, Stanislav / Baburin, Igor / Smith, Godfrey L. / Hering, Steffen et al. | 2016
- 347
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Biophysical and pharmacological characterization of the CiPA ion channel panel and iPSC cardiomyocytes using automated patch-clampScheel, Olaf / Frech, Stefanie / Amuzescu, Bogdan / Crumb, William / Roberts, Mike / Knott, Thomas et al. | 2016
- 348
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Evaluation of acute and chronic effects of kinase inhibitors on electrical and contractile activity of human iPSC-derived cardiomyocytesZhang, X. / Xi, B. / Abassi, Y. et al. | 2016
- 348
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To sum or not to sum: How to assess torsadogenic potential of combination of drugs and their active metabolites—In vitro assessment with loratadine and desloratadine as the exemplary drugsWiśniowska, B. / Badyra, B. / Lisowski, B. / Polak, S. et al. | 2016
- 348
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Assessment of the electromechanical window of human IPSC-derived cardiomyocytes and its modulation by compounds affecting cardiac functionZhang, X. / Xi, B. / Abassi, Y. et al. | 2016
- 349
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Computational models of doxorubicin mitochondria cardiotoxicityde Oliveira, B. / Niederer, S. et al. | 2016
- 349
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Presence of neuromuscular and pulmonary deficits in a mouse model of Pompe diseaseDalton, Jill / Abernathy, Matthew / May, Jonelle / Harter, Marci / Baird, Theodore et al. | 2016
- 349
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What are the challenges and opportunities ahead of any regulatory requirements for in silico cardiac pro-arrhythmia prediction?Davies, M. / Wang, K. / Caruso, A. / Mirams, G. / Noble, D. / Walz, A. / Lave, T. / Schuler, F. / Singer, T. / Polonchuk, L. et al. | 2016
- 350
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Calcium channel blocker increases the anticancer activity of temozolomide by inhibiting autocrine VEGF signalingHanif, Farina / Perveen, Kahkashan / Malhi, Saima Mahmood / Simjee, Shabana Usman et al. | 2016
- 350
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Predicting drug-induced arrhythmia using afterdepolarisationsMcMillan, B. / Gavaghan, D. J. / Mirams, G. R. et al. | 2016
- 350
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Comparison of four in silico models to predict cardiac action potential effects and proarrhythmia liabilityDelaunois, A. / Colomar, A. / Valentin, J. P. et al. | 2016
- 350
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Decreased ejection fraction induced by a MEK inhibitor in spontaneously hypertensive and Wistar rats: Reversibility following co-administration of lisinoprilJu, Haisong / Zhao, Shufang / Martin, Lori / Wolak, Eileen / Hahn, Suzette / Shenoy, Neeta / Chandra, Sudeep / Friedrichs, Greg / Spence, Stan et al. | 2016
- 351
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Zero-magnesium model of seizure like events and anticonvulsant potential of SK-channel agonists in vitroRaza, Muhammad Liaquat / Heinemann, Uwe et al. | 2016
- 351
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Cardiac safety assessment of drugs using three-dimensional heart simulatorOkada, Jun-ichi / Yoshinaga, Takashi / Kurokawa, Junko / Washio, Takumi / Furukawa, Tetsushi / Sawada, Kohei / Sugiura, Seiryo / Hisada, Toshiaki et al. | 2016
- 351
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Towards unravelling the mechanism of cardiotoxicity of citalopram: Utilisation of mechanistic cardiac electrophysiology modelling with the Simcyp cardiac safety simulator (CSS) to explore various hypothesesPatel, N. / Jamei, M. / Polak, S. et al. | 2016
- 352
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A heart compartmental model for the prediction of cardiac amitriptyline concentrationTylutki, Z. / Jornil, J. / Polak, S. et al. | 2016
- 352
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A holistic approach to the safety assessment of exploratory drug targetsVenhorst, J. / Rankouhi, T. R. / Verschuren, L. / van Someren, E. P. / Kuper, F. C. / Wolterbeek, A. P. / van de Brug, F. J. / Folkertsma, S. / Krul, C. A. et al. | 2016
- 352
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Can late sodium current inhibition attenuate QT prolonging effects caused by hERG blockers in in silico modelsRohrbacher, Jutta / Damiano, Bruce P. / Teisman, Ard / Gallacher, David J. et al. | 2016
- 353
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Systems Pharmacology based approach utilized for prediction of the cardiac consequences of drug–drug interactionsWiśniowska, B. / Badyra, B. / Lisowski, B. / Polak, S. et al. | 2016
- 353
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Prediction of clinical risks by analysis of preclinical and clinical adverse eventsClark, Matthew et al. | 2016
- 353
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Identifying site-specific molecular signatures for sub-acute drug induced kidney injurySnelling, S. / Dremier, S. / De Ron, P. / Glineur, S. / Da Costa, A. et al. | 2016
- 354
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Recent cardiac ion channel data helped to better understand the QT prolongation/Torsades de Pointes risk of hydroxyzine (Atarax®), a first generation antihistamineDelaunois, Annie / Colomar, Aurore / Peters, Christopher / Schlit, Anne-Françoise / Valentin, Jean-Pierre et al. | 2016
- 354
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Off-target cardiac Na-channel inhibition in preclinical and clinical development—A case studyDeurinck, Mark / Pruimboom, Ingrid / Ju, Haisong / Dumotier, Berengere / Traebert, Martin et al. | 2016
- 354
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Myocardial electrotonic coupling modulates repolarization heterogeneities in vivo: Implications for the assessment of pro-arrhythmic liabilities in vitro and in silicodel Rio, C. / Hamlin, R. / Billman, G. et al. | 2016
- 355
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Bayesian-hierarchical pharmacokinetic/pharmacodynamic (PK/PD) model to characterize the exposure-QT effect relationship for decision making in early drug developmentDubois, V. F. / Boulton, M. / Bursi, R. et al. | 2016
- 355
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Inclusion of neurobehavioural and respiratory safety pharmacology endpoints in the 4-week rat general toxicology studiesFasdelli, N. / Pecoraro, M. / Pilla, M. et al. | 2016
- 355
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Translational prediction of sensitivity to hERG-mediated QTc-prolongation using a systems pharmacology modelGotta, Verena / Cools, Frank / van Ammel, Karel / Gallacher, David J. / Visser, Sandra A.G. / Sannajust, Frederic / Morissette, Pierre / Danhof, Meindert / van der Graaf, Piet H. et al. | 2016
- 355
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Inter-study variability and translational value of preclinical exposure-QTc predictions—A pharmacokinetic/pharmacodynamic (PK/PD) meta-analysisGotta, Verena / Cools, Frank / van Ammel, Karel / Gallacher, David J. / Visser, Sandra A.G. / Sannajust, Frederic / Morissette, Pierre / Danhof, Meindert / van der Graaf, Piet H. et al. | 2016
- 356
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Mechanistic investigation into a delayed onset QTc prolongationGray, K. / Pointon, A. / Rose, A. / Philp, K. / Moors, J. / Skinner, M. / Bridgland-Taylor, M. / Harmer, A. et al. | 2016
- 356
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Comparison of binding and functional data on a set of safety-related GPCRsJolas, Thierry / Migeon, Jacques / Fouchaq, Benoit et al. | 2016
- 356
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Proactively developing assay schemes based on an understanding of the goal of testing and the nature of the safety endpointLeishman, Derek et al. | 2016
- 357
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The non-invasive translational biomarker — Index of cardiac electrophysiological balance (iCEB) predicts potential risk of cardiac arrhythmias in preclinical models and in patients: Superior to current biomarkers such as QT?Lu, Hua Rong / Robyns, Tomas / Nuyens, Dieter / Janssens, Stefan / Yan, Gan-Xin / Teisman, Ard / Gallacher, David J. et al. | 2016
- 357
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Applying probabilistic ‘weight-of-evidence’ assessments to diverse safety endpointsLeishman, D. et al. | 2016
- 357
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Translation to human: Not just a simple correlation exercise between preclinical and clinical data: A qualitative/semi-quantitative analysisLoenders, B. / Van Ammel, K. / Gallacher, D. J. et al. | 2016
- 358
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Dual inhibition of VEGF and DLL4 ameliorates anti-DLL4 cardiac endothelial hypertrophy in cynomolgus monkeysMeisner, R. / Argast, G. / Liu, Y. W. / Wallace, B. / Wang, M. / Kapoun, A. / Hoey, T. et al. | 2016
- 358
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Biomarkers of hypercoagulability in a rat sepsis-induced model of non-overt disseminated intravascular coagulation (DIC)Brooks, M.B. / Turk, J.R. / Fishman, C.E. / Besteman, E.G. / Wilson, D.W. / Schultze, A.E. / Pierson, J.B. / Parish, S. / Pugsley, M.K. et al. | 2016
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Patient-specific QT risk assessment: Case study of an oncology agent and an anti-emeticPollard, C. / Philp, K. / Easter, A. / Moors, J. / Prior, H. et al. | 2016
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Incorporation of safety pharmacology endpoints in toxicology studies in monkeysQu, L. / Wu, R. / McPherson, S. / Jin, Y. et al. | 2016
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Left ventricular pressure may improve predictivity of preclinical cardiovascular assays to clinical outcomesRoche, B. / Brandon Borders, R. / Appleby, C. / Kieper, J. / Landis, K. / Kearney, K. / Adkins, J. / Vidmar, T. / Atterson, P. et al. | 2016
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Assessment of cardiac biomarkers in patients undergoing coronary artery bypass grafting (CABG) surgerySabah, E. / Kamal, A. / Al-Saffar, A. et al. | 2016
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An in silico PBPK-PD coupled approach to assess zolpidem effect on pre-clinically and clinically measured cardiac repolarisation parameters in the absence and presence of a circadian model of plasma ion concentrationSmall, Ben G / Jamei, Masoud / Rostami-Hodjegan, Amin / Polak, Sebastian et al. | 2016
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Pharmacovigilance study of iron chelators in thalassemic patientsUsta, Coşkun / Kurtoğlu, Erdal / Bedel, Aslı / Kurtoğlu, Ayşegül Uğur et al. | 2016
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In vitro to clinical translation to improve proarrhythmic risk assessmentStrauss, David / Vicente, Jose / Mason, Jay / Crumb, William / Hosseini, Meisam / Stockbridge, Norman / Johannesen, Lars et al. | 2016
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Translation: Lessons learned of a quantitative analysis with 5 clinically tested compounds. Just a walk in the park… or a shot in the dark?Van Ammel, K. / Loenders, B. / Gallacher, D. et al. | 2016
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Tiron offers protection from doxorubicin induced myocardial injuryChiuzbaian, Oana / Gharanei, Mayel / Mee, Christopher / Maddock, Helen / Hatch, Ellen et al. | 2016
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Considerations for in vitro systems to reflect in vivo toxicities to facilitate drug developmentZabka, Tanja / Kim, Amy / Uppal, Hirdesh / Kauss, Ariel / Dhawan, Preeti / Liederer, Bianca / Lin, Tori / McCray, Bobbi / Nguyen, Trung / Chou, Carolina et al. | 2016
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Importance of parameter control in cardiac models for robust pro-arrhythmic risk predictionWang, Ken / Davies, Mark / Caruso, Antonello / Mirams, Gary / Noble, Denis / Walz, Antje-Christine / Lavé, Thierry / Schuler, Franz / Singer, Thomas / Polonchuk, Liudmila et al. | 2016
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An in vitro assay for assessing cardiac contractility effects of test compounds using the rat myocardial work loop assayGharanei, M. / Wallis, R. / Babba, M. / Maddock, H. et al. | 2016
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Work-loop assay to predict inotropic drug effects of checkpoint kinase inhibitorsGharanei, Mayel / Wallis, Rob / Babba, Maryam / Varcianna, Andre / Maddock, Helen et al. | 2016
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Ex vivo model to investigate anticancer drug-induced chronic cardiotoxicityDucroq, Joffrey / Didier, Hélène / Salvetat, Céline / Le Grand, Marie et al. | 2016
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Use of the human trabeculae muscle work loop assay to predict adverse drug effects on heart contractilityGharanei, Mayel / Wallis, Rob / Babba, Maryam / Maddock, Helen et al. | 2016
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PK and cardiac assessment in rats administered doxorubicinHenderson, K. / Ross, J. / Borders, B. / Gibbs, S. / Hong, P. / Wood, B. / Vinci, T. / Roche, B. / Smith, J. et al. | 2016
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Comparative analysis of data sciences international PhysioTel™ D70 and PhysioTel™ digital telemetry platformsKearney, K. / Appleby, C. / Kieper, J. / Atterson, P. et al. | 2016
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Kinetic image cytometry and high content analysis assay of neurotoxicityMcDonough, P. / Basa, R. / Cai, B. / Batchelder, E. / Feng, S. / Price, J. et al. | 2016
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Development of an in vitro rat phrenic nerve–diaphragm muscle preparationRoof, S. / del Rio, C. / Patil, P. / Strauch, S. / Hamlin, R. et al. | 2016
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Preclinical assessment of neuronal network activity and compound-dependent seizure liability using an MEA based in vitro platformCato, Matthew / Shen, Frank / Smith, Randall / Bradley, Jenifer / Murphy, Dennis / Chaudhary, Khuram et al. | 2016
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Addition of left ventricular pressure measurement to a cardio-respiratory model, using telemetry and plethysmography in the conscious ratBeaudoin, S. / Williams, C. / Melliti, K. / Meecham, K. / Milner, V. et al. | 2016
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Comparison of left ventricular contractility to RR interval relationship in freely-moving rats, dogs and monkeysAuthier, S. / Abtout, S. / Ascah, A. / Pouliot, M. / Bujold, K. / Troncy, E. / Forster, R. / Pugsley, M. K. et al. | 2016
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Left ventricular pressure (LVP) and contractility in freely-moving rats: The application of marginal distribution analysisAuthier, S. / Abtout, S. / Bujold, K. / Ascah, A. / Pouliot, M. / Troncy, E. / Forster, R. / Pugsley, M. K. et al. | 2016
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Comparison of dog and guinea pig cardiovascular telemetryCseko, C. / Komlódi, Z. / Makó, v. / Balázs, O. et al. | 2016
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Alterations of the PR interval in chronically instrumented dogs and monkeysDalton, J. / Abernathy, M. / O'Donohue, K. / Gesaman, J. / Harter, M. / May, J. / Baird, T. et al. | 2016
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The tilt test in non-human primate (NHP) using manual restraint: An improved method to investigate orthostatic hypotensionBetat, A. M. / Delpy, E. / Bureau, M. / Veillard, J. r. / La Rochelle, C. D. et al. | 2016
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Evaluation of apnea in the dog: A guidance on preclinical evaluations and correlation to clinical sleep apnea scoringRenninger, J. / DiPasquale, J. / Murphy, D. et al. | 2016
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How preclinical neurobehavioural data can predict drug related effects on cardiovascular parametersGarbati, Nicoletta / Fasdelli, Nicola / Pilla, Maria / Maraschiello, Ciriaco et al. | 2016
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Investigation of hemodynamic changes induced by CompoundX in Wistar Han ratsTang, Hai-Ming / Flaherty, Meghan / Aibo, Daher Ibrahim / Walker, Dana / Shenoy, Neeta / Vostiar, Igor / Stiehl, Daniel / Ju, Haisong / Friedrichs, Gregory et al. | 2016
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QT interval correction for drug-induced changes in body temperature in dogsEl Amrani, Abdel-Ilah / El Amrani, Francine / Loriot, Stephane / Singh, Pramila / Forster, Roy et al. | 2016
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Incorporation of safety pharmacology endpoints in the toxicological assessment of a potential diagnostic positron emission tomography (PET) imaging agentHirani, Ella / Daalsgard, Grethe / Hoppmann, Susan / Evans, Paul et al. | 2016
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Why may the ECG vary so much when a “Modified Lead II” is taken by telemetry?Hamlin, R. et al. | 2016
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Assessment of electrocardiography (ECG) parameter variability when building ECG template librariesRoss, R. / Kremer, J. / Aschcroft-Hawley, K. / Michael Foley, C. / Osinski, M. / Carneal-Frazer, N. et al. | 2016
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Microsampling—A Refinement to the Home Cage Rat Telemetry ModelPhilp, Karen / Moors, Jackie / Skinner, Matt / MacDonald, Ruth / Ngeny, Maryann / Redfern, William et al. | 2016
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Evaluation of minimally invasive blood pressure telemetry devices in conscious Beagle dogsSkinner, Matt / Milne, Aileen / Grant, Claire / Meyer, Olivier / Stanton, Andrea / Sutherland, Joanne / Moors, Jackie / Bradley, Alys et al. | 2016
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A comparison of baseline heart rates, left ventricular and systolic pressure in group housed versus single housed beagle dogs and the effects of housing on sensitivity to detect changes in contractility following Pimobendan administrationSadekova, N. / Boudreau, G. / Norton, K. et al. | 2016
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Evaluation of conscious free moving dual pressure telemetered guinea pigs as a model for safety pharmacology studyUeyama, Yukie / Mittelstadt, Scott / del Rio, Carlos / Roof, Steve / Youngblood, Brad / Wallery, Jeff / Hamlin, Robert et al. | 2016
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Evaluation of Digital Implantable Telemetry in Multiple Social Housing Paradigms for Cynomolgus MonkeyTichenor, Stephen / Regalia, Douglas / Holzgrefe, Henry / Lilly, Brittany / Wilcox, Angela / Kaiser, Robert et al. | 2016
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The electromechanical window (EMw): A heart-rate independent biomarker for delayed repolarization of the heartWaiz, D. / Roberts, S. / Jenni, R. / Greiter-Wilke, A. et al. | 2016
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Comparison of alternative in vivo ECG endpoints for arrhythmia predictionWu, XueJun / Payseur, Jason / Murphy, Dennis / Rossman, Eric et al. | 2016
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Physiological differences between brachycephalic and non-brachycephalic dogs after 6min walking test at high altitudeArango, Susana / Durán, Amelia / Florez, Sebastián / Vargas-Pinto, Pedro et al. | 2016
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Echocardiography in a toxicology settingEngwall, M. / Vargas, H. et al. | 2016
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Assessing cardiotoxicity in the zebrafish embryoAlzualde, Ainhoa / Holgado, Olaia / Bertran, Enric / Geiter-Wilke, Andrea / Muriana, Arantza / Roberts, Sonia et al. | 2016
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Plasma miR-208: A robust early biomarker of cardiac drug induced injury in ratsGlineur, S. / de Ron, P. / Hanon, E. / Valentin, J. P. / Dremier, S. / da Costa, A. N. et al. | 2016
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Promising approach for the preclinical assessment of cardiac risks using left ventricular pressure–volume loop analyses in anesthetized monkeysIshizaka, Tomomichi / Yoshimatsu, Yu / Maeda, Yu / Takasaki, Wataru / Chiba, Katsuyoshi / Mori, Kazuhiko et al. | 2016
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A model of acute congestion with progressive induction of pulmonary edema in sheep with chronic ischemic left-ventricular dysfunction: Preliminary resultsGeist, G. E. / del Rio, C. / Youngblood, B. / Render, K. / Ueyama, Y. / Hamlin, R. et al. | 2016
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Selective actions of lead acetate, aluminum and cadmium sulfate in the corpus cavernosum and their effects on erectile function in ratsSaad, E. / Senbel, A. / Taha, S. / Fouad, H. et al. | 2016
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Inotropy and chronotropy screens in engineered human myocardiumMeyer, T. / Tiburcy, M. / Zimmermann, W. H. et al. | 2016
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Dronedarone prevents atrial fibrillation in dog model of sustained atrial fibrillationSaengklub, N. / Limprasutr, V. / del Rio, C. / Hamlin, R. L. / Kijtawornrat, A. et al. | 2016
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Effects of body weight on electrophysiology, hemodynamics and plasma exposure in anesthetized guinea-pigs: An impact on preclinical safety margin analysisUrmaliya, V. / Lauryssen, L. / Daems, H. / Verrelst, J. / Teisman, A. / Gallacher, D. J. et al. | 2016
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Effects on iCEB and EMw after levcromakalim infusions in normal and reduced coronary flow anesthetized dog modelsvan der Linde, H. / Van Deuren, B. / Somers, Y. / Teisman, A. / Gallacher, D. et al. | 2016
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6min walking test in healthy dogs and in dogs with pulmonary hypertension (before and after sildenafil) at high altitudeVargas-Pinto, Pedro / Tapasco, Lina / Betancourt, Estefanía / Carrero, Maria / Bechara, Estefanía / Pedraza-Toscano, Adriana / Vargas-Pinto, Piero et al. | 2016
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The predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trialsMead, A. / Amouzadeh, H. / Chapman, K. / Ewart, L. / Giarola, A. / Jackson, S. / Jarvis, P. / Jordaan, P. / Redfern, W. / Traebert, M. et al. | 2016
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CNS safety of spadinChamperoux, P. / Maleysson, V. / Bracq, E. / Maurin, A. / Mazella, J. / Heurteaux, C. / Borsotto, M. / Richard, S. et al. | 2016
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Characterization of canine models of heart failure with reduced and preserved ejection fractionYoungblood, Brad / del Rio, Carlos / Render, Kevin / Geist, Beth / Ueyama, Yukie / Wallery, Jeff / Hamlin, Robert et al. | 2016
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Enhance in pentylenetetrazole or maximal electro shock induced seizures in experimental models of ulcerative colitis: An interplay of altered cytokines level, adhesion molecules, blood brain barrier disruptionMedhi, B. / Sewal, R. K. / Modi, M. / Saikia, U. N. / Chakrabarti, A. et al. | 2016
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NeuroSafe: A human integrated in vitro Neurotoxicity Safety PlatformRedaelli, Loredana / Maresca, Giovanna / Tremolada, Sara / Kuhn, Christina / Brioschi, Matteo / Hess, Dietmar / Guenther, Elke / Scarabottolo, Lia et al. | 2016
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Utility of an in vitro platform to assess neuronal toxicity using human iPSC-derived neuronsMisner, Dinah / Snyder, Chelsea / Ngo, Tin / Yu, Lanlan / Stagg, Nicola / Staflin, Karin et al. | 2016
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Use of stem cell derived peripheral neurons as a model of chemotherapeutic induced peripheral neuropathyDelaney, Shannon / Wing, Claudia / Favre, Nicole / Luerman, Greg / Dolan, Eileen et al. | 2016
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Treatment for established hypoxia-semaxanib induced pulmonary arterial hypertension in rats: Riociguat and sildenafil improve pulmonary hemodynamics and right ventricular hypertrophy using a disease intervention strategyHock, F. / Huang, J. / Janssen, D. / Zammit, M. / Neves, L. / Senese, P. / Gralinski, M. et al. | 2016
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How to improve the respiratory safety evaluation: Impact of animal welfare?Dudzicki, Anne / Lemos-de-Andrade, Edineia / Momtaz, Abdelhaq / Baudet, Henri-Michel / Guillon, Jean-Michel / Boixel, Christophe et al. | 2016
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Respiratory measurements in rats as indicator of adverse respiratory reactions to inhaled drugsLarsson, M.H. / Gustavsson, M. / Kärrman-Mårdh, C. / Kirk, S. / Öhlin, S. / Österlund, A. / Åberg, P. / Edmunds, N. / Conlon, K. et al. | 2016
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Effect of a HIF-prolyl hydroxylase inhibitor on aortic pressure, heart rate and peak right ventricular pressure in rats exposed to acute hypoxiaKohrs, L. / Renninger, J. / Murphy, D. et al. | 2016
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Global Cross-company Data-sharing on the Housing of Non-rodents During the Recording of Cardiovascular Telemetry Data on Safety Pharmacology and Toxicology StudiesBottomley, Anna / Prior, Helen / Cordes, Jason et al. | 2016
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Simultaneous evaluation of cardiovascular and respiratory functions in the conscious dogRompion, S. / Guillaume, P. / Goineau, S. / Froget, G. et al. | 2016
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Assessment of HER-2/neu gene amplification and expression as a biomarker for radiotherapy and hormonal treated breast cancer patients in Upper EgyptEsmat, Marwa / AbdelWanis, Mostafa / Mosad, Eman / EL-maghraby, Tarek / Othman, Ahmed et al. | 2016
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Drugs withdrawn from the market over the last 50years: Contribution of adverse effects within the sphere of influence of safety pharmacologyRedfern, Will et al. | 2016
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Safety assessment of a formulation for 68Ga-DOTATOC (68Ga-edotreotide or 68Ga-DOTA0-Tyr3-octreotide) preparation: Case studies in rats and rabbitsChicco, Daniela / Orlandi, Francesca / Venturella, Silvana / Di Manno, Paola / Manno, Rosa Anna et al. | 2016
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How much of a cardiomyocyte can we get from stem cells? Setting up metrics for cardiac cell modelsChabria, Mamta / Hoflack, Jean-Christophe / Badi, Laura / Flint, Nicholas / Burcin, Mark / Graf, Martin / Singer, Thomas / Alvarez-Sanchez, Ruben / Schuler, Franz / Polonchuk, Liudmila et al. | 2016
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Simulated micro-electrode array recordings from stem cell-derived cardiomyocytesBowler, L. / Harris, K. / Gavaghan, D. / Mirams, G. et al. | 2016
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Comprehensive assessment of multiple induced pluripotent stem cell-derived cardiomyocyte cell lines with microelectrode arrays and voltage sensitive dyesBlinova, K. / Stohlman, J. / Vicente, J. / Chan, D. / Hortigon, M. / Rodriguez, V. Z. / Smith, G. / Ross, J. / Brock, M. / Chvatal, S. et al. | 2016
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A highly scalable embryonic stem cell platform for in vitro genetics of drug responseBergseid, Jacqueline / Joshi-Barr, Shivanjali / Page, Lesley / Carlo, Amy / Brown, Stephanie / Choi, Ted et al. | 2016
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Cardiotoxicity testing in human iPSC-derived cardiomyocytes for the CiPA pilot study using all-optical electrophysiologyDempsey, Graham / Atwater, Nicholas / Nguyen, Cuong et al. | 2016
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Impedance based Assay on iPS cardiomyocytes: An efficient way of discriminating between cardioactive and non cardioactive drugsColomar, Aurore / Haen, Lucille / Toussaint, Gaëlle / Loïodice, Simon / Kopp, Benjamin / Atienzar, Franck / Valentin, Jean-Pierre et al. | 2016
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Early screening for cardiac arrhythmic liabilities: Comparison of a new assay measuring Ca2+ transients in human stem cell-derived cardiomyocytes to the more traditional assays (isolated guinea-pig right atrium model and HERG assay)Hermans, An N. / Geyskens, Danny / Rohrbacher, Jutta / Lu, Hua Rong / Lammens, Lieve / Gallacher, David J. et al. | 2016
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Assessing the predictivity of a human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) multielectrode array (MEA) assay for preclinical cardiac electrophysiology safety screeningHarris, K. / Graham, S. / Sridhar, A. / Louttit, J. et al. | 2016
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Human iPS-derived cardiac myocyte-fibroblast 3D co-cultures: A predictive in vitro model to assess drug-induced contractile and metabolic liabilitiesGoßmann, M. / Palm, T. / Kettenhofen, R. / Bohlen, H. / Lu, H. R. / Gallacher, D. J. / Artmann, G. / Epple, M. / Artmann, A. l. et al. | 2016
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Characterization of the physiology and cardiotoxicity of cardiac 3D microtissues of hiPSC-derived cardiomyocytes (hiPSC-CMs)Hortigon-Vinagre, Maria P. / Zamora, Victor / Alageswaran, Viben / Craig, David / Fluri, David / Bruton, Francis L. / Agarkova, Irina / Kelm, Jens M. / Craig, Margaret A. / Smith, Godfrey L. et al. | 2016
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Image-based evaluation of contractile characteristics of hiPS-CMs: A tool for pre-clinical cardiovascular drug discoveryHuang, Minxue / Shi, Hong / Zhu, Jialong / Levesque, Paul et al. | 2016
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Usefulness of motion vector prediction system for evaluating drug-induced functional changes of human induced pluripotent stem cell-derived cardiomyocytesHonda, M. / Ishitomi, A. / Okai, Y. / Kitamura, T. / Isobe, T. / Matsune, K. / Araki, S. i. et al. | 2016
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Human iPSC-derived Cor.4U cardiomyocytes as a predictive tool for different comprehensive in vitro proarrhythmia assay endpointsKettenhofen, Ralf / Duenbostell, Anika / Luerman, Greg / Li, Ping / Yue, Yimei / Bronson, Jared / Horai, Hirofumi / D'Angelo, Jean Marc / Niedereichholz, Thomas / Gibson, John Ken et al. | 2016
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Assessment of drug-induced QT prolongation using human iPS cell-derived mature cardiomyocytesKanda, Yasunari / Li, Min / Ashihara, Takashi / Sekino, Yuko / Furukawa, Tetsushi / Kurokawa, Junko et al. | 2016
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CSAHi study: Evaluation of MED64 multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythmiaKitaguchi, Takashi / Moriyama, Yuta / Miyamoto, Norimasa / Taniguchi, Tomohiko / Ojima, Atsuko / Ando, Hiroyuki / Uda, Takaaki / Otabe, Koji / Oguchi, Masao / Shimizu, Shigekazu et al. | 2016
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CSAHi study: Usability assessment of multi-electrode array in combination with human iPS cell-derived cardiomyocytes for prediction of drug-induced QT prolongation and arrhythmia — Multi Channel Systems (MEA60 and MEA2100)Kunimatsu, T. / Nozaki, Y. / Honda, Y. / Watanabe, H. / Yamanishi, A. / Nogawa, H. / Endo, H. / Saiki, S. / Nagasawa, C. / Nakamori, C. et al. | 2016
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Could in vitro animal assays be replaced by human stem cell-based assays for drug-induced cardiac risks: Beyond QT-prolongation/CIPA?Lu, H. R. / Hermans, A. / Kopljar, I. / Rohrbacher, J. / Teisman, A. / Gallacher, D. J. et al. | 2016
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An in vitro assessment of delayed HDAC inhibitor-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytesKopljar, I. / Vlaminckx, E. / Lu, H. R. / Gallacher, D. et al. | 2016
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Assessment of reverse use-dependent blocking actions of dofetilide in stimulated human induced pluripotent stem cell derived (hiPSC) cardiomyocytesShi, Hong / Huang, Minxue / Levesque, Paul et al. | 2016
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iNCENS (iPSC non-clinical experiments for nervous system): A project to establish the CNS safety pharmacological evaluation to predict risks of cognitive impairment and epilepsy by in vitro use of human induced pluripotent stem cell-derived neuronsSato, K. / Takahashi, K. / Shigemoto-Mogami, Y. / Shimizu, H. / Ikegaya, Y. / Koyama, R. / Hiragi, T. / Miyamoto, N. / Shirao, T. / Sekino, Y. et al. | 2016
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Humoral factor from rodent astrocytes promoted the synaptic transmission and augmented synchronized population bursts in human induced pluripotent stem cell-derived neuronsMiyamoto, N. / Sawada, K. et al. | 2016
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Action potential duration and proarrhythmia assay by kinetic image cytometry in hiPS-cardiomyocytes for the FDA/HESI CiPA initiativePfeiffer, Emily / Whittaker, Ross / Hilton, Jeffrey / Ingermanson, Randy / Price, Jeffrey et al. | 2016
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Comprehensive in vitro cardiac safety assessment using human stem cell technology—Overview of CSAHi HEART initiativeTakasuna, Kiyoshi / Asakura, Keiichi / Araki, Seiichi / Ando, Hiroyuki / Kazusa, Katsuyuki / Kitaguchi, Takashi / Kunimatsu, Takeshi / Suzuki, Shinobu / Miyamoto, Norimasa et al. | 2016
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Differential effects of astemizole on the neurite growth and synaptogenesis of neuronsShirao, Tomoaki / Ishizauka, Yuta / Hanamura, Kenji / Koganezawa, Noriko / Ootsu, Mao / Yamazaki, Hiroyuki et al. | 2016
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Single site CiPA cardiomyocyte pilot study results on two MEA platforms with two hiPSC sourcesShi, H. / Huang, M. / Lewen, G. / Levesque, P. et al. | 2016
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Electrophysiological characterization of iCell2 hiPSC derived cardiomyocytes: The new generation of CDI hiPSC-CMsTaylor, Amy E. / Zamora, Victor / Hortigon-Vinagre, Maria P. / Allan, Andrew / Burton, Francis L. / Anson, Blake D. / Craig, Margaret A. / Smith, Godfrey L. et al. | 2016
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Organ-on-Chip: A synthetic mimic for human myocardiumvan Meer, Berend / Ribeiro, Marcelo / Tertoolen, Leon / Birket, Matthew / Passier, Robert / Mummery, Christine et al. | 2016
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The unbound concentration of multimodal drugs in the assay medium used in the multi-electrode array system for cardiac risk assessment with iPS cell-derived cardiomyocytesYoshinaga, Takashi / Shinkyo, Raku / Kikuchi, Kiyomi / Taniguchi, Tomohiko / Sekino, Yuko / Sawada, Kohei et al. | 2016
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A comparison of drug-induced changes in electrical excitability using optogenetic sensors and conventional field stimulation in hiPS-derived cardiomyocytes (hiPSC-CMs)Zamora, V. / Hortigon-Vinagre, M. / Allan, A. / Lu, H. R. / Burton, F. / Gallacher, D. / Smith, G. et al. | 2016
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Gastroinstestinal motility: Motility and motor migrating complex (MMC) evaluations in rats, dogs and non-human primatesAuthier, Simon / Tang, Hai-Ming / Abtout, Samir / Ascah, Alexis / Pouliot, Mylene / Bujold, Kim / Troncy, Eric / Pugsley, Michael K. / Forster, Roy et al. | 2016
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Use of inulin and PAH for renal drug safety evaluations in conscious dogsAbernathy, M. / Dalton, J. / Harter, M. / Gauvin, D. / Baird, T. et al. | 2016
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Citrulline — A Potential Translational Safety Biomarker for the Small IntestinePipp, Frederic / Hellmann, Jürgen / Poetzsch, Sven / Hewitt, Philip / Schmitt, Michael et al. | 2016
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A HESI consortium update on cardiac contractility endpointsPugsley, Michael K. / Guth, Brian / Chiang, Alan / Doyle, Jennifer / Engwall, Mike / Guillon, Jean-Michel / Hoffmann, Peter / Koerner, John / Mittelstadt, Scott / Ottinger, Sean et al. | 2016
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Cloud analysis of rat cardiac contractility: Determining changes in left ventricular dP/dt without correcting for heart rateBrandon Borders, R. / Pittman, R. / Roche, B. et al. | 2016
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Editorial Board| 2016