Lipid-modifying therapy and low-density lipoprotein cholesterol goal attainment in patients with familial hypercholesterolemia in Germany: The CaReHigh Registry (English)

In: Atherosclerosis   ;  277 ;  314-322  ;  2018
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    0021-9150
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Table of contents – Volume 277

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1
Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis
Olszewski, Andrzej J. / Szostak, Wictor B. / Bialkow, Magdalena / Rudnicki, Stefan / McCully, Kilmer S. | 1988
1
Distribution of low density lipoprotein in the branch and non-branch regions of the aorta
Thubrikar, Mano J. / Keller, Anastasia C. / Holloway, Peter W. / Nolan, Stanton P. | 1992
1
The role of fibrinogen as a cardiovascular risk factor
Ernst, E. | 1993
1
On the pathological diagnosis of acute ischaemic heart disease
Schwartz, Colin J. | 1971
1
Marginal copper deficiency in rats aortal morphology of elastin and cholesterol values in first-generation adult males
Hunsaker, Harry A. / Morita, Michio / Allen, Kenneth G.D. | 1983
1
Artefacts of localization of atherosclerosis in pinned aortas
Roach, Margot R. / Hinton, Patricia / Fletcher, Joan | 1978
1
Carbon monoxide-induced arterial wall hypoxia and atherosclerosis
Schneiderman, Gary / Goldstick, Thomas K. | 1978
1
Toxicity, pharmacokinetics, and cholesterol-inhibitory effect of 7-ketocholesterol
Santillan, G. / Sarma, J.S.M. / Pawlik, G. / Rackl, A. / Grenier, A. / Bing, R.J. | 1979
1
Causes of death in patients with familial hypercholesterolemia
Mabuchi, H. / Miyamoto, S. / Ueda, K. / Oota, M. / Takegoshi, T. / Wakasugi, T. / Takeda, R. | 1986
1
Apolipoprotein B: structure, biosynthesis and role in the lipoprotein assembly process
Olofsson, Sven-Olof / Bjursell, Gunnar / Boström, Kristina / Carlsson, Peter / Elovson, John / Protter, Andrew A. / Reuben, Michael A. / Bondjers, Göran | 1987
1
What causes acute coronary syndromes? Applying Kochs postulates
Monaco, C. / Mathur, A. / Martin, J. F. | 2005
1
High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells
Raposo, B. / Rodriguez, C. / Martinez-Gonzalez, J. / Badimon, L. | 2004
1
Correlates of vascular structure and function measures in asymptomatic young adults: The Bogalusa Heart Study
Bhuiyan, A. R. / Srinivasan, S. R. / Chen, W. / Paul, T. K. / Berenson, G. S. | 2006
1
Risk factors and cardiovascular disease in Turkey
Onat, A. | 2001
1
European guidelines on cardiovascular disease prevention in clinical practice: Executive summary
Graham, I. | 2007
1
Cardiovascular risk changes after lipid lowering medications: are they predictable?
Sirtori, C. R. / Calabresi, L. / Marchioli, R. / Rubins, H. B. | 2000
1
Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease
Erridge, C. | 2011
1
The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: A tribute to the late Dr. Yoshio Watanabe
Shiomi, M. / Ito, T. | 2009
1
Editor in Chief's report for atherosclerosis for 2010
Humphries, S. E. | 2011
1
Determinants of porphyrin fluorescence emission spectra of atheromatous plaques
Kessel, David / Berguer, Ramon | 1987
1
Low density lipoprotein kinetics in African Green monkeys showing variable cholesterolaemic responses to diets realistic for westernised people
Weight, M.J. / Benade, A.J.S. / Lombard, C.J. / Fincham, J.E. / Marais, Martelle / Dando, B. / Seier, J.V. / Kritchevsky, D. | 1988
1
Very early aortic responses during atherosclerosis induction in rabbits: Measurement by duplex ultrasound
Chin, H.P. / Liu, C.R. / Liu, C.H. / Blankenhorn, D.H. | 1990
1
Elucidating the role of plaque rupture in acute coronary events
Fuster, V. | 1994
1
Emerging relationship between hyperlipidemia and endothelial dysfunction
Harrison, D.G. | 1994
1
Early extracoronary atherosclerosis and coronary heart disease risk factors in a sample of civil servants in Southern Italy
Pujia, A. / Gnasso, A. / Cortese, C. / Angotti, E. / Colonna, A. / Mattioli, P.L. | 1993
1
Effect of gemfibrozil on the concentration and composition of very low density and low density lipoprotein subfractions in hypertriglyceridemic patients
Dachet, C. / Cavallero, E. / Martin, C. / Girardot, G. | 1995
1
The relationship of natural androgens to coronary heart disease in males: a review
Alexandersen, P. / Haarbo, J. / Christiansen, C. | 1996
1
Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives
Chapman, M. J. | 2003
1
Changes in composition and distribution of LDL subspecies in hypertriglyceridemic and hypercholesterolemic patients during gemfibrozil therapy
Yuan, Jiana / Tsaic, Michael Y. / Hunninghake, Donald B. | 1994
1
The vascular nervous skeleton: a disregarded factor of vascular pathology
Roth, Milan | 1994
1
Recent observations on the role of hemostatic determinants in the development of the atherothrombotic plaque
Rabbani, LeRoy E. / Loscalzo, Joseph | 1993
1
Modified low density lipoprotein is a potent stimulus for smooth muscle cell outgrowth from rat aortic explant in vitro
Goeroeg, P. | 1997
1
New aspects on the role of plasma lipases in lipoprotein catabolism and atherosclerosis
Beisiegel, U. | 1996
1
Apolipoprotein A-II, HDL metabolism and atherosclerosis
Tailleux, A. / Duriez, P. / Fruchart, J. C. / Clavey, V. | 2002
1
Cellular cholesterol flux studies: methodological considerations
Rothblat, G. H. / de la Llera-Moya, M. / Favari, E. / Yancey, P. G. / Kellner-Weibel, G. | 2002
1
Lipid transfer proteins: Past, present and perspectives
Quintao, E. C. / Cazita, P. M. | 2010
1
Underappreciated opportunities for low-density lipoprotein management in patients with cardiometabolic residual risk
Rosenson, R. S. / Davidson, M. H. / Pourfarzib, R. | 2010
1
Differential metabolic effects of distinct statins
Koh, K. K. / Sakuma, I. / Quon, M. J. | 2011
1
Adipokines and severity and progression of coronary artery calcium: Findings from the Rancho Bernardo Study
Larsen, Britta A. / Laughlin, Gail A. / Cummins, Kevin / Barrett-Connor, Elizabeth / Wassel, Christina L. | 2017
1
Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial
Capoulade, Romain / Chan, Kwan L. / Mathieu, Patrick / Bossé, Yohan / Dumesnil, Jean G. / Tam, James W. / Teo, Koon K. / Yang, Xiaohong / Witztum, Joseph L. / Arsenault, Benoit J. et al. | 2017
1
MicroRNA-132 targeting PTEN contributes to cilostazol-promoted vascular smooth muscle cell differentiation
Chen, Wei-Jan / Chen, Ying-Hwa / Hsu, Yu-Juei / Lin, Kwang-Huei / Yeh, Yung-Hsin | 2018
1
Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis
Plenz, G. A. / Deng, M. C. / Robenek, H. / Volker, W. | 2003
1
Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions
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1
Interleukin-6 is an independent predictor of progressive atherosclerosis in the carotid artery: The Tromsø Study
Eltoft, Agnethe / Arntzen, Kjell Arne / Wilsgaard, Tom / Mathiesen, Ellisiv B. / Johnsen, Stein Harald | 2018
1
Changes in metabolic properties of rabbit very low density lipoproteins by dietary cholesterol, and saturated and polyunsaturated fat
Stange, E. / Alavi, M. / Papenberg, J. | 1977
1
The influence of cholesterol and fat in maternal diet of rats on the development of hepatic cholesterol metabolism in the offspring
Naseem, Syed M. / Khan, Mushtaq A. / Heald, Felix P. / Nair, Padmanabhan P. | 1980
1
Immunohistochemical localization of apolipoprotein E in atherosclerotic lesions of the aorta and coronary arteries
Murase, Toshio / Oka, Teruaki / Yamada, Nobuhiro / Mori, Natsuko / Ishibashi, Shun / Takaku, Fumimaro / Mori, Wataru | 1985
1
On the mechanism by which an ACAT inhibitor (CL 277,082) influences plasma lipoproteins in the rat
Balasubramaniam, S. / Simons, L.A. / Chang, S. / Roach, P.D. / Nestel, P.J. | 1989
1
Effects of diets supplemented with lard fat or mackerel oil on plasma lipoprotein lipid concentrations and lipoprotein lipase activities in domestic swine
Groot, Pieter H.E. / Scheek, Leo M. / Dubelaar, Marie-Louise / Verdouw, Pieter D. / Hartog, Johannes M. / Lamers, Jos M.J. | 1988
1
Studies on apolipoprotein(a) phenotypes. Part 1. Phenotype frequencies in a healthy Japanese population
Abe, Akira / Noma, Akio | 1992
1
Regression of coronary atherosclerosis by combined LDL-apheresis and lipid-lowering drug therapy in patients with familial hypercholesterolemia: a multicenter study
Tatamia, R. / Inoue, N. / Itoh, H. / Kishino, B. / Koga, N. / Nakashima, Y. / Nishide, T. / Okamura, K. / Saito, Y. / Teramoto, T. et al. | 1992
1
Update on factors which determine progression and regression
Brown, B.G. | 1994
1
Hypocholesterolemic agents and mobilization of tissue cholesterol in man
Sodhi, H.S. / Kudchodkar, B.J. / Horlick, L. | 1971
1
Regression de xanthomes et medicaments hypolipidemiants
Buxtorf, J.C. / Beaumont, V. / Jacotot, B. / Beaumont, J.-L. | 1972
1
The influence of a high level of corn oil on rat serum lipoproteins
Narayan, K.Ananth / Mcmullen, J.J. / Butler, D.P. / Wakefield, T. / Calhoun, W.K. | 1975
1
To statin or to non-statin in coronary disease-considering absolute risk is the answer
Rembold, C. M. | 2007
1
Binding to heparan sulfate is a major event during catabolism of lipoprotein lipase by HepG2 and other cell cultures
Sehayek, E. / Olivecrona, T. / Bengtsson-Olivecrona, G. / Vlodavsky, I. | 1995
1
Regression of transplant coronary artery disease during chronic HELP therapy
Park, J.-W. / Vermeltfoort, M. / Braun, P. / May, E. | 1995
1
Homocysteine and carotid intima-media thickness: a critical appraisal of the evidence
Durga, J. / Verhoef, P. / Bots, M. L. / Schouten, E. | 2004
1
An historical perspective on atherosclerosis research in Germany
Siegel, G. | 1999
1
Is reverse cholesterol transport a misnomer for suggesting its role in the prevention of atheroma formation?
Quintao, E. C. R. | 1995
1
LDL-apheresis: results of longterm treatment and vascular outcome
Keller, Christiane | 1990
1
Towards a more relevant hind limb model of muscle ischaemia
Lotfi, S. / Patel, A. S. / Mattock, K. / Egginton, S. / Smith, A. / Modarai, B. | 2013
1
Editor's report
Humphries, S. | 2010
1
Periodontitis and blood pressure: The concept of dental hypertension
Tsioufis, C. / Kasiakogias, A. / Thomopoulos, C. / Stefanadis, C. | 2011
1
Modified forms of low density lipoprotein and atherosclerosis
Aviram, Michael | 1993
1
What targets should lipid-modulating therapy achieve to optimise the prevention of coronary heart disease?
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1
Editors annual report
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1
The metabolism of triglyceride-rich lipoproteins revisited: New players, new insight
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1
Dose–response relationship of serum uric acid levels with risk of stroke mortality
Huang, J. / Hu, D. / Wang, Y. / Zhang, D. / Qu, Y. | 2014
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Response to: ‘Reshape of the arterial wall as a slow reacting vascular structure’
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1
The association between plasma big endothelin-1 levels at admission and long-term outcomes in patients with atrial fibrillation
Wu, Shuang / Yang, Yan-min / Zhu, Jun / Ren, Jia-meng / Wang, Juan / Zhang, Han / Shao, Xing-hui | 2018
1
Adiponectin limits monocytic microparticle-induced endothelial activation by modulation of the AMPK, Akt and NFκB signaling pathways
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1
Potential involvement of type II phospholipase A~2 in atherosclerosis
Hurt-Camejo, E. / Camejo, G. | 1997
1
Prognostic value of lipoprotein-associated phospholipase A2 mass for all-cause mortality and vascular events within one year after acute ischemic stroke
Han, Liyuan / Zhong, Chongke / Bu, Xiaoqing / Xu, Tan / Wang, Aili / Peng, Yanbo / Xu, Tian / Wang, Jinchao / Peng, Hao / Li, Qunwei et al. | 2017
1
Lipoprotein lipase and atherosclerosis
Stein, Y. / Stein, O. | 2003
1
Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties
Wirtz, T. H. / Tillmann, S. / Strüßmann, T. / Kraemer, S. / Heemskerk, J. W. / Grottke, O. / Gawaz, M. / von Hundelshausen, P. / Bernhagen, J. r. | 2015
1
A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia
Marks, D. / Thorogood, M. / Neil, H. A. / Humphries, S. E. | 2003
1
LDL apheresis
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1
Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages
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1
Prevalence of lower extremity peripheral arterial disease in individuals with chronic immune mediated inflammatory disorders
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Hypothyroidism reduces HDL binding to rat liver cells
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Effect of treatment with nicotinic acid for one month on serum lipids in patients with different types of hyperlipidemia
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Familial defective apolipoprotein B-100: a review, including some comparisons with familial hypercholesterolaemia
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Neutral lipid transfer activities in the plasma of patients with abetalipoproteinemia
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Characterization of the fluorescent morphological structures in human arterial wall using ultraviolet-excited microspectrofluorimetry
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Plasma lipids, triglyceride/fatty acid pattern, and plasma insulin in fasted healthy volunteers during continuous ingestion of ethanol
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Plasma lipids and apolipoproteins as discriminators for presence and severity of angiographically defined coronary artery disease
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Metabolism of arachidonic acid by macaque platelets Implications for studies on atherosclerosis
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1
Effect of post-mortem time on the biochemical composition of coronary arteries
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1
Dietary antioxidants in preventing atherogenesis
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1
Alterations in distribution of sudanophilic lesions in rabbits after cessation of a cholesterol-rich diet
Roach, Margot R. / Fletcher, Joan | 1978
1
Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: Clinical evidence and pathophysiological mechanisms
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1
Shear stress-induced atherosclerotic plaque composition in ApoE−/− mice is modulated by connexin37
Pfenniger, A. / Meens, M. J. / Pedrigi, R. M. / Foglia, B. / Sutter, E. / Pelli, G. / Rochemont, V. / Petrova, T. V. / Krams, R. / Kwak, B. R. | 2015
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Tracking atherosclerosis regression: a clinical tool in preventive cardiology
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The role of lipids in nephrosclerosis and glomerulosclerosis
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1
Decrease in oxidized high-density lipoprotein is associated with slowed progression of coronary artery calcification: Subanalysis of a prospective multicenter study
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1
Acute hypertensive response in ischemic stroke is associated with increased aortic stiffness
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1
Activatable fluorescence imaging of macrophages in atherosclerotic plaques using iron oxide nanoparticles conjugated with indocyanine green
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1
Electronegative L5-LDL induces the production of G-CSF and GM-CSF in human macrophages through LOX-1 involving NF-κB and ERK2 activation
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Removal of apolipoprotein E-enriched high density lipoprotein by LDL-apheresis in familial hypercholesterolaemia: a possible activation of the reverse cholesterol transport system
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Plasma apolipoprotein E, high density lipoprotein1 (HDL1) and urinary mevalonate excretion in pancreatectomized diabetic dogs: effects of insulin and lovastatin
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Evaluation of computerized edge tracking for quantifying intima-media thickness of the common carotid artery from B-mode ultrasound images
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Immunohistochemical localization of C5b-9, S-protein, C3d and apolipoprotein B in human arterial tissues with atherosclerosis
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Triglyceride-rich lipoproteins: are links with atherosclerosis mediated by a procoagulant and proinflammatory phenotype?
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The new joint EAS/ESC guidelines for the management of dyslipidaemias
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Estimation of the prevalence of cholesteryl ester storage disorder (CESD) in a cohort of patients with clinical features of familial hypercholesterolaemia
Ashfield-Watt, P. / Haralambos, K. / Edwards, R. / Townsend, D. / Gingell, R. / Li, K. W. / Humphries, S. E. / McDowell, I. | 2016
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Screening mammography: Usefulness beyond early detection of breast cancer
Mantas, D. / Markopoulos, C. | 2016
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HbA1c is significantly associated with arterial stiffness but not with carotid atherosclerosis in a community-based population without type 2 diabetes: The Dong-gu study
Lee, Y. H. / Shin, M. H. / Choi, J. S. / Rhee, J. A. / Nam, H. S. / Jeong, S. K. / Park, K. S. / Ryu, S. Y. / Choi, S. W. / Kim, B. H. | 2016
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Lowering plasma homocysteine with folic acid in cardiovascular disease: what will the trials tell us?
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Publishers note
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Genetics of coronary artery disease: Genome-wide association studies and beyond
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Transfer of low density lipoprotein into the arterial wall and risk of atherosclerosis
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European Guidelines on cardiovascular disease prevention in clinical practice (version 2012):The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)
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Establishing the warranty of a coronary artery calcium score of zero
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Immunotherapy for the prevention of atherosclerotic cardiovascular disease: Promise and possibilities
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4
Beta-carotene, vitamin E and vitamin C prevent the progression of atherosclerosis in hyperlipidemic guinea pigs
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A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease
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A major familial hypercholesterolemia subphenotype (FHC-r) in swine is inherited as an autosomal recessive trait and its gene is not linked to the apo B locus
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The positive relationship of serum paraoxonase-1 activity with apolipoprotein E is abrogated in metabolic syndrome
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Calculation of age and gender related non-HDL-C centiles from the 2003 and 2013 Health Survey for England data- implications for diagnosis of FH
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Obstructive sleep apnea and abdominal aortic calcification: Is there an association independent of comorbid risk factors?
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Validation of low density lipoprotein correction factors in a multi-ethnic familial hypercholesterolaemia population at a North London lipid clinic
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Concordant upregulation of type II-TGF-@b-receptor, the cyclin-dependent kinases inhibitor P27^K^i^p^1 and cyclin E in human atherosclerotic tissue: implications for lesion cellularity
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Type 1 diabetes increases retention of low-density lipoprotein in the atherosclerosis-prone area of the murine aorta
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Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice
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Long-term effects of guar gum on blood lipids
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Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits
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The different relations of PCSK9 and Lp(a) to the presence and severity of atherosclerotic lesions in patients with familial hypercholesterolemia
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Time-course, magnitude and nature of the changes induced in HDL by moderate alcohol intake in young non-drinking males
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Increased growth stimulation of human vascular cells by serum from patients with primary hyper-LDL-cholesterolemia
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Relationship between endothelial cell turnover and permeability to horseradish peroxidase
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Hypercoagulability and high lipoprotein(a) levels in patients with type II diabetes mellitus
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Acyl-coenzyme A:cholesterol-acyltransferase (ACAT) inhibitors modulate monocyte adhesion to aortic endothelial cells
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Gender, depression, anxiety and carotid intima-media thickness and the influence of lipids
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ABCA1 and HDL3 are required to modulate smooth muscle cells phenotypic switch after cholesterol loading
Castiglioni, Silvia / Monti, Matteo / Arnaboldi, Lorenzo / Canavesi, Monica / Ainis Buscherini, Giuditta / Calabresi, Laura / Corsini, Alberto / Bellosta, Stefano | 2017
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Chocolate consumption and risk of stroke among men and women: A large population-based, prospective cohort study
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The impact of myocardial bridge on coronary artery spasm and long-term clinical outcomes in patients without significant atherosclerotic stenosis
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Evaluation of polygenic cause in Korean patients with familial hypercholesterolemia – A study supported by Korean Society of Lipidology and Atherosclerosis
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Spectrum effect and spectrum bias in the oscillometric ankle brachial index to diagnose peripheral arterial disease: Clinical implications
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Effects of a water-soluble bile acid sequestrant, CK-3368, on bile composition
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Mast cell proteases: Physiological tools to study functional significance of high density lipoproteins in the initiation of reverse cholesterol transport
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Surrogate markers in clinical trials-Challenges and opportunities
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Mutational analysis and genotype-phenotype relation in familial hypercholesterolemia: The SAFEHEART registry
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Progression of calcific aortic valve sclerosis in WHHLMI rabbits
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The immune system is not essential for the development of aortic atherosclerotic plaques in mice fed an atherogenic diet
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A positive experience but a negative result in screening for familial hyypercholesterolaemia (FH) in primary care
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Genetic diagnosis of familial hypercholesterolaemia using a rapid biochip array assay for 40 common LDLR, APOB and PCSK9 mutations
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Prostanoid and isoprostanoid pathways in atherogenesis
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Nutritional and nutraceutical approaches to dyslipidemia and atherosclerosis prevention: Focus on dietary proteins
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Genetic diversity of CX3CR1 gene and coronary artery disease: New insights through a meta-analysis
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Improvement in small fibre neuropathy and inflammatory biomarkers after bariatric surgery
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Comparison of the effect of simvastatin versus simvastatin/ezetimibe versus rosuvastatin on markers of inflammation and oxidative stress in subjects with hypercholesterolemia
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Effects of high-intensity interval training on optic nerve head and macular perfusion using optical coherence tomography angiography in healthy adults
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Stabilization of advanced atherosclerosis in low-density lipoprotein receptor-deficient mice by aspirin
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Seasonal variations in plasma lipids and in diet-induced hyperlipidemia in the Syrian hamster
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Development of atherosclerosis in diabetic sand rats (Psammomys obesus)
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The urokinase system in the pathogenesis of atherosclerosis
Fuhrman, B. | 2012
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The effect of statins on carotid plaque morphology: A LDL-associated action or one more pleiotropic effect of statins?
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Cell proliferation in the atherosclerotic plaques of cholesterol-fed rabbits
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Coronary endothelium expresses a pathologic gene pattern compared to aortic endothelium: Correlation of asynchronous hemodynamics and pathology in vivo
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Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice
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Is the fatty meal a trigger for acute coronary syndromes
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A common apolipoprotein B signal peptide polymorphism modifies the relation between plasma non-esterified fatty acids and triglyceride concentration in men
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Pathological and angiographic regression of coronary atherosclerosis by LDL-apheresis in a patient with familial hypercholesterolemia
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Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study
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The assessment of plasma lipoprotein metabolism in the cat (Felis domesticus)
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Interaction of low density lipoproteins from normal and hyperlipemic rhesus monkeys with arterial smooth muscle cells in culture
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Influence of Saireitoh on experimental atherosclerosis
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Ketoconazole inhibits oxidative modification of low density lipoprotein
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The effects of low density lipoprotein and high density lipoprotein on phosphoinositide hydrolysis in bovine aortic endothelial cells
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The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation
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Analysis of gender-specific atherosclerosis susceptibility in transgenic[hCETP]25DS rat model
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Association between change in plasma triglyceride levels and risk of stroke and carotid atherosclerosis
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