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    Análogos de alfa-galactosil-ceramida y su uso en inmunoterapias, adyuvantes, y agentes antivirales, antibacterianos y anticancerígenos (Spanish)

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    2015
    • Patent  /  Electronic Resource

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    Un compuesto representado por la estructura de fórmula 1:**Fórmula** o una sal farmacéuticamente aceptable del mismo; para su uso en medicina.

    The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

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