Iterative Exploration of Big Brain Network Data (Unknown language)

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A current quest in neurscience is the understanding of how genes, structure and behavior relate to one another. In recent years, big brain-initiatives and consortia have created vast resources of publicly available brain data that can be used by neuroscientists for their own research experiments. This includes microscale connectivity data - brain-network graphs with billions of edges - whose analysis for higher order relations in structural or functional neuroanatomy together with genetic data may reveal novel insights into brain functionality. This creates a need for joint exploration of spatial data, such as gene expression patterns, whole brain gene co-expression correlation, structural and functional connectivities together with neuroanatomical parcellations. Current experimental workflows involve time-consuming manual aggregation and extensive graph theoretical analysis of data from different sources, which rarely provide spatial context to operate continuously on different scales. We propose a web-based framework to explore heterogeneous neurobiological data in an integrated visual analytics workflow. On-demand queries on spatial gene expression and connectivity data enable an interactive dissection of dense network graphs - with of billion-edges on voxel-resolution - in real-time based on their spatial context. In order to take higher order connections between brain regions into account, queries can be executed in a cascading way. Relating data to the hierarchical structure of common anatomical atlases allows experts to quantitatively compare multimodal networks on different scales. Additionally, 3D visualizations have been optimized to accommodate for the domain experts’' need for publishable network figures. We demonstrate the relevance of our approach for neuroscience by exploring social-behavior and memory/learning functional neuroanatomy in mice.

Table of contents conference proceedings

The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.

1
Ultrasound Decompression for Large Field-of-View Reconstructions
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11
ICG based Augmented-Reality-System for Sentinel Lymph Node Biopsy
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17
A Prototype Holographic Augmented Reality Interface for Image-Guided Prostate Cancer Interventions
Morales Mojica, Cristina M. / Velazco Garcia, Jose D. / Navkar, Nikhil V. / Balakrishnan, Shidin / Abinahed, Julien / El Ansari, Walid / Al-Rumaihi, Khalid / Darweesh, Adham / Al-Ansari, Abdulla / Gharib, Mohamed et al. | 2018
23
Visual Analytics in Histopathology Diagnostics: a Protocol-Based Approach
Corvò, Alberto / Westenberg, Michel A. / Driel, Marc A. van / Wijk, Jarke J.van | 2018
33
Automatic Generation of Web-Based User Studies to Evaluate Depth Perception in Vascular Surface Visualizations
Meuschke, Monique / Smit, Noeska N. / Lichtenberg, Nils / Preim, Bernhard / Lawonn, Kai | 2018
45
A Critical Analysis of the Evaluation Practice in Medical Visualization
Preim, Bernhard / Ropinski, Timo / Isenberg, Petra | 2018
57
Annotated Dendrograms for Neurons From the Larval Fruit Fly Brain
Strauch, Martin / Hartenstein, Volker / Andrade, Ingrid V. / Cardona, Albert / Merhof, Dorit | 2018
67
A Multilinear Model for Bidirectional Craniofacial Reconstruction
Achenbach, Jascha / Brylka, Robert / Gietzen, Thomas / Hebel, Katja zum / Schömer, Elmar / Schulze, Ralf / Botsch, Mario / Schwanecke, Ulrich | 2018
77
Iterative Exploration of Big Brain Network Data
Ganglberger, Florian / Swoboda, Nicolas / Frauenstein, Lisa / Kaczanowska, Joanna / Haubensak, Wulf / Bühler, Katja | 2018
89
Progressive and Efficient Multi-Resolution Representations for Brain Tractograms
Mercier, Corentin / Gori, Pietro / Rohmer, Damien / Cani, Marie-Paule / Boubekeur, Tamy / Thiery, Jean-Marc / Bloch, Isabelle | 2018
95
Visual Analysis of Evolution of EEG Coherence Networks employing Temporal Multidimensional Scaling
Ji, Chengtao / Maurits, Natasha M. / Roerdink, Jos B. T. M. | 2018
101
Introducing CNN-Based Mouse Grim Scale Analysis for Fully Automated Image-Based Assessment of Distress in Laboratory Mice
Kopaczka, Marcin / Ernst, Lisa / Schock, Justus / Schneuing, Arne / Guth, Alexander / Tolba, Rene / Merhof, Dorit | 2018
107
Uncertainty-Guided Semi-Automated Editing of CNN-based Retinal Layer Segmentations in Optical Coherence Tomography
Zadeh, Shekoufeh Gorgi / Wintergerst, Maximilian W. M. / Schultz, Thomas | 2018
117
A Framework for Visual Comparison of 4D PC-MRI Aortic Blood Flow Data
Behrendt, Benjamin / Ebel, Sebastian / Gutberlet, Matthias / Preim, Bernhard | 2018
123
A New Vessel Enhancement Transform on Retinal Blood Vessels Segmentation
Soares, Ivo / Castelo-Branco, Miguel / Pinheiro, António M. G. | 2018
129
Visual Assessment of Vascular Torsion using Ellipse Fitting
Mistelbauer, Gabriel / Zettwitz, Martin / Schernthaner, Rüdiger / Fleischmann, Dominik / Teutsch, Christian / Preim, Bernhard | 2018
135
Visual Analysis of Regional Anomalies in Myocardial Motion
Sheharyar, Ali / Ruh, Alexander / Aristova, Maria / Scott, Michael / Jarvis, Kelly / Elbaz, Mohammed / Dolan, Ryan / Schnell, Susanne / Lin, Kal / Carr, James et al. | 2018
145
Parameterization and Feature Extraction for the Visualization of Tree-like Structures
Lichtenberg, Nils / Lawonn, Kai | 2018
157
Estimation of Muscle Activity in One-Leg Stance from 3D Surface Deformation
Metzler, Johannes / Neumann, Thomas / Gassel, Stefanie / Friedrich, Jens / Wacker, Markus | 2018
167
VisualFlatter - Visual Analysis of Distortions in the Projection of Biomedical Structures
Grossmann, Nicolas / Köppel, Thomas / Gröller, Eduard / Raidou, Renata Georgia | 2018
179
Global and Local Mesh Morphing for Complex Biological Objects from µCT Data
Knötel, David / Becker, Carola / Scholtz, Gerhard / Baum, Daniel | 2018
185
Improving Perception of Molecular Surface Visualizations by Incorporating Translucency Effects
Hermosilla, Pedro / Maisch, Sebastian / Vázquez, Pere-Pau / Ropinski, Timo | 2018
197
Semantic Screen-Space Occlusion for Multiscale Molecular Visualization
Koch, Thomas Bernhard / Kouril, David / Klein, Tobias / Mindek, Peter / Viola, Ivan | 2018
203
Visual Exploratory Analysis for Multiple T-Maze Studies
Bechtold, Fabrizia / Splechtna, Rainer / Matkovic, Kresimir | 2018