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    Initial sequencing and comparative analysis of the mouse genome (English)

    National licence
    In: Nature ; 420 , 6915 ; 520-562  ; 2002
    • ISSN:
      0028-0836
    • Article (Journal)  /  Electronic Resource

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    The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

    Table of contents – Volume 420, Issue 6915

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    The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.

    3
    An electoral lecture
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    447
    Coping with a budget reversal
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    447
    Promoting animal research
    | 2002
    447
    How to survive Germany's cutbacks- Campaigning for animal research
    | 2002
    449
    Prospect of face transplants gets mixed response
    | 2002
    449
    Surgeons struggle with ethical nightmare of face transplants
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    450
    Prion data suggest BSE link to sporadic CJD
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    450
    European biologists see deficit in bioweapons research- Study suggests deeper danger from prion disease
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    450
    Europe urged to provide boost for bioterror research
    Abbott, Alison et al. | 2002
    451
    US pushes fish farming into deep water
    Dalton, Rex et al. | 2002
    451
    Pathogen-tracking questioned
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    451
    Environmentalists oppose fish-farm proposals- Pathogenmonitoring programme faces criticism
    | 2002
    452
    Germany puts brakes on research spending- Job cuts expected
    | 2002
    452
    Postdoc positions axed as economic crisis takes its toll
    Schiermeier, Quirin et al. | 2002
    452
    Funding freeze leaves eastern Germany out in the cold
    Schiermeier, Quirin et al. | 2002
    453
    Field trials excluded from UK crop appraisal
    Adam, David et al. | 2002
    453
    Field trials discounted in GM crop review- Report identifies institutional sexism in science
    | 2002
    453
    Royal Institution's director blasts scientific sexism
    Adam, David et al. | 2002
    454
    news in brief
    | 2002
    456
    Mouse genome: The real deal
    Abbott, Alison et al. | 2002
    458
    Mouse genome: A forage in the junkyard
    Dennis, Carina et al. | 2002
    458
    A forage in the junkyard
    Dennis, Carina et al. | 2002
    460
    Piecing it all together
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    461
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    461
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    461
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    461
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    462
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    462
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    462
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    463
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    463
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    464
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    464
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    464
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    465
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    467
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    467
    Ultraviolet upset
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    467
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    468
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    Heath, William R. / Scott, Hamish S. et al. | 2002
    469
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    469
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    471
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    472
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    473
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    473
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    475
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    475
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    476
    Mathematics: What is the best way to lace your shoes?
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    476
    Laser–Raman spectroscopy (Communication arising): Images of the Earth's earliest fossils?
    Pasteris, Jill Dill / Wopenka, Brigitte et al. | 2002
    476
    brief communications - Mathematics: What is the best way to lace your shoes?
    Polster, B. et al. | 2002
    476
    brief communications - Replay - COMMUNICATIONS ARISING - Laser-Raman spectroscopy: Images of the Earth's earliest fossils?
    Pasteris, J.D. et al. | 2002
    477
    Palaeontology (Communication arising): Thermal alteration of the Earth's oldest fossils
    Kazmierczak, Józef / Kremer, Barbara et al. | 2002
    477
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    Kazmierczak, J. et al. | 2002
    479
    Drag reduction: Flexing in fluids
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    479
    Drag reduction through self-similar bending of a flexible body
    Alben, Silas / Shelley, Michael / Zhang, Jun et al. | 2002
    479
    letters to nature - Drag reduction through self-similar bending of a flexible body
    Alben, S. et al. | 2002
    482
    letters to nature - Multiple ionization of atom clusters by intense soft X-rays from a free-electron laser
    Wabnitz, H. et al. | 2002
    482
    Multiple ionization of atom clusters by intense soft X-rays from a free-electron laser
    Wabnitz, H. / Bittner, L. / de Castro, A. R. B. / Döhrmann, R. / Gürtler, P. / Laarmann, T. / Laasch, W. / Schulz, J. / Swiderski, A. / von Haeften, K. et al. | 2002
    485
    letters to nature - Non-framework cation migration and irreversible pressure-induced hydration in a zeolite
    Lee, Y. et al. | 2002
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    Lee, Yongjae / Vogt, Thomas / Hriljac, Joseph A. / Parise, John B. / Hanson, Jonathan C. / Kim, Sun Jin et al. | 2002
    489
    A short-term sink for atmospheric CO2 in subtropical mode water of the North Atlantic Ocean
    Bates, Nicholas R. / Pequignet, A. Christine / Johnson, Rodney J. / Gruber, Nicolas et al. | 2002
    489
    letters to nature - A short-term sink for atmospheric CO-2 in subtropical mode water of the North Atlantic Ocean
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    Atmospheric CO-2: A drop in the ocean
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    493
    The role of volatiles in magma chamber dynamics
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    496
    The role of parasites in sympatric and allopatric host diversification
    Buckling, Angus / Rainey, Paul B. et al. | 2002
    499
    Calcium activation of BKCa potassium channels lacking the calcium bowl and RCK domains
    Piskorowski, Rebecca / Aldrich, Richard W. et al. | 2002
    502
    CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
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    502
    Regulatory T cells: Basis for persistent infection
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    508
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    509
    the mouse genome - Human biology by proxy
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    509
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    Gunter, Chris / Dhand, Ritu et al. | 2002
    510
    the mouse genome
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    510
    the mouse genome - Timeline - The life history of the mouse in genetics
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    512
    the mouse genome - commentary - Mining the mouse genome
    Bradley, Allan et al. | 2002
    512
    Mining the mouse genome
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    515
    Comparative genomics: The mouse that roared
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    515
    the mouse genome - Comparative genomics: The mouse that roared
    Boguski, Mark S. et al. | 2002
    517
    Single nucleotide polymorphisms: Tackling complexity
    Nadeau, Joseph H. et al. | 2002
    517
    the mouse genome - Single nucleotide polymorphisms: Tackling complexity
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    518
    the mouse genome - Functional genomics: A time and place for every gene
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    518
    Functional genomics: A time and place for every gene
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    520
    Initial sequencing and comparative analysis of the mouse genome
    Chinwalla, Asif T. / Cook, Lisa L. / Delehaunty, Kimberly D. / Fewell, Ginger A. / Fulton, Lucinda A. / Fulton, Robert S. / Graves, Tina A. / Hillier, LaDeana W. / Mardis, Elaine R. / McPherson, John D. et al. | 2002
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    Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
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    574
    the mouse genome - letters to nature - The mosaic structure of variation in the laboratory mouse genome
    Wade, C.M. et al. | 2002
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    The mosaic structure of variation in the laboratory mouse genome
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    Numerous potentially functional but non-genic conserved sequences on human chromosome 21
    Dermitzakis, Emmanouil T. / Reymond, Alexandre / Lyle, Robert / Scamuffa, Nathalie / Ucla, Catherine / Deutsch, Samuel / Stevenson, Brian J. / Flegel, Volker / Bucher, Philipp / Jongeneel, C. Victor et al. | 2002
    578
    the mouse genome - letters to nature - Numerous potentially functional but non-genic conserved sequences on human chromosome 21
    Dermitzakis, E.T. et al. | 2002
    582
    Human chromosome 21 gene expression atlas in the mouse
    Reymond, Alexandre / Marigo, Valeria / Yaylaoglu, Murat B. / Leoni, Antonio / Ucla, Catherine / Scamuffa, Nathalie / Caccioppoli, Cristina / Dermitzakis, Emmanouil T. / Lyle, Robert / Banfi, Sandro et al. | 2002
    582
    the mouse genome - letters to nature - Human chromosome 21 gene expression atlas in the mouse
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    586
    A gene expression map of human chromosome 21 orthologues in the mouse - The HSA21 expression map initiative
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    586
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