Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer (Unknown language)

in Journal of medicinal chemistry ; 49 , 14 ; 4392-4408
American Chemical Society , Easton, Pa; 2006
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Table of contents – Volume 49, Issue 14

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Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

3999
Approaches to Antiobesity Therapy. An Introduction
Bishop, Michael J. | 2006
4001
Obesity:  The Disease
Bray, George A. | 2006
4008
CB1Cannabinoid Receptor Antagonists for Treatment of Obesity and Prevention of Comorbid Metabolic Disorders
Antel, Jochen / Gregory, Peter C. / Nordheim, Ulrich | 2006
4017
Melanin-Concentrating Hormone-1 Receptor Antagonists for the Treatment of Obesity
Handlon, Anthony L. / Zhou, Huiqiang | 2006
4023
5-Hydroxytryptamine 2C (5-HT2C) Receptor Agonists as Potential Antiobesity Agents
Nilsson, Björn M. | 2006
4035
Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity
Nargund, Ravi P. / Strack, Alison M. / Fong, Tung M. | 2006
4044
Discovery of Novel Triazole-Based Opioid Receptor Antagonists
Zhang, Qiang / Keenan, Susan M. / Peng, Youyi / Nair, Anil C. / Yu, Seong Jae / Howells, Richard D. / Welsh, William J. | 2006
4048
Development of Peptidic Dopamine Transporter Inhibitors via Aromatic Modification-Mediated Conformational Restriction
Ding, Jinguo / Shi, Jiahao / Cui, Dafu / Xu, Linfeng / Duan, Shuhui / Guo, Lihe / Fei, Jian | 2006
4052
Toward Orthopoxvirus Countermeasures:  A Novel Heteromorphic Nucleoside of Unusual Structure
Fan, Xuesen / Zhang, Xinying / Zhou, Longhu / Keith, Kathy A. / Prichard, Mark N. / Kern, Earl R. / Torrence, Paul F. | 2006
4055
Discovery of Potent and Orally Available Malonyl-CoA Decarboxylase Inhibitors as Cardioprotective Agents
Cheng, Jie-Fei / Huang, Yujin / Penuliar, Richard / Nishimoto, Masahiro / Liu, Larry / Arrhenius, Thomas / Yang, Guang / O'Leary, Eoin / Barbosa, Miguel / Barr, Rick et al. | 2006
4059
FK506-Binding Protein Ligands:  Structure-Based Design, Synthesis, and Neurotrophic/Neuroprotective Properties of Substituted 5,5-Dimethyl-2-(4-thiazolidine)carboxylates
Zhao, Liqin / Huang, Wei / Liu, Hongying / Wang, Lili / Zhong, Wu / Xiao, Junhai / Hu, Yuandong / Li, Song | 2006
4072
Design and Synthesis of the First Generation of Dithiolane Thiazolidinedione- and Phenylacetic Acid-Based PPARγ Agonists
Chittiboyina, Amar G. / Venkatraman, Meenakshi S. / Mizuno, Cassia S. / Desai, Prashant V. / Patny, Akshay / Benson, Stephen C. / Ho, Christopher I. / Kurtz, Theodore W. / Pershadsingh, Harrihar A. / Avery, Mitchell A. | 2006
4072
Design and Synthesis of the First Generation of Dithiolane Thiazolidinedione- and Phenylacetic Acid-Based PPARgamma Agonists
Chittiboyina, A. G. / Venkatraman, M. S. / Mizuno, C. S. / Desai, P. V. / Patny, A. / Benson, S. C. / Ho, C. I. / Kurtz, T. W. / Pershadsingh, H. A. / Avery, M. A. | 2006
4085
Pharmacophore Based Receptor Modeling:  The Case of Adenosine A3Receptor Antagonists. An Approach to the Optimization of Protein Models
Tafi, Andrea / Bernardini, Cesare / Botta, Maurizio / Corelli, Federico / Andreini, Matteo / Martinelli, Adriano / Ortore, Gabriella / Baraldi, Pier Giovanni / Fruttarolo, Francesca / Borea, Pier Andrea et al. | 2006
4098
Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers:  Drugs for Cystic Fibrosis and Chronic Bronchitis
Hirsh, Andrew J. / Molino, Bruce F. / Zhang, Jianzhong / Astakhova, Nadezhda / Geiss, William B. / Sargent, Bruce J. / Swenson, Brian D. / Usyatinsky, Alexander / Wyle, Michael J. / Boucher, Richard C. et al. | 2006
4116
Secondary Amides of Sulfonylated 3-Amidinophenylalanine. New Potent and Selective Inhibitors of Matriptase
Steinmetzer, Torsten / Schweinitz, Andrea / Stürzebecher, Anne / Dönnecke, Daniel / Uhland, Kerstin / Schuster, Oliver / Steinmetzer, Peter / Müller, Friedemann / Friedrich, Rainer / Than, Manuel E. et al. | 2006
4127
New 3-Alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells
Nielsen, Flemming E. / Ebdrup, Søren / Jensen, Anette Frost / Ynddal, Lars / Bodvarsdottir, Thora B. / Stidsen, Carsten / Worsaae, Anne / Boonen, Harrie C. M. / Arkhammar, Per O. G. / Fremming, Tinna et al. | 2006
4140
Design, Synthesis, and Biological Evaluation of the Combinatorial Library with a New Spirodiketopiperazine Scaffold. Discovery of Novel Potent and Selective Low-Molecular-Weight CCR5 Antagonists
Habashita, Hiromu / Kokubo, Masaya / Hamano, Shin-ichi / Hamanaka, Nobuyuki / Toda, Masaaki / Shibayama, Shiro / Tada, Hideaki / Sagawa, Kenji / Fukushima, Daikichi / Maeda, Kenji et al. | 2006
4153
Is the σ2Receptor a Histone Binding Protein?
Colabufo, Nicola Antonio / Berardi, Francesco / Abate, Carmen / Contino, Marialessandra / Niso, Mauro / Perrone, Roberto | 2006
4153
Is the sigma~2 Receptor a Histone Binding Protein?
Colabufo, N. A. / Berardi, F. / Abate, C. / Contino, M. / Niso, M. / Perrone, R. | 2006
4159
2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 3. Synthesis, Pharmacokinetics, and in Vivo Potency
Borthwick, Alan D. / Davies, Dave E. / Exall, Anne M. / Hatley, Richard J. D. / Hughes, Jennifer A. / Irving, Wendy R. / Livermore, David G. / Sollis, Steve L. / Nerozzi, Fabrizio / Valko, Klara L. et al. | 2006
4171
Iron Binding Dendrimers:  A Novel Approach for the Treatment of Haemochromatosis
Zhou, Tao / Neubert, Hendrik / Liu, Ding Yong / Liu, Zu Dong / Ma, Yong Min / Kong, Xiao Le / Luo, Wei / Mark, Sykes / Hider, Robert C. | 2006
4183
Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase
Nguyen, Corinne / Ruda, Gian Filippo / Schipani, Alessandro / Kasinathan, Ganasan / Leal, Isabel / Musso-Buendia, Alexander / Kaiser, Marcel / Brun, Reto / Ruiz-Pérez, Luis M. / Sahlberg, Britt-Louise et al. | 2006
4196
Activity of and Initial Mechanistic Studies on a Novel Antileishmanial Agent Identified through in Silico Pharmacophore Development and Database Searching
Delfín, Dawn A. / Bhattacharjee, Apurba K. / Yakovich, Adam J. / Werbovetz, Karl A. | 2006
4208
Back Door Modulation of the Farnesoid X Receptor:  Design, Synthesis, and Biological Evaluation of a Series of Side Chain Modified Chenodeoxycholic Acid Derivatives
Pellicciari, Roberto / Gioiello, Antimo / Costantino, Gabriele / Sadeghpour, Bahman M. / Rizzo, Giovanni / Meyer, Udo / Parks, Derek J. / Entrena-Guadix, Antonio / Fiorucci, Stefano | 2006
4216
Dissociated Nonsteroidal Glucocorticoid Receptor Modulators; Discovery of the Agonist Trigger in a Tetrahydronaphthalene−Benzoxazine Series
Barker, Mike / Clackers, Margaret / Copley, Royston / Demaine, Derek A. / Humphreys, Davina / Inglis, Graham G. A. / Johnston, Michael J. / Jones, Haydn T. / Haase, Michael V. / House, David et al. | 2006
4232
Virtual Screening of DNA Minor Groove Binders
Evans, David A. / Neidle, Stephen | 2006
4239
Further Structural Exploration of Trisubstituted Asymmetric Pyran Derivatives (2S,4R,5R)-2-Benzhydryl-5-benzylamino-tetrahydropyran-4-ol and Their Corresponding Disubstituted (3S,6S) Pyran Derivatives:  A Proposed Pharmacophore Model for High-Affinity Interaction with the Dopamine, Serotonin, and Norepinephrine Transporters
Zhang, Shijun / Fernandez, Fernando / Hazeldine, Stuart / Deschamps, Jeffrey / Zhen, Juan / Reith, Maarten E. A. / Dutta, Aloke K. | 2006
4248
From Ligand to Complexes: Inhibition of Human Immunodeficiency Virus Type 1 Integrase by b-Diketo Acid Metal Complexes
Sechi, M. / Bacchi, A. / Carcelli, M. / Compari, C. / Duce, E. / Fisicaro, E. / Rogolino, D. / Gates, P. / Derudas, M. / Al-Mawsawi, L.Q. et al. | 2006
4248
From Ligand to Complexes:  Inhibition of Human Immunodeficiency Virus Type 1 Integrase by β-Diketo Acid Metal Complexes
Sechi, Mario / Bacchi, Alessia / Carcelli, Mauro / Compari, Carlotta / Duce, Elenia / Fisicaro, Emilia / Rogolino, Dominga / Gates, Paul / Derudas, Marco / Al-Mawsawi, Laith Q. et al. | 2006
4248
From Ligand to Complexes: Inhibition of Human Immunodeficiency Virus Type 1 Integrase by beta-Diketo Acid Metal Complexes
Sechi, M. / Bacchi, A. / Carcelli, M. / Compari, C. / Duce, E. / Fisicaro, E. / Rogolino, D. / Gates, P. / Derudas, M. / Al-Mawsawi, L. Q. | 2006
4261
Docking and Three-Dimensional Quantitative Structure−Activity Relationship (3D QSAR) Analyses of Nonsteroidal Progesterone Receptor Ligands
Söderholm, Annu A. / Lehtovuori, Pekka T. / Nyrönen, Tommi H. | 2006
4269
C-(4,5,6-Trimethoxyindan-1-yl)methanamine:  A Mescaline Analogue Designed Using a Homology Model of the 5-HT2AReceptor
McLean, Thomas H. / Chambers, James J. / Parrish, Jason C. / Braden, Michael R. / Marona-Lewicka, Danuta / Kurrasch-Orbaugh, Deborah / Nichols, David E. | 2006
4275
Naphthyl and Coumarinyl Biarylpiperazine Derivatives as Highly Potent Human β-Secretase Inhibitors. Design, Synthesis, and Enzymatic BACE-1 and Cell Assays
Garino, Cédrik / Tomita, Taisuke / Pietrancosta, Nicolas / Laras, Younes / Rosas, Roselyne / Herbette, Gaëtan / Maigret, Bernard / Quéléver, Gilles / Iwatsubo, Takeshi / Kraus, Jean-Louis | 2006
4275
Naphthyl and Coumarinyl Biarylpiperazine Derivatives as Highly Potent Human beta-Secretase Inhibitors. Design, Synthesis, and Enzymatic BACE-1 and Cell Assays
Garino, C. / Tomita, T. / Pietrancosta, N. / Laras, Y. / Rosas, R. / Herbette, G. / Maigret, B. / Quelever, G. / Iwatsubo, T. / Kraus, J.-L. | 2006
4275
Naphthyl and Coumarinyl Biarylpiperazine Derivatives as Highly Potent Human b-Secretase Inhibitors. Design, Synthesis, and Enzymatic BACE-1 and Cell Assays
Garino, C. / Tomita, T. / Pietrancosta, N. / Laras, Y. / Rosas, R. / Herbette, G. / Maigret, B. / Quelever, G. / Iwatsubo, T. / Kraus, J.-L. | 2006
4286
Structural Requirements for the Substrates of the H+/Peptide Cotransporter PEPT2 Determined by Three-Dimensional Quantitative Structure−Activity Relationship Analysis
Biegel, Annegret / Gebauer, Sabine / Brandsch, Matthias / Neubert, Klaus / Thondorf, Iris | 2006
4297
Validation of a Novel CHX-A‘ ‘ Derivative Suitable for Peptide Conjugation:  Small Animal PET/CT Imaging Using Yttrium-86-CHX-A‘ ‘-Octreotide
Clifford, Thomas / Boswell, C. Andrew / Biddlecombe, Gráinne B. / Lewis, Jason S. / Brechbiel, Martin W. | 2006
4305
Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists:  Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis
Tuccinardi, Tiziano / Calderone, Vincenzo / Rapposelli, Simona / Martinelli, Adriano | 2006
4317
New Furan Side Tetracyclic Allopsoralen Derivatives:  Synthesis and Photobiological Evaluation
Dalla Via, Lisa / Mammi, Stefano / Uriarte, Eugenio / Santana, Lourdes / Lampronti, Ilaria / Gambari, Roberto / Gia, Ornella | 2006
4327
Design and Synthesis of Novel 2-Amino-5-hydroxyindole Derivatives That Inhibit Human 5-Lipoxygenase
Landwehr, Jens / George, Sven / Karg, Eva-Maria / Poeckel, Daniel / Steinhilber, Dieter / Troschuetz, Reinhard / Werz, Oliver | 2006
4333
Design, Synthesis, and Biological Evaluation of Cyclic and Acyclic Nitrobenzylphosphoramide Mustards forE.coliNitroreductase Activation
Jiang, Yongying / Han, Jiye / Yu, Chengzhi / Vass, Simon O. / Searle, Peter F. / Browne, Patrick / Knox, Richard J. / Hu, Longqin | 2006
4344
Kinetics and Mechanisms of Activation of α-Amino Acid Ester Prodrugs of Camptothecins
Song, Lin / Bevins, Robert / Anderson, Bradley D. | 2006
4344
Kinetics and Mechanisms of Activation of alpha-Amino Acid Ester Prodrugs of Camptothecins
Song, L. / Bevins, R. / Anderson, B. D. | 2006
4344
Kinetics and Mechanisms of Activation of a-Amino Acid Ester Prodrugs of Camptothecins
Song, L. / Bevins, R. / Anderson, B.D. | 2006
4356
Antitumor Activity of JS-K [O2-(2,4-Dinitrophenyl) 1-[(4-Ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and RelatedO2-Aryl Diazeniumdiolates in Vitro and in Vivo
Shami, Paul J. / Saavedra, Joseph E. / Bonifant, Challice L. / Chu, Jingxi / Udupi, Vidya / Malaviya, Swati / Carr, Brian I. / Kar, Siddhartha / Wang, Meifeng / Jia, Lee et al. | 2006
4367
Line-Walking Method for Predicting the Inhibition of P450 Drug Metabolism
Hudelson, Matthew G. / Jones, Jeffrey P. | 2006
4374
(R)-3'-(3-Methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo-[2,2,2]octane-3,5'-oxazolidin]-2'-one, a Novel and Potent alpha7 Nicotinic Acetylcholine Receptor Partial Agonist Displays Cognitive Enhancing Properties
Tatsumi, R. / Fujio, M. / Takanashi, S.-i. / Numata, A. / Katayama, J. / Satoh, H. / Shiigi, Y. / Maeda, J.-i. / Kuriyama, M. / Horikawa, T. | 2006
4374
(R)-3‘-(3-Methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5‘-oxazolidin]-2‘-one, a Novel and Potent α7 Nicotinic Acetylcholine Receptor Partial Agonist Displays Cognitive Enhancing Properties
Tatsumi, Ryo / Fujio, Masakazu / Takanashi, Shin-ichi / Numata, Atsushi / Katayama, Jiro / Satoh, Hiroyuki / Shiigi, Yasuyuki / Maeda, Jun-ichi / Kuriyama, Makoto / Horikawa, Takashi et al. | 2006
4374
(R)-3'-(3-Methylbenzo[b]thiophen-5-yl)spiro[1-azabi- cyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a Novel and Potent a7 Nicotinic Acetylcholine Receptor Partial Agonist Displays Cognitive Enhancing Properties
Tatsumi, R. / Fujio, M. / Takanashi, S.-i. / Numata, A. / Katayama, J. / Satoh, H. / Shiigi, Y. / Maeda, J.-i. / Kuriyama, M. / Horikawa, T. et al. | 2006
4384
A New Synthesis of Sulfonamides by Aminolysis ofp-Nitrophenylsulfonates Yielding Potent and Selective Adenosine A2BReceptor Antagonists
Yan, Luo / Bertarelli, Daniela C. G. / Hayallah, Alaa M. / Meyer, Heiko / Klotz, Karl-Norbert / Müller, Christa E. | 2006
4392
Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer
Widdison, Wayne C. / Wilhelm, Sharon D. / Cavanagh, Emily E. / Whiteman, Kathleen R. / Leece, Barbara A. / Kovtun, Yelena / Goldmacher, Victor S. / Xie, Hongsheng / Steeves, Rita M. / Lutz, Robert J. et al. | 2006
4409
Novel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides
Pryde, David C. / Maw, Graham N. / Planken, Simon / Platts, Michelle Y. / Sanderson, Vivienne / Corless, Martin / Stobie, Alan / Barber, Christopher G. / Russell, Rachel / Foster, Laura et al. | 2006
4425
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the alpha7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure-Activity Relationship
Wishka, D. G. / Walker, D. P. / Yates, K. M. / Reitz, S. C. / Jia, S. / Myers, J. K. / Olson, K. L. / Jacobsen, E. J. / Wolfe, M. L. / Groppi, V. E. | 2006
4425
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c&- #93;pyridine-5-carboxamide, an Agonist of the a7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure-Activity Relationship
Wishka, D.G. / Walker, D.P. / Yates, K.M. / Reitz, S.C. / Jia, S. / Myers, J.K. / Olson, K.L. / Jacobsen, E.J. / Wolfe, M.L. / Groppi, V.E. et al. | 2006
4425
Discovery ofN-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia:  Synthesis and Structure−Activity Relationship
Wishka, Donn G. / Walker, Daniel P. / Yates, Karen M. / Reitz, Steven C. / Jia, Shaojuan / Myers, Jason K. / Olson, Kirk L. / Jacobsen, E. Jon / Wolfe, Mark L. / Groppi, Vincent E. et al. | 2006
4437
Imidazole−Dioxolane Compounds as Isozyme-Selective Heme Oxygenase Inhibitors
Vlahakis, Jason Z. / Kinobe, Robert T. / Bowers, Raymond J. / Brien, James F. / Nakatsu, Kanji / Szarek, Walter A. | 2006
4442
Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Pharmacological Characterization of γ-Aminobutyric Acid (GABA) Related Compounds
Lolli, Marco L. / Hansen, Suzanne L. / Rolando, Barbara / Nielsen, Birgitte / Wellendorph, Petrine / Madsen, Karsten / Larsen, Orla Miller / Kristiansen, Uffe / Fruttero, Roberta / Gasco, Alberto et al. | 2006
4442
Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Pharmacological Characterization of gamma-Aminobutyric Acid (GABA) Related Compounds
Lolli, M. L. / Hansen, S. L. / Rolando, B. / Nielsen, B. / Wellendorph, P. / Madsen, K. / Larsen, O. M. / Kristiansen, U. / Fruttero, R. / Gasco, A. | 2006

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