Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation (English)

Elsevier , Amsterdam [u.a.]; 2015

Many neurodegenerative diseases are associated with deposits of aggregated protein in the brain. The molecular pathways through which soluble proteins misfold to form amyloids and large protein aggregates often include diverse oligomeric species, only some of which progress to the amyloid state. Here we show that prefibrillar huntingtin (HTT) oligomers, isolated from Huntington's disease (HD) affected human brain samples or mouse models, stimulate polyglutamine amyloid formation. Fibrillar HTT oligomers have been shown to be unstable under denaturing conditions and appear not to lead to amyloid formation. Here we show that prefibrillar HTT oligomers are remarkably stable and are potent seeds of polyglutamine amyloid formation. Therefore, our findings help to dissect the complex molecular pathway of HTT misfolding. Conformational selection of misfolded HTT by immunopurification complements amyloidogenicity assays. A11‐reactive prefibrillar huntingtin oligomers are on the amyloid formation pathway. A11‐reactive prefibrillar huntingtin oligomers are stable in 6 M guanidine.

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Table of contents – Volume 589, Issue 15

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Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

1703
Cotranslational incorporation of non-standard amino acids using cell-free protein synthesis
Quast, Robert B. / Mrusek, Devid / Hoffmeister, Christian / Sonnabend, Andrei / Kubick, Stefan | 2015
1713
Membrane protein production in Escherichia coli cell-free lysates
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1723
Energizing eukaryotic cell-free protein synthesis with glucose metabolism
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1728
The roles of peripheral serotonin in metabolic homeostasis
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1735
Mechanical dissociation of the M-band titin/obscurin complex is directionally dependent
Caldwell, Tracy A. / Sumner, Isaiah / Wright, Nathan T. | 2015
1740
Protein folding of the SAP domain, a naturally occurring two-helix bundle
Dodson, Charlotte A. / Arbely, Eyal | 2015
1748
Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1
Zandarashvili, Levani / White, Mark A. / Esadze, Alexandre / Iwahara, Junji | 2015
1754
Structure of the free form of the N-terminal VH1 domain of monomeric α-catenin
Shibahara, Takenori / Hirano, Yoshinori / Hakoshima, Toshio | 2015
1761
Characterization of the quinones in purple sulfur bacterium Thermochromatium tepidum
Kimura, Yuuka / Kawakami, Tomoaki / Yu, Long-Jiang / Yoshimura, Miku / Kobayashi, Masayuki / Wang-Otomo, Zheng-Yu | 2015
1766
nagnag: Identification and quantification of NAGNAG alternative splicing using RNA-Seq data
Yan, Xiaoyan / Sablok, Gaurav / Feng, Gang / Ma, Jiaxin / Zhao, Hongwei / Sun, Xiaoyong | 2015
1771
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Shi, Xingjuan / Yao, Yanjun / Wang, Yujue / Zhang, Yu / Huang, Qinghai / Zhou, Jun / Liu, Min / Li, Dengwen | 2015
1778
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1787
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1795
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1802
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1807
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1813
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1819
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Laman, A.G. / Lathe, R. / Savinov, G.V. / Shepelyakovskaya, A.O. / Boziev, Kh.M. / Baidakova, L.K. / Chulin, A.N. / Brovko, F.A. / Svirshchevskaya, E.V. / Kotelevtsev, Y. et al. | 2015
1825
Hyperproduction of IL-6 caused by aberrant TDP-43 overexpression in high-fat diet-induced obese mice
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1832
A neutrophil inhibitory pepducin derived from FPR1 expected to target FPR1 signaling hijacks the closely related FPR2 instead
Winther, Malene / Gabl, Michael / Welin, Amanda / Dahlgren, Claes / Forsman, Huamei | 2015
1840
Functional characterization of Val60, a key residue involved in the membrane-oligomerization of fragaceatoxin C, an actinoporin from Actinia fragacea
Morante, Koldo / Caaveiro, Jose M.M. / Viguera, Ana Rosa / Tsumoto, Kouhei / González-Mañas, Juan Manuel | 2015
1847
Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy
Tian, Weili / Li, Wen / Chen, Yinqin / Yan, Zeming / Huang, Xia / Zhuang, Haixia / Zhong, Wangtao / Chen, Yusen / Wu, Wenxian / Lin, Chunxia et al. | 2015
1855
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1863
Candida albicans erythroascorbate peroxidase regulates intracellular methylglyoxal and reactive oxygen species independently of d-erythroascorbic acid
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1872
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Gittins, John R. | 2015
1879
Cross-linking analysis reveals the putative dimer structure of the cyanobacterial BLUF photoreceptor PixD
Ren, Shukun / Sugimoto, Yuki / Kobayashi, Taichi / Masuda, Shinji | 2015
1883
VirB6 and VirB10 from the Brucella type IV secretion system interact via the N-terminal periplasmic domain of VirB6
Villamil Giraldo, Ana Maria / Mary, Charline / Sivanesan, Durgajini / Baron, Christian | 2015
1890
Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP
Ren, Fangli / Geng, Yongtao / Minami, Takayuki / Qiu, Ying / Feng, Yarui / Liu, Chunxiao / Zhao, Juan / Wang, Yinyin / Fan, Xuanzi / Wang, Yangmeng et al. | 2015
1897
Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation
Morozova, Olga A. / Gupta, Sharad / Colby, David W. | 2015
1904
Altered epidermal lipid processing and calcium distribution in the KID syndrome mouse model Cx26S17F
Bosen, Felicitas / Celli, Anna / Crumrine, Debra / vom Dorp, Katharina / Ebel, Philipp / Jastrow, Holger / Dörmann, Peter / Winterhager, Elke / Mauro, Theodora / Willecke, Klaus | 2015
1911
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1920
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Che, Mei-Xia / Jiang, Lei-Lei / Li, Hai-Yin / Jiang, Ya-Jun / Hu, Hong-Yu | 2015
1929
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Liu, Ruiqin / Tian, Tian / Jia, Jianping | 2015
1935
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Jiang, Jiahong / Wang, Nan / Jiang, Yafei / Tan, Hongwei / Zheng, Jimin / Chen, Guangju / Jia, Zongchao | 2015
1943
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Steinmeyer, Nico / Doller, Anke / Biyanee, Abhiruchi / Brauß, Thilo / Schmid, Tobias / Pfeilschifter, Josef / Eberhardt, Wolfgang | 2015
1951
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Qiu, Hua / Gao, Yueqiu / Mao, Dewen | 2015
1958
MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells
Xie, Chen / Chen, Wei / Zhang, Mengdie / Cai, Qiuxian / Xu, Weiyi / Li, Xiaodi / Jiang, Songshan | 2015
1966
The DRBD13 RNA binding protein is involved in the insect-stage differentiation process of Trypanosoma brucei
Jha, Bhaskar Anand / Gazestani, Vahid H. / Yip, Chun Wai / Salavati, Reza | 2015
1975
E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation
Yang, Wei-Xia / Jin, Rui / Jiang, Chun-Ming / Wang, Xiao-Hua / Shu, Jin / Li, Ling / Zhu, Liang-Hua / Zhuang, Li-Li / Gao, Chao / Zhou, Guo-Ping | 2015
1981
Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute myeloid leukemia
Xing, Chong-yun / Hu, Xiao-qu / Xie, Fei-yan / Yu, Zhi-jie / Li, Hai-ying / Bin-Zhou / Wu, Jian-bo / Tang, Li-yuan / Gao, Shen-meng | 2015
1988
TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573
Lu, Zhengmao / Luo, Tianhang / Nie, Mingming / Pang, Tao / Zhang, Xin / Shen, Xiaojun / Ma, Liye / Bi, Jianwei / Wei, Guo / Fang, Guoen et al. | 2015
1995
The N2-Src neuronal splice variant of C-Src has altered SH3 domain ligand specificity and a higher constitutive activity than N1-Src
Keenan, Sarah / Lewis, Philip A. / Wetherill, Sarah J. / Dunning, Christopher J.R. / Evans, Gareth J.O. | 2015
2001
Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions
Liu, Zhaoli / Lu, Danyu / Wang, Xiang / Wan, Junhu / Liu, Chang / Zhang, Hongquan | 2015
2011
Secretin receptor involvement in prion-infected cells and animals
Kimura, Tomohiro / Nishizawa, Keiko / Oguma, Ayumi / Nishimura, Yuki / Sakasegawa, Yuji / Teruya, Kenta / Nishijima, Ichiko / Doh-ura, Katsumi | 2015
2019
ZNF10 inhibits HIV-1 LTR activity through interaction with NF-κB and Sp1 binding motifs
Nishitsuji, Hironori / Sawada, Leila / Sugiyama, Ryuichi / Takaku, Hiroshi | 2015
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| 2015

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