The discovery of GSK221149A: A potent and selective oxytocin antagonist (Unknown language)

  • ISSN:
  • Article (Journal)  /  Print

How to get this document?

Table of contents – Volume 18, Issue 1

Show all volumes and issues

The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.

1
Graphical contents list
| 2007
23
Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs
Young, Robert J. / Borthwick, Alan D. / Brown, David / Burns-Kurtis, Cynthia L. / Campbell, Matthew / Chan, Chuen / Charbaut, Marie / Chung, Chun-wa / Convery, Máire A. / Kelly, Henry A. et al. | 2007
28
Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Young, Robert J. / Borthwick, Alan D. / Brown, David / Burns-Kurtis, Cynthia L. / Campbell, Matthew / Chan, Chuen / Charbaut, Marie / Convery, Máire A. / Diallo, Hawa / Hortense, Eric et al. | 2007
34
Amino acid derivatives as histone deacetylase inhibitors
Hubbs, Jed L. / Zhou, Hua / Kral, Astrid M. / Fleming, Judith C. / Dahlberg, William K. / Hughes, Bethany L. / Middleton, Richard E. / Szewczak, Alexander A. / Secrist, J. Paul / Miller, Thomas A. | 2007
39
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors
Ly, Kiev S. / Letavic, Michael A. / Keith, John M. / Miller, Jennifer M. / Stocking, Emily M. / Barbier, Ann J. / Bonaventure, Pascal / Lord, Brian / Jiang, Xiaohui / Boggs, Jamin D. et al. | 2007
44
Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones
Bandarage, Upul K. / Wang, Tiansheng / Come, Jon H. / Perola, Emanuele / Wei, Yunyi / Rao, B. Govinda | 2007
49
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
Zhao, Zhijian / Robinson, Ronald G. / Barnett, Stanley F. / Defeo-Jones, Deborah / Jones, Raymond E. / Hartman, George D. / Huber, Hans E. / Duggan, Mark E. / Lindsley, Craig W. | 2007
54
Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity
Hu, Baihua / Quinet, Elaine / Unwalla, Rayomand / Collini, Mike / Jetter, James / Dooley, Rebecca / Andraka, Diane / Nogle, Lisa / Savio, Dawn / Halpern, Anita et al. | 2007
54
Carboxylic acid based quinolines as liver X receptor modulators that have LXRb receptor binding selectivity
Hu, B. / Quinet, E. / Unwalla, R. / Collini, M. / Jetter, J. / Dooley, R. / Andraka, D. / Nogle, L. / Savio, D. / Halpern, A. | 2008
60
Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase
Wisén, Susanne / Androsavich, John / Evans, Christopher G. / Chang, Lyra / Gestwicki, Jason E. | 2007
66
Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines
Douty, Brent / Wayland, Brian / Ala, Paul J. / Bower, Michael J. / Pruitt, James / Bostrom, Lori / Wei, Min / Klabe, Ronald / Gonneville, Lucie / Wynn, Richard et al. | 2007
72
New ultra-short acting hypnotic: Synthesis, biological evaluation, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124)
El-Subbagh, Hussein I. / El-Kashef, Hassan A. / Kadi, Adnan A. / Abdel-Aziz, Alaa A.-M. / Hassan, Ghada S. / Tettey, Justice / Lehmann, Jochen | 2007
78
Delayed fibril formation of amylin(20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis
Brouwer, Arwin J. / Elgersma, Ronald C. / Jagodzinska, Monika / Rijkers, Dirk T.S. / Liskamp, Rob M.J. | 2007
85
1-Toluene-sulfonyl-3-[(3′-hydroxy-5′-substituted)-γ-butyrolactone]-indoles: Synthesis, COX-2 inhibition and anti-cancer activities
Singh, Palwinder / Mittal, Anu / Bhardwaj, Atul / Kaur, Satwinderjeet / Kumar, Subodh | 2007
85
1-Toluene-sulfonyl-3-[(3prime-hydroxy-5prime-substituted)-g-butyrolactone]-indoles: Synthesis, COX-2 inhibition and anti-cancer activities
Singh, P. / Mittal, A. / Bhardwaj, A. / Kaur, S. / Kumar, S. | 2008
90
The discovery of GSK221149A: A potent and selective oxytocin antagonist
Liddle, John / Allen, Michael J. / Borthwick, Alan D. / Brooks, David P. / Davies, David E. / Edwards, Richard M. / Exall, Anne M. / Hamlett, Chris / Irving, Wendy R. / Mason, Andrew M. et al. | 2007
95
Determination of absolute stereochemistry, total synthesis, and evaluation of peptides from the myxomycete Physarum melleum
Hanazawa, Shuwa / Arai, Midori A. / Li, Xiaofan / Ishibashi, Masami | 2007
99
Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine
Huang, Sheng-Tung / Liao, Jian-Sheng / Fang, Hsu-Wei / Lin, Chun-Mao | 2007
104
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives
Oh, Ki-Bong / Lee, Ji Hye / Chung, Soon-Chun / Shin, Jongheon / Shin, Hee Jae / Kim, Hye-Kyeong / Lee, Hyi-Seung | 2007
109
Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex
Chen, Xiaoqiang / Wang, Jingyun / Sun, Shiguo / Fan, Jiangli / Wu, Song / Liu, Jianfeng / Ma, Saijian / Zhang, Lizhu / Peng, Xiaojun | 2007
114
The expedient synthesis of 1,5-benzothiazepines as a family of cytotoxic drugs
Arya, Kapil / Dandia, Anshu | 2007
120
(2S,2′R)-Analogue of LG190178 is a major active isomer
Hakamata, Wataru / Sato, Yukiko / Okuda, Haruhiro / Honzawa, Shinobu / Saito, Nozomi / Kishimoto, Seishi / Yamashita, Atsushi / Sugiura, Takayuki / Kittaka, Atsushi / Kurihara, Masaaki | 2007
120
(2S,2primeR)-Analogue of LG190178 is a major active isomer
Hakamata, W. / Sato, Y. / Okuda, H. / Honzawa, S. / Saito, N. / Kishimoto, S. / Yamashita, A. / Sugiura, T. / Kittaka, A. / Kurihara, M. | 2008
124
Diastereoselective synthesis of (R)-(alkyl)-b-d-galactopyranoside by using b-galactosidase (Aspergillus oryzae) in low-water media
Majumder, A. B. / Singh, B. / Gupta, M. N. | 2008
124
Diastereoselective synthesis of (R)-(alkyl)-β-d-galactopyranoside by using β-galactosidase (Aspergillus oryzae) in low-water media
Majumder, Abir B. / Singh, Bhupender / Gupta, Munishwar N. | 2007
129
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor
Chen, Chen / Jiang, Wanlong / Tran, Joe A. / Tucci, Fabio C. / Fleck, Beth A. / Markison, Stacy / Wen, Jenny / Madan, Ajay / Hoare, Sam R. / Foster, Alan C. et al. | 2007
137
Sulfonate chalcone as new class voltage-dependent K+ channel blocker
Yarishkin, Oleg V. / Ryu, Hyung Won / Park, Jae-Yong / Yang, Min Suk / Hong, Seong-Geun / Park, Ki Hun | 2007
141
2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents
Emami, Saeed / Foroumadi, Alireza / Falahati, Mehraban / Lotfali, Ensieh / Rajabalian, Saeed / Ebrahimi, Soltan-Ahmed / Farahyar, Shirin / Shafiee, Abbas | 2007
147
Development of CXCR3 antagonists. Part 3: Tropenyl and homotropenyl-piperidine urea derivatives
Watson, Robert J. / Allen, Daniel R. / Birch, Helen L. / Chapman, Gayle A. / Galvin, Frances C. / Jopling, Louise A. / Knight, Roland L. / Meier, Dorica / Oliver, Kathryn / Meissner, Johannes W.G. et al. | 2007
152
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studies
Güzel, Özlen / Temperini, Claudia / Innocenti, Alessio / Scozzafava, Andrea / Salman, Aydın / Supuran, Claudiu T. | 2007
159
Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis
Yao, Wenqing / Zhuo, Jincong / Burns, David M. / Li, Yun-Long / Qian, Ding-Quan / Zhang, Colin / He, Chunhong / Xu, Meizhong / Shi, Eric / Li, Yanlong et al. | 2007
159
Design and identification of selective HER-2 sheddase inhibitors via P1prime manipulation and unconventional P2prime perturbations to induce a molecular metamorphosis
Yao, W. / Zhuo, J. / Burns, D. M. / Li, Y. L. / Qian, D. Q. / Zhang, C. / He, C. / Xu, M. / Shi, E. / Li, Y. | 2008
164
Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3
Moulin, Aline / Demange, Luc / Ryan, Joanne / M’Kadmi, Céline / Galleyrand, Jean-Claude / Martinez, Jean / Fehrentz, Jean-Alain | 2007
169
Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone
Rolland, Amandine / Boquet, Isabelle / Norreel, Jean-Chrétien / Moret, Vincent / Laras, Younes / Kraus, Jean-Louis | 2007
175
Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase
Bergstrom, Carl P. / Sloan, Charles P. / Wang, Henry H. / Parker, Michael F. / Smith, David W. / Zheng, Ming / Hansel, Steven B. / Polson, Craig T. / Barber, Lauren E. / Bursuker, Isia et al. | 2007
175
Nitrogen-appended N-alkylsulfonamides as inhibitors of g-secretase
Bergstrom, C. P. / Sloan, C. P. / Wang, H. H. / Parker, M. F. / Smith, D. W. / Zheng, M. / Hansel, S. B. / Polson, C. T. / Barber, L. E. / Bursuker, I. | 2008
179
Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties
Mader, Mary / de Dios, Alfonso / Shih, Chuan / Bonjouklian, Rosanne / Li, Tiechao / White, Wesley / de Uralde, Beatriz López / Sánchez-Martinez, Concepción / del Prado, Miriam / Jaramillo, Carlos et al. | 2007
179
Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38a MAP kinase inhibitors with excellent in vivo antiinflammatory properties
Mader, M. / de Dios, A. / Shih, C. / Bonjouklian, R. / Li, T. / White, W. / de Uralde, B. L. / Sanchez-Martinez, C. / del Prado, M. / Jaramillo, C. | 2008
184
Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives
Rebollo, Oscar / del Olmo, Esther / Ruiz, Grace / López-Pérez, José L. / Giménez, Alberto / San Feliciano, Arturo | 2007
188
7-Azaindole derivatives as potential partial nicotinic agonists
Stoit, Axel R. / den Hartog, Arnold P. / Mons, Harry / van Schaik, Sjoerd / Barkhuijsen, Nynke / Stroomer, Cees / Coolen, Hein K.A.C. / Reinders, Jan Hendrik / Adolfs, Tiny J.P. / van der Neut, Martina et al. | 2007
194
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds
Kwon, Hyun Sook / Kim, Min-Jung / Jeong, Hyung Jae / Yang, Min Suk / Park, Ki Hun / Jeong, Tae-Sook / Lee, Woo Song | 2007
199
Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells
Kim, So-Yeon / Park, Kyoung-Wuk / Kim, Jae-Yong / Jeong, Il-Yun / Byun, Myung-Woo / Park, Jung-Eun / Yee, Sung-Tae / Kim, Kee-Hong / Rhim, Johng S. / Yamada, Koji et al. | 2007
205
Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors
Nam, Dong Hyuk / Lee, Kwang Seob / Kim, Sang Hoon / Kim, Sung Min / Jung, Seo Yun / Chung, Sung Hyun / Kim, Hyoung Ja / Kim, Nam Doo / Jin, Changbae / Lee, Yong Sup | 2007
210
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor
Myers, Michael C. / Shah, Parag P. / Diamond, Scott L. / Huryn, Donna M. / Smith, Amos B. III | 2007
215
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors
McBriar, Mark D. / Clader, John W. / Chu, Inhou / Del Vecchio, Robert A. / Favreau, Leonard / Greenlee, William J. / Hyde, Lynn A. / Nomeir, Amin A. / Parker, Eric M. / Pissarnitski, Dmitri A. et al. | 2007
215
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active g-secretase inhibitors
McBriar, M. D. / Clader, J. W. / Chu, I. / Del Vecchio, R. A. / Favreau, L. / Greenlee, W. J. / Hyde, L. A. / Nomeir, A. A. / Parker, E. M. / Pissarnitski, D. A. | 2008
220
5′-Fluoro-5′-deoxyaristeromycin
Li, Weikuan / Yin, Xueqiang / Schneller, Stewart W. | 2007
220
5prime-Fluoro-5prime-deoxyaristeromycin
Li, W. / Yin, X. / Schneller, S. W. | 2008
223
Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists
Weyler, Stefanie / Baqi, Younis / Hillmann, Petra / Kaulich, Marko / Hunder, Andrea M. / Müller, Ingrid A. / Müller, Christa E. | 2007
228
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists
Biju, Purakkattle / Taveras, Arthur / Yu, Younong / Zheng, Junying / Chao, Jianhua / Rindgen, Diane / Jakway, James / Hipkin, R. William / Fossetta, James / Fan, Xuedong et al. | 2007
232
Sterol C24-methyltransferase: Mechanistic studies of the C-methylation reaction with 24-fluorocycloartenol
Wang, Junqing / Liu, Jialin / Song, Zhihong / Nes, W. David | 2007
236
Development of dimeric modulators for anti-apoptotic Bcl-2 proteins
Wang, Liangyou / Kong, Fansen / Kokoski, Candis L. / Andrews, David W. / Xing, Chengguo | 2007
241
Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Duan, James J.-W. / Chen, Lihua / Lu, Zhonghui / Xue, Chu-Biao / Liu, Rui-Qin / Covington, Maryanne B. / Qian, Mingxin / Wasserman, Zelda R. / Vaddi, Krishna / Christ, David D. et al. | 2007
241
Discovery of b-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Duan, J. J. / Chen, L. / Lu, Z. / Xue, C. B. / Liu, R. Q. / Covington, M. B. / Qian, M. / Wasserman, Z. R. / Vaddi, K. / Christ, D. D. | 2008
247
Azaterphenyl diamidines as antileishmanial agents
Hu, Laixing / Arafa, Reem K. / Ismail, Mohamed A. / Wenzler, Tanja / Brun, Reto / Munde, Manoj / Wilson, W. David / Nzimiro, Sandra / Samyesudhas, Serene / Werbovetz, Karl A. et al. | 2007
252
Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides
Ali, Abdelselam / Altamore, Timothy M. / Bliese, Marianne / Fisara, Petr / Liepa, Andris J. / Meyer, Adam G. / Nguyen, Oahn / Sargent, Roger M. / Sawutz, David G. / Winkler, David A. et al. | 2007
256
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation
Peters, Jens-Uwe / Lübbers, Thomas / Alanine, Alexander / Kolczewski, Sabine / Blasco, Francesca / Steward, Lucinda | 2007
262
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration
Peters, Jens-Uwe / Lübbers, Thomas / Alanine, Alexander / Kolczewski, Sabine / Blasco, Francesca / Steward, Lucinda | 2007
267
Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17
Pinto-Bazurco Mendieta, Mariano A.E. / Negri, Matthias / Jagusch, Carsten / Hille, Ulrike E. / Müller-Vieira, Ursula / Schmidt, Dirk / Hansen, Klaus / Hartmann, Rolf W. | 2007
274
Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2′-deoxycytidines
Sumino, Masanori / Ohkubo, Akihiro / Taguchi, Haruhiko / Seio, Kohji / Sekine, Mitsuo | 2007
274
Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2prime-deoxycytidines
Sumino, M. / Ohkubo, A. / Taguchi, H. / Seio, K. / Sekine, M. | 2008
278
Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst
Khabazzadeh, Hojatollah / Saidi, Kazem / Sheibani, Hassan | 2007
281
Phosphoramidate derivatives of hydroxysteroids as inhibitors of prostate-specific membrane antigen
Wu, Lisa Y. / Do, Jacinda C. / Kazak, Marat / Page, Helen / Toriyabe, Yoko / Anderson, Marc O. / Berkman, Clifford E. | 2007
285
Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening
Usui, Taikou / Ban, Hyun Seung / Kawada, Junpei / Hirokawa, Takatsugu / Nakamura, Hiroyuki | 2007
289
Thiophene containing triarylmethanes as antitubercular agents
Parai, Maloy Kumar / Panda, Gautam / Chaturvedi, Vinita / Manju, Y.K. / Sinha, Sudhir | 2007
293
Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizers
Yao, Jianzhong / Zhang, Wannian / Sheng, Chunquan / Miao, Zhenyuan / Yang, Feng / Yu, Jianxin / Zhang, Ling / Song, Yunlong / Zhou, Ting / Zhou, Youjun | 2007
298
Synthesis, characterization and DNA-binding properties of four Zn(II) complexes with bis(pyrrol-2-yl-methyleneamine) ligands
Wang, Yuan / Yang, Zheng-Yin / Chen, Zhong-Ning | 2007
304
Substituted 2-oxo-azepane derivatives are potent, orally active g-secretase inhibitors
Kitas, E. A. / Galley, G. / Jakob-Roetne, R. / Flohr, A. / Wostl, W. / Mauser, H. / Alker, A. M. / Czech, C. / Ozmen, L. / David-Pierson, P. | 2008
304
Substituted 2-oxo-azepane derivatives are potent, orally active γ-secretase inhibitors
Kitas, Eric A. / Galley, Guido / Jakob-Roetne, Roland / Flohr, Alexander / Wostl, Wolfgang / Mauser, Harald / Alker, André M. / Czech, Christian / Ozmen, Laurence / David-Pierson, Pascale et al. | 2007
309
4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity
Scipione, Luigi / De Vita, Daniela / Musella, Alessandra / Flammini, Lisa / Bertoni, Simona / Barocelli, Elisabetta | 2007
313
pH sensing in living cells using fluorescent microspheres
Bradley, Mark / Alexander, Lois / Duncan, Karen / Chennaoui, Mourad / Jones, Anita C. / Sánchez-Martín, Rosario M. | 2007
318
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode
Angell, Richard M. / Bamborough, Paul / Cleasby, Anne / Cockerill, Stuart G. / Jones, Katherine L. / Mooney, Christopher J. / Somers, Donald O. / Walker, Ann L. | 2007
324
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR
Angell, Richard M. / Angell, Tony D. / Bamborough, Paul / Brown, David / Brown, Murray / Buckton, Jacky B. / Cockerill, Stuart G. / Edwards, Chris D. / Jones, Katherine L. / Longstaff, Tim et al. | 2007
329
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkB activity within two separate high-throughput screens of NFkB activation
Xie, Y. / Deng, S. / Thomas, C. J. / Liu, Y. / Zhang, Y. Q. / Rinderspacher, A. / Huang, W. / Gong, G. / Wyler, M. / Cayanis, E. | 2008
329
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFκB activity within two separate high-throughput screens of NFκB activation
Xie, Yuli / Deng, ShiXian / Thomas, Craig J. / Liu, Yidong / Zhang, Ya-Qin / Rinderspacher, Alison / Huang, Wenwei / Gong, Gangli / Wyler, Michael / Cayanis, Efithia et al. | 2007
336
Discovery of a series of aminopiperidines as novel iNOS inhibitors
Bourdonnec, Bertrand Le / Leister, Lara K. / Ajello, Christopher A. / Cassel, Joel A. / Seida, Pamela R. / O’Hare, Heather / Gu, Minghua / Chu, Guo-Hua / Tuthill, Paul A. / DeHaven, Robert N. et al. | 2007
344
Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides
Liu, Ligong / Bytheway, Ian / Karoli, Tomislav / Fairweather, Jon K. / Cochran, Siska / Li, Caiping / Ferro, Vito | 2007
350
Uncovering false positives on a virtual screening search for cruzain inhibitors
Malvezzi, Alberto / de Rezende, Leandro / Izidoro, Mario Augusto / Cezari, Maria Helena Sedenho / Juliano, Luiz / Amaral, Antonia T.-do | 2007
355
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series
Nersesian, Diana L. / Black, Lawrence A. / Miller, Thomas R. / Vortherms, Timothy A. / Esbenshade, Timothy A. / Hancock, Arthur A. / Cowart, Marlon D. | 2007
360
Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents
Girard, Denis / Weagle, Glenn / Gupta, Atul / Bérubé, Gervais / Chapados, Camille | 2007
366
Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors
Nguyen, Jeffrey-Tri / Zhang, Meihui / Kumada, Henri-Obadja / Itami, Ayako / Nishiyama, Keiji / Kimura, Tooru / Cheng, Maosheng / Hayashi, Yoshio / Kiso, Yoshiaki | 2007
371
Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure–activity relationships
Hosono, Tetsuji / Yokomizo, Kazumi / Hamasaki, Akiyuki / Okamoto, Yoshinari / Okawara, Tadashi / Otsuka, Masami / Mukai, Ryozaburo / Suzuki, Keitarou | 2007
375
Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as γ-secretase inhibitors
Sparey, Tim / Clarke, Earl / Hannam, Joanne / Harrison, Timothy / Madin, Andrew / Shearman, Mark / Sohal, Bindi | 2007
375
Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as g-secretase inhibitors
Sparey, T. / Clarke, E. / Hannam, J. / Harrison, T. / Madin, A. / Shearman, M. / Sohal, B. | 2008
380
Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A
Chenna, Bala Chandra / Shinkre, Bidhan A. / King, Jason R. / Lucius, Aaron L. / Narayana, Sthanam V.L. / Velu, Sadanandan E. | 2007
386
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors
Dai, Yujia / Hartandi, Kresna / Soni, Niru B. / Pease, Lori J. / Reuter, David R. / Olson, Amanda M. / Osterling, Donald J. / Doktor, Stella Z. / Albert, Daniel H. / Bouska, Jennifer J. et al. | 2007
391
Design, synthesis, and studies of small molecule STAT3 inhibitors
Bhasin, Deepak / Cisek, Katryna / Pandharkar, Trupti / Regan, Nicholas / Li, Chenglong / Pandit, Bulbul / Lin, Jiayuh / Li, Pui-Kai | 2007
396
Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines
Verhaeghe, Pierre / Azas, Nadine / Gasquet, Monique / Hutter, Sébastien / Ducros, Christophe / Laget, Michèle / Rault, Sylvain / Rathelot, Pascal / Vanelle, Patrice | 2007
402
Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABAC receptors
Hinton, Tina / Chebib, Mary / Johnston, Graham A.R. | 2007
405
Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)
Zhang, Yue-Mei / Fan, Xiaodong / Yang, Shyh-Ming / Scannevin, Robert H. / Burke, Sharon L. / Rhodes, Kenneth J. / Jackson, Paul F. | 2007
409
1-Hydroxy-2-pyridinone-based MMP inhibitors: Synthesis and biological evaluation for the treatment of ischemic stroke
Zhang, Yue-Mei / Fan, Xiaodong / Chakaravarty, Devraj / Xiang, Bangping / Scannevin, Robert H. / Huang, Zhihong / Ma, Jianya / Burke, Sharon L. / Karnachi, Prabha / Rhodes, Kenneth J. et al. | 2007
414
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors
Iserloh, U. / Wu, Y. / Cumming, J.N. / Pan, J. / Wang, L.Y. / Stamford, A.W. / Kennedy, M.E. / Kuvelkar, R. / Chen, X. / Parker, E.M. et al. | 2007
418
Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor
Iserloh, U. / Pan, J. / Stamford, A.W. / Kennedy, M.E. / Zhang, Q. / Zhang, L. / Parker, E.M. / McHugh, N.A. / Favreau, L. / Strickland, C. et al. | 2007
423
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
Piazzi, Lorna / Cavalli, Andrea / Colizzi, Francesco / Belluti, Federica / Bartolini, Manuela / Mancini, Francesca / Recanatini, Maurizio / Andrisano, Vincenza / Rampa, Angela | 2007
427
Substrate specificity and screening of the integral membrane protease Pla
Agarkov, Anton / Chauhan, Sadhana / Lory, Pedro J. / Gilbertson, Scott R. / Motin, Vladimir L. | 2007
432
Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation
Thimmegowda, N.R. / Nanjunda Swamy, S. / Ananda Kumar, C.S. / Sunil Kumar, Y.C. / Chandrappa, S. / Yip, George W. / Rangappa, K.S. | 2007
436
Eco-friendly and efficient one-pot synthesis of alkyl- or aryl-14H-dibenzo[a,j]xanthenes in water
Dabiri, Minoo / Baghbanzadeh, Mostafa / Nikcheh, Maryam Shakouri / Arzroomchilar, Elham | 2007
I
Instructions to contributors
| 2007
IFC
Editorial board
| 2007