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    Poster session 2 (English)

    In: Europace ; 15 , suppl_2 ; ii56-  ; 2013

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    Purpose: Whether cryoballoon pulmonary veins isolation (CPVI) for paroxysmal AF influences on autonomic nervous system and therefore on the efficacy of the procedure. Patients: 57 patients (36 men, 57±11 years) without structural heart disease, diabetes mellitus, thyroid disorder, chronic kidney disease, sinus bradycardia and av conduction disturbances. Methods: Cryoablation with a 28 mm balloon catheter (Arctic Front, Medtronic Inc.) was applied for 5 minutes twice in each vein. A bradycardic response (heart rate <40 bpm, asystole, AV block, hypotension) was considered as evidence of vagal nerve activation. Heart rate variability (HRV) was used as an indicator of autonomic nervous system activity. 24-hour Holter monitoring was analyzed before and at 3 months after the procedure. All patients were followed for 6 months. Results: At follow-up time 76% of patients were free from arrhythmia. Transient vagal reflexes (VR) were noted in 36 % of patients and were documented during ablation of the left common trunk (12,5%) left superior PV (79%), left inferior PV (37,5%), both left PVs (29%). The presence of VR was not related to age, gender, LA diameter, PV diameter and minimal achieved temperature during application. 3 months after ablation a reduction in HRV was seen suggesting sympathetic overbalance but marked HRV changes were consistent with the presence of VR. At 6 months of follow-up AF recurrence was seen in 19% of patients with VR compared with 27% of patients without VR (p>0,05). Conclusions: Significant VR during CPVI indicate partial parasympathetic denervation that not increases the antiarrhythmic effect of the procedure.

    Table of contents – Volume 15, Issue suppl_2

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    ii1
    Poster session: On behalf of the Working Group on Cardiac Cellular Electrophysiology
    Bingen, B.O. / Ramkisoensing, A.A. / Neshati, Z. / Askar, S.F.A. / Kazbanov, I.V. / Ypey, D.L. / Panfilov, A.V. / Schalij, M.J. / De Vries, A.A.F. / Pijnappels, D.A. et al. | 2013
    ii10
    Main Session: Mechanical stress and cell function
    Vloumidi, E. / Fortmueller, L. / Sakhtivel, S. / Syeda, F. / Kirchhof, P. / Leube, R. / Krusche, C. / Fabritz, L. et al. | 2013
    ii11
    Main Session: Molecular mechanisms in cardiomyopathies
    Rosengarten, J.A. / Scott, P.A. / Larkin, S.E. / Garbis, S. / Curzen, N.P. / Townsend, P.A. / Morgan, J.M. / Lee, H. / Ling, T-Y. / Wang, X-L. et al. | 2013
    ii12
    Moderated Posters session: New challenges in cardiac pacing
    Milasinovic, G / Crijns, HJGM / Smid, J / Klein, H / Gavazzi, A / Raspopovic, S / Borggrefe, M / Zabel, M / De Ferrari, GM / Schwartz, PJ et al. | 2013
    ii16
    Poster session 1
    Liu, C. / Li, G. / Fu, H. / Li, J. / Cheng, L. / Yang, W. / Liu, T. / Bolognesi, M.G. / Rossi, L.R. / Rusticali, G.R.