Influence of Gold Nanoparticles on Radiation Dose Enhancement and Cellular Migration in Microbeam-Irradiated Cells (English)

In: BioNanoScience   ;  1 ,  1  ;  4-13  ;  2011

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Abstract The focus of this research was the enhancement of radiation dose for microbeam radiotherapy (MRT) by the inclusion of gold nanoparticles (AuNPs) in the target. Microbeam radiotherapy is a technique that employs a very high dose rate of X-rays to kill highly resistant tumours such as glioma without jeopardizing the tolerance of normal tissue. The reduction of radiation dose rate used in this technique by using AuNPs may enhance the normal tissue tolerance while achieving better tumour control. In this study, microbeam kilovoltage X-ray of mean energy 125 keV from the SPring8 Synchrotron in Japan was used. The results show dose enhancement effects on endothelial cells by AuNPs which are consistent with previously documented results using broad beams of X-rays. It was also observed in this study that the inclusion of AuNPs accelerates cell migration towards the eradicated area which is important in normal tissue recovery. The phenomenon of cell migration is observed when cell fill depleted gaps that have been created by the microbeams or when such gaps are manually made by scratching the cell culture as a wound. The reason behind this acceleration of the rate of gap fillings is not well understood. However, it has been attributed to various biological processes and has also been thought of as being partially due to the effects of electrostatic charge of such particles. It could also be the combined effects of biological and electrostatic effects due to the charges of the particles inside the cells. Moreover, it is also observed that the cancerous glioma cell fills the gaps in much slower rates in comparison to the normal endothelial cells. This is consistent with the notion on which the MRT techniques are based.

Table of contents – Volume 1, Issue 1

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The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.

1
New Insight on Bio-sensing by Nano-fabricated Memristors
Sacchetto, Davide / Doucey, Marie-Agnès / Micheli, Giovanni / Leblebici, Yusuf / Carrara, Sandro | 2011
4
Influence of Gold Nanoparticles on Radiation Dose Enhancement and Cellular Migration in Microbeam-Irradiated Cells
Rahman, Wan Nordiana / Davidson, Robert / Yagi, Naoto / Bansal, Vipul / Geso, Moshi / Darby, Ian | 2011
14
Dynamic Failure of a Lamina Meshwork in Cell Nuclei under Extreme Mechanical Deformation
Qin, Zhao / Buehler, Markus J. | 2011
24
Material Memristive Device Circuits with Synaptic Plasticity: Learning and Memory
Erokhin, Victor / Berzina, Tatiana / Camorani, Paolo / Smerieri, Anteo / Vavoulis, Dimitris / Feng, Jianfeng / Fontana, Marco P. | 2011
31
Self-Assembled Peptide Nanotubes as an Etching Material for the Rapid Fabrication of Silicon Wires
Larsen, Martin B. / Andersen, Karsten B. / Svendsen, Winnie E. / Castillo-León, Jaime | 2011
38
Detection of Aflatoxin B1 with a Label-Free Ellipsometry Immunosensor
Nabok, Alexei V. / Mustafa, Mohd Kamarulzaki / Tsargorodskaya, Anna / Starodub, Nikolaj F. | 2011
46
Electroanalysis of Cytochrome P450 3A4 Catalytic Properties with Nanostructured Electrodes: The Influence of Vitamin B Group on Diclofenac Metabolism
Makhova, Anna A. / Shumyantseva, Victoria V. / Shich, Evgeniya V. / Bulko, Tatyana V. / Kukes, Vladimir G. / Sizova, Oksana S. / Ramenskaya, Galina V. / Usanov, Sergei A. / Archakov, Alexander I. | 2011
53
Structure, Scaling, and Performance of Natural Micro- and Nanocomposites
Bekah, Sacheen / Rabiei, Reza / Barthelat, Francois | 2011
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