Cancer Cell Damage at Laser-Induced Plasmon-Resonant Photothermal Treatment of Transplanted Liver Tumor (English)

In: BioNanoScience   ;  6 ,  3  ;  256-260  ;  2016

How to get this document?

Download
Commercial Copyright fee: €34.95 Basic fee: €4.00 Total price: €38.95
Academic Copyright fee: €12.50 Basic fee: €2.00 Total price: €14.50

Abstract Here, we report the morphological investigation of gold nanorod (GNR)-mediated photothermal changes in transplanted liver tumors PC-1 and discuss photothermal induced therapeutic pathways of cancer cell damage. Thirty male outbred albino rats with transplanted liver cancer PC-1 are used in the experiment. The GNRs (length 41 ± 8 nm, diameter 10.2 ± 2 nm) suspended in saline with gold concentration of 400 μg/ml are injected intratumorally an hour before laser irradiation. The tumor is irradiated during 15 min with the near infrared (NIR) 808-nm laser at a power density of 2.3 W/cm2. Temperature control of the tumor heating is provided with IR imager. The withdrawal of the animal from the experiment is performed 24 h after the laser exposure. We use the standard histological and immunohistochemical staining with antibodies for Ki-67, p53, FAS receptor, FAS ligand, and EGFR for morphological study of transplanted tumors. After plasmonic photothermal therapy (PPT), the pronounced necrotic changes in the tumor tissue are revealed. The decreasing expression of the proliferation marker Ki-67 and the increasing expression of apoptosis markers (p53, FAS receptor, and FAS ligand) are observed after PPT.

Table of contents – Volume 6, Issue 3

Show all volumes and issues

The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.

177
Molecular Modeling and Mechanics of Acrylic Adhesives on a Graphene Substrate with Roughness
Qin, Zhao / Jin, Kai / Buehler, Markus J. | 2016
185
An Enhanced Design of RF Integrated Differential Active Inductor
Hammadi, Aymen Ben / Mhiri, Mongia / Haddad, Fayrouz / Saad, Sehmi / Besbes, Kamel | 2016
193
Three to Five Gigahertz UWB Transmitter for Vital Sign Monitoring Systems
Barraj, Imen / Neifar, Amel / Masmoudi, Mohamed | 2016
205
Green Synthesis of Gold Nanoparticles Using Root and Leaf Extracts of Vetiveria zizanioides and Cannabis sativa and its Antifungal Activities
Swain, S. / Barik, S. K. / Behera, T. / Nayak, S. K. / Sahoo, S. K. / Mishra, S. S. / Swain, P. | 2016
214
Memristor-Based Volistor Gates Compute Logic with Low Power Consumption
Aljafar, Muayad / Long, Paul / Perkowski, Marek | 2016
235
Magnetic Nanodrug Delivery Through the Mucus Layer of Air-Liquid Interface Cultured Primary Normal Human Tracheobronchial Epithelial Cells
Economou, E. C. / Marinelli, S. / Smith, M. C. / Routt, A. A. / Kravets, V. V. / Chu, H. W. / Spendier, K. / Celinski, Z. J. | 2016
243
1H NMR Characterization of Two New Pyridoxine Derivatives
Rakhmatullin, Ilfat / Galiullina, Leisan / Garipov, Marsel / Strel’nik, Alexey / Shtyrlin, Yurii / Klochkov, Vladimir | 2016
246
Convolutional Neural Networks for Image Steganalysis
Bashkirova, Dina | 2016
249
Cytoskeletal Protein Septins Participate in the Modulation of the Kinetics of Acetylcholine Quanta Release at Neuromuscular Junction
Khuzakhmetova, Venera / Nurullin, Leniz / Bukharaeva, Ellya | 2016
252
A Biocidal Nanocoating Based on the Macromolecular “Chitosan Acetate–Sodium Albuminate–Silver Nanoparticles” System
Gegel, N. O. / Abramov, A. Yu / Shipovskaya, A. B. / Zudina, I. V. | 2016
256
Cancer Cell Damage at Laser-Induced Plasmon-Resonant Photothermal Treatment of Transplanted Liver Tumor
Bucharskaya, A. B. / Maslyakova, G. N. / Dikht, N. I. / Navolokin, N. A. / Terentyuk, G. S. / Bashkatov, A. N. / Genina, E. A. / Tuchin, V. V. / Khlebtsov, B. N. / Khlebtsov, N. G. | 2016
261
Calcium Carbonate-Based Mucoadhesive Microcontainers for Intranasal Delivery of Drugs Bypassing the Blood–Brain Barrier
Borodina, T. N. / Trushina, D. B. / Marchenko, I. V. / Bukreeva, T. V. | 2016
Feedback