The biocompatibility of silk fibroin films containing sulfonated silk fibroin (English)

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Sulfonation reaction may be an effective method for preparation of heparin-like materials. However, no sulfonated polymer based on protein backbone was used for improving the blood compatibility of biomaterials. In the study, the biocompatibility of new kind of composite materials films obtained by blending silk fibroin (SF) with sulfonated silk fibroin (SSF) was evaluated. The anticoagulant activity was characterized with prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT), which all increased remarkably, the clot times exceeded the measurement limit of clot detection instrument. Its platelet adhesion was also investigated as another parameter of blood compatibility. The cell compatibility of composite films was evaluated through cell morphologies on the films and cell viability by methyl thiazolyl tetrazolium (MTT) assay. Tensile strength and elongation at break of the composite films reached to 44.6 MPa and 50.3 %, respectively. All these results indicated that SF/SSF composite film was a potential material for blood-contact materials and tissue engineering matrix.

Table of contents – Volume 78B, Issue 1

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Nanoindentation of dental composites
Drummond, James L. | 2006
Healing pattern of bone defects covered by different membrane types—A histologic study in the porcine mandible
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Porous akermanite scaffolds for bone tissue engineering: Preparation, characterization, and in vitro studies
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A mechanism on why slower polymerization of a dental composite produces lower contraction stress
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Gisep, A. / Curtis, R. / Flütsch, S. / Suhm, N. | 2006
The biocompatibility of silk fibroin films containing sulfonated silk fibroin
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Cytotoxic effects of dental desensitizers on human gingival fibroblasts
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Three‐dimensional printing of porous polyethylene structure using water‐based binders
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The nature of platinum in silicones for biomedical and healthcare use
Lambert, James M. | 2006
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Comparison of two radio‐frequency plasma sterilization processes using microspot evaluation of microbial inactivation
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Wear and fatigue behavior of nano‐structured dental resin composites
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Hydrogen absorption of titanium and nickel‐titanium alloys during long‐term immersion in neutral fluoride solution
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In vivo performance of two different hydroxyapatite coatings on titanium prepared by discharging in electrolytes
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| 2006