Architecture of the photosynthetic oxygen-evolving center (English)

In: Science   ;  303 ,  5665  ;  1831-1838  ;  2004
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Photosynthesis uses light energy to drive the oxidation of water at an oxygen-evolving catalytic site within photosystem II (PSII). We report the structure of PSII of the cyanobacterium Thermosynechococcus elongatus at 3.5 angstrom resolution. We have assigned most of the amino acid residues of this 650-kilodalton dimeric multisubunit complex and refined the structure to reveal its molecular architecture. Consequently, we are able to describe details of the binding sites for cofactors and propose a structure of the oxygen-evolving center (OEC). The data strongly suggest that the OEC contains a cubane-like Mn3CaO4 cluster linked to a fourth Mn by a mono- mu -oxo bridge. The details of the surrounding coordination sphere of the metal cluster and the implications for a possible oxygen-evolving mechanism are discussed.

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1723
SCIENCE ONLINE
| 2004
1725
THIS WEEK IN SCIENCE
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1729
EDITORIAL - Drug Discovery
Kennedy, Donald | 2004
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EDITORS' CHOICE
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CONTACT SCIENCE
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NETWATCH
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NEWS OF THE WEEK - U.S. TRADE POLICY - Editing Ban to Be Eased, But Cuban Travel Blocked
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NEWS OF THE WEEK - TEXAS BIOTERROR CASE - Butter Gets 2 Years for Mishandling Plague Samples
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NEWS OF THE WEEK - PLANETARY SCIENCE - Far-Out Ice World
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NEWS OF THE WEEK - ASTRONOMY - Academy, GAO to Study Possible Robotic Hubble Mission
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NEWS OF THE WEEK - SCIENCESCOPE
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NEWS OF THE WEEK - JAPAN - Older Scientists Win Majority of Funding
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NEWS OF THE WEEK - PARTICLE PHYSICS - Gamma Rays Spotlight a Dark Horse for Dark Matter
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NEWS OF THE WEEK - CONFLICT OF INTEREST - Varmus Backs Some Limits on NIH's Consulting Policy
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1749
NEWS OF THE WEEK - FRENCH PROTESTS - Government Dangles Fresh Carrots to Dispirited Scientific Community
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1750
NEWS FOCUS - ASTRONOMY - Surveys Scour the Cosmic Deep
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1753
NEWS FOCUS - ECOLOGY - A Bid to Save the 'Galápagos of the Indian Ocean'
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1754
NEWS FOCUS - GENOMIC MEDICINE - Gene Expression Tests Foretell Breast Cancer's Future
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NEWS FOCUS - INTELLECTUAL PROPERTY - NIH Roils Academe With Advice on Licensing DNA Patents - Most Academics Eschewing Patents?
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NEWS FOCUS - SCIENTIFIC LIVES - Reflected Glory: Life With a Nobelist Parent
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NEWS FOCUS - RANDOM SAMPLES
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LETTERS - Research on Contraceptives
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LETTERS - Response - The Difficulties of Defining the Term "GM"
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LETTERS - "Physics First" and High School Teachers
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LETTERS - The Difficulties of Defining the Term "GM"
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TECHNICAL COMMENT ABSTRACTS - ATMOSPHERIC SCIENCE - Comment on "Contributions of Anthropogenic and Natural Forcing to Recent Tropopause Height Changes"
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LETTERS - Corrections and Clarifications
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1771
TECHNICAL COMMENT ABSTRACTS - Response to Comment on "Contributions of Anthropogenic and Natural Forcing to Recent Tropopause Height Changes"
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BOOKS ET AL. - Browsings
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BOOKS ET AL. - Nota Bene on Mutants - On Genetic Variety and the Human Body
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POLICY FORUM - SCIENCE AND GOVERNMENT - An International Framework to Promote Access to Data
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PERSPECTIVES - EVOLUTION - Parallel Evolution Is in the Genes
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PERSPECTIVES - CLIMATE - Society and Sea Level Rise
Pilkey, O.H. / Cooper, J.A.G. | 2004
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PERSPECTIVES - BIOCHEMISTRY - Water Photolysis in Biology
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PERSPECTIVES - COMPUTERS AND MATHEMATICS - Quantum Channel Capacities
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INTRODUCTION - Rethinking Drug Discovery
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NEWS - Surviving the Blockbuster Syndrome - Orphan Drugs of the Future?
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1800
REVIEWS AND VIEWPOINTS - Protein Kinase Inhibitors: Insights into Drug Design from Structure
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REVIEWS AND VIEWPOINTS - Polyketide and Nonribosomat Peptide Antibiotics: Modularity and Versatility
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REVIEWS AND VIEWPOINTS - Organic Chemistry in Drug Discovery
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REVIEWS AND VIEWPOINTS - The Many Roles of Computation in Drug Discovery
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1818
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1829
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1831
Architecture of the photosynthetic oxygen-evolving center
Ferreira, K.N. / Iverson, T.M. / Maghlaoui, K. / Barber, J. / Iwata, S. | 2004
1831
RESEARCH ARTICLES - STRUCTURAL BIOLOGY: Architecture of the Photosynthetic Oxygen-Evolving Center - During photosynthesis, right splits water into hydrogen and oxygen using an erzyme with a catalytic site in which three manganese atoms and a calcium atom are arranged at nonadjacent corners of a cube.
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1838
RESEARCH ARTICLES - VIROLOGY: The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin - The protein on the surface of the 1918 flu virus that helps it bind to host cells resembles that of avian flu viruses, and this similarity probably contributed to the extreme infectivity and mortality of the disease.
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Optical frequency synthesis and comparison with uncertainty at the 10-19 level
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REPORTS - PHYSICS: Optical Frequency Synthesis and Comparison with Uncertainty at the 10-19 Level - A laser-based optical "comb" is used to synthesize and compare light frequencies with high precision, useful for atomic clocks.
Ma, L.-S. / Bi, Z. / Bartels, A. / Robertsson, L. / Zucco, M. / Windeler, R.S. / Wilpers, G. / Oates, C. / Hollberg, L. | 2004
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REPORTS - CHEMISTRY: A Molecular Elevator - An attached molecular platform moves stepwise along three aligned molecular rods in response to acid-base switching.
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REPORTS - CHEMISTRY: Electrical or Photocontrol of the Rotary Motion of a Metallacarborane - The rotation of two ligands on a nickel complex can be controlled by photolysis and electron transfer, forming a singie-molecule motor.
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REPORTS - CHEMISTRY: Directional Dynamics in the Photodissociation of Oriented Molecules - Ion trapping and imaging reveals that CO recolis in one direction when an OCS molecule is dissociated by light, revealing the mechanism of an important class of reactions.
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1855
REPORTS - CLIMATE: On the Cause of the 1930s Dust Bowl - Unusually cold sea surface temperatures in the Pacific Ocean coupled with unusually warm temperatures in the Atlantic caused the Dust Bowl drought in North America during the 1930S.
Schubert, S.D. / Suarez, M.J. / Pegion, P.J. / Koster, R.D. / Bacmeister, J.T. | 2004
1859
REPORTS - GEOPHYSICS: Laboratory Earthquakes: The Sub-Rayleigh-to-Supershear Rupture Transition - Laboratory experiments indicate that earthquakes that rupture faster than the speed of sound will tend to occur on long ruptures when the tectonic stress is dose to the strength of the fault.
Xia, K. / Rosakis, A.J. / Kanamori, H. | 2004
1862
REPORTS - CELL BIOLOGY: Stathmin-Tubulin Interaction Gradients in Motile and Mitotic Cells An internal gradient of the functional form of a protein that regulates the cell's cytoskeleton helps cells move and divide.
Niethammer, P. / Bastiaens, P. / Karsenti, E. | 2004
1866
REPORTS - VIROLOGY: Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus - The protein on the surface of the 1918 flu virus that helps it bind to host cells resembles that of avian flu viruses, and this similarity probably contributed to the extreme infectivity and mortality of the disease.
Stevens, J. / Corper, A.L. / Basler, C.F. / Taubenberger, J.K. / Palese, P. / Wilson, I.A. | 2004
1870
REPORTS - EVOLUTION: Conserved Genetic Basis of a Quantitative Plumage Trait Involved in Mate Choice - In two distantly related birds, lesser snow geese and arctic skuas, the pigmentation pattern of their plumage, which influences mating, reflects recent independent mutations of the same gene.
Mundy, N.I. / Badcock, N.S. / Hart, T. / Scribner, K. / Janssen, K. / Nadeau, N.J. | 2004
1873
REPORTS - IMMUNOLOGY: Genetic Basis of Natural Variation in D. melanogaster Antibacterial Immunity Genes for pathogen resistance in insects vary widely among individuals, allowing the population as a whole to defend effectively against multiple bacterial infections.
Lazzaro, B.P. / Sceurman, B.K. / Clark, A.G. | 2004
1876
REPORTS - ECOLOGY: Impact of Nitrogen Deposition on the Species Richness of Grasslands - The loss of plant diversity in grasslands of the United Kingdom partly reflects the application of fertilizer, which eliminates species such as sorbs and mosses that are adapted to low-fertility conditions.
Stevens, C.J. / Dise, N.B. / Mountford, J.O. / Gowing, D.J. | 2004
1879
REPORTS - ECOLOGY: Comparative Losses of British Butterflies, Birds, and Plants and the Global Extinction Crisis Amalgamation of six exhaustive surveys of British butterflies, birds, and plants over the past 40 years shows numerous extinctions in all groups but a precipitous decline in butterflies.
Thomas, J.A. / Telfer, M.G. / Roy, D.B. / Preston, C.D. / Greenwood, J.J.D. / Asher, J. / Fox, R. / Clarke, R.T. / Lawton, J.H. | 2004
1896
SCIENCE CAREERS
| 2004
SPECIAL ISSUE - DRUG DISCOVERY - The inhibitor Gleevec bound to the catalytic domain of Abl tyrosine kinase, as rendered by the program Aesop from coordinates in the Protein Data Bank. A special section, along with associated online material, describes how new technologies are being applied to overcome the challenges of drug discovery.
| 2004