Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications (English)

In: Biomaterials   ;  26 ,  18  ;  3995-4021  ;  2005
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Superparamagnetic iron oxide nanoparticles (SPION) with appropriate surface chemistry have been widely used experimentally for numerous in vivo applications such as magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, hyperthermia, drug delivery and in cell separation, etc. All these biomedical and bioengineering applications require that these nanoparticles have high magnetization values and size smaller than 100 nm with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties. In addition, these applications need special surface coating of the magnetic particles, which has to be not only non-toxic and biocompatible but also allow a targetable delivery with particle localization in a specific area. To this end, most work in this field has been done in improving the biocompatibility of the materials, but only a few scientific investigations and developments have been carried out in improving the quality of magnetic particles, their size distribution, their shape and surface in addition to characterizing them to get a protocol for the quality control of these particles. Nature of surface coatings and their subsequent geometric arrangement on the nanoparticles determine not only the overall size of the colloid but also play a significant role in biokinetics and biodistribution of nanoparticles in the body. The types of specific coating, or derivatization, for these nanoparticles depend on the end application and should be chosen by keeping a particular application in mind, whether it be aimed at inflammation response or anti-cancer agents. Magnetic nanoparticles can bind to drugs, proteins, enzymes, antibodies, or nucleotides and can be directed to an organ, tissue, or tumour using an external magnetic field or can be heated in alternating magnetic fields for use in hyperthermia. This review discusses the synthetic chemistry, fluid stabilization and surface modification of superparamagnetic iron oxide nanoparticles, as well as their use for above biomedical applications.

Table of contents – Volume 26, Issue 18

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The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.

3771
Chemosynthesis of bioresorbable poly(γ-butyrolactone) by ring-opening polymerisation: a review
Moore, Tim / Adhikari, Raju / Gunatillake, Pathiraja | 2004
3771
Chemosynthesis of bioresorbable poly(#x003B;-butyrolactone) by ring-opening polymerisation: a review
Moore, Tim / Adhikari, Raju / Gunatillake, Pathiraja | 2005
3771
Chemosynthesis of bioresorbable poly(g-butyrolactone) by ring-opening polymerisation: a review
Moore, T. / Adhikari, R. / Gunatillake, P. | 2005
3771
Chemosynthesis of bioresorbable poly(gamma-butyrolactone) by ring-opening polymerisation: a review
Moore, Tim / Adhikari, Raju / Gunatillake, Pathiraja | 2005
3783
A potentiostatic study of oxygen transport through poly(2-ethoxyethyl methacrylate-co-2,3-dihydroxypropylmethacrylate) hydrogel membranes
Compañ, Vicente / Tiemblo, Pilar / García, F. / García, J.M. / Guzmán, Julio / Riande, Evaristo | 2004
3793
A new anti-adhesion film synthesized from polygalacturonic acid with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide crosslinker
Lee, Ming-Wei / Hung, Chia-Lu / Cheng, Jian-Chuan / Wang, Yng-Jiin | 2004
3801
The effect of hydrophilic adhesive monomers on the stability of type I collagen
Nezu, Takashi / Nishiyama, Norihiro / Nemoto, Kimiya / Terada, Yoshihiro | 2004
3809
Influence of electron-beam radiation on the hydrolytic degradation behaviour of poly(lactide-co-glycolide) (PLGA)
Chye Joachim Loo, Say / Ping Ooi, Chui / Chiang Freddy Boey, Yin | 2004
3819
Electron spin resonance in silicon substituted apatite and tricalcium phosphate
Pietak, Alexis M. / Reid, Joel W. / Sayer, Michael | 2004
3831
Stable plasma-deposited acrylic acid surfaces for cell culture applications
Detomaso, Loredana / Gristina, Roberto / Senesi, Giorgio S. / d’Agostino, Riccardo / Favia, Pietro | 2004
3843
Fluoridated apatite coatings on titanium obtained by electron-beam deposition
Lee, Eung-Je / Lee, Su-Hee / Kim, Hae-Won / Kong, Young-Min / Kim, Hyoun-Ee | 2004
3853
Electrochemical activation of titanium for biomimetic coating of calcium phosphate
Zhang, Qiyi / Leng, Yang | 2004
3861
Evaluation of mechanical properties and biological response of an alumina-forming Ni-free ferritic alloy
González-Carrasco, J.L. / Ciapetti, G. / Montealegre, M.A. / Pagani, S. / Chao, J. / Baldini, N. | 2004
3873
The effect of bioactive glasses on bone marrow stromal cells differentiation
Bosetti, Michela / Cannas, Mario | 2004
3881
Phospholipase A2 pathway association with macrophage-mediated polycarbonate-urethane biodegradation
Dinnes, Donna Lee M. / Paul Santerre, J. / Labow, Rosalind S. | 2004
3891
Protein adsorption on 18-alkyl chains immobilized on hydroxyl-terminated self-assembled monolayers
Gonçalves, Inês Castro / Martins, Ma Cristina L. / Barbosa, Mário A. / Ratner, Buddy D. | 2004
3901
Tissue reactions of in situ formed dextran hydrogels crosslinked by stereocomplex formation after subcutaneous implantation in rats
Bos, Gert W. / Hennink, Wim E. / Brouwer, Linda A. / den Otter, Wim / Veldhuis, Theo F.J. / van Nostrum, Cornelus F. / van Luyn, Marja J.A. | 2004
3911
An in vivo evaluation of a biodegradable genipin-cross-linked gelatin peripheral nerve guide conduit material
Chen, Yueh-Sheng / Chang, Ju-Ying / Cheng, Chun-Yuan / Tsai, Fuu-Jen / Yao, Chun-Hsu / Liu, Bai-Shuan | 2004
3919
Chitosan#x0201;alginate hybrid scaffolds for bone tissue engineering
Li, Zhensheng / Ramay, Hassna R. / Hauch, Kip D. / Xiao, Demin / Zhang, Miqin | 2005
3919
Chitosan–alginate hybrid scaffolds for bone tissue engineering
Li, Zhensheng / Ramay, Hassna R. / Hauch, Kip D. / Xiao, Demin / Zhang, Miqin | 2004
3929
Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential
Keun Kwon, Il / Kidoaki, Satoru / Matsuda, Takehisa | 2004
3941
Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds
Balakrishnan, Biji / Jayakrishnan, A. | 2004
3953
The role of muscle-derived stem cells in bone tissue engineering
Sun, Jui-Sheng / Wu, Steven Yueh-Hsiu / Lin, Feng-Huei | 2004
3961
Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications
Guan, Jianjun / Fujimoto, Kazuro L. / Sacks, Michael S. / Wagner, William R. | 2004
3973
Shear bond strength of experimental methacrylated beta-cyclodextrin-based formulations
Hussain, Latiff A. / Dickens, Sabine H. / Bowen, Rafael L. | 2004
3981
Effect of LED curing on the microleakage, shear bond strength and surface hardness of a resin-based composite restoration
Oberholzer, Theunis G. / Du Preez, Ignatius C. / Kidd, M. | 2004
3987
Development of an RNA isolation procedure for the characterisation of human endothelial cell interactions with polyurethane cardiovascular bypass grafts
Vara, Dina S. / Punshon, Geoffrey / Sales, Kevin M. / Salacinski, Henryk J. / Dijk, Sas / Brown, Robert A. / Hamilton, George / Seifalian, Alexander M. | 2004
3995
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Gupta, Ajay Kumar / Gupta, Mona | 2004
4023
Collagen–chondroitin sulfate-based PLLA–SAIB-coated rhBMP-2 delivery system for bone repair
Keskin, Dilek Sendil / Tezcaner, Aysen / Korkusuz, Petek / Korkusuz, Feza / Hasirci, Vasif | 2004
4023
Collagen#x0201;chondroitin sulfate-based PLLA#x0201;SAIB-coated rhBMP-2 delivery system for bone repair
Keskin, Dilek Sendil / Tezcaner, Aysen / Korkusuz, Petek / Korkusuz, Feza / Hasirci, Vasif | 2005
4035
Short term in vivo biocompatibility testing of biodegradable poly(D,L-lactide)—growth factor coating for orthopaedic implants
Wildemann, Britt / Sander, Andre / Schwabe, Philipp / Lucke, Martin / Stöckle, Ulrich / Raschke, Michael / Haas, Norbert P. / Schmidmaier, Gerhard | 2004
4035
Short term in vivo biocompatibility testing of biodegradable poly(D,L-lactide)#x0201;growth factor coating for orthopaedic implants
Wildemann, Britt / Sander, Andre / Schwabe, Philipp / Lucke, Martin / Stöckle, Ulrich / Raschke, Michael / Haas, Norbert P. / Schmidmaier, Gerhard | 2005
4041
Photomediated crosslinking of C6-cinnamate derivatized type I collagen
Dong, Chang-Ming / Wu, Xiaoyi / Caves, Jeffrey / Rele, Shyam S. / Thomas, Benjamin S. / Chaikof, Elliot L. | 2004
4051
Effects of aging on the mechanical behavior of human dentin
Arola, D. / Reprogel, R.K. | 2004
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