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Fractured reservoir development process are often faced with the angle wells flooded serious and side wells don’t get the effect of water injection. In order to increase the water flooding sweep efficiency. Profile control plugging is a measure that is frequently used. Traditional plugging program design does not take into account the fluid loss, Program design of the blocking agent dosage is always small, the result is not satisfactory. In this paper, the classic percolation theory is used, seepage equation of the fracture system and matrix system is established, the blocking agent Filtrate analytical solution that considers the different reservoir properties and different blocking agent performance is obtained, that can be used to guide the design of profile control water plugging program and can calculate the best blocking agent dosage. Through the actual implementation of the effect, the proposed method can be more substantial increase in the effect of plugging.