Piperine Inhibits Gastric Emptying and Gastrointestinal Transit in Rats and Mice (English)

in Planta Medica ; 67 , 02 ; 176-179
Planta Medica
; 2001
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Piperine (1), an alkaloid of black and long peppers, inhibited gastric emptying (GE) of solids/liquids in rats and gastrointestinal transit (GT) in mice in a dose and time dependent manner. Compound 1 significantly inhibited GE of solids and GT at the doses extrapolated from humans (1 mg/kg and 1.3 mg/kg P.O. in rats and mice, respectively). However, at the same dose the effect was insignificant for GE of liquids. One week oral treatment of 1 mg/kg and 1.3 mg/kg in rats and mice, respectively, did not produce a significant change in activity as compared to single dose administration. GE inhibitory activity of 1 is independent of gastric acid and pepsin secretion.

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Table of contents – Volume 67, Issue 02

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Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

103
A Sesquiterpene Lactone, Costunolide, from Magnolia grandiflora Inhibits NF-κB by Targeting IκB Phosphorylation
Koo, Tae Hyeon / Lee, Jeong-Hyung / Park, Yun Joo / Hong, Young-Soo / Kim, Hang Sub / Kim, Kyu-Won / Lee, Jung Joon | 2001
108
Influence of Natural and Synthetic Compounds on Cell Surface Expression of Cell Adhesion Molecules, ICAM-1 and VCAM-1
Tanaka, Shigeo / Sakata, Yoichi / Morimoto, Katsushi / Tambe, Yukihiro / Watanabe, Yoshihiko / Honda, Gisho / Tabata, Mamoru / Oshima, Tikashi / Masuda, Toru / Umezawa, Toshiaki et al. | 2001
114
Structure-Antinociceptive Activity Studies of Incarvillateine, a Monoterpene Alkaloid from Incarvillea sinensis
Nakamura, Motoyuki / Chi, Yu-Ming / Yan, Wen-Mei / Yonezawa, Akihiko / Nakasugi, Yumiko / Yoshizawa, Toyokichi / Hashimoto, Fumio / Kinjo, Junei / Nohara, Toshihiro / Sakurada, Shinobu | 2001
118
Kalopanaxsaponin A is a Basic Saponin Structure for the Anti-Tumor Activity of Hederagenin Monodesmosides
Park, Hee-Juhn / Kwon, Sang-Hyuk / Lee, Joo-Han / Lee, Kyou-Heung / Miyamoto, Ken-ichi / Lee, Kyung-Tae | 2001
122
Nitric Oxide is Involved in the Immunomodulating Activities of Acidic Polysaccharide from Panax ginseng
Park, Kyeong Mee / Kim, Young Sook / Jeong, Tae Cheon / Joe, Cheol O. / Shin, Han Jae / Lee, You Hui / Nam, Ki Yeul / Park, Jong Dae | 2001
127
Mutagenicity of Natural Anthraquinones from Rubia tinctorum in the Drosophila Wing Spot Test
Marec, František / Kollárová, Ivana / Jegorov, Alexandr | 2001
132
Inhibitory Effect of Baicalein, a Flavonoid in Scutellaria Root, on Eotaxin Production by Human Dermal Fibroblasts
Nakajima, Toshiharu / Imanishi, Masako / Yamamoto, Kazuhiko / Cyong, Jong-Chol / Hirai, Koichi | 2001
136
Anticonvulsant Properties and Bio-Guided Isolation of Palmitone from Leaves of Annona diversifolia1
González-Trujano, María Eva / Navarrete, Andrés / Reyes, Benito / Cedillo-Portugal, Ernestina / Hong, Enrique | 2001
142
Neuroprotective Effects in Gerbils of Spiramine T from Spiraea japonica var. acuta
Li, Ling / Nie, Jinlei / Shen, Zhiqiang / Wu, Wanling / Chen, Zhihe / Hao, Xiaojiang | 2001
146
In Vitro Propagation of Withania somnifera and Isolation of Withanolides with Immunosuppressive Activity
Furmanowa, Mirosława / Gajdzis-Kuls, Dorota / Ruszkowska, Joanna / Czarnocki, Zbigniew / Obidoska, Grażyna / Sadowska, Ałła / Rani, R. / Upadhyay, Shakti N. | 2001
150
Growth and Production of Camptothecin by Cell Suspension Cultures of Nothapodytes foetida
Fulzele*, Devanand P. / Satdive, Ramesh K. / Pol, B. B. | 2001
153
A New Diterpenoid with Antispasmodic Activity from Salvia cinnabarina
Romussi, Giovanni / Ciarallo, Giovanni / Bisio, Angela / Fontana, Nadia / De Simone, Francesco / De Tommasi, Nunziatina / Mascolo, Nicola / Pinto, Luisa | 2001
156
Pheophorbide A from Solanum diflorum Interferes with NF-κB Activation
Heinrich, Michael / Bork, Peter M. / Schmitz, M. Lienhard / Rimpler, Horst / Frei, Barbara / Sticher, Otto | 2001
158
Inhibition of Xanthine and Monoamine Oxidases by Stilbenoids from Veratrum taliense
Zhou, C. X. / Kong, L. D. / Ye, W. C. / Cheng, Christopher H. K. / Tan, R. X. | 2001
161
In Vitro Anti-Helicobacter pylori Activity of Irisolidone Isolated from the Flowers and Rhizomes of Pueraria thunbergiana
Bae, Eun-Ah / Han, Myung Joo / Kim, Dong-Hyun | 2001
164
In Vitro Activity of a Solanum tuberosum Extract against Mammary Carcinoma Cells
De Lorenzo, Mariana S. / Menna, Pablo Lorenzano / Alonso, Daniel F. / Gomez*, Daniel E. | 2001
166
Lignans as Anti-Tumor-Promoter from the Seeds of Hernandia ovigera
Ito, Chihiro / Itoigawa, Masataka / Ogata, Masakazu / Mou, Xiao Yang / Tokuda, Harukuni / Nishino, Hoyoku / Furukawa, Hiroshi | 2001
168
Essential Oils and Hexane Extracts from Leaves and Fruits of Cistus monspeliensis. Cytotoxic Activity of ent-13-epi-Manoyl Oxide and its Isomers
Angelopoulou, Dimitra / Demetzos, Costas / Dimas, Costas / Perdetzoglou, Dimitrios / Loukis, Anargyros | 2001
172
Cnidicin, a Coumarin, from the Root of Angelica koreana, Inhibits the Degranulation of Mast Cell and the NO Generation in RAW 264.7 Cells
Ryu, Shi Yong / Kou, Na Youn / Choi, Hong Seok / Ryu, Hyun / Kim, Tae Sung / Kim, Kyeong Man | 2001
174
Local Anaesthetic Activity of (+)- and (-)-Menthol
Galeotti, Nicoletta / Ghelardini, Carla / Di Cesare Mannelli, Lorenzo / Mazzanti, Gabriela / Baghiroli, Laura / Bartolini, Alessandro | 2001
176
Piperine Inhibits Gastric Emptying and Gastrointestinal Transit in Rats and Mice
Bajad, Sunil / Bedi, K. L. / Singla, A. K. / Johri, R. K. | 2001
179
Modulatory Effect of Aliphatic Acid Amides from Zanthoxylum piperitum on Isolated Gastrointestinal Tract
Hashimoto, Kazunori / Satoh, Kazuko / Kase, Yoshio / Ishige, Atsushi / Kubo, Masayoshi / Sasaki, Hiroshi / Nishikawa, Shigeto / Kurosawa, Susumu / Yakabi, Koji / Nakamura, Takashi | 2001
181
In Vitro Plantlet Regeneration in Panax sikkimensis
Mathur*, Archana / Mathur, Ajay Kumar / Gangwar, Anita | 2001
183
Authentic Identification of Stigma Croci (Stigma of Crocus sativus) from its Adulterants by Molecular Genetic Analysis
Ma, X. Q. / Zhu, D. Y. / Li, S. P. / Dong, T. T. X. / Tsim, K. W. K. | 2001
186
Dihydrochalcones from Piper longicaudatum
Joshi, A. S. / Li, X.-C. / Nimrod, A. C. / ElSohly, H. N. / Walker, L. A. / Clark, A. M. | 2001
189
Isoquinoline Alkaloids from Thalictrum delavayi
Li, Mai / Chen, Xin / Tang, Qin-Mei / Zhang*, Jin-Sheng | 2001
191
Crinane and Lycorane Type Alkaloids from Zephyranthes citrina
Herrera, María R. / Machocho, Alex K. / Brun, Reto / Viladomat, Francesc / Codina, Carles / Bastida, Jaume | 2001
194
Acutudaurin from Cultured Roots of Menispermum dauricum
Furumoto, Toshio / Sugimoto, Yukihiro | 2001
196
Steroidal Saponins from Tribulus terrestris
Cai, Lifeng / Wu, Yijie / Zhang, Jianguo / Pei, Fengkui / Xu, Yajuan / Xie, Shengxu / Xu, Dongming | 2001

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