Distribution of 4a‐hydroxytetrahydropterin dehydratase in rat tissues Comparison with the aromatic amino acid hydroxylases (English)

in FEBS Letters ; 302 , 1 ; 73-76
FEBS Letters
; 1992
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A 4a‐carbinolamine intermediate is generated stoichiometrically during the tetrahydrobiopterin‐dependent phenylalanine hydroxylation reaction catalyzed by phenylalanine hydroxylase. The dehydration of the carbinolamine is catalyzed by the enzyme, 4a‐hydroxytetrahydropterin dehydratase. We have now examined the distribution of the dehydratase activity in various rat tissues by activity measurements and by immunoblot analysis to explore the possibility that the dehydratase may also play a role in tyrosine and tryptophan hydroxylation. The only two tissues that express relatively high dehydratase activity are liver and kidney, which are also the only two tissues that express phenylalanine hydroxylase activity. The dehydratase activity was generally very low in those tissues which contain high levels of tyrosine and tryptophan hydroxylase activity, except for the pineal gland. These results suggest that the dehydratase may not play an important role in the regulation of the synthesis of those neurotransmitters which are derived from the hydroxylated aromatic amino acids.

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Pseudouridine in the large‐subunit (23 S‐like) ribosomal RNA The site of peptidyl transfer in the ribosome?
Lane, Byron G. / Ofengand, James / Gray, Michael W. | 1992
Production of a unique multi‐lamella structure in the nuclei of yeast expressing Drosophila copia gag precursor
Yoshioka, Katsuji / Fujita, Atsushi / Kondo, Shunzo / Miyake, Tadashi / Sakaki, Yoshiyuki / Shiba, Tadayoshi | 1992
Left‐handed topology of super‐secondary structure formed by aligned α‐helix and β‐hairpin
Kajava, A.V. | 1992
(Model) studies on vanadate‐dependent bromo/iodoperoxidase from Ascophyllum nodosum VO2+ is not incorporated into the active site
Knüttel, Karlheinz / Müller, Achim / Rehder, Dieter / Vilter, Hans / Wittneben, Volker | 1992
Assembly and processing of subunit II (PsaD) precursor in the isolated photosystem‐I complex
Cohen, Yuval / Nechushtai, Rachel | 1992
Involvement of a non‐proton pump factor (possibly Donnan‐type equilibrium) in maintenance of an acidic pH in lysosomes
Moriyama, Yoshinori / Maeda, Masatomo / Futai, Masamitsu | 1992
Level of expression controls modes of gating of a K+ channel
Moran, Ofira / Schreibmayer, Wolfgang / Weigl, Lukas / Dascal, Nathan / Lotan, Ilana | 1992
C‐CAM (Cell‐CAM 105) is a calmodulin binding protein
Blikstad, Ingrid B. / Wikström, Tarja / Aurivillius, Magnus / Öbrink, Björn | 1992
Cloning of a bovine voltage‐gated K+ channel gene utilising partial amino acid sequence of a dendrotoxin‐binding protein from brain cortex
Reid, Paul F. / Pongs, Olaf / Dolly, J.Oliver | 1992
Up‐regulation of interleukin (IL)‐6 receptor gene expression in vitro and in vivo in IL‐6 deprived myeloma cells
Portier, Marielle / Lees, Delphine / Caron, Emmanuelle / Jourdan, Michel / Boiron, Jean-Michel / Bataille, Regis / Klein, Bernard | 1992
Recognition of an antiparallel β‐sheet structure of human epidermal growth factor by its receptor Site‐directed mutagenesis studies of Ala‐30 and Asn‐32
Koide, Hiroshi / Muto, Yutaka / Kasai, Hidefumi / Hoshi, Kumiko / Takusari, Hiromi / Kohri, Kaoru / Takahashi, Seizo / Sasaki, Tetsuyuki / Tsukumo, Ken-ichi / Miyake, Tetsuo et al. | 1992
Basic fibroblast growth factor (bFGF) in rodent testis Presence of bFGF mRNA and of a 30 kDa bFGF protein in pachytene spermatocytes
Lahr, Georgia / Mayerhofer, Artur / Seidl, Klaus / Bucher, Sabine / Grothe, Claudia / Knöchel, Walter / Gratzl, Manfred | 1992
The influence of the target structure on the efficiency of alkylation of single‐stranded DNA with the reactive derivatives of antisense oligonucleotides
Fedorova, O.S. / Podust, L.M. / Maksakova, G.A. / Gorn, V.V. / Knorre, D.G. | 1992
Murine ST2 gene is a member of the primary response gene family induced by growth factors
Yanagisawa, Ken / Tsukamoto, Toshihiko / Takagi, Toshimitsu / Tominaga, Shin-ichi | 1992
A comparative study of the relationship between thermostability and function of phenylalanyl‐tRNA synthetases from Escherichia coli and Thermus thermophilus
Bobkova, Ekaterina V. / Stepanov, Victor G. / Lavrik, Ol'ga I. | 1992
The path of a protein chain can be approximated by the conformation dictated by interpeptide ionic bridges
Lim, Valery I. / Venclovas, Česlovas / Kurochkina, Natalya A. | 1992
Rapid agonist‐induced beta‐adrenergic receptor kinase translocation in C6 glioma cells
Garcia-Higuera, Irene / Mayor, Federico | 1992
Kinetic analysis of translocation into isolated chloroplasts of the purified ferredoxin precursor
Pilon, Marinus / Weisbeek, Peter J. / de Kruijff, Ben | 1992
Purification of the 28.5 kDa cytosolic protein involved in the activation of NADPH oxidase from guinea pig neutrophils
Someya, Akimasa / Yomogida, Shin / Nagaoka, Isao / Iwabuchi, Kazuhisa / Yamashita, Tatsuhisa | 1992
Distribution of 4a‐hydroxytetrahydropterin dehydratase in rat tissues Comparison with the aromatic amino acid hydroxylases
Davis, Michael D. / Kaufman, Seymour / Milstien, Sheldon | 1992
Cellobiose oxidase of Phanerochaete chrysosporium enhances crystalline cellulose degradation by cellulases
Bao, Wenjun / Renganathan, V. | 1992
A large conductance ion channel in the nuclear envelope of a higher plant cell
Matzke, A.J.M. / Behensky, C. / Weiger, T. / Matzke, M.A. | 1992
A Ca2+‐dependent protein kinase phosphorylates phosphoenolpyruvate carboxylase in maize
Ogawa, Noriyuki / Okumura, Satoru / Izui, Katsura | 1992
Solution structure of FK506 bound to FKBP‐12
Lepre, Christopher A. / Thomson, John A. / Moore, Jonathan M. | 1992
Design, synthesis and solution structure of a renin inhibitor Structural constraints from NOE, and homonuclear and heteronuclear coupling constants combined with distance geometry calculations
Reily, Michael D. / Thanabal, Venkataraman / Lunney, Elizabeth A. / Repine, Joseph T. / Humblet, Christine C. / Wagner, Gerhard | 1992
Editorial board
| 1992

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