INTRARENAL OXYGEN IN DIABETES AND A POSSIBLE LINK TO DIABETIC NEPHROPATHY (English)

Clinical and Experimental Pharmacology and Physiology

Diabetic nephropathy is a major cause of morbidity and mortality. The exact mechanism mediating the negative influence of hyperglycaemia on renal function remains unclear, although several hypotheses have been postulated. The cellular mechanisms include glucose‐induced excessive formation of reactive oxygen species, increased glucose flux through the polyol pathway and formation of advanced glycation end‐products. The renal effects in vivo of each and every one of these mechanisms are even less clear. However, there is growing evidence that hyperglycaemia results in altered renal oxygen metabolism and decreased renal oxygen tension and that these changes are linked to altered kidney function.

Clinical data regarding renal oxygen metabolism and oxygen tension are currently rudimentary and our present understanding regarding renal oxygenation during diabetes is predominantly derived from data obtained from animal models of experimental diabetic nephropathy.

This review will present recent findings regarding the link between hyperglycaemia and diabetes‐induced alterations in renal oxygen metabolism and renal oxygen availability.

A possible link between reduced renal oxygen tension and the development of diabetic nephropathy includes increased polyol pathway activity and oxidative stress, which result in decreased renal oxygenation and subsequent activation of hypoxia‐inducible factors. This initiates increased gene expression of numerous genes known to be involved in development of diabetic nephropathy.

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Table of contents – Volume 33, Issue 10

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Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

893
COMPUTER SIMULATIONS OF TRANSPORT THROUGH MEMBRANES: PASSIVE DIFFUSION, PORES, CHANNELS AND TRANSPORTERS
Tieleman, D Peter | 2006
904
ROLE OF HYPOTHALAMIC a2-ADRENOCEPTOR ACTIVITY IN FRUCTOSE-INDUCED HYPERTENSION
Mayer, M. A. / Hocht, C. / Opezzo, J. A. / Peredo, H. A. / Navacchia, D. / Taira, C. A. / Fernandez, B. E. / Puyo, A. M. | 2006
904
ROLE OF HYPOTHALAMIC α2‐ADRENOCEPTOR ACTIVITY IN FRUCTOSE‐INDUCED HYPERTENSION
Mayer, Marcos A / Höcht, Christian / Opezzo, Javier AW / Peredo, Horacio A / Navacchia, Daniel / Taira, Carlos A / Fernández, Belisario E / Puyó, Ana M | 2006
910
PARADOXICALLY ENHANCED HEART TOLERANCE TO ISCHAEMIA IN TYPE 1 DIABETES AND ROLE OF INCREASED OSMOLARITY
Chen, Hong / Shen, Wei‐Li / Wang, Xu‐Hui / Chen, Hong‐Zhuan / Gu, Jian‐Zhong / Fu, Jie / Ni, Ya‐Feng / Gao, Ping‐Jin / Zhu, Ding‐Liang / Higashino, Hideaki | 2006
917
EXTENT OF RENAL EFFECT OF CYCLO‐OXYGENASE‐2‐SELECTIVE INHIBITORS IS PHARMACOKINETIC DEPENDENT
Harirforoosh, Sam / Aghazadeh‐Habashi, Ali / Jamali, Fakhreddin | 2006
925
HEPATOPROTECTIVE AND HYPOLIPIDAEMIC EFFECTS OF GLYCOPROTEIN ISOLATED FROM GARDENIA JASMINOIDES ELLIS IN MICE
Lee, Sei‐Jung / Oh, Phil‐Sun / Lim, Kye‐Taek | 2006
934
DOCOSAHEXAENOIC ACID-INDUCED PROTECTIVE EFFECT AGAINST IMPAIRED LEARNING IN AMYLOID b-INFUSED RATS IS ASSOCIATED WITH INCREASED SYNAPTOSOMAL MEMBRANE FLUIDITY
Hashimoto, M. / Hossain, S. / Shimada, T. / Shido, O. | 2006
934
DOCOSAHEXAENOIC ACID‐INDUCED PROTECTIVE EFFECT AGAINST IMPAIRED LEARNING IN AMYLOID β‐INFUSED RATS IS ASSOCIATED WITH INCREASED SYNAPTOSOMAL MEMBRANE FLUIDITY
Hashimoto, Michio / Hossain, Shahdat / Shimada, Toshio / Shido, Osamu | 2006
940
CURCUMIN, THE ACTIVE PRINCIPLE OF TURMERIC (CURCUMA LONGA), AMELIORATES DIABETIC NEPHROPATHY IN RATS
Sharma, Sameer / Kulkarni, Shrinivas K / Chopra, Kanwaljit | 2006
946
PROSTAGLANDINS, CAPSAICIN‐SENSITIVE SENSORY NERVES AND NEUTROPHIL INFILTRATION, BUT NOT NITRIC OXIDE, CONTRIBUTE TO COLD RESTRAINT STRESS‐INDUCED GASTRIC ADAPTATION IN RATS
Tan, Ruken / Bülbül, Mehmet / Öngüt, Gözde / Tosun, Özgür / İzgüt‐Uysal, V Nimet | 2006
952
A PROTEOMIC ANALYSIS OF THE ACUTE EFFECTS OF HIGH‐INTENSITY EXERCISE ON SKELETAL MUSCLE PROTEINS IN FASTED RATS
Guelfi, Kym J / Casey, Tammy M / Giles, Jeffrey J / Fournier, Paul A / Arthur, Peter G | 2006
958
INTRODUCTION
Evans, Roger G / Denton, Kate M | 2006
961
RENAL OXYGEN DELIVERY: MATCHING DELIVERY TO METABOLIC DEMAND
O’Connor, Paul M | 2006
968
HYPOXIA‐INDUCED ERYTHROPOIETIN PRODUCTION: A PARADIGM FOR OXYGEN‐REGULATED GENE EXPRESSION
Stockmann, Christian / Fandrey, Joachim | 2006
980
RENAL PARENCHYMAL OXYGENATION AND HYPOXIA ADAPTATION IN ACUTE KIDNEY INJURY
Rosenberger, Christian / Rosen, Seymour / Heyman, Samuel N | 2006
989
INTRARENAL OXYGENATION IN CHRONIC RENAL FAILURE
Norman, Jill T / Fine, Leon G | 2006
997
INTRARENAL OXYGEN IN DIABETES AND A POSSIBLE LINK TO DIABETIC NEPHROPATHY
Palm, Fredrik | 2006
1002
INTRARENAL OXYGEN AND HYPERTENSION
Welch, William J | 2006
1006
Scientific Writing: Easy When You Know How; Successful Scientific Writing: A Step‐by‐Step Guide for the Biological and Medical Sciences; Writing Successfully in Science
Ludbrook, John | 2006

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