RENAL OXYGEN DELIVERY: MATCHING DELIVERY TO METABOLIC DEMAND (English)

Clinical and Experimental Pharmacology and Physiology

The kidneys are second only to the heart in terms of O2 consumption; however, relative to other organs, the kidneys receive a very high blood flow and oxygen extraction in the healthy kidney is low. Despite low arterial–venous O2 extraction, the kidneys are particularly susceptible to hypoxic injury and much interest surrounds the role of renal hypoxia in the development and progression of both acute and chronic renal disease.

Numerous regulatory mechanisms have been identified that act to maintain renal parenchymal oxygenation within homeostatic limits in the in vivo kidney. However, the processes by which many of these mechanisms act to modulate renal oxygenation and the factors that influence these processes remain poorly understood.

A number of such mechanisms specific to the kidney are reviewed herein, including the relationship between renal blood flow and O2 consumption, pre‐ and post‐glomerular arterial–venous O2 shunting, tubulovascular cross‐talk, the differential control of regional kidney blood flow and the tubuloglomerular feedback mechanism.

The roles of these mechanisms in the control of renal oxygenation, as well as how dysfunction of these mechanisms may lead to renal hypoxia, are discussed.

How to get this document?
Download
Commercial Copyright fee: €44.08 Basic fee: €4.00 Total price: €48.08
Academic Copyright fee: €44.08 Basic fee: €2.00 Total price: €46.08

Document information


Table of contents – Volume 33, Issue 10

Show all volumes and issues

Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

893
COMPUTER SIMULATIONS OF TRANSPORT THROUGH MEMBRANES: PASSIVE DIFFUSION, PORES, CHANNELS AND TRANSPORTERS
Tieleman, D Peter | 2006
904
ROLE OF HYPOTHALAMIC α2‐ADRENOCEPTOR ACTIVITY IN FRUCTOSE‐INDUCED HYPERTENSION
Mayer, Marcos A / Höcht, Christian / Opezzo, Javier AW / Peredo, Horacio A / Navacchia, Daniel / Taira, Carlos A / Fernández, Belisario E / Puyó, Ana M | 2006
904
ROLE OF HYPOTHALAMIC a2-ADRENOCEPTOR ACTIVITY IN FRUCTOSE-INDUCED HYPERTENSION
Mayer, M. A. / Hocht, C. / Opezzo, J. A. / Peredo, H. A. / Navacchia, D. / Taira, C. A. / Fernandez, B. E. / Puyo, A. M. | 2006
910
PARADOXICALLY ENHANCED HEART TOLERANCE TO ISCHAEMIA IN TYPE 1 DIABETES AND ROLE OF INCREASED OSMOLARITY
Chen, Hong / Shen, Wei‐Li / Wang, Xu‐Hui / Chen, Hong‐Zhuan / Gu, Jian‐Zhong / Fu, Jie / Ni, Ya‐Feng / Gao, Ping‐Jin / Zhu, Ding‐Liang / Higashino, Hideaki | 2006
917
EXTENT OF RENAL EFFECT OF CYCLO‐OXYGENASE‐2‐SELECTIVE INHIBITORS IS PHARMACOKINETIC DEPENDENT
Harirforoosh, Sam / Aghazadeh‐Habashi, Ali / Jamali, Fakhreddin | 2006
925
HEPATOPROTECTIVE AND HYPOLIPIDAEMIC EFFECTS OF GLYCOPROTEIN ISOLATED FROM GARDENIA JASMINOIDES ELLIS IN MICE
Lee, Sei‐Jung / Oh, Phil‐Sun / Lim, Kye‐Taek | 2006
934
DOCOSAHEXAENOIC ACID-INDUCED PROTECTIVE EFFECT AGAINST IMPAIRED LEARNING IN AMYLOID b-INFUSED RATS IS ASSOCIATED WITH INCREASED SYNAPTOSOMAL MEMBRANE FLUIDITY
Hashimoto, M. / Hossain, S. / Shimada, T. / Shido, O. | 2006
934
DOCOSAHEXAENOIC ACID‐INDUCED PROTECTIVE EFFECT AGAINST IMPAIRED LEARNING IN AMYLOID β‐INFUSED RATS IS ASSOCIATED WITH INCREASED SYNAPTOSOMAL MEMBRANE FLUIDITY
Hashimoto, Michio / Hossain, Shahdat / Shimada, Toshio / Shido, Osamu | 2006
940
CURCUMIN, THE ACTIVE PRINCIPLE OF TURMERIC (CURCUMA LONGA), AMELIORATES DIABETIC NEPHROPATHY IN RATS
Sharma, Sameer / Kulkarni, Shrinivas K / Chopra, Kanwaljit | 2006
946
PROSTAGLANDINS, CAPSAICIN‐SENSITIVE SENSORY NERVES AND NEUTROPHIL INFILTRATION, BUT NOT NITRIC OXIDE, CONTRIBUTE TO COLD RESTRAINT STRESS‐INDUCED GASTRIC ADAPTATION IN RATS
Tan, Ruken / Bülbül, Mehmet / Öngüt, Gözde / Tosun, Özgür / İzgüt‐Uysal, V Nimet | 2006
952
A PROTEOMIC ANALYSIS OF THE ACUTE EFFECTS OF HIGH‐INTENSITY EXERCISE ON SKELETAL MUSCLE PROTEINS IN FASTED RATS
Guelfi, Kym J / Casey, Tammy M / Giles, Jeffrey J / Fournier, Paul A / Arthur, Peter G | 2006
958
INTRODUCTION
Evans, Roger G / Denton, Kate M | 2006
961
RENAL OXYGEN DELIVERY: MATCHING DELIVERY TO METABOLIC DEMAND
O’Connor, Paul M | 2006
968
HYPOXIA‐INDUCED ERYTHROPOIETIN PRODUCTION: A PARADIGM FOR OXYGEN‐REGULATED GENE EXPRESSION
Stockmann, Christian / Fandrey, Joachim | 2006
980
RENAL PARENCHYMAL OXYGENATION AND HYPOXIA ADAPTATION IN ACUTE KIDNEY INJURY
Rosenberger, Christian / Rosen, Seymour / Heyman, Samuel N | 2006
989
INTRARENAL OXYGENATION IN CHRONIC RENAL FAILURE
Norman, Jill T / Fine, Leon G | 2006
997
INTRARENAL OXYGEN IN DIABETES AND A POSSIBLE LINK TO DIABETIC NEPHROPATHY
Palm, Fredrik | 2006
1002
INTRARENAL OXYGEN AND HYPERTENSION
Welch, William J | 2006
1006
Scientific Writing: Easy When You Know How; Successful Scientific Writing: A Step‐by‐Step Guide for the Biological and Medical Sciences; Writing Successfully in Science
Ludbrook, John | 2006

Similar titles