ANGIOTENSIN II‐INDUCED GROWTH OF VASCULAR SMOOTH MUSCLE CELLS IS ASSOCIATED WITH MODULATION OF CELL SURFACE AREA AND PLATELET‐DERIVED GROWTH FACTOR RECEPTOR EXPRESSION (English)

Clinical and Experimental Pharmacology and Physiology

Excessive growth of vascular smooth muscle cells (VSMC) can lead to critical problems in the treatment of some vascular diseases. Recent studies suggest a connection between this abnormal growth of VSMC and the octapeptide hormone angiotensin (Ang) II. However, the growth‐promotive potential of AngII on VSMC is unclear.

Using the novel AngII inhibitor E4177 and an original animal model, we confirmed that AngII does function in abnormal growth of VSMC induced after transplantation of vein grafts in an animal model.

Furthermore, using a primary culture of human aortic smooth muscle cells (HASMC), we found that AngII augmented the growth of HASMC in a serum‐dependent manner and induced enlargement of the cell surface area in HASMC, both effects being nullified by E4177. The latter effect of AngII was associated with an increase in the expression level of platelet‐derived growth factor (PDGF) receptors. In specimens obtained from the animal model, PDGF receptors were highly expressed.

These data obtained in vitro and in vivo imply that AngII has the potential to promote growth of VSMC and suggest that this growth promotion may be mediated by enlargement of the cell surface area.

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Table of contents – Volume 34, Issue 3

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135
CHOLESTEROL, STATINS AND CANCER
Brown, Andrew J | 2007
142
EFFICACY OF SARGASSUM POLYCYSTUM (PHAEOPHYCEAE) SULPHATED POLYSACCHARIDE AGAINST PARACETAMOL‐INDUCED DNA FRAGMENTATION AND MODULATION OF MEMBRANE‐BOUND PHOSPHATASES DURING TOXIC HEPATITIS
Raghavendran, HB / Sathivel, A / Yogeeta, RSSK / Devaki, T | 2007
148
FUNCTIONAL IMPAIRMENT OF CARDIAC TRANSIENT OUTWARD K+ CURRENT AS A RESULT OF ABNORMALLY ALTERED CELLULAR ENVIRONMENT
Du, Zhimin / Chaoqian, Xu / Shan, Hongli / Lu, Yanjie / Ren, Nanqi | 2007
153
ANGIOTENSIN II‐INDUCED GROWTH OF VASCULAR SMOOTH MUSCLE CELLS IS ASSOCIATED WITH MODULATION OF CELL SURFACE AREA AND PLATELET‐DERIVED GROWTH FACTOR RECEPTOR EXPRESSION
Kuma, Sosei / Oki, Eiji / Onohara, Toshihiro / Komori, Kimihiro / Maehara, Yoshihiko | 2007
161
CHANGES IN THE IN VITRO PHARMACODYNAMIC PROPERTIES OF METOPROLOL IN ATRIA ISOLATED FROM SPONTANEOUSLY HYPERTENSIVE RATS
Di Verniero, Carla / Höcht, Christian / Opezzo, Javier A W / Taira, Carlos A | 2007
166
CARDIOPROTECTIVE EFFECTS OF A NON‐ALCOHOLIC EXTRACT OF RED WINE DURING ISCHAEMIA AND REPERFUSION IN SPONTANEOUSLY HYPERTENSIVE RATS
Fantinelli, Juliana C / Mosca, Susana M | 2007
170
EFFECTS OF SHRIMP (MACROBRACIUM ROSENBERGII)‐DERIVED CHITOSAN ON PLASMA LIPID PROFILE AND LIVER LIPID PEROXIDE LEVELS IN NORMO‐ AND HYPERCHOLESTEROLAEMIC RATS
Hossain, Shahdat / Rahman, Azizur / Kabir, Yearul / Shams, Ali Ahmed / Afros, Fahmida / Hashimoto, Michio | 2007
177
NEUROPROTECTIVE EFFECTS OF DAURICINE AGAINST APOPTOSIS INDUCED BY TRANSIENT FOCAL CEREBRAL ISCHAEMIA IN RATS VIA A MITOCHONDRIAL PATHWAY
Li, Yan‐Hong / Gong, Pei‐Li | 2007
185
FIBRIN D‐DIMER FRAGMENTS ENHANCE INFLAMMATORY RESPONSES IN MACROPHAGES: ROLE IN ADVANCING ATHEROSCLEROSIS
Zhou, Dong / Yang, Peng‐Yuan / Zhou, Bin / Rui, Yao‐Cheng | 2007
191
DIFFERENTIAL DEVELOPMENT OF CARBACHOL‐INDUCED DESENSITIZATION IN RECEPTOR‐MEDIATED Ca2+ INFLUX AND Ca2+ RELEASE PATHWAYS IN SMOOTH MUSCLE OF GUINEA‐PIG TAENIA CAECI
Hishinuma, Shigeru / Matsumoto, Yukio / Sato, Ryo / Saito, Masaki | 2007
198
AMINO ACID AND FATTY ACID COMPOSITION OF AN AQUEOUS EXTRACT OF CHANNA STRIATUS (HARUAN) THAT EXHIBITS ANTINOCICEPTIVE ACTIVITY
Zakaria, ZA / Mat Jais, AM / Goh, YM / Sulaiman, MR / Somchit, MN | 2007
205
ANGIOTENSIN II INCREASES TISSUE‐SPECIFIC INHIBITOR OF METALLOPROTEINASE‐2 EXPRESSION IN RAT AORTIC SMOOTH MUSCLE CELLS IN VIVO: EVIDENCE OF A PRESSURE‐INDEPENDENT EFFECT
Castoldi, G / Di Gioia, CRT / Travaglini, C / Busca, G / Redaelli, S / Bombardi, C / Stella, A | 2007
210
STOBADINE PROTECTS RAT KIDNEY AGAINST ISCHAEMIA/REPERFUSION INJURY
Guz, Galip / Demirogullari, Billur / Ulusu, Nuray N / Dogu, Cihangir / Demirtola, Arzu / Kavutcu, Mustafa / Omeroglu, Suna / Stefek, Milan / Karasu, Cimen | 2007
217
POTENTIAL FOR ENDOTHELIN‐1‐MEDIATED IMPAIRMENT OF CONTRACTILE ACTIVITY IN HYPERTENSION
Kolka, Cathryn M / Rattigan, Stephen / Richards, Stephen M / Clark, Michael G | 2007
223
ROLE OF DORSAL HIPPOCAMPAL CANNABINOID RECEPTORS AND NITRIC OXIDE IN ANXIETY LIKE BEHAVIOURS IN RATS USING THE ELEVATED PLUS‐MAZE TEST
Roohbakhsh, Ali / Moghaddam, Akbar Hajizadeh / Massoudi, Roohollah / Zarrindast, Mohammad‐Reza | 2007
230
DIFFERENTIAL GROWTH INHIBITION AND INDUCTION OF APOPTOSIS BY GOSSYPOL BETWEEN HCT116 AND HCT116/BAX−/– COLORECTAL CANCER CELLS
Zhang, Manchao / Liu, Hongpeng / Tian, Zhenkun / Huang, Jenny / Remo, Mylene / Li, Q Quentin | 2007
238
BENEFICIAL EFFECT OF XANTHOANGELOL, A CHALCONE COMPOUND FROM ANGELICA KEISKEI, ON LIPID METABOLISM IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Ogawa, Hiroshi / Okada, Yukiko / Kamisako, Toshinori / Baba, Kimiye | 2007
244
AMELIORATIVE EFFECT OF CHLOROPHYTUM BORIVILIANUM ROOT ON LIPID METABOLISM IN HYPERLIPAEMIC RATS
Visavadiya, NP / Narasimhacharya, AVRL | 2007
250
ACUTE CORONARY LIGATION IN THE DOG INDUCES TIME‐DEPENDENT TRANSITIONAL CHANGES IN MITOCHONDRIAL CRISTA IN THE NON‐ISCHAEMIC VENTRICULAR MYOCARDIUM
McLachlan, Craig Steven / Almsherqi, Zakaria A / Chua, Kerin Sze Yi / Liew, Yu Ying / Low, Chwee Wah / Deng, Yuru | 2007
254
LETTER TO THE EDITOR
Palomeque, Jesús CG / Ruiz, Hugo G | 2007

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