EFFECTS OF LANDIOLOL ON MECHANICAL AND METABOLIC CHANGES IN RAT REPERFUSED ISCHAEMIC HEARTS (English)

Clinical and Experimental Pharmacology and Physiology

The aim of the present study was to clarify the effects of landiolol, a short‐acting selective β1‐adrenoceptor blocking agent, on mechanical and metabolic changes in postischaemic perfused hearts.

Rat isolated hearts (n = 30) were randomly separated into non‐ischaemic or ischaemic groups. The latter group was further divided into Krebs’–Henseleit solution (KHS)‐ and landiolol (30, 100 or 300 µmol/L)‐treated groups. Ischaemic hearts were subjected to 25 min global ischaemia and 20 min reperfusion under atrial pacing. Time‐course changes in left ventricular (LV) end‐diastolic pressure (LVEDP), LV developed pressure (LVDP), peak positive velocity of change of LV pressure (LVdP/dtmax) and coronary flow were observed along with tissue contents of adenosine triphosphate (ATP), creatine phosphate, inorganic phosphate (Pi), malondialdehyde (MDA) and lactate dehydrogenase (LDH) release in coronary effluent. The effects of landiolol on rat isolated aortic preparations under KCl contraction were also investigated.

Ischaemia–reperfusion significantly impaired cardiodynamics, such as LVEDP, LVDP and LVdP/dtmax, decreased myocardial ATP content and increased Pi and LDH release. In the 30 µmol/L landiolol‐treated group, cardiovascular parameters impaired by ischaemia–reperfusion and increased LDH release were further exacerbated and myocardial MDA content was significantly increased. In the 300 µmol/L landiolol‐treated group, cardiac contractile dysfunction was improved and myocardial MDA, ATP and Pi contents were preserved. All measurements in the 100 µmol/L landiolol‐treated group were similar to those in the ischaemic KHS group. Furthermore, significant relaxations of isolated aortic preparations were obtained with landiolol 30–1000 µmol/L, suggesting a possible calcium antagonism with landiolol.

In conclusion, landiolol, at low concentrations, aggravated myocardial ischaemia–reperfusion injuries, whereas at high concentrations it ameliorated them. The former effect may be mediated by the production of reactive oxygen species, whereas the latter may involve calcium antagonist activity.

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Table of contents – Volume 34, Issue 1-2

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Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

1
SLEEP AND METABOLIC CONTROL: WAKING TO A PROBLEM?
Trenell, Michael I / Marshall, Nathaniel S / Rogers, Naomi L | 2007
10
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Freitas, Cristiane F / Morganti, Rafael P / Annichino‐Bizzacchi, Joyce M / De Nucci, Gilberto / Antunes, Edson | 2007
15
Ca2+‐DEPENDENT DIFFERENTIAL DEVELOPMENT OF CARBACHOL‐INDUCED DESENSITIZATION TO RECEPTOR AGONISTS AND HIGH K+ IN GUINEA‐PIG TAENIA CAECI
Hishinuma, Shigeru / Matsumoto, Yukio / Sato, Ryo / Saito, Masaki | 2007
22
THE SPECIFIC FREE RADICAL SCAVENGER EDARAVONE SUPPRESSES BLEOMYCIN‐INDUCED ACUTE PULMONARY INJURY IN RABBITS
Asai, Toshihiro / Ohno, Yasushi / Minatoguchi, Shinya / Funaguchi, Norihiko / Yuhgetsu, Hideyuki / Sawada, Masahiro / Takemura, Genzou / Komada, A / Fujiwara, Takako / Fujiwara, Hisayoshi | 2007
27
EFFECTS OF FENOFIBRATE AND XUEZHIKANG ON HIGH‐FAT DIET‐INDUCED NON‐ALCOHOLIC FATTY LIVER DISEASE
Hong, Xue Zhi / Li, Lian Da / Wu, Li Mao | 2007
36
CYCLO‐OXYGENASE‐2 INHIBITION ATTENUATES THE PROGRESSION OF NEPHROPATHY IN UNINEPHRECTOMIZED DIABETIC RATS
Komers, Radko / Lindsley, Jessie N / Oyama, Terry T / Anderson, Sharon | 2007
42
EFFECT OF α1‐ADRENOCEPTOR SUBTYPE‐SELECTIVE INVERSE AGONISTS ON NON‐PREGNANT AND LATE‐PREGNANT CERVICAL RESISTANCE IN VITRO IN THE RAT
Kolarovszki‐Sipiczki, Zoltán / Gáspár, Róbert / Ducza, Eszter / Páldy, Eszter / Benyhe, Sándor / Borsodi, Anna / Falkay, George | 2007
42
EFFECT OF a1-ADRENOCEPTOR SUBTYPE-SELECTIVE INVERSE AGONISTS ON NON-PREGNANT AND LATE-PREGNANT CERVICAL RESISTANCE IN VITRO IN THE RAT:
Kolarovszki-Sipiczki, Z. / Gaspar, R. / Ducza, E. / Paldy, E. / Benyhe, S. / Borsodi, A. / Falkay, G. | 2007
48
IMPAIRED EFFECT OF SALT LOADING ON NITRIC OXIDE‐MEDIATED RELAXATION IN AORTAS FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Kagota, Satomi / Kubota, Yoko / Nejime, Namie / Nakamura, Kazuki / Kunitomo, Masaru / Shinozuka, Kazumasa | 2007
55
EFFECTS OF LANDIOLOL ON MECHANICAL AND METABOLIC CHANGES IN RAT REPERFUSED ISCHAEMIC HEARTS
Sakanashi, Makiko / Sakanashi, Mayuko / Sugahara, Kazuhiro / Sakanashi, Matao | 2007
61
ENDOTOXIN‐INDUCED ACUTE LUNG INJURY IS ENHANCED IN RATS WITH SPONTANEOUS HYPERTENSION
Liu, Demeral D / Hsiang Hsu, Yung / Chen, Hsing I | 2007
70
EFFECTS OF HYPERBARIC OXYGEN ON GLUCOSE, LACTATE, GLYCEROL AND ANTI‐OXIDANT ENZYMES IN THE SKELETAL MUSCLE OF RATS DURING ISCHAEMIA AND REPERFUSION
Bosco, Gerardo / Yang, Zhong‐jin / Nandi, Jyotirmoy / Wang, Jingping / Chen, Chung / Camporesi, Enrico M | 2007
77
MOUSE STRAIN‐SPECIFIC DIFFERENCES IN CARDIAC METABOLIC ENZYME ACTIVITIES OBSERVED IN A MODEL OF ISOPROTERENOL‐INDUCED CARDIAC HYPERTROPHY
Faulx, Michael D / Chandler, Margaret P / Zawaneh, Michael S / Stanley, William C / Hoit, Brian D | 2007
81
CARDIAC‐SPECIFIC OVEREXPRESSION OF CATALASE PROLONGS LIFESPAN AND ATTENUATES AGEING‐INDUCED CARDIOMYOCYTE CONTRACTILE DYSFUNCTION AND PROTEIN DAMAGE
Wu, Shan / Li, Qun / Du, Min / Li, Shi‐Yan / Ren, Jun | 2007
88
PULMONARY VASCULAR REACTIVITY OF SPONTANEOUSLY HYPERTENSIVE RATS IS EXACERBATED IN RESPONSE TO THE CENTRAL ADMINISTRATION OF EXOGENOUS NITRIC OXIDE
Schwenke, Daryl O / Pearson, James T / Tsuchimochi, Hirotsugu / Kangawa, Kenji / Shirai, Mikiyasu | 2007
95
ENDOGENOUS NITRIC OXIDE ATTENUATES β‐ADRENOCEPTOR‐MEDIATED RELAXATION IN RAT AORTA
Kang, Khong Bee / Van Der Zypp, Andrea / Majewski, Henryk | 2007
95
ENDOGENOUS NITRIC OXIDE ATTENUATES b-ADRENOCEPTOR-MEDIATED RELAXATION IN RAT AORTA:
Kang, K. B. / van der Zypp, A. / Majewski, H. | 2007
102
GENETIC POLYMORPHISMS OF CYTOCHROME P450 ENZYMES 2C9 AND 2C19 IN A HEALTHY IRANIAN POPULATION
Zand, Negin / Tajik, Nader / Moghaddam, Alireza Salek / Milanian, Iraj | 2007
106
INTERACTIONS BETWEEN METOCLOPRAMIDE AND MORPHINE: ENHANCED ANTINOCICEPTION AND MOTOR DYSFUNCTION IN RATS
Kamerman, Peter R / Becker, Nicole / Fick, Linda G | 2007
113
CARNITINE PALMITOYL TRANSFERASE‐I INHIBITION IS NOT ASSOCIATED WITH CARDIAC HYPERTROPHY IN RATS FED A HIGH‐FAT DIET
Okere, Isidore C / Chandler, Margaret P / McElfresh, Tracy A / Rennison, Julie H / Kung, Theodore A / Hoit, Brian D / Ernsberger, Paul / Young, Martin E / Stanley, William C | 2007
120
MECHANISMS MEDIATING SEROTONIN‐INDUCED CONTRACTION OF COLONIC MYOCYTES
Xu, Long / Yu, Bao‐Ping / Chen, Jian‐Guo / Luo, He‐Sheng | 2007
129
COMPARISON OF THE ELECTROPHYSIOLOGICAL PROPERTIES OF THE SHEEP ISOLATED COSTAL AND DIAPHRAGMATIC PARIETAL PLEURA
Zarogiannis, Sotirios / Hatzoglou, Chrissi / Stefanidis, Ioannis / Ioannou, Maria / Paraskeva, Efrosini / Gourgoulianis, Konstantinos / Molyvdas, Paschalis‐Adam | 2007
132
A MOUSE MODEL FOR ASSESSING THE IMPACT OF INGESTED NUTRIENTS ON GASTRIC EMPTYING RATE
Symonds, Erin L / Butler, Ross / Omari, Taher I | 2007

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