DIFFERENTIAL EFFECTS OF VASOPRESSINERGIC AND OXYTOCINERGIC PRE‐AUTONOMIC NEURONS ON CIRCULATORY CONTROL: REFLEX MECHANISMS AND CHANGES DURING EXERCISE (English)

Clinical and Experimental Pharmacology and Physiology

The role of vasopressinergic and oxytocinergic (VPergic and OTergic, respectively) projections to the brain stem in the modulation of heart rate control is discussed on the basis of both changes in the peptide content of the dorsal brain stem (DBS) and functional effects following reflex‐ and exercise‐induced activation in the presence and/or absence of receptor blockade within the nucleus tractus solitarius (NTS) and/or peripheral autonomic block.

Experimental data showed a dual effect of NTS VPergic projections on reflex control: (i) to maintain tonically the reflex sensitivity; and (ii) to reset reflex bradycardia towards higher heart rate values when transiently activated. The VPergic drive causes less sympathetic inhibition during pressure increases, mainly by reducing peripheral information going to NTS second‐order neurons. Treadmill running increases the vasopressin content within the DBS. This activates NTS V1 receptors to cause a significant improvement of exercise tachycardia in both sedentary and trained rats.

The OTergic drive to DBS areas (NTS/dorsal motor nucleus of the vagus) is also tonic for baroreceptor reflex control: it improves reflex bradycardia by facilitating vagal outflow to the heart. An acute bout of exercise increases DBS oxytocin (OT) content in trained rats, causing a significant blunting of exercise tachycardia only in this group. In both sedentary and trained groups, basal heart rate varies inversely with DBS OT content, the resting bradycardia of trained rats being associated with higher OT content.

Specific coordinated activation of VPergic and OTergic suprabulbar pathways is essential to adjust heart rate and cardiac output to circulatory demand at rest and during exercise in both sedentary and trained individuals.

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Table of contents – Volume 34, Issue 4

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Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

255
DIFFERENCES BETWEEN PATHOLOGICAL AND PHYSIOLOGICAL CARDIAC HYPERTROPHY: NOVEL THERAPEUTIC STRATEGIES TO TREAT HEART FAILURE
McMullen, Julie R / Jennings, Garry L | 2007
263
INVESTIGATION OF THE MICROCIRCULATION AND THE STATE OF OXIDATIVE STRESS IN THE RAT AFTER SCORPION ENVENOMATION
Sahnoun, Z / Chaker‐Krichen, S / Kassis, M / Hakim, A / Hammami, S / Ghozzi, H / Bouayed, N / Bellasfar, Z / Zeghal, KM / Rebai, T | 2007
269
SPATIAL PULMONARY FLOW DISTRIBUTION IN RABBIT ISOLATED LUNGS IS A POOR REPRESENTATION OF THE SITUATION IN VIVO*
Hübler, M / Heller, AR / Bleyl, JU / Rössel, T / Stehr, SN / Koch, T | 2007
274
EFFECT OF HIGH SALT INTAKE ON LOCAL RENIN–ANGIOTENSIN SYSTEM AND VENTRICULAR DYSFUNCTION FOLLOWING MYOCARDIAL INFARCTION IN RATS
De Resende, Micheline M / Mill, José G | 2007
280
INVOLVEMENT OF THE ENDOTHELIN ETB RECEPTOR IN GENDER DIFFERENCES IN DEOXYCORTICOSTERONE ACETATE‐SALT‐INDUCED HYPERTENSION
Kawanishi, Hideaki / Hasegawa, Youichi / Nakano, Daisuke / Ohkita, Mamoru / Takaoka, Masanori / Ohno, Yukihiro / Matsumura, Yasuo | 2007
286
IDENTIFICATION OF LIGANDS BINDING SPECIFICALLY TO INFLAMMATORY INTESTINAL MUCOSA USING PHAGE DISPLAY
Takagi, Tamaki / Arisawa, Tomiyasu / Yamamoto, Kazumasa / Hirata, Ichiro / Nakano, Hiroshi / Sawada, Makoto | 2007
290
PHARMACOKINETICS AND PHARMACODYNAMICS OF A NITRIC OXIDE‐RELEASING DERIVATIVE OF ENALAPRIL IN MALE BEAGLES
Okuyama, Cristina E / Mendes, Gustavo Duarte / Faro, Renato / Rezende, Vinicius M / Lagos, Rodolfo Monaco / Astigarraga, Rafael E B / Antunes, Edson / De Nucci, Gilberto | 2007
296
MORPHOLOGICAL AND FUNCTIONAL CHANGES IN P‐GLYCOPROTEIN DURING DEXAMETHASONE‐INDUCED HEPATOMEGALY
Micuda, Stanislav / Fuksa, Leos / Mundlova, Lucie / Osterreicher, Jan / Mokry, Jaroslav / Cermanova, Jolana / Brcakova, Eva / Staud, Frantisek / Pokorna, Pavla / Martinkova, Jirina | 2007
304
INHIBITION OF NAD(P)H OXIDASE REDUCES FIBRONECTIN EXPRESSION IN STROKE‐PRONE RENOVASCULAR HYPERTENSIVE RAT BRAIN
Cui, Chunmei / Chen, Alex F / Jiang, Zongpei / Wu, Qingqing / Lin, Jianwen / Wen, Hongmei / Zeng, Jinsheng | 2007
310
CALCIUM ANTAGONIST PROPERTY OF CPU228, A DOFETILIDE DERIVATIVE, CONTRIBUTES TO ITS LOW INCIDENCE OF TORSADES DE POINTES IN RABBITS
Huang, Zhi‐Jiang / Dai, De‐Zai / Li, Na / Na, Tao / Ji, Min / Dai, Yin | 2007
318
DOES NITRIC OXIDE MODULATE TRANSMITTER RELEASE AT THE MAMMALIAN NEUROMUSCULAR JUNCTION?
Nickels, Travis J / Reed, Grant W / Drummond, Justin T / Blevins, Dustin E / Lutz, Megan C / Wilson, David F | 2007
327
NITRIC OXIDE, ERECTILE DYSFUNCTION AND BETA‐BLOCKER TREATMENT (MR NOED STUDY): BENEFIT OF NEBIVOLOL VERSUS METOPROLOL IN HYPERTENSIVE MEN
Brixius, K / Middeke, M / Lichtenthal, A / Jahn, E / Schwinger, R H G | 2007
332
EFFECTS OF HYPOXIA/REPERFUSION INJURY ON DRUG DISPOSITION IN THE RAT ISOLATED PERFUSED LIVER
Arab, HA / Cheung, K / Hickman, PE / Potter, JM / Kadkhodaee, M / Roberts, MS | 2007
339
INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE ATTENUATES ACUTE ENDOTOXIN‐INDUCED LUNG INJURY IN RATS
Su, Chain Fa / Yang, Fwu Lin / Chen, Hsing I | 2007
347
ADMINISTRATION OF EXOGENOUS ERYTHROPOIETIN b AFFECTS LIPID PEROXIDATION AND SERUM PARAOXONASE-1 ACTIVITY AND CONCENTRATION IN PREDIALYSIS PATIENTS WITH CHRONIC RENAL DISEASE AND ANAEMIA:
Marsillach, J. / Martinez-Vea, A. / Marcas, L. / Mackness, B. / Mackness, M. / Ferre, N. / Joven, J. / Camps, J. | 2007
347
ADMINISTRATION OF EXOGENOUS ERYTHROPOIETIN β AFFECTS LIPID PEROXIDATION AND SERUM PARAOXONASE‐1 ACTIVITY AND CONCENTRATION IN PREDIALYSIS PATIENTS WITH CHRONIC RENAL DISEASE AND ANAEMIA
Marsillach, Judit / Martínez‐Vea, Albert / Marcas, Luis / Mackness, Bharti / Mackness, Michael / Ferré, Natàlia / Joven, Jorge / Camps, Jordi | 2007
350
METHODS OF ANALYSIS AND PHYSIOLOGICAL RELEVANCE OF RHYTHMS IN SYMPATHETIC NERVE DISCHARGE
Barman, Susan M / Kenney, Michael J | 2007
356
SYMPATHETIC RHYTHMS AND NERVOUS INTEGRATION
Gilbey, Michael P | 2007
362
IDENTIFICATION OF BLOOD PRESSURE CONTROL MECHANISMS BY POWER SPECTRAL ANALYSIS
Stauss, Harald M | 2007
369
DIFFERENTIAL EFFECTS OF VASOPRESSINERGIC AND OXYTOCINERGIC PRE‐AUTONOMIC NEURONS ON CIRCULATORY CONTROL: REFLEX MECHANISMS AND CHANGES DURING EXERCISE
Michelini, Lisete Compagno | 2007
377
EXERCISE TRAINING AND SYMPATHETIC NERVOUS SYSTEM ACTIVITY: EVIDENCE FOR PHYSICAL ACTIVITY DEPENDENT NEURAL PLASTICITY
Mueller, Patrick J | 2007
385
CORRIGENDUM
| 2007