COMPARISON OF THE EFFECTS OF VITAMIN E AND/OR QUERCETIN IN ATTENUATING CHRONIC CYCLOSPORINE A‐INDUCED NEPHROTOXICITY IN MALE RATS (English)

Clinical and Experimental Pharmacology and Physiology

The aim of the present study was to investigate the effects of vitamin E and/or quercetin (Q) on renal function, oxygen radical concentrations in the kidney and some anti‐oxidant enzyme activities in rats treated with cyclosporine A (CsA).

Groups of rats (270 ± 15 g), on standard rat chow and water, received all their treatments by gavage for either 4 or 8 weeks. Control groups received either olive oil (0.5 mL) or 25% ethanol (0.5 mL) + olive oil (0.5 mL) per day as vehicle. All experimental groups received 25 mg CsA/kg per day in 0.5 mL olive oil. The vitamin E group received 100 mg vitamin E/kg per day in olive oil in addition to CsA treatment. The quercetin group received 15 mg of Q/kg per day in 0.5 mL of 25% ethanol in addition to CsA treatment. The vitamin E + quercetin group received the two anti‐oxidants at the concentrations given in addition to CsA treatment.

Quercetin, at a concentration less than one‐quarter of vitamin E, was more efficient in lowering blood urea nitrogen, serum creatinine and kidney malondialdehyde in CsA‐treated rats. However, neither of the two anti‐oxidants was able to normalize these analytes to control values after either 4 or 8 weeks treatment.

Quercetin (50 µmol/kg per day) elevated all renal anti‐oxidant enzyme activities to values observed in the negative controls. However, vitamin E (232 µmol/kg per day) only normalized glutathione peroxidase activity at the end of either 4 or 8 weeks treatment. Combination treatment with the two anti‐oxidants abolished all the ill‐effects of CsA.

Combination treatment with the two anti‐oxidants of renal transplant patients receiving CsA may be beneficial in ameliorating the chronic nephrotoxic effects of the important immunosuppressive drug CsA.

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Table of contents – Volume 34, Issue 8

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695
CEREBRAL UPTAKE OF DRUGS IN HUMANS
Upton, Richard N | 2007
702
KETANSERIN‐INDUCED BAROREFLEX ENHANCEMENT IN SPONTANEOUSLY HYPERTENSIVE RATS DEPENDS ON CENTRAL 5‐HT2A RECEPTORS
Shen, Fu‐Ming / Wang, Jin / Ni, Can‐Rong / Yu, Jian‐Guang / Wang, Wei‐Zhong / Su, Ding‐Feng | 2007
708
SPONTANEOUS OSCILLATORY CONTRACTIONS IN AORTAS OF RATS WITH ARTERIAL PRESSURE LABILITY CAUSED BY SINOAORTIC DENERVATION
Rocha, Matheus L / Bendhack, Lusiane M | 2007
714
BISOPROLOL INHIBITS SODIUM CURRENT IN VENTRICULAR MYOCYTES OF RATS WITH DIASTOLIC HEART FAILURE
Tang, Hui‐Fang / Wu, Shu‐Lin / Deng, Chun‐Yu / Zhang, Wen‐Chang / Kuang, Su‐Juan | 2007
720
COMPARISON OF THE EFFECTS OF VITAMIN E AND/OR QUERCETIN IN ATTENUATING CHRONIC CYCLOSPORINE A‐INDUCED NEPHROTOXICITY IN MALE RATS
Zal, Fatemeh / Mostafavi‐Pour, Zohreh / Vessal, Mahmood | 2007
725
SERUM NITRIC OXIDE METABOLITE (NOX) LEVELS IN HYPERTENSIVE PATIENTS AT REST: A COMPARISON OF AGE, GENDER, BLOOD PRESSURE AND COMPLICATIONS USING NORMOTENSIVE CONTROLS
Higashino, Hideaki / Miya, Hirohisa / Mukai, Hidenori / Miya, Yoshihisa | 2007
732
IDENTIFICATION OF ANTIMICROBIAL ACTIVITY FROM GOAT CERVICAL EPITHELIUM
Rana, Manish / Mittal, Deepak / Pereira, Ben MJ | 2007
737
TOCOLYTIC EFFECT OF PARECOXIB, A NEW PARENTERAL CYCLO‐OXYGENASE‐2‐SPECIFIC INHIBITOR, ON THE SPONTANEOUS AND PROSTAGLANDIN‐INDUCED CONTRACTIONS OF RAT ISOLATED MYOMETRIUM
Ayar, A | 2007
742
EXTRACELLULAR SIGNAL‐REGULATED KINASE PATHWAYS MAY MEDIATE THE PROTECTIVE EFFECT OF ELECTRICAL STIMULATION OF THE PARAVENTRICULAR NUCLEUS AGAINST ISCHAEMIA–REPERFUSION INJURY OF THE GASTRIC MUCOSA
Zhang, Yong‐Mei / Wei, Er‐Qing / Li, Li / Qiao, Wei‐Li / Wang, Lin / Zhang, Jian‐Fu | 2007
753
RENOPROTECTIVE EFFECT OF TROLOX AGAINST ISCHAEMIA–REPERFUSION INJURY IN RATS
Wongmekiat, Orawan / Thamprasert, Kamthorn / Lumlertgul, Dusit | 2007
760
MAXIMAL LACTATE STEADY STATE IN RUNNING MICE: EFFECT OF EXERCISE TRAINING
Ferreira, Julio CB / Rolim, Natale PL / Bartholomeu, Jan B / Gobatto, Claudio A / Kokubun, Eduardo / Brum, Patricia C | 2007
766
NARIRUTIN INHIBITS AIRWAY INFLAMMATION IN AN ALLERGIC MOUSE MODEL
Funaguchi, Norihiko / Ohno, Yasushi / La, Bu Lin Bai / Asai, Toshihiro / Yuhgetsu, Hideyuki / Sawada, Masahiro / Takemura, Genzou / Minatoguchi, Shinya / Fujiwara, Takako / Fujiwara, Hisayoshi | 2007
771
VASODILATOR EFFECTS OF LEPTIN ON CANINE ISOLATED MESENTERIC ARTERIES AND VEINS
Mohammed, MMJ / Myers, DS / Sofola, OA / Hainsworth, R / Drinkhill, MJ | 2007
775
IN VITRO EFFECTS OF ANTIPSYCHOTICS ON HUMAN PLATELET ADHESION AND AGGREGATION AND PLASMA COAGULATION
Axelsson, Stina / Hägg, Staffan / Eriksson, Andreas C / Lindahl, Tomas L / Whiss, Per A | 2007
781
TOTAL ANTI‐OXIDANT CAPACITY OF CELL CULTURE MEDIA
Lewinska, Anna / Wnuk, Maciej / Slota, Ewa / Bartosz, Grzegorz | 2007
787
TIME‐DEPENDENT COURSE OF HYPERBARIC OXYGEN‐INDUCED OXIDATIVE EFFECTS IN RAT LUNG AND ERYTHROCYTES
Ay, Hakan / Topal, Turgut / Uysal, Bülent / Özler, Mehmet / Öter, Sükrü / Korkmaz, Ahmet / Dündar, Kadir | 2007
792
PROTECTIVE EFFECTS OF ICARIIN AGAINST LEARNING AND MEMORY DEFICITS INDUCED BY ALUMINIUM IN RATS
Luo, Yong / Nie, Jing / Gong, Qi‐Hai / Lu, Yuan‐Fu / Wu, Qin / Shi, Jing‐Shan | 2007
796
EXISTENCE OF β3‐ADRENOCEPTORS IN RAT HEART: FUNCTIONAL IMPLICATIONS
Barbier, J / Mouas, C / Rannou‐Bekono, F / Carré, F | 2007
796
EXISTENCE OF b3-ADRENOCEPTORS IN RAT HEART: FUNCTIONAL IMPLICATIONS
Barbier, J. / Mouas, C. / Rannou-Bekono, F. / Carre, F. | 2007
799
INTRODUCTION
Man, Ricky YK / Leung, Susan WS | 2007
801
CEREBROVASCULAR EFFECTS OF OESTROGEN: MULTIPLICITY OF ACTION
Duckles, Sue P / Krause, Diana N | 2007
809
RALOXIFENE, TAMOXIFEN AND VASCULAR TONE
Leung, Fung Ping / Tsang, Suk Ying / Wong, Chi Ming / Yung, Lai Ming / Chan, Yau Chi / Leung, Hok Sum / Yao, Xiaoqiang / Huang, Yu | 2007
814
AGEING, OESTROGEN, PLATELETS AND THROMBOTIC RISK
Miller, Virginia M / Jayachandran, Muthuvel / Owen, Whyte G | 2007
822
NON‐GENOMIC VASCULAR ACTIONS OF FEMALE SEX HORMONES: PHYSIOLOGICAL IMPLICATIONS AND SIGNALLING PATHWAYS
Leung, Susan WS / Teoh, Hwee / Keung, Wendy / Man, Ricky YK | 2007

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