VASODILATATION INDUCED BY SINOMENINE LOWERS BLOOD PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS (English)

Clinical and Experimental Pharmacology and Physiology

Sinomenine is an alkaloid with a wide range of pharmacological actions. In the present study, we investigated the effect of sinomenine on blood pressure and its possible mechanisms of action.

Spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto (WKY) rats were given intraperitoneal injections of sinomenine. At 30 min, 2.5–10 mg/kg sinomenine decreased systolic blood pressure (SBP) in a dose‐dependent manner in SHR, but had no effect on the SBP in WKY rats.

The vascular effect of sinomenine was then examined in aortic rings isolated from Wistar rats. Sinomenine (0.1–10 mmol/L) produced concentration‐dependent relaxation in aortic rings precontracted with phenylephrine (10 nmol/L) or KCl (40 mmol/L). Glibenclamide (1–100 mmol/L), a specific inhibitor of ATP‐sensitive K+ channels attenuated the sinomenine‐induced relaxation, but this effect was not observed when inhibitors of other types of K+ channels were used.

We further investigated the effects of sinomenine on changes in intracellular Ca2+ concentrations ([Ca2+]i) in cultured aortic smooth muscle (A7r5) cells by using the Ca2+‐sensitive dye fura‐2 as an indicator. Sinomenine, over the concentration range 0.1–10 mmol/L, decreased the increases in [Ca2+]i elicited by phenylephrine (1 mmol/L) or KCl (40 mmol/L) in a concentration‐dependent manner. Glibenclamide (1–100 mmol/L) abolished the effects of sinomenine.

In conclusion, sinomenine causes vascular relaxation by opening ATP‐sensitive K+ channels, thus decreasing [Ca2+]i.

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Table of contents – Volume 34, Issue 10

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972
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979
VASODILATATION INDUCED BY SINOMENINE LOWERS BLOOD PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS
Lee, Ping‐Ying / Chen, Wency / Liu, I‐Min / Cheng, Juei‐Tang | 2007
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998
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1029
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1029
β2‐ADRENOCEPTOR POLYMORPHISMS AND OBSTRUCTIVE AIRWAY DISEASES: IMPORTANT ISSUES OF STUDY DESIGN
Yang, Ian A / Ng, Taria / Molenaar, Peter / Fong, Kwun M | 2007
1037
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1044
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1058
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1064
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1070
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1077
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1084
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