ANTICONVULSANT, BUT NOT ANTIEPILEPTIC, ACTION OF VALPROATE ON AUDIOGENIC SEIZURES IN METAPHIT–TREATED RATS (English)

Clinical and Experimental Pharmacology and Physiology

1. The blocking effects of valproate (2‐propylpentanoic acid), a standard anti‐epileptic drug, on metaphit (1‐[1‐(3‐isothiocyanatophenyl)‐cyclohexyl]‐piperidine)‐induced audiogenic seizures as a model of generalized, reflex audiogenic epilepsy in adult Wistar male rats were studied.

Rats were stimulated using an electric bell (100 ± 3 dB, 5–8 kHz, 60 s) 60 min after i.p. metaphit (10 mg/kg) injection and afterwards at hourly intervals. For power spectra and electroencephalograph (EEG) recordings, three gold‐plated screws were implanted into the skull. Different doses of valproate (50, 75 and 100 mg/kg) were injected i.p. into rats with fully developed metaphit seizures after the eighth audiogenic testing.

In metaphit‐treated animals, the EEG appeared as polyspikes, spike–wave complexes and sleep‐like patterns, whereas the power spectra were increased compared with the corresponding controls.

Valproate reduced the incidence and intensity of convulsions and prolonged the duration of the latency period in a dose‐dependent manner 4 h after administration.

The ED50 of valproate in the first hour after injection was 63.19 mg/kg (95% confidence interval 51.37–77.71 mg/kg).

None of the doses of valproate applied eliminated the EEG signs of metaphit‐provoked epileptiform activity.

Taken together, these results suggest that all doses of valproate examined acted to suppresse behavioural but not epileptic EEG spiking activity in metaphit‐induced seizures.

Commercial Copyright fee: €37.48 Basic fee: €4.00 Total price: €41.48


Students Copyright fee: €37.48 Basic fee: €2.00 Total price: €39.48

Buy PDF

Document information


Table of contents – Volume 34, Issue 10

Show all volumes and issues

Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

955
SENSORY NEURAL TARGETS FOR THE TREATMENT OF COUGH
Mazzone, Stuart B / McGovern, Alice E | 2007
963
WHAT MAKES A CGRP2 RECEPTOR?
Hay, DL | 2007
972
17b-OESTRADIOL PARTIALLY ATTENUATES THE INHIBITION OF NITRIC OXIDE SYNTHASE-3 BY ADVANCED GLYCATION END-PRODUCTS IN HUMAN PLATELETS
Chen, L. / Liu, Y. / Cui, B. / Mi, Q. / Huang, Y. / Fan, L. / Chen, Q. / Tang, J. / Ferro, A. / Ji, Y. | 2007
972
17β‐OESTRADIOL PARTIALLY ATTENUATES THE INHIBITION OF NITRIC OXIDE SYNTHASE‐3 BY ADVANCED GLYCATION END‐PRODUCTS IN HUMAN PLATELETS
Chen, Lu / Liu, Yuan / Cui, Bota / Mi, Qiongyu / Huang, Yan / Fan, Leming / Chen, Qi / Tang, James / Ferro, Albert / Ji, Yong | 2007
979
VASODILATATION INDUCED BY SINOMENINE LOWERS BLOOD PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS
Lee, Ping‐Ying / Chen, Wency / Liu, I‐Min / Cheng, Juei‐Tang | 2007
985
EFFECT OF ANGIOTENSIN AT1 RECEPTOR ANTAGONIST ON d‐GALACTOSAMINE‐INDUCED ACUTE LIVER INJURY
Chan, Herman / Leung, Po‐Sing / Tam, Michael S‐C | 2007
992
SIMULTANEOUS GENOTYPING OF CYP2D6*3, *4, *5 AND *6 POLYMORPHISMS IN A SPANISH POPULATION THROUGH MULTIPLEX LONG POLYMERASE CHAIN REACTION AND MINISEQUENCING MULTIPLEX SINGLE BASE EXTENSION ANALYSIS
Crescenti, A / Mas, S / Gassó, P / Baiget, M / Bernardo, M / Lafuente, A | 2007
998
17b-OESTRADIOL REGULATES THE EXPRESSION OF Na+/K+-ATPase b1-SUBUNIT, SARCOPLASMIC RETICULUM Ca2+-ATPase AND CARBONIC ANHYDRASE IV IN H9C2 CELLS
Liu, C. G. / Xu, K. Q. / Xu, X. / Huang, J. J. / Xiao, J. C. / Zhang, J. P. / Song, H. P. | 2007
998
17β‐OESTRADIOL REGULATES THE EXPRESSION OF Na+/K+‐ATPase β1‐SUBUNIT, SARCOPLASMIC RETICULUM Ca2+‐ATPase AND CARBONIC ANHYDRASE IV IN H9C2 CELLS
Liu, Chen‐Geng / Xu, Ke‐Qian / Xu, Xia / Huang, Jian‐Jun / Xiao, Jing‐Chuan / Zhang, Jie‐Ping / Song, Hui‐Ping | 2007
1005
INDICES OF VASCULAR STIFFNESS AND WAVE REFLECTION IN RELATION TO BODY MASS INDEX OR BODY FAT IN HEALTHY SUBJECTS
Wykretowicz, Andrzej / Adamska, Karolina / Guzik, Przemyslaw / Krauze, Tomasz / Wysocki, Henryk | 2007
1010
ANTICONVULSANT, BUT NOT ANTIEPILEPTIC, ACTION OF VALPROATE ON AUDIOGENIC SEIZURES IN METAPHIT–TREATED RATS
Stanojlović, Olivera P / Hrnčić, Dragan R / Živanović, Dragana P / Šušić, Veselinka T | 2007
1016
ROLE OF MACROPHAGES IN COMPLICATIONS OF TYPE 2 DIABETES
Tesch, GH | 2007
1020
HUMAN HEART β‐ADRENOCEPTORS: β1‐ADRENOCEPTOR DIVERSIFICATION THROUGH ‘AFFINITY STATES’ AND POLYMORPHISM
Molenaar, P / Chen, L / Semmler, ABT / Parsonage, WA / Kaumann, AJ | 2007
1020
HUMAN HEART b-ADRENOCEPTORS: b1-ADRENOCEPTOR DIVERSIFICATION THROUGH `AFFINITY STATES' AND POLYMORPHISM
Molenaar, P. / Chen, L. / Semmler, A. / Parsonage, W. / Kaumann, A. | 2007
1029
b2-ADRENOCEPTOR POLYMORPHISMS AND OBSTRUCTIVE AIRWAY DISEASES: IMPORTANT ISSUES OF STUDY DESIGN
Yang, I. A. / Ng, T. / Molenaar, P. / Fong, K. M. | 2007
1029
β2‐ADRENOCEPTOR POLYMORPHISMS AND OBSTRUCTIVE AIRWAY DISEASES: IMPORTANT ISSUES OF STUDY DESIGN
Yang, Ian A / Ng, Taria / Molenaar, Peter / Fong, Kwun M | 2007
1037
EFFECT OF GENDER AND SEX HORMONES ON VASCULAR OXIDATIVE STRESS
Miller, Alyson A / De Silva, T Michael / Jackman, Katherine A / Sobey, Christopher G | 2007
1044
COMBUSTION‐DERIVED NANOPARTICLES: MECHANISMS OF PULMONARY TOXICITY
BéruBé, Kelly / Balharry, Dominique / Sexton, Keith / Koshy, Lata / Jones, Tim | 2007
1051
POTENTIATION OF 3,4‐METHYLENEDIOXYMETHAMPHETAMINE‐INDUCED 5‐HT RELEASE IN THE RAT SUBSTANTIA NIGRA BY CLORGYLINE, A MONOAMINE OXIDASE A INHIBITOR
Hewton, Ryan / Salem, Abdallah / Irvine, Rodney J | 2007
1058
GLUTAMATE RECEPTOR PLASTICITY AT EXCITATORY SYNAPSES IN THE BRAIN
Genoux, David / Montgomery, Johanna M | 2007
1064
INHIBITORY INTERNEURONS IN THE PIRIFORM CORTEX
Suzuki, Norimitsu / Bekkers, John M | 2007
1070
DOES SPIKE TIMING‐DEPENDENT SYNAPTIC PLASTICITY UNDERLIE MEMORY FORMATION?
Letzkus, Johannes J / Kampa, Björn M / Stuart, Greg J | 2007
1077
FUNCTIONS OF SK CHANNELS IN CENTRAL NEURONS
Faber, ES Louise / Sah, Pankaj | 2007
1084
INTRACELLULAR CALCIUM IN THE FERTILIZATION AND DEVELOPMENT OF MAMMALIAN EGGS
Jones, Keith T | 2007

Similar titles