ACTIONS OF THE ENDOCANNABINOID TRANSPORT INHIBITOR AM404 IN NEUROPATHIC AND INFLAMMATORY PAIN MODELS (English)

in Clinical and Experimental Pharmacology and Physiology ; 34 , 11 ; 1186-1190
Clinical and Experimental Pharmacology and Physiology
Blackwell Publishing Asia ; 2007

Although cannabinoid receptor agonists have analgesic activity in chronic pain states, they produce a spectrum of central cannabinoid CB1 receptor‐mediated motor and psychotropic side‐effects. The actions of endocannabinoids, such as anandamide, are terminated by uptake and subsequent intracellular enzymatic degradation. In the present study, we examined the effect of acute administration of the anandamide transport inhibitor AM404 in rat models of chronic neuropathic and inflammatory pain.

Systemic administration of AM404 (10 mg/kg) reduced mechanical allodynia in the partial sciatic nerve ligation (PNL) model of neuropathic pain, but not in the complete Freund's adjuvant (CFA) model of inflammatory pain.

The effect of AM404 in the PNL model was abolished by coapplication with the selective cannabinoid CB1 receptor antagonist AM251 (1 mg/kg). AM404 did not produce a reduction in motor performance in either the PNL or CFA models.

These findings suggest that acute administration of AM404 reduces allodynia in a neuropathic pain model via cannabinoid CB1 receptor activation, without causing the undesirable motor disruption associated with cannabinoid receptor agonists.

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Table of contents – Volume 34, Issue 11

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1091
AGE‐RELATED CHANGES IN THE STRUCTURE AND FUNCTION OF SKELETAL MUSCLES
Faulkner, John A / Larkin, Lisa M / Claflin, Dennis R / Brooks, Susan V | 2007
1097
MODULATION OF SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION (STAT) FACTOR PATHWAYS DURING FOCAL CEREBRAL ISCHAEMIA: A GENE EXPRESSION ARRAY STUDY IN RAT HIPPOCAMPUS AFTER MIDDLE CEREBRAL ARTERY OCCLUSION
Sun, Sheng‐Li / Li, Tie‐Jun / Yang, Peng‐Yuan / Qiu, Yan / Rui, Yao‐Cheng | 2007
1102
PROTEASOME INHIBITOR LACTACYSTIN ABLATES LIVER INJURY INDUCED BY INTESTINAL ISCHAEMIA–REPERFUSION
Yao, Ji‐Hong / Li, Ying‐Hua / Wang, Zhen‐Zhen / Zhang, Xue‐Song / Wang, Yu‐Zhu / Yuan, Jin‐Chan / Zhou, Qin / Liu, Ke‐Xin / Tian, Xiao‐Feng | 2007
1109
EFFECTS OF RESVERATROL ON NUMBER AND ACTIVITY OF ENDOTHELIAL PROGENITOR CELLS FROM HUMAN PERIPHERAL BLOOD
Wang, Xiao‐Bin / Huang, Jun / Zou, Jian‐Gang / Su, En‐Ben / Shan, Qi‐Jun / Yang, Zhi‐Jian / Cao, Ke‐Jiang | 2007
1116
FLAVONE INHIBITS VASCULAR CONTRACTION BY DECREASING PHOSPHORYLATION OF THE MYOSIN PHOSPHATASE TARGET SUBUNIT
Jeon, Su Bun / Kim, Gutae / Kim, Jee In / Seok, Young Mi / Kim, Sang‐Hyun / Suk, Kyoungho / Shin, Heung‐Mook / Lee, Young‐Ho / Kim, In Kyeom | 2007
1121
SPINAL a-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTORS MAY MEDIATE THE ANALGESIC EFFECTS OF EMULSIFIED HALOGENATED ANAESTHETICS
Hang, L. H. / Shao, D. H. / Yang, Y. H. / Dai, T. J. / Zeng, Y. M. | 2007
1121
SPINAL α‐AMINO‐3‐HYDROXY‐5‐METHYL‐4‐ISOXAZOLEPROPIONIC ACID RECEPTORS MAY MEDIATE THE ANALGESIC EFFECTS OF EMULSIFIED HALOGENATED ANAESTHETICS
Hang, Li‐Hua / Shao, Dong‐Hua / Yang, Ying‐Hong / Dai, Ti‐Jun / Zeng, Yin‐Ming | 2007
1126
S100B LEVELS IN THE CEREBROSPINAL FLUID OF RATS ARE SEX AND ANAESTHETIC DEPENDENT
Vicente, Évelin / Tramontina, Francine / Leite, Marina C / Nardin, Patricia / Silva, Mariane / Karkow, Ana R / Adolf, Rafael / Lucion, Aldo B / Netto, Carlos A / Gottfried, Carmem et al. | 2007
1131
STRONTIUM FRUCTOSE 1,6‐DIPHOSPHATE RESCUES ADENINE‐INDUCED MALE HYPOGONADISM AND UPREGULATES THE TESTICULAR ENDOTHELIN‐1 SYSTEM
Feng, Yu / Zhang, Qi / Dai, De‐Zai / Ying, Han‐Jie / Dai, Yin | 2007
1138
EXPRESSION OF CYP3A ISOFORMS AND P‐GLYCOPROTEIN IN HUMAN STOMACH, JEJUNUM AND ILEUM
Canaparo, Roberto / Finnström, Niklas / Serpe, Loredana / Nordmark, Anna / Muntoni, Elisabetta / Eandi, Mario / Rane, Anders / Zara, Gian Paolo | 2007
1145
DESENSITIZATION OF GUINEA‐PIG TAENIA CAECI SMOOTH MUSCLE INDUCED BY A LOW CONCENTRATION OF CARBACHOL
Hishinuma, Shigeru / Sato, Ryo / Saito, Masaki | 2007
1151
EFFECTS OF AGAR AND PECTIN ON GASTRIC EMPTYING AND POST‐PRANDIAL GLYCAEMIC PROFILES IN HEALTHY HUMAN VOLUNTEERS
Sanaka, Masaki / Yamamoto, Takatsugu / Anjiki, Hajime / Nagasawa, Kunitaka / Kuyama, Yasushi | 2007
1156
ACTIVATION OF PERIPHERAL CHEMORECEPTORS CAUSES POSITIVE INOTROPIC EFFECTS IN A WORKING HEART–BRAINSTEM PREPARATION OF THE RAT
Braga, Valdir A / Zoccal, Daniel B / Soriano, Renato N / Antunes, Vagner R / Paton, Julian F / Machado, Benedito H / Nalivaiko, Eugene | 2007
1160
RESTORATION OF ANTIBIOTIC SUSCEPTIBILITY IN METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS BY TARGETING MECR1 WITH A PHOSPHOROTHIOATE DEOXYRIBOZYME
Hou, Zheng / Meng, Jing‐Ru / Niu, Chao / Wang, Hai‐Fang / Liu, Jie / Hu, Ben‐Quan / Jia, Min / Luo, Xiao‐Xing | 2007
1165
LOW CORONARY DRIVING PRESSURE IS ASSOCIATED WITH SUBENDOCARDIAL REMODELLING AND LEFT VENTRICULAR DYSFUNCTION IN AORTOCAVAL FISTULA
Guido, Maria C / De Carvalho Frimm, Clovis / Koike, Márcia K / Cordeiro, Fernanda F / Moretti, Ana IS / Godoy, Luiz C | 2007
1173
NITRIC OXIDE MODULATES AIR EMBOLISM‐INDUCED LUNG INJURY IN RATS WITH NORMOTENSION AND HYPERTENSION
Liu, Yen Chin / Kao, Shang Jyh / Chuang, I Chun / Chen, Hsing I | 2007
1181
NOVEL EVIDENCE SUGGESTING AN ANTI‐OXIDANT PROPERTY FOR ERYTHROPOIETIN ON VANCOMYCIN‐INDUCED NEPHROTOXICITY IN A RAT MODEL
Cetin, Hasan / Olgar, şeref / Oktem, Faruk / Ciris, Metin / Uz, Efkan / Aslan, Çaǧatay / Ozguner, Fehmi | 2007
1186
ACTIONS OF THE ENDOCANNABINOID TRANSPORT INHIBITOR AM404 IN NEUROPATHIC AND INFLAMMATORY PAIN MODELS
Mitchell, Vanessa A / Greenwood, Ruth / Jayamanne, Angelo / Vaughan, Christopher W | 2007
1191
ANGIOTENSIN II RECEPTORS SUBTYPES MEDIATE DIVERSE GENE EXPRESSION PROFILE IN ADULT HYPERTROPHIC CARDIOMYOCYTES
Zhou, Juan / Xu, Xin / Liu, Jin‐Jun / Lin, Yuan‐Xi / Gao, Guang‐Dao | 2007
1199
DIABETES‐INDUCED CHANGES IN 5‐HYDROXYTRYPTAMINE MODULATION OF VAGALLY INDUCED BRADYCARDIA IN RAT HEART
García, Mónica / Morán, Asunción / Martín, M Luisa / Ortizde Urbina, A Vega / San Román, Luis | 2007
1207
GENOTYPE AND ALLELE FREQUENCIES OF N‐ACETYLTRANSFERASE 2 AND GLUTATHIONE S‐TRANSFERASE IN THE IRANIAN POPULATION
Torkaman‐Boutorabi, Anahita / Hoormand, Mahmood / Naghdi, Naser / Bakhshayesh, Masoomeh / Milanian, Iraj | 2007
1212
EARLY RENAL DENERVATION PREVENTS DEVELOPMENT OF HYPERTENSION IN GROWTH‐RESTRICTED OFFSPRING
Ojeda, Norma B / Johnson, W Russell / Dwyer, Terry M / Alexander, Barbara T | 2007
1217
AMELIORATION OF l‐THYROXINE‐INDUCED HYPERTHYROIDISM BY COUMARIN (1,2‐BENZOPYRONE) IN FEMALE RATS
Panda, Sunanda / Kar, Anand | 2007

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