EFFECTS OF AGAR AND PECTIN ON GASTRIC EMPTYING AND POST‐PRANDIAL GLYCAEMIC PROFILES IN HEALTHY HUMAN VOLUNTEERS (English)

Clinical and Experimental Pharmacology and Physiology

Dietary fibre, such as pectin, delays gastric emptying and may enhance post‐prandial glucose tolerance. Agar, which is high in fibre content, is widely used in the traditional Japanese diet. Although long‐term diet therapy with agar decreases fasting plasma glucose levels in diabetes, knowledge is lacking about the acute effects of agar on gastric emptying and the post‐prandial glycaemic profiles. The present study was designed to investigate the acute effects of agar.

Ten healthy male volunteers were studied on three occasions with three different test meals (450 kcal/500 mL): (i) a fibre‐free meal; (ii) a meal with 2.0 g agar; or (iii) a meal with 5.2 g pectin. On each occasion, participants underwent a [13C]‐acetate breath test along with serial blood sampling. To quantify gastric emptying, the half [13CO2] excretion time () and the time for maximal [13CO2] excretion rate (tlag) were determined. The post‐prandial glycaemic response was expressed as an incremental change from the fasting value at each sampling time. Data were analysed using repeated‐measures analysis of variance (anova), followed by a post hoc paired Student's t‐test with Bonferroni adjustment.

The time‐course for respiratory [13CO2] excretion differed significantly among the three test meals (P = 0.0004, anova). Compared with the control meal, [13CO2] excretion was significantly lower following consumption of the agar meal (between 40 and 105 min post‐prandially; P <� 0.025, Student's t‐test) and the pectin meal (between 40 and 180 min post‐prandially; P <� 0.025, Student's t‐test). Among the three meals, significant differences were found in (P = 0.002,anova) and tlag (P = 0.011, anova). Compared with the control meal, the agar and pectin meals exhibited a significantly prolonged (P = 0.007 and P <� 0.0001, respectively, Student's t‐test) and tlag (P = 0.006 and P = 0.002, respectively, Student's t‐test). Neither the agar nor pectin meal affected the post‐prandial glucose profile.

In healthy adults, agar and pectin delay gastric emptying but have no impact on the post‐prandial glucose response.

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Table of contents – Volume 34, Issue 11

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1091
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Faulkner, John A / Larkin, Lisa M / Claflin, Dennis R / Brooks, Susan V | 2007
1097
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Sun, Sheng‐Li / Li, Tie‐Jun / Yang, Peng‐Yuan / Qiu, Yan / Rui, Yao‐Cheng | 2007
1102
PROTEASOME INHIBITOR LACTACYSTIN ABLATES LIVER INJURY INDUCED BY INTESTINAL ISCHAEMIA–REPERFUSION
Yao, Ji‐Hong / Li, Ying‐Hua / Wang, Zhen‐Zhen / Zhang, Xue‐Song / Wang, Yu‐Zhu / Yuan, Jin‐Chan / Zhou, Qin / Liu, Ke‐Xin / Tian, Xiao‐Feng | 2007
1109
EFFECTS OF RESVERATROL ON NUMBER AND ACTIVITY OF ENDOTHELIAL PROGENITOR CELLS FROM HUMAN PERIPHERAL BLOOD
Wang, Xiao‐Bin / Huang, Jun / Zou, Jian‐Gang / Su, En‐Ben / Shan, Qi‐Jun / Yang, Zhi‐Jian / Cao, Ke‐Jiang | 2007
1116
FLAVONE INHIBITS VASCULAR CONTRACTION BY DECREASING PHOSPHORYLATION OF THE MYOSIN PHOSPHATASE TARGET SUBUNIT
Jeon, Su Bun / Kim, Gutae / Kim, Jee In / Seok, Young Mi / Kim, Sang‐Hyun / Suk, Kyoungho / Shin, Heung‐Mook / Lee, Young‐Ho / Kim, In Kyeom | 2007
1121
SPINAL α‐AMINO‐3‐HYDROXY‐5‐METHYL‐4‐ISOXAZOLEPROPIONIC ACID RECEPTORS MAY MEDIATE THE ANALGESIC EFFECTS OF EMULSIFIED HALOGENATED ANAESTHETICS
Hang, Li‐Hua / Shao, Dong‐Hua / Yang, Ying‐Hong / Dai, Ti‐Jun / Zeng, Yin‐Ming | 2007
1121
SPINAL a-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTORS MAY MEDIATE THE ANALGESIC EFFECTS OF EMULSIFIED HALOGENATED ANAESTHETICS
Hang, L. H. / Shao, D. H. / Yang, Y. H. / Dai, T. J. / Zeng, Y. M. | 2007
1126
S100B LEVELS IN THE CEREBROSPINAL FLUID OF RATS ARE SEX AND ANAESTHETIC DEPENDENT
Vicente, Évelin / Tramontina, Francine / Leite, Marina C / Nardin, Patricia / Silva, Mariane / Karkow, Ana R / Adolf, Rafael / Lucion, Aldo B / Netto, Carlos A / Gottfried, Carmem et al. | 2007
1131
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1138
EXPRESSION OF CYP3A ISOFORMS AND P‐GLYCOPROTEIN IN HUMAN STOMACH, JEJUNUM AND ILEUM
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1145
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1151
EFFECTS OF AGAR AND PECTIN ON GASTRIC EMPTYING AND POST‐PRANDIAL GLYCAEMIC PROFILES IN HEALTHY HUMAN VOLUNTEERS
Sanaka, Masaki / Yamamoto, Takatsugu / Anjiki, Hajime / Nagasawa, Kunitaka / Kuyama, Yasushi | 2007
1156
ACTIVATION OF PERIPHERAL CHEMORECEPTORS CAUSES POSITIVE INOTROPIC EFFECTS IN A WORKING HEART–BRAINSTEM PREPARATION OF THE RAT
Braga, Valdir A / Zoccal, Daniel B / Soriano, Renato N / Antunes, Vagner R / Paton, Julian F / Machado, Benedito H / Nalivaiko, Eugene | 2007
1160
RESTORATION OF ANTIBIOTIC SUSCEPTIBILITY IN METHICILLIN‐RESISTANT STAPHYLOCOCCUS AUREUS BY TARGETING MECR1 WITH A PHOSPHOROTHIOATE DEOXYRIBOZYME
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1165
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Guido, Maria C / De Carvalho Frimm, Clovis / Koike, Márcia K / Cordeiro, Fernanda F / Moretti, Ana IS / Godoy, Luiz C | 2007
1173
NITRIC OXIDE MODULATES AIR EMBOLISM‐INDUCED LUNG INJURY IN RATS WITH NORMOTENSION AND HYPERTENSION
Liu, Yen Chin / Kao, Shang Jyh / Chuang, I Chun / Chen, Hsing I | 2007
1181
NOVEL EVIDENCE SUGGESTING AN ANTI‐OXIDANT PROPERTY FOR ERYTHROPOIETIN ON VANCOMYCIN‐INDUCED NEPHROTOXICITY IN A RAT MODEL
Cetin, Hasan / Olgar, şeref / Oktem, Faruk / Ciris, Metin / Uz, Efkan / Aslan, Çaǧatay / Ozguner, Fehmi | 2007
1186
ACTIONS OF THE ENDOCANNABINOID TRANSPORT INHIBITOR AM404 IN NEUROPATHIC AND INFLAMMATORY PAIN MODELS
Mitchell, Vanessa A / Greenwood, Ruth / Jayamanne, Angelo / Vaughan, Christopher W | 2007
1191
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Zhou, Juan / Xu, Xin / Liu, Jin‐Jun / Lin, Yuan‐Xi / Gao, Guang‐Dao | 2007
1199
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García, Mónica / Morán, Asunción / Martín, M Luisa / Ortizde Urbina, A Vega / San Román, Luis | 2007
1207
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1212
EARLY RENAL DENERVATION PREVENTS DEVELOPMENT OF HYPERTENSION IN GROWTH‐RESTRICTED OFFSPRING
Ojeda, Norma B / Johnson, W Russell / Dwyer, Terry M / Alexander, Barbara T | 2007
1217
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