INVOLVEMENT OF SOMATOSTATIN RECEPTOR SUBTYPES IN MEMBRANE ION CHANNEL MODIFICATION BY SOMATOSTATIN IN PITUITARY SOMATOTROPES (English)

Clinical and Experimental Pharmacology and Physiology

Growth hormone (GH) secretion from pituitary somatotropes is mainly regulated by two hypothalamic hormones, GH‐releasing hormone (GHRH) and somatotrophin releasing inhibitory factor (SRIF).

Somatotrophin releasing inhibitory factor inhibits GH secretion via activation of specific membrane receptors, somatostatin receptors (SSTRs) and signalling transduction systems in somatotropes.

Five subtypes of SSTRs, namely SSTR1, 2, 3, 4 and 5, have been identified, with the SSTR2 subtype divided into SSTR2A and SSTR2B. All SSTRs are G‐protein‐coupled receptors.

Voltage‐gated Ca2+ and K+ channels on the somatotrope membrane play an important role in regulating GH secretion and SRIF modifies both channels to reduce intracellular free Ca2+ concentration and GH secretion.

Using specific SSTR subtype‐specific agonists, it has been found that reduction in Ca2+ currents by SRIF is mediated by SSTR2 and an increase in K+ currents is mediated by both SSTR2 and SSTR4 in rat somatotropes.

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Table of contents – Volume 34, Issue 12

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Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

1221
INVOLVEMENT OF SOMATOSTATIN RECEPTOR SUBTYPES IN MEMBRANE ION CHANNEL MODIFICATION BY SOMATOSTATIN IN PITUITARY SOMATOTROPES
Yang, Seung‐Kwon / Chen, Chen | 2007
1228
UPREGULATED ENDOTHELIN SYSTEM IN DIABETIC VASCULAR DYSFUNCTION AND EARLY RETINOPATHY IS REVERSED BY CPU0213 AND TOTAL TRITERPENE ACIDS FROM FRUCTUS CORNI
Su, Wei / Dai, De‐Zai / Liu, Hao‐Ran / Na, Tao / Dai, Yin | 2007
1234
PROTECTIVE EFFECTS OF MAGNESIUM AGAINST ISCHAEMIA–REPERFUSION INJURY THROUGH INHIBITION OF P‐SELECTIN IN RATS
Ying, Shu‐Qin / Fang, Lu / Xiang, Mei‐Xiang / Xu, Geng / Shan, Jiang / Wang, Jian‐An | 2007
1240
OATP1B1 POLYMORPHISM IS A MAJOR DETERMINANT OF SERUM BILIRUBIN LEVEL BUT NOT ASSOCIATED WITH RIFAMPICIN‐MEDIATED BILIRUBIN ELEVATION
Zhang, Wei / He, Yi‐Jing / Gan, Zhou / Fan, Lan / Li, Qing / Wang, An / Liu, Zhao‐Qian / Deng, Sheng / Huang, Yuan‐Fei / Xu, Lin‐Yong et al. | 2007
1245
RESISTANCE TO FAS‐MEDIATED APOPTOSIS IN MALIGNANT TUMOURS IS RESCUED BY KN‐93 AND CISPLATIN VIA DOWNREGULATION OF c‐FLIP EXPRESSION AND PHOSPHORYLATION
Yang, Bao‐Feng / Xiao, Chang / Li, Hong / Yang, Shi‐Jie | 2007
1252
REVERSAL OF CISPLATIN‐INDUCED CARNITINE DEFICIENCY AND ENERGY STARVATION BY PROPIONYL‐l‐CARNITINE IN RAT KIDNEY TISSUES
Aleisa, Abdulaziz M / Al‐Majed, Abdulhakeem A / Al‐Yahya, Abdulaziz A / Al‐Rejaie, Salim S / Bakheet, Saleh A / Al‐Shabanah, Othman A / Sayed‐Ahmed, Mohamed M | 2007
1260
ENDOTHELIUM‐TARGETED TRANSGENIC GTP‐CYCLOHYDROLASE I OVEREXPRESSION INHIBITS NEOINTIMA FORMATION IN MOUSE CAROTID ARTERY
Liao, Song‐Jie / Lin, Li / Zeng, Jin‐Sheng / Huang, Ru‐Xun / Channon, Keith M / Chen, Alex F | 2007
1267
INHIBITORY EFFECTS OF ENDOGENOUS l‐ARGININE ANALOGUES ON NITRIC OXIDE SYNTHESIS IN PLATELETS: ROLE IN PLATELET HYPERAGGREGABILITY IN HYPERTENSION
De Meirelles, Luisa R / Mendes‐Ribeiro, Antônio C / Santoro, Marcelle M / Mendes, Michely AP / Da Silva, Michele NSB / Mann, Giovanni E / Brunini, Tatiana MC | 2007
1272
EFFECT OF THE HEME OXYGENASE INDUCER HEMIN ON BLOOD HAEMOSTASIS MEASURED BY HIGH‐FREQUENCY ULTRASOUND
Rochefort, Gaël Y / Libgot, Rachel / Desbuards, Nicolas / Schlecht, Deborah / Halimi, Jean‐Michel / Ossant, Frederic / Eder, Veronique / Antier, Daniel | 2007
1276
Gαq‐PROTEIN CARBOXYL TERMINUS IMITATION POLYPEPTIDE GCIP‐27 ATTENUATES CARDIAC HYPERTROPHY IN VITROAND IN VIVO
Zhang, Hai‐Gang / Li, Xiao‐Hui / Zhou, Jian‐Zhi / Liu, Ya / Jia, Yi / Yuan, Zhi‐Bing | 2007
1276
Gaq-PROTEIN CARBOXYL TERMINUS IMITATION POLYPEPTIDE GCIP-27 ATTENUATES CARDIAC HYPERTROPHY IN VITRO AND IN VIVO
Zhang, H. G. / Li, X. H. / Zhou, J. Z. / Liu, Y. / Jia, Y. / Yuan, Z. B. | 2007
1282
EXPRESSION OF P2X PURINOCEPTORS IN PC12 PHAEOCHROMOCYTOMA CELLS
Sun, Ji‐Hu / Cai, Guo‐Jun / Xiang, Zheng‐Hua | 2007
1287
ASSOCIATIONS BETWEEN 45T/G POLYMORPHISM OF THE ADIPONECTIN GENE AND PLASMA ADIPONECTIN LEVELS WITH TYPE 2 DIABETES
Li, Lin‐Lin / Kang, Xiao‐Long / Ran, Xin‐Jian / Wang, Ye / Wang, Chang‐Hui / Huang, Lin / Ren, Jun / Luo, Xin / Mao, Xin‐Min | 2007
1291
SYSTEMIC PLASMA LEVELS OF NITRITE/NITRATE (NOX) REFLECT BRACHIAL FLOW‐MEDIATED DILATION RESPONSES IN YOUNG MEN AND WOMEN
Casey, Darren P / Beck, Darren T / Braith, Randy W | 2007
1294
CHRONIC SUPPLEMENTATION OF CREATINE AND VITAMINS C AND E INCREASES SURVIVAL AND IMPROVES BIOCHEMICAL PARAMETERS AFTER DOXORUBICIN TREATMENT IN RATS
Santos, Ronaldo VT / Batista, Miguel L Jr / Caperuto, Érico C / Costa Rosa, Luis FBP | 2007
1300
PRESERVATION OF MECHANICAL AND ENERGETIC FUNCTION AFTER ADENOVIRAL GENE TRANSFER IN NORMAL RAT HEARTS
Sakata, Susumu / Liang, Lifan / Sakata, Naoya / Sakata, Yuri / Chemaly, Elie R / Lebeche, Djamel / Takewa, Yoshiaki / Chen, Jiqiu / Park, Woo Jin / Kawase, Yoshiaki et al. | 2007
1307
CELLULAR DISTRIBUTION OF THE RENAL BUMETANIDE‐SENSITIVE Na–K–2Cl COTRANSPORTER BSC‐1 IN THE INNER STRIPE OF THE OUTER MEDULLA DURING THE DEVELOPMENT OF HYPERTENSION IN THE SPONTANEOUSLY HYPERTENSIVE RAT
Sonalker, Prajakta A / Tofovic, Stevan P / Jackson, Edwin K | 2007
1313
FUNCTIONAL INTERACTION BETWEEN DPI 201‐106, A DRUG THAT MIMICS CONGENITAL LONG QT SYNDROME, AND SEVOFLURANE ON THE GUINEA‐PIG CARDIAC ACTION POTENTIAL
Kang, Jiesheng / Chen, Xiao‐Liang / Reynolds, William P / Rampe, David | 2007
1317
DECREASED THRESHOLD FOR THE NITRIC OXIDE DONOR GLYCERYL TRINITRATE IN CORTISOL‐INDUCED HYPERTENSION IN HUMANS
Kelly, JJ / Tam, SH / Williamson, PM / Whitworth, JA | 2007
1319
DETECTION OF PERIVASCULAR BLOOD FLOW IN VIVO BY CONTRAST‐ENHANCED INTRACORONARY ULTRASONOGRAPHY AND IMAGE ANALYSIS: AN ANIMAL STUDY
Vavuranakis, Manolis / Papaioannou, Theodore G / Kakadiaris, Ioannis A / O'Malley, Sean M / Naghavi, Morteza / Filis, Konstantinos / Sanidas, Elias A / Papalois, Apostolos / Stamatopoulos, Ilias / Stefanadis, Christodoulos | 2007
1324
REFEREES
| 2007
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CONTENTS
| 2007

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