Dofetilide‐Induced Long QT and Torsades de Pointes (English)

in Annals of Noninvasive Electrocardiology ; 12 , 3 ; 197-202
Annals of Noninvasive Electrocardiology

Dofetilide, a new class III antiarrhythmic agent, has been approved as an antiarrhythmic agent for the treatment of atrial fibrillation and atrial flutter. Dofetilide selectively inhibits the rapid component of the delayed rectifier potassium current resulting in a prolongation of the effective refractory period. Like other drugs that affect potassium currents, the prolonged QT interval occurring in the patients treated with dofetilide can be complicated by torsades de pointes. We report four cases of dofetilide‐induced QT prolongation and torsades de pointes. We discuss the risk factors for the development of dofetilide‐induced long QT and torsades de pointes and review the current literature.

Document information

Table of contents – Volume 12, Issue 3

Show all volumes and issues

Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

Circadian Variation in QT Dispersion Determined from a 12‐Lead Holter Recording: A Methodological Study of an Age‐ and Sex‐Stratified Group of Healthy Subjects
Hansen, Stig / Rasmussen, Verner / Larsen, Klaus / Torp‐Pedersen, Christian / Jensen, Gorm Boje | 2007
Dofetilide‐Induced Long QT and Torsades de Pointes
Aktas, Mehmet K. / Shah, Abrar H. / Akiyama, Toshio | 2007
Relationship between Beat‐to‐Beat Variability of RT‐Peak and RT‐End Intervals in Normal Controls, Patients with Anxiety, and Patients with Cardiovascular Disease
Yeragani, Vikram Kumar / Berger, Ronald / Desai, Nagaraj / Bar, Karl Juergen / Chokka, Pratap / Tancer, Manuel | 2007
Association of P‐Wave Duration, Dispersion, and Terminal Force in Relation to P‐Wave Axis among Outpatients
Prajapat, Laxman / Ariyarajah, Vignendra / Frisella, Mary E. / Apiyasawat, Sirin / Spodick, David H. | 2007
C‐Reactive Protein Is Associated with Heart Rate Variability
Madsen, Trine / Christensen, Jeppe Hagstrup / Toft, Egon / Schmidt, Erik Berg | 2007
Pacemaker Longevity: The World's Longest‐Lasting VVI Pacemaker
Katz, David / Akiyama, Toshio | 2007
Variable Interatrial Conduction Illustrated in a Hypertrophic Cardiomyopathy Population
Holmqvist, Fredrik / Platonov, Pyotr G. / Carlson, Jonas / Havmöller, Rasmus / Waktare, Johan E.P. / McKenna, William J. / Olsson, S. Bertil / Meurling, Carl J. | 2007
Computer‐Aided Systematized Approach to Pediatric ECG Analysis
Molina, Marcos S. / Benjo, Alexandre M. / Molina, Alessandra I. / Favarato, Desiderio / Tobias, Nancy / Garcia, Euler de Vilhena / Ramires, José A. F. / Pastore, Carlos Alberto | 2007
Dynamic Changes in T‐Wave Amplitude during Tilt Table Testing: Correlation with Outcomes
Mayuga, Kenneth A. / Fouad‐Tarazi, Fetnat | 2007
Mental Stress May Induce QT‐Interval Prolongation and T‐Wave Notching
Andrássy, Gábor / Szabo, Attila / Ferencz, Gyöngyvér / Trummer, Zsófia / Simon, Eszter / Tahy, Ádám | 2007
Electrical and Structural Remodeling in Left Ventricular Hypertrophy—A Substrate for a Decrease in QRS Voltage?
Bacharova, Ljuba | 2007
Antiarrhythmic Induced Electrical Storm in Brugada Syndrome: A Case Report
Joshi, Sandeep / Raiszadeh, Farbod / Pierce, Walter / Steinberg, Jonathan S. | 2007
Electrocardiographic Predictors of Arrhythmic Death –“What is the Role of Atrial Fibrillation?”
Dandapantula, Hari / Chandu, Laxman | 2007
Reply to Letter to the Editor from Drs. Dandapantula and Chandu entitled “Electrocardiographic Predictors of Arrhythmic Death –“What is the Role of Atrial Fibrillation?”
McLaughlin, Michael / Zimetbaum, Peter J. | 2007

Similar titles