C‐Reactive Protein Is Associated with Heart Rate Variability (English)

In: Annals of Noninvasive Electrocardiology ;  12 ,  3 ;  216-222 ;  2007

Background: The aim of this study was to investigate the relation between low‐grade inflammation and autonomic dysfunction, both of which may be risk markers for sudden cardiac death.

Methods: A total of 269 subjects referred for elective coronary angiography because of clinically suspected coronary heart disease were included in the study. Of these 27% had a previous myocardial infarction and 70% had significant coronary stenoses. A 24‐hour Holter‐recording was obtained from all subjects, and time‐domain heart rate variability indices were analyzed. C‐reactive protein was measured using a high‐sensitivity assay.

Results: Mean SDNN was significantly higher in the lower compared to the upper hs‐CRP quartile (140 ± 34 ms vs 113 ± 29 ms; P < 0.001). Similar results were found for SDNNindex (54 ± 16 ms vs 46 ± 12 ms; P = 0.002) and SDANN (125 ± 33 ms vs 101 ± 31 ms; P < 0.001). The association was strongest for subjects with a previous myocardial infarction, subjects with significant coronary stenoses, and males. In a linear regression analysis, hs‐CRP remained an independent determinant of each of these three heart rate variability indices (all P < 0.001).

Conclusion: C‐reactive protein and heart rate variability are independently associated. This may support a link between low‐grade inflammation and autonomic dysfunction.

Table of contents – Volume 12, Issue 3

Show all volumes and issues

Tables of content are generated automatically and are based on records of articles contained that are available in the TIB-Portal index. Due to missing records of articles, the volume display may be incomplete, even though the whole journal is available at TIB.

185
Circadian Variation in QT Dispersion Determined from a 12‐Lead Holter Recording: A Methodological Study of an Age‐ and Sex‐Stratified Group of Healthy Subjects
Hansen, Stig / Rasmussen, Verner / Larsen, Klaus / Torp‐Pedersen, Christian / Jensen, Gorm Boje | 2007
197
Dofetilide‐Induced Long QT and Torsades de Pointes
Aktas, Mehmet K. / Shah, Abrar H. / Akiyama, Toshio | 2007
203
Relationship between Beat‐to‐Beat Variability of RT‐Peak and RT‐End Intervals in Normal Controls, Patients with Anxiety, and Patients with Cardiovascular Disease
Yeragani, Vikram Kumar / Berger, Ronald / Desai, Nagaraj / Bar, Karl Juergen / Chokka, Pratap / Tancer, Manuel | 2007
210
Association of P‐Wave Duration, Dispersion, and Terminal Force in Relation to P‐Wave Axis among Outpatients
Prajapat, Laxman / Ariyarajah, Vignendra / Frisella, Mary E. / Apiyasawat, Sirin / Spodick, David H. | 2007
216
C‐Reactive Protein Is Associated with Heart Rate Variability
Madsen, Trine / Christensen, Jeppe Hagstrup / Toft, Egon / Schmidt, Erik Berg | 2007
223
Pacemaker Longevity: The World's Longest‐Lasting VVI Pacemaker
Katz, David / Akiyama, Toshio | 2007
227
Variable Interatrial Conduction Illustrated in a Hypertrophic Cardiomyopathy Population
Holmqvist, Fredrik / Platonov, Pyotr G. / Carlson, Jonas / Havmöller, Rasmus / Waktare, Johan E.P. / McKenna, William J. / Olsson, S. Bertil / Meurling, Carl J. | 2007
237
Computer‐Aided Systematized Approach to Pediatric ECG Analysis
Molina, Marcos S. / Benjo, Alexandre M. / Molina, Alessandra I. / Favarato, Desiderio / Tobias, Nancy / Garcia, Euler de Vilhena / Ramires, José A. F. / Pastore, Carlos Alberto | 2007
246
Dynamic Changes in T‐Wave Amplitude during Tilt Table Testing: Correlation with Outcomes
Mayuga, Kenneth A. / Fouad‐Tarazi, Fetnat | 2007
251
Mental Stress May Induce QT‐Interval Prolongation and T‐Wave Notching
Andrássy, Gábor / Szabo, Attila / Ferencz, Gyöngyvér / Trummer, Zsófia / Simon, Eszter / Tahy, Ádám | 2007
260
Electrical and Structural Remodeling in Left Ventricular Hypertrophy—A Substrate for a Decrease in QRS Voltage?
Bacharova, Ljuba | 2007
274
Antiarrhythmic Induced Electrical Storm in Brugada Syndrome: A Case Report
Joshi, Sandeep / Raiszadeh, Farbod / Pierce, Walter / Steinberg, Jonathan S. | 2007
279
Electrocardiographic Predictors of Arrhythmic Death –“What is the Role of Atrial Fibrillation?”
Dandapantula, Hari / Chandu, Laxman | 2007
280
Reply to Letter to the Editor from Drs. Dandapantula and Chandu entitled “Electrocardiographic Predictors of Arrhythmic Death –“What is the Role of Atrial Fibrillation?”
McLaughlin, Michael / Zimetbaum, Peter J. | 2007

Similar titles