C‐Reactive Protein Is Associated with Heart Rate Variability (English)

In: Annals of Noninvasive Electrocardiology ;  12 ,  3 ;  216-222 ;  2007

Background: The aim of this study was to investigate the relation between low‐grade inflammation and autonomic dysfunction, both of which may be risk markers for sudden cardiac death.

Methods: A total of 269 subjects referred for elective coronary angiography because of clinically suspected coronary heart disease were included in the study. Of these 27% had a previous myocardial infarction and 70% had significant coronary stenoses. A 24‐hour Holter‐recording was obtained from all subjects, and time‐domain heart rate variability indices were analyzed. C‐reactive protein was measured using a high‐sensitivity assay.

Results: Mean SDNN was significantly higher in the lower compared to the upper hs‐CRP quartile (140 ± 34 ms vs 113 ± 29 ms; P < 0.001). Similar results were found for SDNNindex (54 ± 16 ms vs 46 ± 12 ms; P = 0.002) and SDANN (125 ± 33 ms vs 101 ± 31 ms; P < 0.001). The association was strongest for subjects with a previous myocardial infarction, subjects with significant coronary stenoses, and males. In a linear regression analysis, hs‐CRP remained an independent determinant of each of these three heart rate variability indices (all P < 0.001).

Conclusion: C‐reactive protein and heart rate variability are independently associated. This may support a link between low‐grade inflammation and autonomic dysfunction.

Table of contents – Volume 12, Issue 3

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Circadian Variation in QT Dispersion Determined from a 12‐Lead Holter Recording: A Methodological Study of an Age‐ and Sex‐Stratified Group of Healthy Subjects
Hansen, Stig / Rasmussen, Verner / Larsen, Klaus / Torp‐Pedersen, Christian / Jensen, Gorm Boje | 2007
Dofetilide‐Induced Long QT and Torsades de Pointes
Aktas, Mehmet K. / Shah, Abrar H. / Akiyama, Toshio | 2007
Relationship between Beat‐to‐Beat Variability of RT‐Peak and RT‐End Intervals in Normal Controls, Patients with Anxiety, and Patients with Cardiovascular Disease
Yeragani, Vikram Kumar / Berger, Ronald / Desai, Nagaraj / Bar, Karl Juergen / Chokka, Pratap / Tancer, Manuel | 2007
Association of P‐Wave Duration, Dispersion, and Terminal Force in Relation to P‐Wave Axis among Outpatients
Prajapat, Laxman / Ariyarajah, Vignendra / Frisella, Mary E. / Apiyasawat, Sirin / Spodick, David H. | 2007
C‐Reactive Protein Is Associated with Heart Rate Variability
Madsen, Trine / Christensen, Jeppe Hagstrup / Toft, Egon / Schmidt, Erik Berg | 2007
Pacemaker Longevity: The World's Longest‐Lasting VVI Pacemaker
Katz, David / Akiyama, Toshio | 2007
Variable Interatrial Conduction Illustrated in a Hypertrophic Cardiomyopathy Population
Holmqvist, Fredrik / Platonov, Pyotr G. / Carlson, Jonas / Havmöller, Rasmus / Waktare, Johan E.P. / McKenna, William J. / Olsson, S. Bertil / Meurling, Carl J. | 2007
Computer‐Aided Systematized Approach to Pediatric ECG Analysis
Molina, Marcos S. / Benjo, Alexandre M. / Molina, Alessandra I. / Favarato, Desiderio / Tobias, Nancy / Garcia, Euler de Vilhena / Ramires, José A. F. / Pastore, Carlos Alberto | 2007
Dynamic Changes in T‐Wave Amplitude during Tilt Table Testing: Correlation with Outcomes
Mayuga, Kenneth A. / Fouad‐Tarazi, Fetnat | 2007
Mental Stress May Induce QT‐Interval Prolongation and T‐Wave Notching
Andrássy, Gábor / Szabo, Attila / Ferencz, Gyöngyvér / Trummer, Zsófia / Simon, Eszter / Tahy, Ádám | 2007
Electrical and Structural Remodeling in Left Ventricular Hypertrophy—A Substrate for a Decrease in QRS Voltage?
Bacharova, Ljuba | 2007
Antiarrhythmic Induced Electrical Storm in Brugada Syndrome: A Case Report
Joshi, Sandeep / Raiszadeh, Farbod / Pierce, Walter / Steinberg, Jonathan S. | 2007
Electrocardiographic Predictors of Arrhythmic Death –“What is the Role of Atrial Fibrillation?”
Dandapantula, Hari / Chandu, Laxman | 2007
Reply to Letter to the Editor from Drs. Dandapantula and Chandu entitled “Electrocardiographic Predictors of Arrhythmic Death –“What is the Role of Atrial Fibrillation?”
McLaughlin, Michael / Zimetbaum, Peter J. | 2007

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