Low‐dose methotrexate – a therapeutical kick in TNF‐alpha antagonist treatment for recalcitrant psoriasis vulgaris (English)

In: Dermatologic Therapy   ;  27 ,  1  ;  55-59  ;  2014

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In contrast to the treatment of rheumatoid arthritis, there are few data in psoriasis vulgaris regarding the efficacy of combining tumor necrosis factor (TNF)‐alpha inhibitors and methotrexate (MTX). Indeed, combination of MTX with different TNF‐alpha inhibitors may enhance the therapeutic effects and reduce side effects because of less dosage of the single agent. The present authors present five cases in which low‐dose MTX combined with TNF‐alpha inhibitors led to impressive improvement in Psoriasis Area and Severity Index scores. Here, the present authors initiated very low‐dose MTX treatment in addition to existing TNF‐alpha inhibitor therapy to exhaust current therapy and prevent premature change of the biologic. These observations support the concept of combined treatment in recalcitrant cases of psoriasis, which need a systemically lifelong treatment when both first‐line and second‐line monotherapies fail to provide sufficient clinical response.

Table of contents – Volume 27, Issue 1

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The clinical significance of drug interactions between dermatological and psychoactive medications
Frew, John W. | 2014
Itch in familial lichen amyloidosis: effective treatment with amitriptyline in two cases
Yew, Yik Weng / Tey, Hong Liang | 2014
Desferrioxamine treatment of porphyria cutanea tarda in a patient with HIV and chronic renal failure
Vasconcelos, Pedro / Luz‐Rodrigues, H. / Santos, Carla / Filipe, Paulo | 2014
Extramammary Paget disease successfully treated with topical imiquimod 5% and tazarotene
Frances, Laura / Pascual, Jose C. / Leiva‐Salinas, Maria / Betlloch, Isabel | 2014
Efficacy of treatment with oral alitretinoin in patient suffering from lichen simplex chronicus and severe atopic dermatitis of hands
D'Erme, Angelo Massimiliano / Milanesi, Nicola / Agnoletti, Arianna Fay / Maio, Vincenza / Massi, Daniela / Gola, Massimo | 2014
Sequential treatment with intradermal incision (intracision) and 2,940‐nm Er:YAG laser for chicken pox scars
Lee, Sang Ju / Kim, Young Koo / Choi, Sun Young / Park, Kui Young / Seo, Seong Jun | 2014
Streptococcal infections of skin and PANDAS
Carelli, Rosanna / Pallanti, Stefano | 2014
Pulsed dye laser treatment for facial flat warts
Grillo, E. / Boixeda, P. / Ballester, A. / Miguel‐Morrondo, A. / Truchuelo, T. / Jaén, P. | 2014
Successful treatment of angiolymphoid hyperplasia with eosinophilia and Kimura's disease in the same patient with surgery
Jun, Ren / Liu, Xiao‐kun / Zeng, Kang | 2014
Deep vein thrombosis and lung cancer in a patient with psoriasis under anti‐tumor necrosis factor treatment: a case study
Tatarkova, Iva / Cetkovska, Petra | 2014
Randomized controlled trial comparing photodynamic therapy based on methylene blue dye and fluconazole for toenail onychomycosis
Figueiredo Souza, L. W. / Souza, S. V. T. / Botelho, A. C. C. | 2014
A combination of nonoperative treatment modalities used for treatment of keloids
Yan, Daojin / Zhao, Bocheng / Yang, Haiping / Zhu, Bin / Wang, Jing | 2014
Multiple cutaneous malignancies and cherry hemangiomas in a vitiligo patient treated with topical nitrogen mustard
Zhu, Li‐li / Zheng, Song / Wei, Huachen / Hong, Yu‐xiao / Zhang, Lan / Zhang, Li / Chen, Hong‐Duo / Gao, Xing‐Hua | 2014
Low‐dose methotrexate – a therapeutical kick in TNF‐alpha antagonist treatment for recalcitrant psoriasis vulgaris
Wilsmann‐Theis, Dagmar / Fronhoffs, Kristina / Ehler, Lin‐Kristin / Wenzel, Joerg / Bieber, Thomas / Klingmueller, Karin | 2014
Epidermolysis bullosa pruriginosa showing good response to low‐dose thalidomide – a report of two cases
Ranugha, P. S. S. / Mohanan, S. / Chandrashekar, L. / Basu, D. / Thappa, D. M. / Rajesh, N. G. | 2014
Issue Information
| 2014